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Osteoinduction by Ca-P biomaterials implanted into the muscles of mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 582-590页

作者： Rui-na YANG Feng YE li-jia cheng Jin-jing WANG Xiao-feng LU Yu-jun SHI Hong-song FAN Xing-dong ZHANG Hong BU Key Laboratory of Transplant Engineering and lmmunology Ministry of Health West China Hospital Sichuan University Chengdu 610041 China National Engineering Research Center for Biomaterials Sichuan University Chengdu 610065 China Department of Pathology West China Hospital Sichuan University Chengdu 610041 China

The osteoinduction of porous biphasic calcium phosphate ceramics (BCP) has been widely reported and documented,but little research has been performed on rodent animals,e.g.,*** this study,we report osteoinduction in a mouse *** mice were divided into two *** materials (Sample A) and control ceramics (Sample B) were implanted into the leg muscle,*** mice in each group were killed at 15,30,and 45 d after *** A and Sample B were harvested and used for hematoxylin and eosin (HE) staining,immunohistochemistry (IHC) staining,and Alizarin Red S staining to check bone formation in the *** analysis showed that no bone tissue was formed 15 d after implantation (0/5) in either of the two ***-formed bone tissues were observed in Sample A at 30 d (5/5) and 45 d (5/5) after implantation;the average amounts of newly-formed bone tissues were approximately 5.2% and 8.6%,***,we did not see any bone tissue in Sample B until 45 d after ***-related molecular makers such as bone morphogenesis protein-2 (BMP-2),collagen type I,and osteopontin were detected by IHC staining in Sample A 30 d after *** addition,the newly-formed bone was also confirmed by Alizarin Red S *** this is the report of osteoinduction in the rodent animal on which all the biotechnologies were available,our results may contribute to further mechanism research.

关键词： Osteoinduction Hydroxyapatite/β-tricalcium phosphate Biphasic calcium phosphate Osteogenesis

Multi-USV Formation Collision Avoidance via Deep Reinforcement Learning and COLREGs

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2349-2351页

作者： cheng-cheng Wang Yu-Long Wang li jia the Shanghai Key Laboratory of Power Station Automation Technology and also with the School of Mechatronic Engineering and Automation Shanghai University IEEE

Dear Editor,This letter focuses on the collision avoidance for a multi-unmanned surface vehicle(multi-USV) system. A novel multi-USV collision avoidance(MUCA) algorithm is proposed. Firstly, in order to get a more reasonable collision avoidance policy, reward functions are constructed according to international regulations for preventing collisions at sea(COLREGS) and USV dynamics.

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The Crystallization Behavior of L-Poly(lactic acid)/Polypropylene Blends:The Acceleration for Both L-Poly(lactic acid)and Polypropylene

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Chinese Journal of Polymer Science 2024年第6期42卷 775-786页

作者： Shuang-cheng li Wei-jia Zhou Wen-Jie Wu Jun Shao Shui-liang Chen Hao-Qing Hou Sheng Xiang College of Chemistry&Chemical Engineering and Nanofiber Engineering Center of jiangxi Province Jiangxi Normal UniversityNanchang330022China National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China

For a polymer/polymer dismissible blend with two crystallizable components,the crystallization behavior of different components and the reciprocal influences between different crystals are interesting and important,but did not investigate in *** this study,the L-poly(lactic acid)/polypropylene(PLLA/PP)blends with different weight ratios were prepared by melt mixing and the crystallization behavior of the blends were *** showed that the crystalline structures of PLLA and PP were not altered by the *** the crystallization of PLLA,both the diffusion of chain segments and crystallization rate were enhanced under the existence of PP *** the crystallization of PP,its crystallization rate was depressed under the existence of amorphous PLLA molecular *** the PP crystallized from the existence of PLLA crystals,although the diffusion rate of PP was reduced by PLLA crystals,the nucleation positions were obviously enhanced,which accelerated the formation of PP *** investigation would supply more basic data for the application of PLLA/PP blend.

关键词： L-poly(lactic acid) Polypropylene Blends Crystalization behavior Crystallization acceleration

Implementation of Flight Simulation System with Vega

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Computer Aided Drafting,Design and Manufacturing 2007年第1期17卷 50-53页

作者： YANG Wei-jia li cheng-gui School of Instrumentation Science ＆ Optoelectronics Engineering Beijing University of Aeronautics and Astronautics Beijing 100083 China

Flight path and plane maneuver are controlled by joystick. Collision detection is supported to verify the bumping of plane against surrounding objects. Crash of plane is highlighted by generating explosive flames.

关键词： computer application flight simulation Vega collision detection visualization

Weak Merging Scenario of CLASH Cluster A209

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Research in Astronomy and Astrophysics 2024年第4期24卷 174-182页

作者： Wen-cheng Feng Heng Yu Hai-Hui Zhao Xiao-Lan Hou Shu-Mei jia cheng-Kui li Yu-lin cheng Paolo Tozzi Ming Sun Yong Chen Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China Department of Astronomy Yunnan UniversityKunming 650091China INAF—Osservatorio Astrofisico di Arcetri Largo E.Fermi50122 FirenzeItaly Department of Astronomy University of VirginiaP.O.Box 400325CharlottesvilleVA 22904-4325USA

We study the structural and dynamical properties of A209 based on Chandra and XMM-Newton *** obtain detailed temperature,pressure,and entropy maps with the contour binning method,and find a hot region in the NW *** X-ray brightness residual map and corresponding temperature profiles reveal a possible shock front in the NW direction and a cold front feature in the SE *** with the galaxy luminosity density map we propose a weak merger scenario.A young sub-cluster passing from the SE to NW direction could explain the optical subpeak,the intracluster medium temperature map,the X-ray surface brightness excess,and the X-ray peak offset together.

关键词： X rays:galaxies:clusters galaxies:clusters:intracluster medium galaxies:clusters:Abell 209

Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea

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Defence Technology（防务技术） 2024年第1期31卷 179-191页

作者： Shiyu jia cheng Wang Wenlong Xu Dong Ma Fangfang Qi State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute for Advanced Technology Shandong UniversityJinan250061China

In recent years,explosion shock wave has been considered as a signature injury of the current military *** strong shock wave is lethal to the human body,weak shock wave can cause many more lasting *** investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual *** results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not *** shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic *** overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample *** the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three *** this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are *** layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective *** the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm *** overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of s

关键词： Free-field explosion Weak shock wave mitigation Polyurea Polyurethane foam Multi-layered composites

Propagation Properties of Shock Waves in Polyurethane Foam based on Atomistic Simulations

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Defence Technology（防务技术） 2024年第1期31卷 117-129页

作者： Zhiqiang Hu jianli Shao Shiyu jia Weidong Song cheng Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Porous materials are widely used in the field of protection because of their excellent energy absorption *** this work,a series of polyurethane microscopic models are established and the effect of porosity on the shock waves is studied with classical molecular dynamics ***,shock Hugoniot relations for different porosities are obtained,which compare well with the experimental *** pores collapse and form local stress wave,which results in the complex multi-wave structure of the shock *** microstructure analysis shows that the local stress increases and the local velocity decreases gradually during the process of pore collapse to complete ***,it leads to stress relaxation and velocity *** shock stress peaks can be fitted with two exponential functions,and the amplitude of attenuation coefficient decreases with the increase of ***,the pore collapse under shock or non-shock are discussed by the entropy increase rate of the *** energy is dissipated mainly through the multiple interactions of the waves under *** energy is dissipated mainly by the friction between atoms under non-shock.

关键词： Polyurethane foam Shock wave Attenuation Atomistic simulation

Constrained reinforcement learning with statewise projection: a control barrier function approach

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Science China(Information Sciences) 2024年第3期67卷 136-154页

作者： Xinze JIN Kuo li Qingshan jia Department of Automation Tsinghua University

Safety is a critical issue for reinforcement learning(RL), as it may be risky for some actual applications if the learning process involves unsafe exploration. Instead of formulating constraints as expectationbased in constrained RL, considering statewise safety in constrained RL is more meaningful. This work aims to address the issue of safe projection in RL by introducing a control barrier function that inherently learns a safe policy through a set certificate. We seek to analyze some theoretical properties of safe projection in the learning process, including convergence and performance bound, and extend the discussion into ensembles and guided controllers. Moreover, we approach analytical solutions for deterministic and stochastic system dynamics. Experimental results in different tasks show that the proposed method achieves better effects in terms of both performance and safety.

关键词： reinforcement learning safe projection control barrier function

Isoferulic acid affords the antiviral potential and restrains white spot syndrome virus proliferation in crayfish(Procambarus clarkii)

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Aquaculture and Fisheries 2024年第4期9卷 581-589页

作者： cheng Chen jia liu Bingke li Tao Wang Erlong Wang Gaoxue Wang Northwest A&F University Shenzhen Research Institute ShenzhenGuangdong518057China College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi712100China

White spot syndrome virus(WSSV),the causative agent of White spot disease(WSD),not only caused huge economic losses,but also greatly limited the development of crustacean breeding *** herbs are widely used and have great application potential in antiviral *** thist study,the antiviral effects of 11 Chinese herb extracts were evaluated in Procambarus clarkii(crayfish)model of WSSV infection,among which Cimicifuga foetida *** showed the highest inhibition rate(88.22%)against WSSV *** this basis,the anti-WSSV effect of Isoferulic acid(IFA),a major bioactive component of Cimicifuga foetida L.,was further *** results showed that IFA significantly inhibited WSSV replication(96.57%,50 mg/kg)in a dose-dependent manner and significantly improved the survival of WSSV-challenged *** had the potential preventive and therapeutic effect against WSSV infection,and the preventive effect was better than the therapeutic ***,IFA suppressed the expression of the immediate early gene ie1,the DNA polymerase gene DNApol and envelope protein gene Vp28 to inhibit WSSV replication,activated TLR,CTL and ProPo genes expression to block ie1 transcription,and suppressed BAF,STAT,NF-κb and Crustin 1 genes expression to elevate innate immunity against WSSV ***,IFA upregulated the cMnSOD,mMnSOD,CAT and GST genes expression,and downregulated the COX-1 and COX-2 genes expression to balance the oxidative stress and inflammatory damage caused by WSSV *** study provides a theoretical basis and meaningful reference for the development of IFA as a highly effective and practical anti-WSSV drug.

关键词： Isoferulic acid(IFA) Anti-WSSV Innate immunity Anti-oxidative Anti-inflammatory Procambarus clarkii