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Impaired pericyte-Müller glia interaction via PDGFRβsuppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1800-1808页

作者： Wei Xu li-jin cui Xiao-Ying Yang Xiao-Yuan cui Jian Guo Guo-Xing Xu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350212Fujian ProvinceChina Fujian Institute of Ophthalmology Fuzhou 350001Fujian ProvinceChina

AIM:To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptorβ(PDGFRβ)signaling pathway in retinal pericytes on photoreceptor loss and Müller glial ***:Sprague-Dawley rats were exposed to intense light to induce retinal *** antibody against PDGFRβwere deployed to block the signaling pathway in retinal pericytes through intravitreal *** histology and Müller glial reaction were assessed following light *** vitro,normal and PDGFRβ-blocked retinal pericytes were cocultured with Müller cell line(rMC-1)to examine morphological and protein expression changes upon supplementation with light-injured supernatants of homogenized retinas(SHRs).RESULTS:PDGFRβblockage 24h prior to intense light exposure resulted in a significant exacerbation of photoreceptor *** upregulation of GFAP and p-STAT3,observed after intense light exposure,was significantly inhibited in the PDGFRβblockage *** ther upregulation of cytokines monocyte chemoattractant protein 1(MCP-1)and interleukin-1β(IL-1β)was also observed following PDGFRβ*** the in vitro coculture system,the addition of light-injured SHRs induced pericyte deformation and upregulation of proliferating cell nuclear antigen(PCNA)expression,while Müller cells exhibited neuron-like morphology and expressed ***,PDGFRβblockage in retinal pericytes abolished these cellular responses to light-induced damage,consistent with the in vivo PDGFRβblockage ***:Pericyte-Müller glia interaction plays a potential role in the endogenous repair process of retinal *** of this interaction exacerbates photoreceptor degeneration in light-induced retinal injury.

关键词： pericyte Müller glia light-induced retinal injury platelet-derived growth factor receptorβ signal pathway

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2020-2022年山东省海阳市农村中小学生吸烟状况调查

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预防医学论坛 2024年第1期30卷 61-63,80页

作者：李金萃孙发平杨新斐海阳市疾病预防控制中心山东烟台265100

目的了解2020-2022年山东省海阳市农村中小学生的吸烟状况及二手烟暴露情况,为制定中小学生控烟措施提供依据。方法采用随机整群分层抽样的方法,2020-2022年每年9-10月从山东省海阳市农村学校中选取2所小学、2所初中和1所高中的学生为... 详细信息

目的了解2020-2022年山东省海阳市农村中小学生的吸烟状况及二手烟暴露情况,为制定中小学生控烟措施提供依据。方法采用随机整群分层抽样的方法,2020-2022年每年9-10月从山东省海阳市农村学校中选取2所小学、2所初中和1所高中的学生为调查对象,进行问卷调查。共发放问卷4621份,回收有效问卷4536份。分析农村中小学生的尝试吸烟率、现在吸烟率及二手烟暴露情况。结果2020-2022年海阳市农村中小学生的尝试吸烟率为3.06%(139/4536),现在吸烟率为2.07%(94/4536)。高年级学生的尝试吸烟率、现在吸烟率较高(χ^(2)值分别为119.5、95.82,P0.05)。中小学生二手烟暴露率为44.78%(2031/4536)。高年级学生的二手烟暴露率高于低年级(χ^(2)=404.16,P<0.01),男生的二手烟暴露率高于女生(χ^(2)=98.49,P<0.01)。暴露场所为家庭1082人、其他公共场所429人、餐馆(小饭桌)349人、学校171人,差异有统计学意义(χ^(2)=1053.80,P<0.01)。结论海阳市农村中小学生存在尝试吸烟和现在吸烟现象,而且二手烟暴露率较高,家庭是农村中小学生二手烟暴露的主要场所。

关键词：中小学生农村尝试吸烟现在吸烟二手烟

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Inter-chromosomal insertions into wild-type chromosomes induced by SCRaMbLE

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 125-135页

作者： Sijie Zhou Junyanrui li Xichen cui Ying Wang Ying-jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a crucial role in shaping biological phenotypic diversity and driving species *** chromosome rearrangement and modification by LoxP-mediated evolution(SCRaMbLE)has been applied to explore large-scale genomic rearrangements,yet it has been observed that these rearrangements occur exclusively in genomic regions containing loxPsym ***,we found that SCRaMbLE of synthetic yeast harboring synthetic chromosome V and X can generate a variety of synthetic segment insertions into wild-type chromosomes,ranging from 1 to 300 ***,it was revealed that the novel insertions impacted the transcriptional level of neighboring regions and affected the production of exemplar pathway of ***,our results improve the understanding of the ability of SCRaMbLE to generate complex structural variations in nonsynthetic regions and provide a potential model to explore genomic transposable events.

关键词： genomic rearrangements synthetic yeast genome SCRaMbLE inter-chromosomal insertions synthetic biology

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Pt nanoclusters modified porous g-C_(3)N_(4)nanosheets to significantly enhance hydrogen production by photocatalytic water reforming of methanol

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Chinese Journal of Chemical Engineering 2024年第2期66卷 40-50页

作者： Yi-Fei liang jin-Rong Lu Shang-Kun Tian Wen-Quan cui li liu Hebei Provincial Key Laboratory of Environmental Photocatalytic and Electrocatalytic Materials College of Chemical EngineeringNorth China University of Science and TechnologyTangshan 063210China

For the use of green hydrogen energy,it is crucial to have efficient photocatalytic activity for hydrogen generation by water reforming of methanol under mild *** attention has been paid to gC_(3)N_(4)as a promising photocatalyst for the generation of *** improve the separation of photogenerated charge,porous nanosheet g-C_(3)N_(4)was modified with Pt nanoclusters(Pt/g-C_(3)N_(4))through impregnation and following photo-induced *** catalyst showed excellent photocatalytic activity of water reforming of methanol fo r hydrogen production with a 17.12 mmol·g^(-1)·h^(-1)rate at room temperature,which was 311 times higher than that of the unmodified g-C_(3)N_(4).The strong interactions of Pt-N in Pt/g-C_(3)N_(4)constructed effective electron transfer channels to promote the separation of photogenerated electrons and holes *** addition,in-situ infrared spectroscopy was used to investigate the intermediates of the hydrogen production reaction,which proved that methanol and water eventually turn into H_(2)and CO_(2)via formaldehyde and *** study provides insights for understanding the photocatalytic hydrogen production in the water reforming of methanol.

关键词： Water reforming of methanol Photocatalysis g-C_(3)N_(4) Pt nanoclusters Hydrogen production

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Research on the flow stability and noise reduction characteristics of quasi-periodic elastic support skin

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Defence Technology（防务技术） 2024年第3期33卷 222-236页

作者： Lu Chen Shao-gang liu Dan Zhao li-qiang Dong Kai li Shuai Tang jin cui Hong Guo Department of Mechanical and Electrical Engineering Harbin Engineering UniversityHarbin150001China

To enhance flow stability and reduce hydrodynamic noise caused by fluctuating pressure,a quasiperiodic elastic support skin composed of flexible walls and elastic support elements is proposed for fluid noise *** arrangement of the elastic support element is determined by the equivalent periodic distance and quasi-periodic *** this paper,a dynamic model of skin in a fluid environment is *** influence of equivalent periodic distance and quasi-periodic coefficient on flow stability is *** results suggest that arranging the elastic support elements in accordance with the quasi-periodic law can effectively enhance flow ***,the hydrodynamic noise calculation results demonstrate that the skin exhibits excellent noise reduction performance,with reductions of 10 dB in the streamwise direction,11 dB in the spanwise direction,and 10 dB in the normal *** results also demonstrate that the stability analysis method can serve as a diagnostic tool for flow fields and guide the design of noise reduction structures.

关键词： Flow stability Quasi-period Flexible wall Elastic support element Hydrodynamic noise

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子午岭林区木质素降解菌的筛选鉴定及降解特性研究

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陇东学院学报 2024年第5期35卷 1-6页

作者：尚菲李进翠杨佳琪刘舒婷王苇魏亚岗陇东学院农业与生物工程学院甘肃庆阳745000 甘肃省陇东生物资源保护利用与生态修复重点实验室甘肃庆阳745000 甘肃省子午岭生态系统野外科学观测研究站甘肃庆阳745000

为了筛选高效木质素降解菌,探索其产酶活性及降解情况,以碱性木质素为唯一碳源,从子午岭林区腐木样品中分离纯化,采用愈创木酚显色法、苯胺蓝脱色法进行定性复筛,对筛选出的菌株通过形态学和ITS基因序列分析进行鉴定。测定其产漆酶(Lac... 详细信息

为了筛选高效木质素降解菌,探索其产酶活性及降解情况,以碱性木质素为唯一碳源,从子午岭林区腐木样品中分离纯化,采用愈创木酚显色法、苯胺蓝脱色法进行定性复筛,对筛选出的菌株通过形态学和ITS基因序列分析进行鉴定。测定其产漆酶(Lac)、锰过氧化物酶(Mnp)、木质素过氧化物酶(lip)活性以及对碱性木质素降解率,通过扫描电镜观察其降解效果。筛选得到1株具有产木质素降解酶能力的菌株,命名为JC01,经鉴定为毛栓菌(Tramete shirsuta)。菌株JC01的产锰过氧化物酶活性最强,第6d达到最大值为120U/L;菌株JC01对碱性木质素的降解率第7d达到最高,为89.2%;通过扫描电镜观察经JC01发酵处理7d前后的碱性木质素的形态变化,发现经JC01处理后碱木质素结构呈片状,且表面疏松,出现清晰可见的孔状结构。该研究结果为木质素高效降解提供了优质菌种资源,在农业废弃物资源化利用方面具有良好的应用前景。

关键词：子午岭林区木质素降解菌降解率

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A Composite Elastomer with Photo-responsive Shape Memory and Programmable Hygroscopic Actuation Functionalities

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Chinese Journal of Polymer Science 2024年第10期42卷 1470-1478,I0009页

作者： Xiang-Xi cui li Shang Zhong-Wen liu Zhao-Tie liu jin-Qiang Jiang Guo li Key Laboratory of Syngas Conversion of Shaanxi Province School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710062China

Developing hydroscopic actuators with simultaneous high elasticity,shape programmability and tunable actuating behaviors are highly desired but still *** this study,we propose an orthogonal composite design to develop such a *** developed composite elastomer comprises carboxyl group-grafted polystyrene-block-poly(ethylene-co-butylene)-block-polystyrene(SEBS-g-COOH)as the elastic substrate,and a synthesized azobenzene derivative as the functional filler(Azo12).By surface treatment using acidic and base solutions,the carboxyl groups on the surface can reversibly transform into carboxylate groups,which render the composite tunable hygroscopic actuating *** another aspect,the added filler undergoes trans-to-cis isomerization when exposed to UV light irradiation,leading to liquefaction of the crystalline aggregates formed by Azo12 *** liquefied Azo12 molecules can autonomously resotre their trans form and reform the crystalline *** reversible change in crystralline structure is utilized to realize the shape memory property,and 5 wt%of Azo12addition is adequate for the composite to exhibit photo-responsive shape memory behavior without compromising much of the *** regualtion of external geometry by shape memory effect is effective in altering the actuating *** proposed method can be extend to designing different composites with the demonstrated functionalities.

关键词： Actuator Shape memory Photo-responsive Hygroscopic responsive Azobenzene

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Preventive effect of kiwi berry(Actinidia arguta)on loperamide-induced constipation

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Food Science and Human Wellness 2024年第3期13卷 1410-1421页

作者： Jiyue Zhang Bin li Ningxuan Gao Haikun li Xingyue cui Hanqian Jiang Siyi Tang Chenyu jin jinlong Tian College of Food Science Shenyang Agricultural UniversityShenyang 110866China

Constipation is a common intestinal *** berries can effectively prevent ***,studies have yet to be done to determine how kiwi berries prevent *** two weeks,mice in this study were continually orally gavaged with kiwi berry,loperamide,or a combination of the *** study found that the kiwi group's feces had more water than the constipated *** addition,kiwi berries can speed up gastrointestinal transit(GI),shorten the time it takes to pass the first dark stool,and dramatically enhance body weight *** the interstitial cells of Caj al(ICC)cells and colon tissues,alterations in the protein expression of vasoactive intestinal peptide(VIP),cyclic adenosine monophosphate(cAMP),protein kinase A(PKA),and aquapcrin-3(AQP3)were *** 3,6,and 12 h of ICC cells and mouse colon,the kiwi group's VIP,cAMP,PKA,and AQP3 protein expression levels were lower than those of the constipated *** kiwi berry can decrease the Firmicutes to Bacteroidetes ratio and boost the diversity and quantity of gut *** influencing the gut microbiota and VIP-cAMP-PKA-AQP3 signaling pathway,kiwi berries prevent constipation.

关键词： Kiwi berry Constipation VIP-cAMP-PKA-AQP3 Gut microbiota

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Quantum advantages for image filtering on images with efficient encoding and lower-bounded signal-to-noise ratio

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 2-12页

作者： Zidong cui Shan jin Akira Sone Xiaoting Wang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610051China Key Laboratory of Quantum Physics and Photonic Quantum Information Ministry of EducationUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Physics University of MassachusettsBoston 02125USA

Quantum image processing has long been a fascinating field,but establishing the existence of quantum speedup for all images remains *** this study,we aim to identify a subset of images for which a quantum algorithm can be developed with a guaranteed ***,we present a quantum image filtering algorithm that exhibits an exponential speedup for efficiently encoded images with a lower-bounded signal-to-noise *** approach relies on a fixed-point Grover's search to emulate the effect of Hadamard multiplication with the filtering *** demonstrate its effectiveness,we apply our method to three typical filtering ***,we emphasize the significance of the efficient-encoding assumption by illustrating that the quantum speedup may diminish for images lacking efficient *** work underscores the importance of exploring image types and features to realize potential quantum advantages in image processing.

关键词： quantum computing quantum image filtering quantum speedup

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Group Decision-Making Method of Entry Policy During a Pandemic

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Tsinghua Science and Technology 2024年第1期29卷 56-65页

作者： Chunsheng cui Baiqiu li Xianfeng Chen College of Computer and Information Engineering Henan University of Economics and LawZhengzhou 450046China Tourism College Beijing Union UniversityBeijing 100101China

Omicron,the new mutant coronavirus,has spread rapidly globally,attracting close attention from different stakeholders *** complex and constantly changing epidemic situation has had a new impact on the ***,this paper focuses on the characteristics of the rapid spread of the COVID-19 variant ***,epidemic prevention experts conduct preliminary screening as part of the existing epidemic plan database according to the current local situation,after which they sort the alternatives deemed more suitable for the *** the decision-makers identify the most divergent expert group,plan for consultation and adjustments,and finally obtain the plan with the smallest *** article aims to integrate the experts'opinions with the method of minimizing the differences,which can maximize the expert consensus and help organize the schemes that best meet the epidemic *** experts'negotiation and iteration of the differences in the initial plan align with the current complex and dynamic epidemic situation and are of great significance to the rapid formulation of plans to achieve effective prevention and control.

关键词： epidemic prevention and control group decision-making alternative ranking control policy

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