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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue li Hua Zhang lian-lian Wang Wen-Wen liu Xin Yang Ming-Zhao Xiao Hao-ling Zhang juan li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Plitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

Multi-path planning algorithm based on fitness sharing and species evolution

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Journal of Marine Science and Application 2003年第1期2卷 60-65页

作者： ZHANG Jing-juan, li Xue-lian, HAO Yan-ling College of Automation, Harbin Engineering University, Harbin 150001, China College of Automation Harbin Engineering University Harbin China

A new algorithm is proposed for underwater vehicles multi-path planning. This algorithm is based on fitness sharing genetic algorithm, clustering and evolution of multiple populations, which can keep the diversity of the solution path, and decrease the operating time because of the independent evolution of each subpopulation. The multi-path planning algorithm is demonstrated by a number of two-dimensional path planning problems. The results show that the multi-path planning algorithm has the following characteristics: high searching capability, rapid convergence and high reliability.

关键词： genetic algorithm subpopulation evolution fitness sharing multi-path planning

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潞安矿区南区水化学特征述评

河北建筑科技学院学报 2000年第4期17卷 84-86页

作者：李连娟中国煤田水文地质局河北邯郸056004

从水化学角度，利用所取得的26组样品，分析论述勘察区岩溶水水化学成分形成及演化规律，全面了解勘察区岩溶水水化学组分，揭示了岩溶地下水补、迳、排条件及水质特征。

关键词：岩溶水化学特征

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong Hu Wenyi lian Kang Hu Qiuju li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

Outcome of fertility preserving treatment in patients with well-defferentiated endometrial carcinoma and severe atypical hyperplasia of the endometrium

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Outcome of fertility preserving treatment in patients with w...

中华医学会第十次全国妇产科学术会议妇科肿瘤会场（妇科肿瘤学组、妇科病理学组）

作者： Mei YU Keng SHEN Jia-xin YANG Hui-fang HUANG Ming WU ling-ya PAN Jing-he LANG li-juan lian lina GUO Jie CHEN Peking Union Medical College Chinese Academy of Medical Science

Objective To evaluate the efficiency of progestin therapy on well-differentiated endometrial carcinoma (EC) and severe atypical hyperplasia of the emdometrium(AH) and to assess the fertility outcome of the patients after treatment. Methods 44 patients(mean:29 years) were entered to our study according to our criteria including 31 cases with EC and 13 cases with *** evaluation,all patients were treated by medroxyprogesterone acetate

关键词： Outcome of fertility preserving treatment in patients with well-defferentiated endometrial carcinoma and severe atypical hyperplasia of the endometrium

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离心式喷嘴液膜破碎过程实验

推进技术 2011年第4期32卷 539-543页

作者：刘娟李清廉刘卫东王振国国防科技大学航天与材料工程学院湖南长沙410073

为了研究离心式喷嘴出口液膜破碎以及雾化锥角变化规律,对直径2.5~6 mm之间6个不同直径、不同几何特性参数的离心式喷嘴运用高速阴影设备进行实验,喷注压降从0.1~3 MPa,每次实验间隔0.2 MPa。通过实验,得到液膜破碎长度、液膜锥角随喷... 详细信息

为了研究离心式喷嘴出口液膜破碎以及雾化锥角变化规律,对直径2.5~6 mm之间6个不同直径、不同几何特性参数的离心式喷嘴运用高速阴影设备进行实验,喷注压降从0.1~3 MPa,每次实验间隔0.2 MPa。通过实验,得到液膜破碎长度、液膜锥角随喷注压降、喷孔直径以及几何特性参数的变化规律。随着喷注压降的增加,液膜破碎长度减小,液膜锥角增大,该种类型喷嘴破碎长度在40 mm左右,液膜锥角不大于60°;随着几何特性参数A值增加,同一喷注压降下的液膜破碎长度增大,液膜锥角增加;将液膜锥角实验结果与Abromvich,Lefebvre等理论公式进行了比较,在常用的喷嘴特性参数范围内,液膜锥角的变化趋势与理论公式相吻合,但实验值远小于公式计算值。

关键词：离心式喷嘴高速阴影破碎长度液膜锥角

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消糜栓质量标准研究

现代中药研究与实践 2017年第1期31卷 48-51,55页

作者：陈利娟张家连重庆市公共卫生医疗救治中心重庆400036 重庆市大足区中医院重庆402360

目的建立消糜栓的定性鉴别和含量测定的方法。方法用薄层色谱法定性鉴别消糜栓中人参茎叶总皂苷、黄柏、紫草;用HPLC法测定苦参中苦参碱、氧化苦参碱含量。结果薄层色谱方法斑点清晰,分离度好,阴性对照无干扰;苦参碱在0.316~2.528μg范... 详细信息

目的建立消糜栓的定性鉴别和含量测定的方法。方法用薄层色谱法定性鉴别消糜栓中人参茎叶总皂苷、黄柏、紫草;用HPLC法测定苦参中苦参碱、氧化苦参碱含量。结果薄层色谱方法斑点清晰,分离度好,阴性对照无干扰;苦参碱在0.316~2.528μg范围内呈良好线性关系,平均回收率为98.23%,RSD为0.82%(n=6);氧化苦参碱在0.414~3.312μg范围内呈良好线性关系,平均回收率为98.36%,RSD为0.60%(n=6)。结论所建立的定性、定量分析方法可用于该制剂的质量控制。

关键词：质量标准消糜栓苦参人参茎叶皂苷黄柏紫草

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang Jian-Qin liu Jie Chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis