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Modeling of air quality with a modified two-dimensional Eulerian model: A case study in the Pearl River Delta (PRD) region of China

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Journal of Environmental Sciences 2007年第5期19卷 572-577页

作者： CHENG Yan-li BAI Yu-hua li jin-long liU zhao-rong College of Environmental Sciences Peking University Beijing 100871 China

A modified two-dimensional Eulerian air quality model was used to simulate both the gaseous and particulate pollutant concentrations during October 21-24, 2004 in the Pearl River Delta （PRD） region, China. The most significant improvement to the model is the added capability to predict the secondary organic aerosols （SOA） concentrations because of the inclusion of the SOA formation chemistry. The meteorological input data were prepared using the CALMET meteorological model. The concentrations of aerosol-bound species such as NO3^-, NH4^＋, SO4^2-, and SOA were calculated in the fine particle size range （〈2.5 μm）. The results of the two-dimensional model were compared to the measurements at the ground level during the PRD Intensive Monitoring Campaign （IMC）. Overall, there were good agreements between the measured and modeled concentrations of inorganic aerosol components and O3. Both the measured and the modeled results indicated that the maximum hourly O3 concentrations exceeded the China National Air Quality Standard. The predicted 24-h average SOA concentrations were in reasonable agreement with those predicted by the method of minimum OC/EC ratio.

关键词： air quality model numerical simulation secondary organic aerosol inorganic aerosol

Exosomal mi R-182 regulates the effect of RECK on gallbladder cancer

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World Journal of Gastroenterology 2020年第9期26卷 933-946页

作者： Hong Zheng jin-jing Wang li-jin zhao Xiao-Rong Yang Yong-lin Yu Department of Pathology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND As the most common biliary malignancy,gallbladder cancer(GC)is an elderlybiased *** extensive studies have elucidated the molecular mechanism of microRNA 182(miR-182)and reversion-inducing-cysteine-rich protein with kazal motifs(RECK)in various cancers,the specific role of exosomal miR-182 and RECK in GC remains poorly *** To explore the relationship between exosomal miR-182/RECK and metastasis of *** Paired GC and adjacent normal tissues were collected from 78 *** polymerase chain reaction was employed to detect miR-182 and exosomal miR-182 expression,and Western blotting was conducted to determine RECK *** addition,the effects of exosomal miR-182/RECK on the biological function of human GC cells were ***,the double luciferase reporter gene assay was applied to validate the targeting relationship between miR-182 and *** Compared with normal gallbladder epithelial cells,miR-182 was highly expressed in GC cells,while RECK had low *** miR-182 could be absorbed and transferred by *** miR-182 inhibited RECK expression and promoted the migration and invasion of GC *** Exosomal miR-182 can significantly promote the migration and invasion of GC cells by inhibiting RECK;thus miR-182 can be used as a therapeutic target for GC.

关键词： Exosome miR-182 RECK Gallbladder cancer Quantitative polymerase chain reaction Therapeutic target

Cytological Behavior of Hybridization Barriers Between Oryza sativa and Oryza officinalis

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Agricultural Sciences in China 2011年第10期10卷 1489-1500页

作者： FU Xue-lin LU Yong-gen liU Xiang-dong li jin-quan zhao Xing-juan Key Laboratory of Plant Molecular Breeding Guangdong Province/College of Agriculture South China Agricultural University Guangzhou510642 P.R. China

Oryza officinalis is one of the important wild species in the tertiary gene pool of Oryza sativa. It has a number of elite genes for rice breeding in resistance or tolerance. However, breeding barriers are so serious that the gene transfer is much difficult by sexual cross method between O. sativa and O. officinalis. Characteristics of the breeding barriers were systemically studied in this paper. When both the diploid （AA, 2n=2x=24） and autotetraploid （AAAA, 2n=4x=48） cultivated rice were crossed as maternal parents with O. officinalis （CC, 2n=2x=24）, none F1 hybrid seeds were obtained. The young hybrid ovaries aborted at 13-16 d after pollinations （DAP）. By rescuing hybrid embryos, in vitro F1 plantlets were obtained in 2x×2x combinations with the crossabilities lower than 0.5%. Lower rates of double-fertilization and abnormal development of hybrid embryo and endosperm were mainly observed in both combinations of 2x×2x and 4x×2x. Free endosperm nuclei in hybrid degenerated early at 1 DAP in a large scale. Almost no normal endosperm cells formed at 3 DAP. Development of a lot of embryos ceased at globularor pear-shaped stage as well as some degenerated gradually. The hybrid plantlets were both male and female sterility. Due to the abnormal development, a diversity of abnormal embryo sacs formed in hybrids, and hybrid pollen grains were typically abortive. It showed that conflicts of genome A and C in hybrid induced abnormal meioses of meiocytes.

关键词： breeding barriers interspecific hybridization crossability hybrid sterility Oryza sativa Oryza officinalis

A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin

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Chinese Chemical Letters 2010年第5期21卷 568-571页

作者： Hai Shan jin,li Ming zhao School of Chemistry and Chemical Engineering,Xuzhou Normal University,Xuzhou 221116,China School of Chemistry and Chemical Engineering Xuzhou Normal University Xuzhou 221116 China

Hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk *** influence of the amount of solvent,base and formaldehyde toward the hydroxymethylation was *** results showed that a relatively dilute reaction solution facilitated the generation of the desired 2-hydromethyl product,while the thick reaction solution benefited the generation of the methylated quinizarins.

关键词： Marschalk reaction Hydroxymethylation Emodin Antitumor activity

Synthesis and biological evaluation of hydrazino-containing polyamine skeletons as drug delivery system

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Chinese Chemical Letters 2011年第1期22卷 119-122页

作者： Jian Hong Wang Jun Jun Zhou Song Qing Xie Qian li jin zhao Chao Jie Wang Key Lab of Natural Medicinal and Immunotechnology of Henan Province Henan University Kaifeng 475004 China

A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons. The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines （e.g., L I 210, HeLa and B16） and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B 16 cell line. Of these compounds, 6c show significant cytotoxicity on L 1210, HeLa and B 16 cell lines （IC50 value, 3.74 μmol/L, 5.66μmol/L and 4.04 μmol/L, respectively）. The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.

关键词： Polyamine conjugates Polyamine transporter Synthesis Biological activity

Novel cellular therapies for hepatobiliary malignancies

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 450-454页

作者： jing-Nan Xue Yan-Yu Wang Yun-Chao Wang Nan Zhang Long-Hao Zhang Zheng-Hui Lu li-jin zhao Hai-Tao zhao Department of liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Hepatobiliary and Pancreatic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563000China Hepatobiliary and Pancreatic Surgery Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000China

Background:The mortalities of hepatobiliary malignancies are *** the failure of conventional chemotherapy and unsatisfactory outcome of molecular targeted drugs,immune-based therapy has become a new focus of research in hepatobiliary cancers *** sources:We performed a Pub Med search with relevant articles published up to May 2022 and the following keywords:cellular immunotherapy,hepatobiliary cancer,antigen receptor T cell therapy,and receptor-engineered T *** of clinical trials was obtained from https://***/.Results:Cell therapies for hepatobiliary malignancies are at early stage of *** current review showed that cellular therapies are safe and feasible in *** findings provide an important platform for future lager scale clinical trials on immunotherapy in patients with hepatobiliary ***:With the continuous advances of cellular immunotherapy,the combination of cellular immunotherapy with surgery,chemotherapy and radiotherapy will be new therapeutic strategies for patients with hepatobiliary cancer.

关键词： Cellular therapy Chimeric antigen receptor T cell therapy Receptor-engineered T cell Hepatobiliary malignancy

Cholesterol oxidase biosensor based on a glassy carbon electrode modified with Nafion and methyl viologen

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Chinese Journal of Chemistry 1994年第4期12卷 343-347页

作者： jin, li-Tong zhao, Gui-Zhu FANG, Yu-ZhiDepartment of Chemistry, East China Normal University, Shanghai 200062, China Department of Chemistry East China Normal University Shanghai 200062 China

Cholesterol oxidase biosensor has been constructed by using bovine serum albumin and glutaraldehyde as cross linker to immobilize cholesterol oxidase and cholesterol esterase on a glassy carbon electrode modified with Nafion and methyl viologen. The biosensor has been used to determine total cholesterol in blood. The linear range of the determination is 2.5×10~7 to 1.0×10-4 mol/L. The detection limit is about 5.0×10~8 mol/L. The response time is 12 s. This biosensor has the advantage of high selectivity, sensitivity and short response time.

关键词： Biosensor cholesterol oxidase enzyme electrode.

The special shaped laser spot for driving indirect-drive hohlraum with multi-beam incidence

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High Power Laser Science and Engineering 2017年第3期5卷 49-54页

作者： Ping li Sai jin Runchang zhao Wei Wang Fuquan li Mingzhong li jingqin Su Xiaofeng Wei Research Center of Laser Fusion of China Academy of Engineering Physics

In indirect drive, reducing peak intensity of a single beam and controlling overlap of multi-beams are two opposite requirements for laser focal spot design. In this paper, an improved laser spot design technique for indirect drive built upon the geometric structures of laser propagation into hohlraum has been introduced. The proposed technique is able to generate appropriate continuous phase plate(CPP) producing a special shaped spot that can balance the opposite requirements. The corresponding CPP does not bring difficulties to the design and fabrication. Phase aberrations are more sensitive to the special shaped spot; however, it can be tolerable for the current beam control level.

关键词： beam aberration CPP focal spot optimization ICF Laser systems

Efficacy and safety of triple-antiplatelet therapy after percutaneous coronary intervention： a meta-analysis

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Chinese Medical Journal 2013年第9期126卷 1750-1754页

作者： ZHANG Yong TANG Hai-qin li jin FU zhao-xin Department of Geriatrics First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China

Background The combination of cilostazol, aspirin and clopidogrel （triple antiplatelet therapy, TAT） after a percutaneous coronary intervention has been used as an alternative therapy. We performed a meta-analysis to evaluate the efficacy and safety of TAT for patients after percutaneous coronary intervention （PCI）. Methods We systematically searched Pubmed, Embase and Web of Science databases to identify all randomized controlled trials （RCTs） that compared dual antiplatelet therapy （DAT） with and without cilostazol after PCI. All analyses were conducted using Review Manager 5.0. Results The final analysis consisted of 4474 patients from ten studies. The combined results suggested that there was a lower risk of cardiac death （relative risk （RR）=0.55, 95% confidence interval （Cl）： 0.31-0.98, P 〈0.05） and major adverse cardiac events （MACEs）（RR=0.63, 95% Cl： 0.54-0.74, P 〈0.05） in patients treated with TAT as compared to those with DAT follow-ups after six months to one year; no significant difference was observed in bleeding and non-fatal myocardial infarction （MI）（RR=1.14, 95% Cl： 0.80-1.64, P 〉0.055 RR=0.87, 95% Cl： 0.42-1.83, P 〉0.05）. However, the rate of adverse drug reaction was higher in patients receiving TAT than in patients receiving DAT （RR=2.21, 95% Cl： 1.84-2.66, P 〈0.05）. Moreover, there was a lower risk of stent thrombosis in patients treated with TAT as compared to those treated with DAT （RR=0.44, 95% Cl： 0.21-0.94, P 〈0.05）. The TAT group had a reduced risk of target lesion revascularization （TLR）（RR=0.60, 95% Cl： 0.43-0.82, P=-0.001） and target vessel revascularization （TVR） than the DAT group （RR=0.56, 95% Cl： 0.45-0.71, P 〈0.05）. The number of MACEs was lower for patients in the TAT group than in the DAT group with diabetes mellitus sub-analysis （RR=0.41, 95% Cl： 0.28-0.61, P 〈0.05）. But no significant difference was observed between the two groups regarding MACEs in patients with drug-eluting stent implantations （RR=0.82, 95% Cl： 0.65-1.03, P

关键词： triple antiplatelet therapy dual antiplatelet therapy percutaneous coronary intervention meta-analysis