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新时代基础教育教研队伍建设的路径探索

教学与管理 2024年第24期 37-41页

作者：刘晓宇李高建于亚楠泰山学院教师教育研究院山东泰安271021

近年来,教育教学改革不断深入,基础教育教研工作的地位和作用日益凸显,教研队伍建设和培养已成为教育教学改革的关键和核心。新时代基础教育教研队伍建设是完善我国教育治理体系的重要举措。随着“双减”政策实施,教育教学改革和教育质... 详细信息

近年来,教育教学改革不断深入,基础教育教研工作的地位和作用日益凸显,教研队伍建设和培养已成为教育教学改革的关键和核心。新时代基础教育教研队伍建设是完善我国教育治理体系的重要举措。随着“双减”政策实施,教育教学改革和教育质量提升对教研工作提出了新要求,同时,传统的教研活动已经不能适应新形势的需要。但目前基础教育教研队伍建设存在专业素养不高、培训体系不健全、制度保障缺失等问题,需要不断提高教研队伍的综合素养、强化教研队伍的专业发展、建立完善的教研员培养机制。对此,应制定科学、合理的策略,着力解决当前教研存在的现实问题。

关键词：新时代基础教育教研队伍建设教研员 “信息技术+”

Maximizing benefit of drug-eluting stent by direct coronary stenting because of further reduction of inflammatory response

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Chinese Medical Journal 2009年第6期122卷 732-735页

作者： li jian-jun gao Run-lin Department of Cardiology Fu Wai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Coronary stents have been used as standard mechanical devices for percutaneous coronary intervention （PCI） in patients with coronary artery disease （CAD）.They provide vessel wall scaffolding and prevent early elastic recoil and restenosis, which are major limitations of balloon angioplasty. Consequently, coronary stenting has a higher successful rate of PCI and improves the clinical outcome of the patients with CAD. Because of the permanent nature of metallic stents, however, their presence on the intimal surface of a coronary artery poses a risk associated with the continuous interaction between the metal and the surrounding tissue. This can lead to long-term endothelial dysfunction or chronic inflammation and may result in many potential concerns such as in-stent neointimal hyperplasia and thrombogenesis7

关键词： drug-eluting stent direct stenting inflammation restenosis

High selectively oxidative bromination of toluene derivatives by the H_2O_2-HBr system

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Chinese Chemical Letters 2011年第4期22卷 382-384页

作者： Jie Ju Yu Jin li jian Rong gao jian Hong Jia liang Han Wei jian Sheng Yi Xia Jia The State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology Zhejiang University of TechnologyHangzhou 310032China

An aqueous solution of hydrogen peroxide and hydrogen bromide illuminated by a 60 W incandescent light bulb serves as a source of bromine *** substituted toluenes（NO2,Cl,Br,H,CH3） were high selectively brominated at the benzyl position for monobromination in CH2C12 at ice water with catalyst *** simple but effective bromination of toluene derivatives with an aqueous H2O2-HBr system is characterized with the use of inexpensive reagents and a lower impact on the environment, which make it a good alternative to the existing bromination methods.

关键词： Oxidative bromination Toluene derivatives H2O2-HBr

Effect of advanced age on plasma homocysteine levels and its association with ischemic stroke in non-valvular atrial fibrillation

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Journal of Geriatric Cardiology 2017年第12期14卷 743-749页

作者： Yan YAO li-jian gao Yong ZHOU Jing-Hua ZHAO Qiang LV jian-Zeng DONG Mei-Sheng SHANG Department of Cardiology Beijing Anzhen Hospital CapitalMedical University Beijing China Center for coronary heart disease Department of Cardiology Cardiovascular Institute & Fuwai Hospital CAMS & PUMC National Center for Heart Dis- ease Beijing China Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University Beijing China

Background Elevated homocysteine （Hcy） has been reported to be associated with cardiovascular events in atrial fibrillation （AF） pa- tients, while the age-related expression pattern of plasma Hcy in AF remains unknown. The study was aimed to investigate the effect of ad- vanced age on plasma Hcy levels and its association with ischemic stroke in non-valvular AF patients. Methods A total of 2562 consecu- tive patients with non-valvular AF and 535 controls were enrolled and divided into six age groups. Plasma Hcy levels were analyzed among different age groups, and the effect of advanced age on Hcy was investigated. Results Plasma Hcy levels did not show any difference among groups aged below 65 years, while it increased sharply in patients aged 65-74 years and aged over 75 years （15.7 ±4.6 μmol/L, 17.1 ±4.9 μmol/L, both P 〈 0.01 compared with the first four age groups）. Hcy was much higher in AF patients than in controls at the same age group （all P 〈 0.05）. The proportion of patients with hyperhomocysteinemia increased gradually with age from 32.3%, 29.2%, 31.2%, 32.4%, 45.9%, to 51.4% in six age groups. The concentration of Hcy in AF patients with ischemic stroke increased progressively with age, and was higher than those without stroke at the same age. Logistic regression analysis demonstrated that age 65-74 years [odds ratios （OR）： 1.742, 95% confidence interval （CI）： 1.223-2.482, P = 0.002] and age ≥ 75 years （OR： 2.637, 95% CI： 1.605-4.335, P 〈 0.001） were significantly independent predictors of elevated plasma Hcy levels. Conclusions Advanced age was significantly associated with elevated Hcy levels, which may provide a possible explanation for the progressive increase in ischemic stroke especially in elderly AF patients.

关键词： Advanced age Atrial fibrillation Homocysteine Ischemic stroke

Validation of Predictive Value of Patterns of Nonadherence to Antiplatelet Regimen in Stented Patients Thrombotic Risk Score in Chinese Population Undergoing Percutaneous Coronary Intervention:A Prospective Observational Study

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Chinese Medical Journal 2018年第22期131卷 2699-2704页

作者： Xue-Yan Zhao jian-Xin li Xiao-Fang Tang Jing-Jing Xu Ying Song lin jiang Jue Chen Lei Song li-jian gao Zhan gao Shu-Bin Qiao Yue-Jin Yang Run-lin gao Ro Xu Jin-Qing Yuan Coronary Heart Disease Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Epidemiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Background: The patterns of nonadherence to antiplatelet regimen in stented patients(PARIS) thrombotic risk score are a novel score for predicting the risk of coronary thrombotic events(CTEs) after percutaneous coronary intervention(PCI) with drug?eluting ***, the prognostic value of this score has not been fully evaluated in non?Euro?American PCI ***: We performed a prospective, observational study of 10,724 patients who underwent PCI in Fuwai hospital, China and evaluated the PARIS thrombotic risk score’s predictive value of CTEs in the PCI population. The area under the receiver operating characteristic curve(AUROC) was used to assess the predictive value of the PARIS score for ***: Among 9782 patients without in?hospital events, a total of 95 CTEs occurred during the 2?year follow?up. The PARIS score was significantly higher in patients with CTEs(3.38 ± 2.04) compared with patients without events(2.53 ± 1.70, P < 0.001).According to the risk stratification of the PARIS thrombotic score, the risk of CTEs in the high?risk group was 3.14 times higher than that in the low?risk group(hazard ratio [HR], 3.14; 95% confidence interval [CI], 1.92–5.13; P < 0.001). However, the risk of CTEs in the intermediate?risk and low?risk groups was not significant(HR, 1.39; 95% CI, [0.86–2.24]; P = 0.184). The PARIS score showed prognostic value in evaluating CTEs in the overall population(AUROC, 0.621; 95% CI, 0.561–0.681), the acute coronary syndrome(ACS) population(AUROC, 0.617; 95% CI, 0.534–0.700; P = 0.003), and the non?ACS population(AUROC, 0.647; 95%CI, 0.558–0.736; P = 0.001).Conclusions: In a real?world Chinese population, the PARIS thrombotic risk score shows a modest prognostic value for CTEs in patients after PCI. This score also has a predictive value for CTEs in the ACS and non?ACS subgroup populations.

关键词： Coronary Thrombosis Percutaneous Coronary Intervention Prognosis Risk Assessment

Evaluation of the Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Bleeding Score for Predicting the Long-term Out-of-hospital Bleeding Risk in Chinese Patients after Percutaneous Coronary Intervention

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Chinese Medical Journal 2018年第12期131卷 1406-1411页

作者： Xue-Yan Zhao jian-Xin li Xiao-Fang Tang Jing-Jing Xu Ying Song lin jiang Jue Chen Lei Song li-jian gao Zhan gao Shu-Bin Qiao Yue-Jin Yang Run-lin gao Bo Xu Jin-Qing Yuan Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Epidemiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： The Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients （PARIS） bleeding score is a novel score for predicting the out-of-hospital bleeding risk after percutaneous coronary intervention （PCI）. However, whether this score has the same value in non-European and American populations is unclear. This study aimed to assess the PARIS bleeding score＇s predictive value of bleeding in patients alter PCI in the Chinese population. Methods： We perforined a prospective, observational study of 10,724 patients who underwent PCI from January to December 2013, in Fuwai Hospital, China. We defined the primary end point as major bleeding （MB） according to Bleeding Academic Research Consortium definition criteria including Type 2, 3, or 5. The predictive value of the PARIS bleeding score was assessed with the area under the receiver operating characteristic （AUROC） curve. Results： Of 9782 patients, 245 （2.50%） MB events occurred during the 2 years of follow-up. The PAP, IS bleeding score was significantly higher in the MB group than that of non-MB group （4.00 [3.00, 5.00] vs. 3.00 [2.00, 5.00], Z=3.71, P 〈 0.001 ）. According to risk stratification of the PARIS bleeding score, the bleeding risk in the intermediate- and high-risk groups was 1.50 times （hazard ratio [HR]： 1.50; 95% confidence interval [CI]： 1.160-1.950; P=0.002） and 2.27 times higher （HR： 2.27; 95% CI： 1,320-3.900： P=0.003） than that in the low-risk group. The PARIS bleeding score showed a moderate predictive value for MB in the overall population （AUROC： 0.568, 95% CI： 0.532-0.605; P 〈 0.001 ） and acute coronary syndrome （ACS） subgroup （AUROC： 0.578, 95% CI： 0.530-0.626; P = 0.001 ） and tended to be predictive in the non-ACS subgroup （AUROC： 0.556, 95% CI： 0,501 0.611; P = 0.054）.

关键词： Bleeding: Percutaneous Coronary Intervention Prognosis

Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

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Asian Pacific Journal of Tropical Medicine 2014年第5期7卷 402-406页

作者： Wei gao Hai-Ying li li-Xin Wang li-Jun Hao jian-li gao Rong-Juan Zheng Chun-jiang Cai Yan-ling Si Department of Gastroenterology Tangshan Workers' Hospital Department of Spleen and Stomach Tangshan TCM Hospital

Objective:To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension ***:All rats were randomly divided into normal control group,cirrhosis and treatment *** was used to establish rat model of cirrhotic portal *** necrotic tissue of gastric mucosa ulcer focus,degree of neutrophils infiltration at the ulcer margin,portal pressure,portal venous flow,abdominal aortic pressure,abdominal aortic blood flow at front end,gastric mucosal blood flow（GMBF）,glycoprotein（GP）of gastric mucosa,basal acid secretion,H’ back-diffusion,gastric mucosal damage index,NO,prostaglandin E2（PGE2） and tumor necrosis factor-α（TNF-α） were determined respectively,and the pathological changes of gastric mucosa were also observed by ***:Compared with cirrhosis group and the control group,the ulcer bottom necrotic material,gastric neutrophil infiltration and UI of the treatment group were all decreased significantly（P<0.01）,GMBF value,GP values,serum NO,PGE2,TNF- a were all significantly ***:Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

关键词： Omeprazole Cirrhotic portal hypertension Gastric mucosal injury Prostaglandins Tumor necrosis factor-alpha

Novel process for facile preparation of mesoporous silica-based materials with controllable pore structure from coal fly ash Author links open overlay panel

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Particuology 2024年第8期91卷 128-137页

作者： jian-ming gao Zhen li Shujia Ma Yuanyuan Zhang Fangqin Cheng Institute of Resources and Environment Engineering State Environmental Protection Key Laboratory of Efficient Utilization Technology of Coal Waste ResourcesShanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related WastesShanxi UniversityTaiyuan 030006China

Extraction of silica from fly ash to produce mesoporous silica materials is one of the most important utilization *** silica could not be synthesized on a large-scale by conventional sol-gel *** this paper,facile preparation of mesoporous silica with controllable pore structure from fly ash by the template-free process via two steps of mineral phase transformation and selective acid etching was *** influence of crystalline structure and acid etching degree on structure of as-synthesized mesoporous silica materials was revealed,as well as mechanism of crystalline structure transformation and pore structure *** results show that mullite and quartz could be transformed into acid-soluble kaliophilite when fly ash reacted with K_(2)CO_(3)at temperature of 800-1100℃.The hexagonal kaliophilite would be transformed into orthorhombic KAlSiO_(4)-O1 phase when the temperature is controlled at 1100℃.Mesoporous silica with specific surface area of 475.93 m^(2)/g and 642.57 m^(2)/g could be synthesized from activated fly ash with kaliophilite and KAlSiO_(4)-O1 phase crystalline *** controlling the degree of acid etching,mesoporous silica materials with different pore structures can be *** paper provides a cost-effective and large-scale process for the preparation of mesoporous silica materials with controllable pore structure from solid waste fly ash.

关键词： Fly ash Mesoporous silica Crystal transformation Acid etching Controllable pore structure

Impact of Proton-pump Inhibitors on the Pharmacodynamic Effect and Clinical Outcomes in Patients Receiving Dual Antiplatelet Therapy after Percutaneous Coronary Intervention： A Propensity Score Analysis

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Chinese Medical Journal 2017年第24期130卷 2899-2905页

作者： Pei Zhu Zhan gao Xiao-Fang Tang Jing-Jing Xu Yin Zhang li-jian gao Jue Chen Shu-Bin Qiao Yue-Jin Yang Run-lin gao Bo Xu Jin-Qing Yuan Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China

Background：Prior studies have reported controversial conclusions regarding the risk of adverse cardiovascular events in patients using proton-pump inhibitors （PPIs） combined with clopidogrel therapy,causing much uncertainty in clinical *** sought to evaluate the safety of PPIs use among high-risk cardiovascular patients who underwent percutaneous coronary intervention （PCI） in a long-term follow-up ***：A total of 7868 consecutive patients who had undergone PCI and received dual antiplatelet therapy （DAPT） at a single center from January 2013 to December 2013 were *** diphosphate （ADP）-induced platelet aggregation inhibition was measured by modified thromboelastography （mTEG） in 5042 *** score matching （PSM） was applied to control differing baseline *** proportional hazards regression was used to evaluate the 2-year major adverse cardiovascular and cerebrovascular events （MACCEs）,as well as individual events,including all-cause death,myocardial infarction,unplanned target vessel revascularization,stent thrombosis,and ***：Among the whole cohort,27.2% were prescribed *** ADP-induced platelet aggregation inhibition by mTEG was significantly lower in PPI users than that in non-PPI users （42.0 ± 30.9% vs.46.4 ± 31.4%,t =4.435,P 〈 0.001）.Concomitant PPI use was not associated with increased MACCE through 2-year follow-up （12.7% vs.12.5%,x2 =0.086,P =0.769）.Other endpoints showed no significant differences after multivariate adjustment,regardless of ***：In this large cohort of real-world patients,the combination of PPIs with DAPT was not associated with increased risk of MACCE in patients who underwent PCI at up to 2 years of follow-up.

关键词： Clopidogrel Drug Interactions Percutaneous Coronary Intervention Proton-pump lnhibitors