检索结果-南通市图书馆

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun lin Hou Huang Jin-jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng tang Guo-Wen Ding li-Ming Wang li-jie tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cyano migration-mediated radical-polar crossover cyclopropanation

引用

Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang Wang Yasu Chen jie li Chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China

We report a novel cyano migration-mediated radical-polar crossover process,whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently *** transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic *** studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution,leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aerodynamic Optimization and Flow Mechanism for a Compressor Cascade at Low Reynolds Number

引用

Journal of Thermal Science 2025年第1期34卷 92-109页

作者： li lin ZHANG Jianshe CHEN Caiyan tan Wei ZHANG Yanfeng Key Laboratory of light-Duty Gas-Turbine Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Key Laboratory of Science and Technology on Advanced light-duty Gas-turbine Beijing 100190China

Low-Reynolds-number effect is an important factor affecting the performance of compressors and other main components of high-altitude long-endurance unmanned aerial *** improve the flow condition and reduce flow loss under the condition of high altitude and low Reynolds number(Re),this paper proposes an optimization process based on a surrogate model,which combines the class-shape transformation method(CST),the Latin hypercube sampling(LHS)method,the light gradient-boosting machine algorithm(lightGBM),and a genetic algorithm(GA)to optimize a high-subsonic compressor *** surrogate model is verified to be accurate and can be used in the optimization *** accuracy of the GA is higher than the other algorithms under common test *** optimization results are verified by numerical simulation,and the flow differences before and after optimization are compared,especially the flow within the boundary *** changing the blade shape,the optimization process adjusts the loading distribution to delay the transition of the optimized blade on the suction surface,which changes the turbulent reattachment in the laminar separation bubble(LSB)into laminar ***,the mixing loss induced by the turbulent reattachment of the LSB and the wake loss of turbulent separation at the trailing edge are significantly reduced,and the performance of the compressor profile is finally *** addition,turbulent separation of the optimized profile is delayed reducing the range of the wake region on the suction *** this optimization process,the reduction of total pressure loss coefficient at Re of 2.5×10^(5),3.5×10^(5),and 4.5×10^(5) are 16.32%,20.76%,and 22.16%,respectively.

关键词： low Reynolds numbers compressor optimization boundary layer transition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interpreting hourly mass concentrations of PM_(2.5)chemical components with an optimal deep-learning model

引用

Journal of Environmental Sciences 2025年第5期151卷 125-139页

作者： Hongyi li Ting Yang Yiming Du Yining tan Zifa Wang State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry(LAPC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Shenyang Environmental Monitoring Center Shenyang 110167China

PM_(2.5)constitutes a complex and diversemixture that significantly impacts the environment,human health,and climate ***,existing observation and numerical simulation techniques have limitations,such as a lack of data,high acquisition costs,andmultiple *** limitations hinder the acquisition of comprehensive information on PM_(2.5)chemical composition and effectively implement refined air pollution protection and control *** this study,we developed an optimal deep learning model to acquire hourly mass concentrations of key PM_(2.5)chemical components without complex chemical *** model was trained using a randomly partitioned multivariate dataset arranged in chronological order,including atmospheric state indicators,which previous studies did not *** results showed that the correlation coefficients of key chemical components were no less than 0.96,and the root mean square errors ranged from 0.20 to 2.11μg/m^(3)for the entire process(training and testing combined).The model accurately captured the temporal characteristics of key chemical components,outperforming typical machine-learning models,previous studies,and global reanalysis datasets(such asModern-Era Retrospective analysis for Research and Applications,Version 2(MERRA-2)and Copernicus Atmosphere Monitoring Service ReAnalysis(CAMSRA)).We also quantified the feature importance using the random forest model,which showed that PM_(2.5),PM_(1),visibility,and temperature were the most influential variables for key chemical *** conclusion,this study presents a practical approach to accurately obtain chemical composition information that can contribute to filling missing data,improved air pollution monitoring and source *** approach has the potential to enhance air pollution control strategies and promote public health and environmental sustainability.

关键词： Pm2.5 chemical composition Hourly mass concentration Deep learning Bayesian optimization Feature importance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Subsection cooling system of hot rolling silicon steel and its industrial application

引用

Journal of Iron and Steel Research International 2025年第1期32卷 159-170页

作者： Qiu-na Wang Ji-quan Sun li-po Yang Hai-shen Wang li-jie Dong jie-ming li Zhen-yang Zhi Yan-wen Bi National Engineering Research Center of Flat Rolling Equipment University of Science and Technology BeijingBeijing100083China Hot Rolling Department of Qian’an Iron and Steel Corporation Shougang Company LimitedTangshan064404HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina

An online subsection cooling method for hot rolling silicon steel was designed to achieve local adjustment of transverse roll ***,it was able to meet the requirements of edge drop of the strip by using the features of online thermal ***,after the new subsection spray beam was installed at the exit of mill,the special local cooling rules were analyzed for altering the thermal crown of roll according to rolling process ***,the dynamic impact of subsection cooling on the local thermal crown could just be obtained according to the measured ***,the heat transfer coefficient was determined by different subsection cooling curves under varied rolling ***,the rolling rhythm and variable conditions were important dynamic factors of transient roll temperature in practical rolling ***,real-time calculation and presetting of the thermal crown were carried out to maximize special requirements of load roll gap on local strip *** this new method,the transient temperature and the thermal crown of roll could be quantitatively controlled *** the practical results showed that the predicted temperature was able to match the measured value by more than 95%.Meanwhile,the adjustable range of thermal crown increased by more than 2.5 ***,the qualification rate of strip edge crown has increased from the original 30%to over 70%.

关键词： Subsection cooling Thermal roll crown Multi-parameter coupling Hot rolling Silicon steel

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantum public-key crypto via EPR pairs

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 54-59页

作者： Xiang-Qun Fu Hong-Wei li Jian-Hong Shi tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering UniversityZhengzhou 450004China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

With the development of quantum computing technology,quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key *** paper designs a quantum trapdoor one-way function via EPR pairs and quantum *** on this,a new quantum public-key cryptosystem is presented,which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext *** with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition,which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Catalytic production of high-energy-density spiro polycyclic jet fuel with biomass derivatives

引用

Journal of Energy Chemistry 2025年第2期101卷 760-768页

作者： Wen-Jing Zhang Yan-Cheng Hu Yan-Hong tan Jia li Ning li Jing-Pei Cao School of Chemical Engineering and Technology China University of Mining and Technology CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

High-energy-density（HED） fuel（*** used JP-10 and RJ-4）,featuring compact 3D polycyclic structure with high strain,is of critical importance for volume-limited military aircraft,since their high density and combustion heat can provide more propulsion *** reduce the reliance on petroleum source,it is highly desirable to develop renewable alternatives for the production of strained polycyclic HED fuel,but which remains a big challenge because of the inaccessibility caused by the high strain,We herein demonstrate a three-step catalytic route towards highly strained C17and C18spirofuel with biomass *** process includes catalytic aldol condensation of renewable cyclohexanone/cyclopentanone with benzaldehyde,catalytic spiro Diels-Alder（D-A） reaction of aldol adduct with isoprene,and catalytic *** key spiro D-A reaction is enabled by the catalysis of heterogeneous Lewis acidic ionic *** chloroaluminate IL,formed by benign urea and AICl3,exhibits good catalytic performance and reusability for this *** eventual hydrodeoxygenation（HDO）over Pd/C and H-Y produces strained tricyclic spirofuel with density>0.93 g/mL,combustion heat>41 MJ/L and freezing point <-40℃,which are better than the properties of tactical fuel ***,it is anticipated that the as-prepared renewable fuels have the potential to replace traditional petroleum-derived HED fuels.

关键词： Biomass derivatives Cycloaddition High-energy-density Lewis acidic ionic liquid Spiro polycyclic fuel

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Numerical simulation for large baseline interferometric imaging altimeter

引用

Geodesy and Geodynamics 2025年第1期16卷 111-126页

作者： jie liu Bo liu Xiaonan An Haifeng Kou Bing li China Academy of Aerospace Science and Innovation

Sea topography information holds significant importance in oceanic research and the climate change detection. Radar imaging altimetry has emerged as the leading approach for global ocean observation,employing synthetic aperture radar(SAR) interferometry to enhance the spatial resolution of Sea topography. Nevertheless, current payload capacity and satellite hardware limitations prevent the extension of the interferometric baseline by enlarging the physical antenna size. This constraint hinders achieving centimeter-level accuracy in interferometric altimetry. To address this challenge, we conducted a numerical simulation to assess the viability of a large baseline interferometric imaging altimeter(LB-IIA). By controlling the baseline within the range of 600-1000 m through spiral orbit design in two satellites and mitigating baseline de-correlation with the carrier frequency shift(CFS) technique, we aimed to overcome the above limitations. Our findings demonstrate the efficacy of the CFS technique in compensating for baseline decoherence, elevating coherence from less than 0.1 to over 0.85. Concurrently. The height difference accuracy between neighboring sea surfaces reaches 1 cm within a 1 km resolution. This study is anticipated to serve as a foundational reference for future interferometric imaging altimeter development, catering to the demand for high-precision sea topography data in accurate global bathymetry inversion.

关键词： Sea topography Numerical simulation Carrier frequency shift (CFS) Large baseline interferometric imaging altimeter (LB-IIA)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Advantages of the Multimodel Ensemble Approach for Subseasonal Precipitation Prediction in China and the Driving Factor of the MJO

引用

ADVANCES IN ATMOSPHERIC SCIENCES 2025年第3期42卷 551-563页

作者： Guo, li Wu, jie li, Qingquan Jia, Xiaolong China Meteorol Adm Natl Climate Ctr Key Lab Climate Predict Studies Beijing 100081 Peoples R China Nanjing Univ Informat Sci & Technol Collaborat Innovat Ctr Forecast & Evaluat Meteorol Nanjing 210066 Peoples R China

Based on the hindcasts from five subseasonal-to-seasonal (S2S) models participating in the S2S Prediction Project, this study evaluates the performance of the multimodel ensemble (MME) approach in predicting the subseasonal precipitation anomalies during summer in China and reveals the contributions of possible driving factors. The results suggest that while single-model ensembles (SMEs) exhibit constrained predictive skills within a limited forecast lead time of three pentads, the MME illustrates an enhanced predictive skill at a lead time of up to four pentads, and even six pentads, in southern China. Based on both deterministic and probabilistic verification metrics, the MME consistently outperforms SMEs, with a more evident advantage observed in probabilistic forecasting. The superior performance of the MME is primarily attributable to the increase in ensemble size, and the enhanced model diversity is also a contributing factor. The reliability of probabilistic skill is largely improved due to the increase in ensemble members, while the resolution term does not exhibit consistent improvement. Furthermore, the Madden-Julian Oscillation (MJO) is revealed as the primary driving factor for the successful prediction of summer precipitation in China using the MME. The improvement by the MME is not solely attributable to the enhancement in the inherent predictive capacity of the MJO itself, but derives from its capability in capturing the more realistic relationship between the MJO and subseasonal precipitation anomalies in China. This study establishes a scientific foundation for acknowledging the advantageous predictive capability of the MME approach in subseasonal predictions of summer precipitation in China, and sheds light on further improving S2S predictions. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(S2S)(sic)(sic)(sic)(sic)(sic)5(sic)S2S(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(

关键词： multimodel ensemble subseasonal predictions summer precipitation S2S model MJO (sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic) S2S(sic)(sic)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combustion aerosols and suspended dust with controlled processes in Lhasa:Elemental analysis and size distribution characteristics

引用

Journal of Environmental Sciences 2025年第2期148卷 591-601页

作者： Jinglin li Zhuoga Deqing jie liang Tao Guo Jian Yao Wei liu Shanghai Institute of Applied Physics Chinese Academy of ScienceShanghai 201800China University of Chinese Academy of Science Beijing 100049China Meteorological Bureau of Tibet Autonomous Region Lhasa 850000China

To explore air contamination resulting from special biomass combustion and suspended dust in Lhasa,the present study focused on the size distribution and chemical characteristics of particulate matter(PM)emission resulting from 7 types of non-fossil pollution *** investigated the concentration and size distribution of trace elements from 7 pollution sources collected in *** Lhasa’s atmospheric particulate matter data,enrichment factors(EFs)have been calculated to examine the potential impact of those pollution sources on the atmosphere quality of *** highest mass concentration of total elements of biomass combustion appeared at PM_(0.4),and the second highest concentration existed in the size fraction 0.4-1μm;the higher proportion(12%)of toxicmetals was produced by biomass *** elemental composition of suspended dust and atmospheric particulate matter was close(except for As and Cd);the highest concentration of elements was all noted in PM_(2.5-10)(PM3-10).Potassium was found to be one of the main biomass *** proportion of Cu in suspended dust is significantly lower than that of atmospheric particulate matter(0.53%and 3.75%),which indicates that there are other anthropogenic *** EFs analysis showed that the Cr,Cu,Zn,and Pb produced by biomass combustion were highly enriched(EFs>100)in all particle *** EFs of most trace elements increased with decreasing particle size,indicating the greater influence of humanfactors on smaller particles.

关键词： Size distribution Trace elements Particulate matter Enrichment factors Lhasa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：