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Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 951-960页

作者： Jing liANG Fan li Ya-li ZHANG Zong-lou GUO li-hong xu Department of Biochemistry and Genetics School of Medicine Zhejiang University Hangzhou 310058 China Department of Biosystem Engineering College of Biosystem Engineering and Food Science Zhejiang University Hangzhou 310058 China

Due to their toxicity,the increased distribution of microcystins(MCs) has become an important worldwide *** have been recognized as inhibitors of protein phosphatase 2A(PP2A) through their binding to the PP2A catalytic ***,the exact mechanism of MC toxicity has not been elucidated,especially concerning the cellular response and its *** further dissect the role of PP2A in MC-induced toxicity,the present study was undertaken to determine the response of PP2A in human amniotic epithelial(FL) cells treated with microcystin-LR(MCLR),one of the MC *** results show that a low-dose treatment of MCLR in FL cells for 6 h induced an increase in PP2A activity,and a high-dose treatment of MCLR for 24 h decreased the activity of PP2A,as *** increased mRNA and protein levels of the PP2A C subunit may explain the increased activity of ***,MCLR altered microtubule post-translational modifications through *** results further clarify the underlying mechanism how MCLR affects PP2A and may be helpful for elucidating the complex toxicity of MCLR.

关键词： Microcystin-LR Protein phosphatase 2A Phosphatase activity Hormesis Tubulin B55α

Effects of climate change on water resources in Tarim River Basin, Northwest China

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Journal of Environmental Sciences 2007年第4期19卷 488-493页

作者： CHEN Ya-ning li Wei-hong xu Chang-chun HAO Xin-ming Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China.

Based on hydrology, temperature, and precipitation data from the past 50 years, the effects of climate change on water resources in Tarim River Basin in Northwest China were investigated. The long-term trends of the hydrological time series were detected using both parametric and nonparametric techniques. The results showed that the increasing tendency of the temperature has a 5% level of significance, and the temperature increased by nearly 1℃ over the past 50 years. The precipitation showed a significant increase in the 1980s and 1990s, and the average annual precipitation exhibited an increasing trend with a magnitude of 6.8 mm per decade. A step change occurred in both the temperature and precipitation time series around 1986. The streamflow from the headwater of the Tarim River exhibited a significant increase during the last 20 years. The increase in temperature, precipitation, and streamflow may be attributed to global climate change.

关键词： climate change temperature precipitation streamflow Tarim River

Spore production in the solid-state fermentation of stevia residue by Trichoderma guizhouense and its effects on corn growth

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Journal of Integrative Agriculture 2021年第5期20卷 1147-1156页

作者： liU hong-jun DUAN Wan-dong liU Chao MENG ling-xue li hong-xu li Rong SHEN Qi-rong Jiangsu Provincial Key Lab of Solid Organic Waste Utilization/Key Laboratory of Plant Immunity Jiangsu Collaborative Innovation Center of Solid Organic Wastes/Educational Ministry Engineering Center of Resource-saving fertilizers/Nanjing Agricultural UniversityNanjing 210095P.R.China Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014P.R.China

Trichoderma is an important and widely used plant growth-promoting fungus(PGPF).In this study,stevia residue amended with amino acids hydrolyzed from animal carcasses was used for the production of Trichoderma guizhouense NJAU 4742 by solid-state fermentation,and then its potential to promote corn plant growth was evaluated in combination with chemical fertilizer(CF)or organic fertilizer(OF).The highest spore number of 7×10^(9) CFU g^(–1) fresh weight was obtained under the following optimal parameters:material ratio of 50%(stevia residue:rice bran=1:1),pH value of 3.0(amended with 6.67%amino acids),initial moisture content of 60%,inoculum size of 10%,material thickness of 3 cm and an incubation time of 4 *** aboveground corn plant biomass obtained with *** applied alone and with CF treatments were slightly higher than those of no fertilizer control and CF treatments,***,*** applied with OF significantly(Plications primarily influenced the fungal bulk soil community composition,among which three OTUs(OTU_(2) and OTU_(9) classified as Chaetomium,and OTU_(4)classified as Trichoderma)were stimulated in both bulk and rhizosphere ***,a specific OTU_(3)(Phymatotrichopsis)was only stimulated by *** applied with OF,possibly leading to high soil *** results show that it is feasible to employ stevia residue in the eco-friendly fermentation of ***,which is strongly suggested for enhancing OF applications.

关键词： Trichoderma solid-state fermentation stevia residue plant growth-promoting fungi soil fungal community

Dimesitylborylphenyl substituted 1,3,4-oxadiazole:Synthesis,characterization and sensitivity to F^-

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Chinese Chemical Letters 2011年第5期22卷 599-602页

作者： Xiang hong li Bo xu, Kang Le Lv Ai Qing Zhang College of Chemistry and Materials South-Central University for Nationalities Wuhan 430074 China

A new 1,3,4-oxadiazole compound with a dimesitylboryl group was synthesized and characterized by ~1H NMR,MS,element analysis and X-ray single-crystal *** exhibits good blue emission at 425 nm and high sensitivity to f... 详细信息

关键词： 1 3.4-Oxadiazole Dimesitylboryl Fluoride anion Chemo-sensor

A Granularity-Aware Parallel Aggregation Method for Data Streams

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 133-137页

作者： WANG Yong-li xu hong-bing xu li-zhen QIAN Jiang-bo liU xue-jun Department of Computer Science and Engineering Southeast University Nanjing 210096 Jiangsu China

This paper focuses on the parallel aggregation processing of data streams based on the shared-nothing architecture. A novel granularity-aware parallel aggregating model is proposed. It employs parallel sampling and linear regression to describe the characteristics of the data quantity in the query window in order to determine the partition granularity of tuples, and utilizes equal depth histogram to implement partitio ning. This method can avoid data skew and reduce communi cation cost. The experiment results on both synthetic data and actual data prove that the proposed method is efficient, practical and suitable for time-varying data streams processing.

关键词： data streams parallel processing linear regression aggregation data skew

Reversal of idiopathic hypogonadotropic hypogonadism： a cohort study in Chinese patients

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Asian Journal of Andrology 2015年第3期17卷 497-502页

作者： Jiang-Feng Mao hong-li xu Jin Duan Rong-Rong Chen li li Bin li Min Nie Le Min hong-Bing Zhang xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China Department of Physiology State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100005 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China Division of Endocrinology Diabetes and Hypertension Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

Although idiopathic hypogonadotropic hypogonadism （IHH） has traditionally been viewed as a life-long disease caused by a deficiency of gonadotropin-releasing hormone neurons, a portion of patients may gradually regain normal reproductive axis function during hormonal replacement therapy. The predictive factors for potential IHH reversal are largely unknown. The aim of our study was to investigate the incidence and clinical features of IHH male patients who had reversed reproductive axis function. In this retrospective cohort study, male IHH patients were classified into a reversal group （n = 18） and a nonreversal group （n = 336）. Concentration of gonadotropins and testosterone, as well as testicle sizes and sperm counts, were determined. Of 354 IHH patients, 18 （5.1%） acquired normal reproductive function during treatment. The median age for reversal was 24 years old （range 21-34 years）. Compared with the nonreversal group, the reversible group had higher basal luteinizing hormone （LH）（1,0±0.7 IU 1-1 vs 0.4±0.4 IU 1-1, P 〈 0.05） and stimulated LH （28.3 ± 22.6 IU 1-1 vs 1.9 ±1.1 IU 1-1, P 〈 0.01） levels, as well as larger testicle size （5.1 ±2.6 ml vs 1.5± 0.3 ml, P〈 0.01）, at the initial visit. In summary, larger testicle size and higher stimulated LH concentrations are favorite parameters for reversal. Our finding suggests that reversible patients may retain partially active reproductive axis function at initial diagnosis.

关键词： hypothalamic-pituitary-gonadal axis idiopathic hypogonadotropic hypogonadism reversal

Analysis of Vitamin K_3 by a Fluorescent Spectroelectrochemistry Method

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Chemical Research in Chinese Universities 2010年第5期26卷 742-745页

作者： ZHAO Chang-zhi li Ying DU hong xu Hua-jun JIAO Kui Key Laboratory of Eeo-Chemical Engineering Ministry of Education College of Chemistry ＆ Molecular Engineering Qingdao University of Science ＆ Technology Qingdao 266042 P. R. China

A simple and sensitive spectroelectrochemistry method for the determination of vitamin K3 was developed by combining electrolysis and fluoremetry. This method was based on that vitamin K3 was reduced at a glassy carbon electrode, and its product with characteristic fluorescence at 420 nm was determined with excitation wavelength at 309 nm. Under optimized electrochemical reaction conditions and fluorescent experiment parameters, the fluorescence intensity was proportional to the concentration of vitamin K3 in a range from 3.50×10^-7 to 1.05×10^-5 mol/L with a correlation coefficient of 0.9991, and detection limit was estimated to be 7.50× 10^-8 mol/L at a signal/noise ra- tio of 3. The relative standard deviation was less than 4.3%（n=5） and the recovery was in a range of 97%-105% for the determination of vitamin K3 in pharmaceutical preparations. The result is satisfactory for the determination of vitamin K3 as comparison to that from HPLC method.

关键词： Spectroelectrochemistry Fluorescence Electro-reduced Vitamin K3

Damping capacity of Fe_(83)Ga_(17) magnetostrictive alloy under magnetic field

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Rare Metals 2024年第1期43卷 402-409页

作者： Shao-Wen Yan Xing Mu Bing-Jie liu li-hong xu Shi-Hai Guo Yan Qi hong-Ping Zhang Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China

The damping performance of Fe_(83)Ga_(17) alloys has been investigated in the static magnetic field (H). The results demonstrate that the damping peak value can be adjusted between 0.020 and 0.085 under the magnetic f... 详细信息

关键词： alloy magnetic alloys

Synthesis of water-soluble cystine C_(60) derivative with catalyst and its active oxygen radical scavenging ability

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Chinese Chemical Letters 2007年第1期18卷 51-54页

作者： Zhen Hu Wen Chao Guan Xiang Ying Tang li Zhen Huang hong xu Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 China

A novel water-soluble cystine C60 derivative was synthesized in the presence of the catalyst, tetrabutylammonium hydroxide （TBAH）. The product was characterized by FT-IR, UV, ^1H NMR, ^13C NMR, MS and elemental analysis. Furthermore, the scavenging ability to superoxygen anion radical O2^·- and hydroxyl radical ^·OH was studied by chemiluminescence. It was found that cystine C60 derivative showed an excellent efficiency in eliminating superoxygen anion radical and hydroxyl radical. The 50% inhibition concentration （IC50） for superoxygen anion radical and hydroxyl radical were 0.167 and 0.008 mg/mL, respectively.

关键词： Cystine C60 derivatives TBAH Superoxygen anion radical Hydroxyl radical Chemiluminescence