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多中心成人早期前体T细胞白血病/淋巴瘤的临床特征及预后研究

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中国实验血液学杂志 2024年第1期32卷 120-124页

作者：李晸华罗澜杨萍李艳邹德慧高春记景红梅北京大学第三医院血液内科北京100191 中国医学科学院、北京协和医学院血液病医院(血液学研究所) 天津300020 解放军总医院第一医学中心血液内科北京100853

目的:对3个血液学中心的成人早期前体T细胞白血病/淋巴瘤(ETP-ALL/LBL)患者进行回顾性分析,总结其临床特点、治疗及预后影响因素。方法:收集2006年1月至2019年1月来自北京大学第三医院、解放军第一医学中心和中国医学科学院血液学研究所... 详细信息

目的:对3个血液学中心的成人早期前体T细胞白血病/淋巴瘤(ETP-ALL/LBL)患者进行回顾性分析,总结其临床特点、治疗及预后影响因素。方法:收集2006年1月至2019年1月来自北京大学第三医院、解放军第一医学中心和中国医学科学院血液学研究所3个血液研究中心共113例T淋巴母细胞白血病/淋巴瘤(T-ALL/LBL)患者的临床数据资料,对其中ETP-ALL/LBL及非ETP-ALL/LBL患者的临床特征及预后进行分析比较。结果:113例T-ALL/LBL患者中,13例诊断为ETP-ALL/LBL(11.5%),其中男性患者11例(84.6%),中位年龄28(18-53)岁。与非ETP-ALL/LBL患者相比,ETP-ALL/LBL患者在年龄、性别、纵隔大包块发生率、临床分期、IPI评分、白细胞水平、乳酸脱氢酶水平方面差异无统计学意义。在13例ETP-ALL/LBL患者中,9例(69.2%)获得完全缓解,ETP-ALL/LBL患者较非ETP-ALL/LBL患者化疗诱导缓解率无统计学差异。在单纯化疗未进行异基因造血干细胞移植的患者中,ETP-ALL/LBL组较非ETP-ALL/LBL组显示出更差的5年生存率(0 vs 7.1%,P=0.008),而在进行异基因造血干细胞移植的患者中,两组5年生存率无统计学差异(37.5%vs 40.2%,P>0.05)。多因素Cox回归分析提示,诱导治疗达到完全缓解、异基因造血干细胞移植以及乳酸脱氢酶水平为影响T-ALL/LBL的独立预后因素。结论:ETP-ALL/LBL较其他类型T-ALL/LBL患者诱导化疗反应率无显著差异,诱导缓解后续贯异基因造血干细胞移植巩固治疗对于提高ETP-ALL/LBL患者远期生存率具有重要意义。

关键词：早期前体T细胞白血病/淋巴瘤 T淋巴母细胞白血病/淋巴瘤预后

Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing 1,2,4-Triazolinone Moiety

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Chemical Research in Chinese Universities 2013年第3期29卷 466-472页

作者： liU Zhuo PAN li liYong-hong WANG Su-hua li zheng-ming State Key Laboratory of Elemento-Organic Chemistry Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China

A series of new sulfonylureas incorporating 1,2,4-triazolinone moiety was synthesized, which were further bio-assayed for the herbicidal activity against four herbs, representative of monocotyledons and dicotyledons. Some of them exhibited high potency to inhibit the growth of dicotyledons（Bassica napus and Arnaranthus retroflexus） in the pot experiment. Compounds 9a and 9b also displayed an excellent herbicidal activity against Bassica napus at a concentration of 15 g/hectare, which were comparable with commercial triasulfuron.

关键词： Sulfonylurea herbicide Acetohydroxyacid synthetase(AHAS) 1,2,4-Triazolinone derivative Protox Herbicidal activity

PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality

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动物学研究 2024年第5期 1037页

作者： Chun-Xue Niu Jia-Wei li Xiao-li li lin-lin Zhang Yan Lang Zhen-Bo Song Chun-Lei Yu Xiao-Guang Yang Hai-Feng Zhao Jia-ling Sun li-hua zheng Xue Wang Ying Sun Xiao-Hong Han Guan-Nan Wang Yong-li Bao National Engineering Laboratory for Druggable Gene and Protein Screening Northeast Normal University China International Joint Research Center for Human Stem Cell Bank Northeast Normal University Jilin Institute for Drug Control

Serine protease 50（PRSS50/TSP50） is highly expressed in spermatocytes. Our study investigated its role in testicular development and spermatogenesis. Initially,PRSS50 knockdown was observed to impair DNA synthesis in spermatocytes. To further explore this, we generated PRSS50 knockout(Prss50-/-) mice（Mus musculus）, which exhibited abnormal spermatid nuclear compression and reduced male fertility. Furthermore,dysplastic seminiferous tubules and decreased sex hormones were observed in 4-week-old Prss50-/-mice,accompanied by meiotic progression defects and increased apoptosis of spermatogenic cells. Mechanistic analysis indicated that PRSS50 deletion resulted in increased phosphorylation of extracellular signal-regulated protein kinases 1 and 2（ERK1/2） and elevated levels of MAP kinase phosphatase 3（MKP3）, a specific ERK antagonist, potentially accounting for testicular dysplasia in adolescent Prss50-/-mice. Taken together, these findings suggest that PRSS50 plays an important role in testicular development and spermatogenesis, with the MKP3/ERK signaling pathway playing a significant role in this process.

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Synthesis, Crystal Structure and Insecticidal Activities of Novel Neonicotinoid Derivatives

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Chemical Research in Chinese Universities 2010年第3期26卷 380-383页

作者： ZHAO Yu WANG Gang li Yong-qiang WANG Su-hua li zheng-ming State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic Chemistry National Pesticide Engineering Research Center（Tianjin） Nankai University Tianjin 300071 P. R. China

Ten new N-oxalyl derivatives of neonicotinoid compound were designed and synthesized. Their structures were confirmed by ^1H NMR spectra, elemental analysis and X-ray diffraction. The preliminary insecticidal activities of the new compounds were evaluated. The results of bioassays indicate that the title Compounds exhibit moderate insecticidal activities. Surprisingly, the insecticidal activity of compound 7b against bean aphids at 200 mg/kg is 100%, which is comoarable to that of the commercialized imidacloprid.

关键词： Neonicotinoid N-Oxalyl derivative Insecticidal activity Bean aphid Imidacloprid

Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing Thiadiazol Moiety

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Chemical Research in Chinese Universities 2008年第1期24卷 32-35页

作者： GUO Wan-cheng liU Xing-hai li Yong-hong WANG Su-hua li zheng-ming Institute of Elemento-Organic Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China

Thirteen novel sulfonylureas containing thiadiazole moiety were synthesized in a two-step reaction. Their structures were determined using IR, ^1H NMR, HRFTMS, and elemental analysis. Herbicidal activities of these compounds were determined in the green house bio-assay. The results show that four compounds among them exhibit some activity toward four tested herbs.

关键词： Sulfonylurea Synthesis Herbicidal activity

Data Mining Ontology Development for High User Usability

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 51-56页

作者： li Yu-hua LU zheng-ding SUN Xiao-lin WEN Kun-mei li Rui-xuan College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074Hubei China

This paper mainly introduces the development and implementation of the user centered data mining service ontology on Universal Knowledge Grid （UKG）. UKG is an ontology-based grid architecture model to build large-scale distributed knowledge discovery system on the grid. The data mining ontology services are the main service offering by UKG. It can meet the user requirements of knowledge discovery in different domains and different hierarchies and make the system exoteric, extensible and high usable. A data min- ing solution for money laundering is introduced.

关键词： data mining ontology usability universal knowledge grid

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智能电网低频振荡均匀阻尼控制研究

自动化技术与应用 2024年第1期43卷 9-13页

作者：李晶赵宏伟叶萌陈志聪李政华广东电网有限责任公司广州供电局电力调度控制中心广东广州510620 东方电子有限公司山东烟台264000

低频振荡会破坏电气设备,严重的会导致智能电网的崩溃,传统控制方法在参数调节方面存在不足。为此提出智能电网低频振荡均匀阻尼控制方法。应用Prony算法辨识低频振荡模态,提取模态信息,深入分析低频振荡共振机理,选取低频振荡抑制设备(... 详细信息

低频振荡会破坏电气设备,严重的会导致智能电网的崩溃,传统控制方法在参数调节方面存在不足。为此提出智能电网低频振荡均匀阻尼控制方法。应用Prony算法辨识低频振荡模态,提取模态信息,深入分析低频振荡共振机理,选取低频振荡抑制设备(PSS),计算PSS的等值阻尼系数,合理调节PSS参数,再通过多台PSS的协作实现了智能电网低频振荡的均匀阻尼控制。实验数据表明:所研究方法有效地缩短了低频振荡抑制设备参数调节时间,增大了不同低频振荡模式的阻尼比,应用效果较好。

关键词：智能电网低频振荡均匀阻尼控制等值阻尼系数参数调节

Role of Vickers ligament in the Pathogenesis of Madelung Deformity

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当代医学科学（英文） 2024年第4期44卷 735-740页

作者： Ge XIONG Wei zheng li-hua GONG Department of Hand Surgery Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China Department of Pathology Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

Objective:The Vickers ligament is thought to hinder the growth of palmar ulnar radius by tethering the lunate to the radius,leading to Madelung *** purpose of this study was to clarify the nature of the Vickers ligament and investigate its pathogenesis in Madelung deformities based on our observation of the Vickers ***:All 22 patients(33 wrists)with Madelung deformities treated surgically between 2018 and 2022 were *** diagnosis was confirmed radiographically in all *** three-dimensional computed tomography(3D-CT)data of 16 patients(19 wrists)were *** resonance imaging(MRI)data were available for 9 patients(14 wrists).Wrist arthroscopy was used in 4 *** Vickers ligament was resected and submitted for histopathological examination in 8 *** outcomes,3D-CT,MRI,arthroscopy,surgical findings,and histopathology of the Vickers ligament were ***:The 3D-CT revealed that the Vickers ligament originated in the metaphysis and formed a metaphyseal defect at the palmar ulnar *** the sequential MR coronal images,the Vickers ligament could be divided into 3 branches,extending to the lunate,triquetrum and ulnar *** and surgical findings revealed that the nature of the Vickers ligament was the stretched palmar ligament of the *** histopathology results revealed ligamentous tissue and fibrocartilaginous metaplasia with a structure similar to that of the triangular fibrocartilage complex(TFCC).Conclusions:The Vickers ligament is not a separate aberrant *** nature of the Vickers ligament is a combination of the stretched TFCC ligament(palmar radioulnar ligament,ulnotriquetral ligament and ulnolunate ligament)and radiolunate *** possible pathogenesis of Madelung deformity might be focal early epiphyseal closure at the middle part of the sigmoid notch,which leads to focal growth retardation of the radius and pulls palmar ligaments proximally to for

关键词： Madelung deformity Vickers ligament computed tomography magnetic resonance imaging pathogenesis

5种豆科绿肥作物种子萌发期与苗期的抗旱性研究

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草原与草坪 2024年第2期44卷 182-191页

作者：彭亚萍朱文露吴基正李正华唐云会周凯云南农业大学动物科学技术学院云南昆明650000

【目的】本文围绕绿肥作物抗旱性的研究,为筛选出适宜干旱地区的绿肥品种提供理论依据。【方法】以毛苕子(Vicia villosa)、光叶紫花苕(*** ***)、紫云英(Astragalus sini⁃cus)、草木樨(Melilotus officinalis)、箭筈豌豆(***)5种绿肥... 详细信息

【目的】本文围绕绿肥作物抗旱性的研究,为筛选出适宜干旱地区的绿肥品种提供理论依据。【方法】以毛苕子(Vicia villosa)、光叶紫花苕(*** ***)、紫云英(Astragalus sini⁃cus)、草木樨(Melilotus officinalis)、箭筈豌豆(***)5种绿肥作物为研究对象,设置0%、5%、10%、15%和20%的聚乙二醇(PEG-6000)高渗溶液模拟干旱胁迫,萌发期测定发芽率、发芽势并计算萌发指数、抗旱指数和隶属函数值,苗期测定可溶性糖、脯氨酸、丙二醛含量以及电导率等指标,计算隶属函数值。【结果】PEG-6000浓度为5%和10%时,除箭筈豌豆外,其他绿肥作物的发芽率均高于对照,说明低浓度的PEG-6000对种子萌发具有一定的促进作用。随着胁迫浓度的升高,5种绿肥作物的发芽率、发芽势、萌发指数及抗旱系数不断下降,根据隶属函数综合分析评估指标值得出5种绿肥种子抗旱性顺序为:紫云英>草木樨>光叶紫花苕>箭筈豌豆>毛苕子。苗期可溶性糖含量、脯氨酸含量、丙二醛含量及电导率与对照相比均有所升高,其中草木樨的可溶性糖与丙二醛含量相比对照分别增加了16.27 mg/g和0.39μmol/g,毛苕子、光叶紫花苕的脯氨酸含量增加幅度较大,与CK相比较脯氨酸增加量分别为46.13μg/g、31.03μg/g,毛苕子的电导率较CK增加22.06%,在5种豆科绿肥中增加量最大,苗期各指标整合分析显示抗旱性强弱顺序为:箭筈豌豆>毛苕子>草木樨>光叶紫花苕>紫云英。【结论】综合萌发期及苗期5种绿肥作物的抗旱性,箭筈豌豆、光叶紫花苕这2种绿肥作物较草木樨、紫云英、毛苕子更适宜在干旱缺水地区推广种植。

关键词：绿肥萌发期苗期抗旱性能 PEG胁迫