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Impact of next-generation sequencing on antimicrobial treatment in immunocompromised adults with suspected infections

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World Journal of Emergency Medicine 2024年第2期15卷 105-110页

作者： jia li jiazhen Luo Tao Hu ling cheng Weiwei Shang li Yan Department of Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

BACKGROUND:Prompt pathogen identification can have a substantial impact on the optimization of antimicrobial *** objective of the study was to assess the diagnostic value of next-generation sequencing(NGS)for identifying pathogen and its clinical impact on antimicrobial intervention in immunocompromised patients with suspected ***:This was a retrospective *** January and August 2020,47 adult immunocompromised patients underwent NGS testing under the following clinical conditions:1)prolonged fever and negative conventional cultures;2)new-onset fever despite empiric antimicrobial treatment;and 3)afebrile with suspected infections on *** data,including conventional microbial test results and antimicrobial treatment before and after NGS,were *** were analyzed according to documented changes in antimicrobial treatment(escalated,no change,or deescalated)after the NGS ***:The median time from hospitalization to NGS sampling was 19 *** relevant pathogens were detected via NGS in 61.7% of patients(29/47),more than half of whom suffered from fungemia(n=17),resulting in an antimicrobial escalation in 53.2% of patients(25/47)and antimicrobial de-escalation in 0.2% of patients(1/47).Antimicrobial changes were mostly due to the identification of fastidious organisms such as Legionella,Pneumocystis jirovecii,and *** the remaining three cases,NGS detected clinically relevant pathogens also detected by conventional cultures a few days *** antimicrobial treatment was subsequently adjusted according to the susceptibility test ***,NGS changed antimicrobial management in 55.3%(26/47)of patients,and conventional culture detected clinically relevant pathogens in 14.9% of the patients(7/47).CONCLUSION:With its rapid identification and high sensitivity,NGS could be a promising tool for identifying relevant pathogens and enabling rapid appropriate treatment in immunocompromised patients w

关键词： Immunocompromised patients Next-generation sequencing Antimicrobial management

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Inner-shell ionization cross sections of atoms by positron impact

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Communications in Theoretical Physics 2024年第6期76卷 142-147页

作者： Yuan-cheng Wang jia Ma li-Guang jiao Stephan Fritzsche College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China Helmholtz-Institut Jena D-07743 JenaGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH D-64291 DarmstadtGermany College of Science Shenyang Aerospace UniversityShenyang 110136China College of Physics Jilin UniversityChangchun 130012China Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena07743 JenaGermany

The relativistic binary-encounter-Bethe model with Wannier-type threshold law is employed to obtain the inner-shell ionization cross sections of multi-electron atoms(Ni,Cu,Y,Ag,Au,Yb,Ta,and Pb)for positron impact energies from the thresholds up to 105ke *** is good agreement between the present calculations and the experimental *** constant in the acceleration term derived from the Wannier law is determined to be 0.2 and 0.5 for the K-and L-shells,respectively.

关键词： positron scattering ionization cross section binary-encounter-Bethe model

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BaCe_(0.8)Fe_(0.1)Ni_(0.1)O_(3−δ)-impregnated Ni-GDC by phase-inversion as an anode of solid oxide fuel cells with on-cell dry methane reforming

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Journal of Advanced Ceramics 2024年第6期13卷 834-841页

作者： Yanya liu Jun Luo cheng li Bo liu Dong Yan jian li lichao jia School of Materials Science and Engineering State Key Laboratory of Materials Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074China

BaCe_(0.8)Fe_(0.1)Ni_(0.1)O_(3−δ)(BCFN)in a perovskite structure is impregnated consecutively by BCFN solution and BCFN suspension into a phase-inversion prepared NiO–Gd_(0.1)Ce_(0.9)O_(2−δ)(GDC)scaffold as an anode for solid oxide fuel cells(SOFCs)with on-cell dry reforming of methane(DRM).The whole pore surface of the scaffold is covered by small BCFN particles formed by BCFN solution impregnation;the large pores near the scaffold surface are filled by BCFN aerogels with a high specific surface area produced by BCFN suspension impregnation,which act as a catalytic layer for on-cell *** reduction,the anode consists of a Ni–GDC scaffold and BCFN particles with exsolved FeNi3 *** BCFN-impregnated Ni–GDC anode has higher electrical conductivity,electrochemical activity,and resistance to carbon deposition,with which the cell shows maximum power densities between 1.44 and 0.92 W·cm^(−2) when using H_(2) and between 1.09 and 0.50 W·cm^(−2) when using CO_(2)–CH_(4) at temperatures ranging from 750 to 600℃.A stable performance at 400 mA·cm^(−2) and 700℃is achieved using 45%CO_(2)–45%CH_(4)–10%N_(2) for more than 400 h without carbon deposition,benefiting from the impregnated BCFN aerogel with a high specific surface area and water adsorbability.

关键词： aerogel solid oxide fuel cells(SOFCs) phase-inversion dry reforming of methane(DRM) carbon resistance

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Increase of chiral sensing ability in host-guest chemistry by magnetic anisotropy

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Science China Chemistry 2024年第8期67卷 2775-2782页

作者： jia-liang Chen Bin li Feng Yang Tiesheng Shi Xun-cheng Su State Key Laboratory of Elemento-organic Chemistry Tianjin Key Laboratory of Biosensing and Molecular RecognitionCollege of ChemistryNankai UniversityTianjin 300071China College of Chemistry Chemical Engineering and Materials ScienceZaozhuang UniversityZaozhuang 277160China

Enantiomeric molecules generally play distinct functions in chemistry,biology,and *** physical and chemical properties of chiral analytes lay difficulty in discrimination and quantification of the *** report herein an efficient approach of increasing the chiral sensing ability ofβ-cyclodextrin(β-CD),a widely used host molecule,in the hostguest chemistry by magnetic anisotropy.A rigid and chiral lanthanide binding tag was attached to theβ-CD to amplify the changes of nuclear magnetic resonance(NMR)signals in the host-guest recognition *** installation of the paramagnetic lanthanide ion inβ-CD greatly enhances the enantiomeric discrimination up to 30-fold in comparison with the diamagneticβ-CD *** addition,the magnitude of the paramagnetic effects is tunable according to the diverse range of paramagnetic strength of the lanthanide *** reported method significantly increases the chiral sensing ability ofβ-CD,which can be applied to other host *** transferred paramagnetic effects,pseudocontact shifts(PCSs)and paramagnetic relaxation enhancements(PREs),from the host to the guest molecules,are valuable structural restraints to determine the absolute stereochemistry of the chiral *** strategy does not need modification of the analytes and is complementary to the reported analytical methods that rely on the functionalization of the chiral analytes.

关键词： chiral recognition nuclear magnetic resonance host-guest chemistry magnetic anisotropy lanthanide ions

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Stress-assisted corrosion mechanism of 3Ni steel by using gradient boosting decision tree machining learning method

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1311-1321页

作者： Xiaojia Yang Jinghuan jia Qing li Renzheng Zhu Jike Yang Zhiyong liu Xuequn cheng Xiaogang li Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China AECC Key Laboratory of Advanced Corrosion and Protection of Aeronautical Materials AECC Beijing Institute of Aeronautical MaterialsBeijing 100095China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China

Traditional 3Ni weathering steel cannot completely meet the requirements for offshore engineering development,resulting in the design of novel 3Ni steel with the addition of microalloy elements such as Mn or Nb for strength enhancement becoming a *** stress-assisted corrosion behavior of a novel designed high-strength 3Ni steel was investigated in the current study using the corrosion big data *** information on the corrosion process was recorded using the galvanic corrosion current monitoring *** gradi-ent boosting decision tree(GBDT)machine learning method was used to mine the corrosion mechanism,and the importance of the struc-ture factor was *** exposure tests were conducted to verify the calculated results using the GBDT *** indic-ated that the GBDT method can be effectively used to study the influence of structural factors on the corrosion process of 3Ni ***-ferent mechanisms for the addition of Mn and Cu to the stress-assisted corrosion of 3Ni steel suggested that Mn and Cu have no obvious effect on the corrosion rate of non-stressed 3Ni steel during the early stage of *** the corrosion reached a stable state,the in-crease in Mn element content increased the corrosion rate of 3Ni steel,while Cu reduced this *** the presence of stress,the increase in Mn element content and Cu addition can inhibit the corrosion *** corrosion law of outdoor-exposed 3Ni steel is consistent with the law based on corrosion big data technology,verifying the reliability of the big data evaluation method and data prediction model selection.

关键词： weathering steel stress-assisted corrosion gradient boosting decision tree machining learning

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Strong,tough,and thermally conductive nacre-inspired boron nitride nanosheet/epoxy layered nanocomposites

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Nano Research 2024年第2期17卷 820-828页

作者： Huagao Wang Rongjian Lu Lei li cheng liang jia Yan Rui liang Guoxing Sun Lei jiang Qunfeng cheng School of Chemistry Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of EducationBeihang UniversityBeijing 100191China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China Department of Stomatology Fifth Medical CenterChinese PLA General HospitalBeijing 100039China Department of Engineering Science Faculty of Innovation EngineeringMacao University of Science and TechnologyAvenida Wai LongTaipaMacao 999078 China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipaMacao 999078China Institute of Energy Materials Science(IEMS) University of Shanghai for Science and TechnologyShanghai 200093China

Thermally conductive polymer nanocomposites integrated with lightweight,excellent flexural strength,and high fracture toughness(KIc)would be of great use in many ***,achieving all of these properties simultaneously remains a great *** by natural nacre,here we demonstrate a lightweight,strong,tough,and thermally conductive boron nitride nanosheet/epoxy layered(BNNEL)*** of the layered structure and enhancing the interfacial interactions through hydrogen bonding and Si–O–B covalent bonding,the resulting nacre-inspired BNNEL nanocomposites show high fracture toughness of~4.22 MPa·m^(1/2),which is 7 folds as high as pure ***,the BNNEL nanocomposites demonstrate sufficient flexural strength(~168.90 MPa,comparable to epoxy resin),while also being lightweight(~1.23 g/cm^(3)).Additionally,the BNNEL nanocomposites display a thermal conductivity(κ)of~0.47 W/(m·K)at low boron nitride nanosheet loading of 2.08 vol.%,which is 2.7 times higher than that of pure epoxy *** developed nacre-inspired strategy of layered structure design and interfacial enhancement provides an avenue for fabricating high mechanical properties and thermally conductive polymer nanocomposites.

关键词： nacre-inspiration nanocomposites flexural strength fracture toughness(KIc) thermal conductivity

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Synergistic effects of multiscale TiC and dual-phase structure on tensile properties of particle-reinforced steel

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Journal of Iron and Steel Research International 2024年第5期31卷 1232-1245页

作者： Ye jia Xiang-tao Deng Qi Wang cheng-ru li Hao Wu Zhao-dong Wang State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

The conventional melting methods were used to obtain in situ TiC particle-reinforced dual-phase steel,followed by hot rolling and heat treatment *** aim was to investigate the effect of TiC particles on the fracture behavior of dual-phase steel at different annealing temperatures,by analyzing the microstructure and tensile behavior of the multiscale TiC particle-reinforced dual-phase *** results showed that TiC particles precipitated in the as-cast microstructure of dual-phase steel were distributed along the grain *** hot rolling,the grain boundary-like morphology of the micron-sized TiC particles was disrupted,and the particles became more refined and evenly distributed in the *** tensile tests revealed that the strength of the TiC particle-reinforced dual-phase steel increased with increasing martensite content,while the elongation *** results were similar to those of conventional *** addition of 1 vol.%multiscale TiC particles improved the strength of the dual-phase steel but did not affect elongation of the *** and holes were primarily concentrated around the TiC particles rather than at the interface of martensite and *** main causes of crack sprouting were TiC particle interface cracking and TiC particle internal ***,the study demonstrated the potential of multiscale TiC particle-reinforced dual-phase steel as a strong and tough *** refined distribution of TiC particles in the matrix improved the strength of the material without compromising its *** results also highlighted the importance of careful selection of reinforcement particles to avoid detrimental effects on the fracture behavior of the material.

关键词： TiC particle Dual-phase structure TiC-reinforced dual-phase steel Tension Fracture behavior

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CO_(2)flooding in shale oil reservoir with radial borehole fracturing for CO_(2)storage and enhanced oil recovery

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Petroleum Science 2024年第1期21卷 519-534页

作者： jia-cheng Dai Tian-Yu Wang Jin-Tao Weng Kang-jian Tian li-Ying Zhu Gen-Sheng li State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China China National Oil and Gas Exploration and Development Company limited Beijing100034China

This study introduces a novel method integrating CO_(2)flooding with radial borehole fracturing for enhanced oil recovery and CO_(2)underground storage,a solution to the limited vertical stimulation reservoir volume in horizontal well fracturing.A numerical model is established to investigate the production rate,reservoir pressure field,and CO_(2)saturation distribution corresponding to changing time of CO_(2)flooding with radial borehole fracturing.A sensitivity analysis on the influence of CO_(2)injection location,layer spacing,pressure difference,borehole number,and hydraulic fractures on oil production and CO_(2)storage is *** CO_(2)flooding process is divided into four *** in layer spacing will significantly improve oil production rate and gas storage ***,serious gas channeling can occur when the spacing is lower than 20 *** the pressure difference between the producer and injector,the borehole number,the hydraulic fracture height,and the fracture width can also increase the oil production rate and gas storage *** analysis shows that layer spacing and fracture height greatly influence gas storage and oil *** outcomes are expected to provide a theoretical basis for the efficient development of shale oil reservoirs in the vertical direction.

关键词： Shale oil Radial borehole fracturing Embedded discrete fracture model Enhanced oil recovery Carbon storage

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Work-function-induced interfacial electron redistribution of MoO_(2)/WO_(2) heterostructures for high-efficiency electrocatalytic hydrogen evolution reaction

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Rare Metals 2024年第2期43卷 489-499页

作者： Tong-Fei li Jing li Lu-Ping Zhang jia-Wei Ke Meng-Xing Fan li-Fang Zhang cheng-Wei Deng Yi Sun Tao Qian cheng-lin Yan School of Chemistry and Chemical Engineering Nantong UniversityNantong226019China jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China Aerospace Hydrogen Energy Technology(Shanghai)Co.Ltd. Shanghai201800China Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou215006China light Industry Institute of Electrochemical Power Sources Suzhou215006China

The engineering of the electronic configurations of active sites,together with the production of more accessible active sites through heterostructure design,has been established as a forceful methodology for boosting water electrolysis ***,a facile approach is developed to fabricate well-dispersed MoO_(2) and WO_(2) nanoparticles with abundant heterointerfaces entrapped in N,P-doped carbon nanofibers(referred to as MoO_(2)/WO_(2)@N,P-CNFs hereafter)as hydrogen evolution reaction(HER)electrocatalysts in alkaline and acidic *** spectroscopic analyses and theoretical findings manifest that the heterointerface formed by the work function modulation of MoO_(2)/WO_(2) triggers the spontaneous electron redistribution from MoO_(2)to WO_(2) and a built-in electric field,which is essential to promote water adsorption,optimize the H-intermediate adsorption energy,result in the enhanced charge transfer efficiency,and ultimately increase the intrinsic HER ***,the intimate confinement of MoO_(2)/WO_(2) heterostructures in the porous carbon substrate can restrain the active sites from unfavorable coarsening and detachment,thus ensuring facilitated HER kinetics and outstanding structural *** a result,MoO_(2)/WO_(2)@N,P-CNFs exhibit superior catalytic HER performance in acidic and basic solutions,requiring 118 and 95 mV overpotentials to achieve 10 mA·cm^(−2),respectively,surpassing a number of reported non-noble metal-based *** work provides guidelines for the rational design and construction of special metallic heterocomponents with optimized interfacial electronic structure for various electrochemical technologies.

关键词： Electrospinning MoO_(2)/WO_(2) heterostructure Work function Hydrogen evolution reaction

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Numerical analysis of the correlation between fluid dynamic modes and hydrodynamic noise in flows around a three-dimensional circular cylinder

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Journal of Hydrodynamics 2024年第1期36卷 119-129页

作者： jia-jia Qin Ming-xin Zou Yuan Zhuang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Wuhan Second Ship Design and Research Institute Wuhan430205China

The flow around a circular cylinder for Re=1000 is characterized by flow separation and Karman vortex *** typical flow features can be captured to study the correlation between fluid fields and sound *** this paper,the three-dimensional circular cylinder is taken as the research object,and the probes of surface fluctuating pressure and far field sound pressure are arranged every 10°.The directional diagram and the coherence of fluctuating pressure and sound pressure are *** relationship between the flow mode and hydrodynamic noise is studied by using dynamic mode decomposition(DMD).The characteristics of the dipole and quadrupole sound source term of a long span cylinder are *** results show that at the angles between 30°–120°and 190°–350°,the fluctuating pressure contributes more to the generation of dipole *** quadrupole sound source shows three-dimensional effects,which is more obvious in a cylinder with large spanwise length.

关键词： Pressure coherence dynamic mode decomposition flow-sound correlation circular cylinder

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