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Constructing lithium-Free Anode/Separator Interface via 3D Carbon Fabric Scaffold for Ultrasafe lithium Metal Batteries

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Research 2024年第3期2023卷 359-368页

作者： Dongdong li Shengchen Yang Zijian zheng Wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China Department of Materials Chemistry Huzhou University1 Xueshi RoadHuzhou 313000China Laboratory for Advanced Interfacial Materials and Devices School of Fashion and TextilesDepartment of Applied Biology and Chemical TechnologyResearch Institute for Intelligent Wearable Systems(RI-IWEAR)Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityHong Kong SAR 999077China

Metallic lithium represents a promising anode candidate to be utilized in future high-energy lithium ***,the undesirable dendrite growth and fragile solid-electrolyte interphase(SEI)pose critical challenge for pursuing further practical *** contrast to traditional approaches of using inert/lithiophilicity coating,here,we demonstrate a reverse strategy of introducing a highly conductive and lithophobic carbon fabric(CF)scaffold on lithium foil to guide a favorable nucleation site of lithium far away from the anode/separator *** CF scaffold with high conductivity can couple with inner electric field for achieving a uniform distribution of the lithium-ion flux,while the lithophobic feature offers the condition to guide the preferred deposition of lithium onto the underlying lithium foil,which greatly reduces the risk of dendrite-induced short ***,the SEI immersed in the CF scaffold is well supported by CF fibers and therefore exhibits extremely high stability during charge–discharge *** a result,the lithium/CF anodes show>2,000-h stable cycling at 0.5 mA cm−*** metal batteries equipped with our lithium/CF anode deliver a high capacity retention of~99.99%per cycle,i.e.,retain~97.3%capacity after 200 *** unique interface-regulation strategy is versatile for various conductive scaffolds(e.g.,ultrathin and ultralight conductive fabrics),exhibiting high superiority for highly safe lithium metal batteries.

关键词： lithium equipped versatile

Side Information-Based Stealthy False Data Injection Attacks Against Multi-Sensor Remote Estimation

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1054-1056页

作者： Haibin Guo Zhong-hua Pang Chao li the Key Laboratory of Fieldbus Technology and Automation of Beijing North China University of TechnologyBeijing 100144China

Dear Editor,This letter investigates a novel stealthy false data injection(FDI)attack scheme based on side information to deteriorate the multi-sensor estimation performance of cyber-physical systems(CPSs).Compared with most existing works depending on the full system knowledge,this attack scheme is only related to attackers'sensor and physical process *** design principle of the attack signal is derived to diverge the system estimation ***,it is proven that the proposed attack scheme can successfully bypass the residual-based ***,all theoretical results are verified by numerical simulation.

关键词： estimation scheme system

The crosstalk between enteric nervous system and immune system in intestinal development,homeostasis and diseases

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Science China(life Sciences) 2024年第1期67卷 41-50页

作者： Xindi Wang Chenbo Ding hua-Bing li Shanghai Institute of Immunology State Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism Shanghai Jiao Tong University School of MedicineShanghai 200025China

The gut is the largest digestive and absorptive organ,which is essential for induction of mucosal and systemic immune responses,and maintenance of metabolic-immune *** intestinal components contain the epithelium,stromal cells,immune cells,and enteric nervous system(ENS),as well as the outers,such as gut microbiota,metabolites,and *** dyshomeostasis of intestinal microenvironment induces abnormal intestinal development and functions,even colon diseases including dysplasia,inflammation and *** recent studies have identified that ENS plays a crucial role in maintaining the immune homeostasis of gastrointestinal(GI)*** crosstalk between ENS and immune cells,mainly macrophages,T cells,and innate lymphoid cells(ILCs),has been found to exert important regulatory roles in intestinal tissue programming,homeostasis,function,and *** this review,we mainly summarize the critical roles of the interactions between ENS and immune cells in intestinal homeostasis during intestinal development and diseases progression,to provide theoretical bases and ideas for the exploration of immunotherapy for gastrointestinal diseases with the ENS as potential novel targets.

关键词： enteric nervous system macrophages T cells innate lymphoid cells neuro-immune interactions

Unconventional Fluorescent and Multi-responsive Polysiloxane:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第5期42卷 579-590,I0006页

作者： Xiao-Di li Shu-Sheng li Xu-Bao Jiang Xiao-li Zhu Xiang zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China College of Chemical Engineering Tianjin UniversityTianjin300072China Foshan(Southern China)Institute for New Materials Foshan528200China

Owing to their high significance in fundamental study and diverse applications,stimuli-responsive and fluorescent polymers,particularly those with cluster-triggered emission(CTE)featured by non-conjugated chromophores,have drawn tremendous attention in recent *** this work,fluorescent and multi-responsive polysiloxane(FRPS)was synthesized by hydrolytic condensation polymerization of 3-aminopropyl methyl diethoxysilane(APMS)with 3-(N-isopropyl propionamide)iminopropyl methyl diethoxysilane(APMS-NIP),which was formed in situ through aza-Michael addition between APMS and N-isopropyl *** was not only highly sensitive to temperature,pH and CO_(2) in water,but also showed an enhanced and stimuli-adjustable fluorescence *** effects of monomer feeding,pH and CO_(2) on its lower critical solution temperature and fluorescent property were *** fluorescence emission was ascribed to CTE *** addition,FRPS was shown to be highly potential as physiological indicator for cell imaging,and for controlled release and trace detection of *** study provides therefore a type of stimuli-responsive and fluorescent material for potential applications in biomedical fields,and it is also of great significance for understanding of the fluorescence mechanism of polysiloxane-based stimuli-responsive polymers.

关键词： Polysiloxane Multi-responsiveness Cluster-triggered emission Cell imaging Controlled drug release

Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells

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World Journal of Stem Cells 2024年第3期16卷 267-286页

作者： Tong Wu Fu zheng Hong-Yi Tang hua-Zhi li Xin-Yu Cui Shuai Ding Duo liu Cui-Ying li Jiu-Hui Jiang Rui-li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root ***-intensity pulsed ultrasound(liPUS),a noninvasive physical therapy,has been shown to promote bone fracture *** is also reported that liPUS could reduce the duration of orthodontic treatment;however,how liPUS regulates the bone metabolism during the orthodontic treatment process is still *** To investigate the effects of liPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying *** A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue *** vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and liPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red *** expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via *** The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),*** could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by ***,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by ***,the osteogenic differentiation of hBMSCs increased by liPUS could be attenuated by YAP siRNA ***,liPUS increased alveolar

关键词： Low-intensity pulsed ultrasound Bone resorption Osteogenesis Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells Orthodontic tooth movement

Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 744-757页

作者： lifan lin Xinmiao li Yifei li Zhichao Lang Yeping li Jianjian zheng Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Department of Urology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China

liver fibrosis is primarily driven by the activation of hepatic stellate cells(HSCs),a process associated with *** Rb1(GRb1),a major active component extracted from Panax ginseng,inhibits HSC ***,the potential role of GRb1 in mediating HSC ferroptosis remains *** study examined the effect of GRb1 on liver fibrosis both in vivo and in vitro,using CCl4-induced liver fibrosis mouse model and primary HSCs,LX-2 *** findings revealed that GRb1 effectively inactivated HSCs in vitro,reducing alpha-smooth muscle actin(a-SMA)and type I collagen(Col1A1)***,GRb1 significantly alleviated CCl4-induced liver fibrosis in *** a mechanistic standpoint,the ferroptosis pathway appeared to be central to the antifibrotic effects of ***,GRb1 promoted HSC ferroptosis both in vivo and in vitro,characterized by increased glutathione depletion,malondialdehyde production,iron overload,and accumulation of reactive oxygen species(ROS).Intriguingly,GRb1 increased Beclin 1(BECN1)levels and decreased the System Xc-key subunit *** experiments showed that BECN1 silencing inhibited GRb1-induced effects on HSC ferroptosis and mitigated the reduction of SLC7A11 caused by ***,BECN1 could directly interact with SLC7A11,initiating HSC *** conclusion,the suppression of BECN1 counteracted the effects of GRb1 on HSC inactivation both in vivo and in ***,this study highlights the novel role of GRb1 in inducing HSC ferroptosis and promoting HSC inactivation,at least partly through its modulation of BECN1 and SLC7A11.

关键词： Ginsenoside Rb1 Ferroptosis liver fibrosis Hepatic stellate cells

A case study of continental shelf waves in the northwestern South China Sea induced by winter storms in 2021

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Acta Oceanologica Sinica 2024年第1期43卷 59-69页

作者： Junyi li Chen Zhou Min li Quanan zheng Mingming li lingling Xie Laboratory of Coastal Ocean Variation and Disaster Prediction College of Ocean and MeteorologyGuangdong Ocean UniversityZhanjiang 524088China Key Laboratory of Climate Resources and Environments in Continent Shelf Sea and Deep OceanDepartment of Education of Guangdong ProvinceZhanjiang 524088China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081China Department of Atmospheric and Oceanic Science University of MarylandCollege ParkMaryland 20742USA

This study aims to investigate characteristics of continental shelf wave(CSW)on the northwestern continental shelf of the South China Sea(SCS)induced by winter storms in *** and cruise observations,tidal gauge data at stations Hong Kong,Zhapo and Qinglan and sea surface wind data from January 1 to February 28,2021 are used to examine the relationship between along-shelf wind and sea level *** events of CSWs driven by the along-shelf sea surface wind are detected from wavelet spectra of tidal gauge *** signals are triply peaked at periods of 56 h,94 h and 180 h,propagating along the coast with phase speed ranging from 6.9 m/s to18.9 m/*** dispersion relation shows their property of the Kelvin mode of *** develop a simple method to estimate amplitude of sea surface fluctuation by along-shelf *** results are comparable with the observation data,suggesting it is *** mode 2 CSWs fits very well with the mooring current velocity *** results from rare current help to understand wave-current interaction in the northwestern SCS.

关键词： continental shelf waves Ekman transport Kelvin mode wavelet analysis northwestern South China Sea

Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao Rong Song-hua liu Ming-zheng Tang Zhi-Hang Wu Guo-Rong Ma Xiao-Feng li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis liver cancer

Effective peroxydisulfate activation by CQDs-MnFe_(2)O_(4)@ZIF-8 catalyst for complementary degradation of bisphenol A by free radicals and non-radical pathways

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Chinese Chemical Letters 2024年第5期35卷 371-379页

作者： Shuo li Xinran liu Yongjie zheng Jun Ma Shijie You Heshan zheng College of Chemistry and Chemical Engineering Qiqihar UniversityQiqihar 161006China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

The present study reported fabrication of novel carbon quantum dots-MnFe_(2)O_(4)@ZIF-8(CQDs-MFO@ZIF-8)by using co-precipitation hydrothermal method for activation of peroxydisulfate(PDS)to degrade bisphenol A(BPA),one of important emerging organic pollutants in water ***-MFO@ZIF-8 served as a highly efficient thermal activated PDS catalyst with high catalytic degradation efficiency,reusability and *** catalyst achieved almost completely removal of 20.0 mg/L BPA within 5.0 min,and the degradation efficiency remained higher than 83%after 5 consecutive *** radicals(^(·)OH,SO_(4)^(·-)and^(·)O_(2)^(-))and non-free radicals((1)O_(2))were generated in the thermal PDS-activation system,in which singlet oxygen((1)O_(2))played a dominant role in the degradation of *** potential toxicity of BPA degradation intermediates was analyzed upon the culture of *** and Chlorella sorokiniana by using Ecological Structure-Activity Relationship Model(ECOSAR)*** catalytic performances of BPA degradation by CQDs-MFO@ZIF-8 were evaluated for treatment of different practical water samples to further verify the feasibility of practical *** study provides proof-in-concept demonstration of new nanomaterials for enhanced catalytic water decontamination.

关键词： Bisphenol A Degradation Peroxydisulfate ^(1)O_(2) Toxicity analysis