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Determination of Pesticide Residue Cartap Using a Sensitive Fluorescent Probe

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Journal of Integrative Agriculture 2012年第11期11卷 1861-1870页

作者： JING Xu DU li-ming wu hao wu Wen-ying CHANG Yin-xia Analytical and Testing Center Shanxi Normal University Linfen 041000 P.R.China

The insecticide cartap （CP） is non-fluorescent in aqueous solutions. This property makes its determination through direct fluorescent method difficult. In acidic medium and at room temperature, palmatine （PAL） can react with cucurbit[7]uril （CB[7]） to form stable complexes, and the fluorescence intensity of the complex is greatly enhanced. Significant quenching of the fluorescence intensity of the CB[7]-PAL complex was observed with the addition of cartap. Based on the significant quenching of the supramolecular complex fluorescence intensity, a new spectrofluorimetric method with high sensitivity and selectivity was developed to determine cartap in aqueous solution. The fluorescence quenching values （AF） showed good linear relationship with cartap concentrations from 0.009 to 2.4 ~tg mL-~ with a detection limit 0.0029 ~tg mE-x. The proposed method had been successfully applied to the determination of cartap residues in grain and vegetable with recoveries of 87.4-103%. In addition, the association constants of the complexes formed between the host and the guest were determined. The competing reaction and the supramolecular interaction mechanisms between the cartap and PAL as they fight for occupancy of the CB[7] cavity were studied using spectrofluorimetry, xH NMR and molecular modeling calculations.

关键词： cartap cucurbituril palmatine fluorescent probe

Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia

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World Journal of Clinical Cases 2022年第11期10卷 3401-3413页

作者： Jin-Rong Cai Xin-Wen Chen Yu-Jian He Bin wu Min Zhang li-hao wu School of Clinical Medicine Guangdong Pharmaceutical UniversityGuangzhou 510030Guangdong ProvinceChina Department of Epidemiology and Health Statistics Guangdong Pharmaceutical UniversityGuangzhou 510220Guangdong ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510030Guangdong ProvinceChina Research Center Engineering Techniques of Microbiota-Targeted Therapies of Guangdong ProvinceGuangzhou 510030Guangdong ProvinceChina

BACKGROUND Previous studies have found that hyperuricaemia(HUA)is closely related to intestinal flora *** The current study investigated the effects and safety of washed microbiota transplantation(WMT)on serum uric acid(SUA)levels in different *** A total of 144 patients who received WMT from July 2016 to April 2020 in the First Affiliated Hospital of Guangdong Pharmaceutical University and had SUA data before treatment were *** in SUA levels before and after treatment were retrospectively reviewed based on short-term and mid-term effects of WMT *** levels measured in the last test within 3 mo after the first WMT represented the short-term effect,and SUA levels measured in the last test within 3-6 mo after the first WMT represented the mid-term *** patients were divided into an HUA group(SUA>416μM)and a normal uric acid(NUA)group(SUA≥202μM to≤416μM)based on pretreatment SUA *** Average short-term SUA levels in the HUA group decreased after WMT(481.00±99.85 vs 546.81±109.64μM,n=32,P0.05).Only 1/144 patients developed mild diarrhea after *** WMT reduces short-term SUA levels in patients with HUA with mild side effects but has no obvious effect on SUA levels in patients with NUA.

关键词： Washed microbiota transplantation Hyperuricaemia Intestinal flora Effect Safety Retrospective study

Hair regrowth following fecal microbiota transplantation in an elderly patient with alopecia areata: A case report and review of the literature

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World Journal of Clinical Cases 2019年第19期7卷 3074-3081页

作者： Wen-Rui Xie Xiao-Ya Yang Harry Hua-Xiang Xia li-hao wu Xing-Xiang He Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Physiology Guangzhou Health Sciences CollegeGuangzhou 510180Guangdong ProvinceChina

BACKGROUND Alopecia areata is a hair loss disease associated with genetics,autoimmunity,and other *** is an intriguing link between alopecia areata and gut *** microbiota transplantation(FMT)has been recommended to treat Clostridium difficile(previously known as Clostridioides difficile)infection,and has also shown potentials in the treatment of inflammatory bowel disease,irritable bowel syndrome,and non-alcohol fatty liver *** SUMMARY An 86-year-old man,with a history of sigmoid colon carcinoma,suffered from recurrent abdominal pain and distension,and diarrhea for six months,with *** admission,he was also diagnosed with *** physical examination,the patient presented with a 1.5 cm×2.0 cm alopecia areata on his right *** to the negative results of laboratory testing,capsule endoscopy,and colonoscopy,the patient was diagnosed with noninfectious diarrhea,depressive disorder,and patchy alopecia *** that noninfectious diarrhea in the elderly patient was mainly caused by gut dysbiosis,he was given six rounds of *** diarrhea improved remarkably one month after FMT,with improved appetite and disappearance of abdominal pain,distension,and depressive ***,he reported new hair growth on the affected region of his scalp,with some of his white hair gradually turning to black,without taking any other therapies for alopecia areata before and after *** FMT might act as a potential therapy for patients who suffer from alopecia *** and well-designed studies are required to confirm the role of FMT in alopecia areata.

关键词： Fecal microbiota transplantation Alopecia areata Gut microbiota Autoimmune disease Psychopathogenesis Case report

Long-term efficacy and safety of cap-assisted endoscopic sclerotherapy with long injection needle for internal hemorrhoids

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1120-1130页

作者： Ya-Ting Xie Yu Yuan Hui-Min Zhou Tao liu li-hao wu Xing-Xiang He Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Hemorrhoids are a common anal condition and can afflict an individual at any *** survey results in China show that the prevalence of anorectal diseases is as high as 50.1%among which 98.08%of patients have hemorrhoid *** To assess long-term efficacy and safety of cap-assisted endoscopic sclerotherapy(CAES)with long injection needle for internal *** This study was *** from patients with symptomatic internal hemorrhoids treated with CAES using endoscopic long injection needle from April 2016 to December 2019 were *** were telephoned and followed at two time points,December 2020 and 2021,to evaluate the improvements in symptoms,complications,recurrence,and *** Two hundreds and one patients with internal hemorrhoids underwent CAES with the long *** first median follow-up was performed 33 mo *** improved in 87.5%of patients after the first *** did not decrease with treatment time ***-four patients underwent colonoscopy after the first CAES treatment of which 21 underwent CAES again,and 4 underwent *** the first follow-up,62.7%of patients had both improved hemorrhoid grades and symptoms,and 27.4%had a significant improvement in both *** the second follow-up,61.7%of the patients showed satisfactory improvement in their hemorrhoid grade and symptoms when compared with pre-surgery values.90%of patients reported CAES was painless,and 85%were satisfied/very satisfied with CAES treatment *** The present study based on the largest sample size reported the long-term follow-up of the treatment for internal hemorrhoid with the CAES using endoscopic long injection *** findings demonstrate that CAES should be a micro-invasive endoscopic technology yields satisfactory long-term efficacy and safety.

关键词： Hemorrhoids Cap-assisted endoscopic sclerotherapy Long injection needle Efficacy Prolapse

Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial

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Current Medical Science 2021年第6期41卷 1087-1095页

作者： li-hao wu Zhi-ning YE Ping PENG Wen-rui XIE Jia-ting XU Xue-yuan ZHANG Harry Hua-xiang XIA Xing-xiang HE Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080China Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080China Guangzhou Eighth People's Hospital Guangzhou 510060China

Objective:Coronavirus disease 2019(COVTD-19)is often accompanied by gastrointestinal symptoms,which are related to gut microbiota dysbiosis(GMD).Whether washed microbiota transplantation(WMT)is an effective treatment for COV1D-19 patients suspected of having GMD by restoring the gut microbiota is *** study is designed to explore the efficacy and safety of WMT in COVID-19 patients suspected of having ***:This is a randomized,multicenter,single-blind prospective ***-19 patients suspected of having GMD will be randomly divided to receive routine treatment only or to receive routine treatment and *** frequency of WMT will be once a day for three consecutive *** and imaging examinations will be performed at admission,1 and 2 weeks after treatment,and on the day of *** a telephone follow-up will be conducted at 1st week,2nd week,and 6th month after *** clinical efficacy and safety of WMT in COVD-19 patients suspected of having GMD and the effects of WMT on the organ function,homeostasis,inflammatory response,intestinal mucosal barrier function,and immunity of the patients will be ***:By following the proposed protocol,WMT is expected to be efficacious and safe for the treatment of COVID-19 patients suspected of having GMD,and the therapeutic effect is expected to be associated with improvement of the intestinal mucosal barrier function,inflammatory response,and ***:The findings from this study may offer a new approach for the prevention and treatment of COVID-19 patients suspected of having GMD.

关键词： COVID-19 SARS-Cov-2 virus gut microbiota microbiome dysbiosis washed microbiota transplantation

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自适应非线性流采样算法的硬件实现

北京邮电大学学报 2016年第3期39卷 85-90页

作者：黎阳武昊刘斌清华大学计算机科学与技术系北京100084

针对自适应非线性流采样(DISCO)算法硬件实现面临的一系列挑战,设计了利于硬件处理的改进算法,采用多查找表结构和"归一化"方法进行处理,完成了正确性仿真和基于现场可编程门阵列(FPGA)平台的原型验证.实验结果表明,改进算法能够实现40 ... 详细信息

针对自适应非线性流采样(DISCO)算法硬件实现面临的一系列挑战,设计了利于硬件处理的改进算法,采用多查找表结构和"归一化"方法进行处理,完成了正确性仿真和基于现场可编程门阵列(FPGA)平台的原型验证.实验结果表明,改进算法能够实现40 Gbit/s链路的线速每流统计,消耗FPGA上的硬件逻辑资源较少,并且平均相对误差和最大相对误差均与基准DISCO算法性能接近.

关键词：网络流测量现场可编程门阵列非线性流量测量

Treatment of type C3 distal radius fracture resulted from high-energy injuries by volar plate in combination with external fixator

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Chinese Medical Journal 2009年第13期122卷 1517-1520页

作者： ZHANG Qiu-lin ZHU Xiao-dong li Guo-dong TANG hao li Ming wu Da-jiang Department of Orthopedics Changhal Hospital Second Military Medical University Shanghai 200433 China

Background With a type C3 distal radius fracture it is extremely difficult to maintain the reduction and to restore congruity of the articular surface because the support for the volar and dorsal bone cortex has been lost. An external fixator crossing wrist in combination with Kirschner wire （K-wire） fixation was popularly used by most studies in recent years. But loss of reduction often occurred especially in the volar sides. Methods A total of 30 cases of type C3 distal radius fracture were treated by a volar buttress plate combined with a transarticular external fixator and other techniques such as K-wire fixation and bone grafting if necessary. The postoperative volar tilt angles, ulnar inclinations, radial heights, range of motion, grip strength and complications were recorded to assess the therapeutic effects. Results Of the 30 patients, 27 patients were followed up for 12-29 （mean 18） months and all fractures healed in 8-13 weeks after surgery （mean 10 weeks）. The wrist function was excellent in 8 cases, good in 16 cases and fair in 3 cases according to the Sarmiento scoring system （modified by Stewart）. Conclusions For type C3 comminuted fracture with severe volar and dorsal instability, fixation by volar buttress plate combined with transarticular external fixator should be adopted. Dorsal instability could be further stabilized by other techniques such as Kirschner wire fixation, and bone grafting.

关键词： distal radius fracture internal fixation external fixator

Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease

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World Journal of Gastroenterology 2021年第6期27卷 513-522页

作者： Ya-Mei Zheng Xian-Yun Chen Jie-Yi Cai Yu Yuan Wen-Rui Xie Jia-Ting Xu Harry Hua-Xiang Xia Min Zhang Xing-Xiang He li-hao wu Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityResearch Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong ProvinceGuangzhou 510030Guangdong ProvinceChina Department of Science and Education The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510030Guangdong ProvinceChina Department of Epidemiology and Health Statistics Guangdong Pharmaceutical UniversityGuangzhou 510220Guangdong ProvinceChina

BACKGROUND The pathogenesis of gastroesophageal reflux disease(GERD)is closely associated with the intestinal bacteria composition and their *** To investigate whether washed microbiota transplantation(WMT)improves symptoms of nonerosive reflux disease(NERD)with proton pump inhibitor(PPI)*** Patients with recurrent NERD and PPI dependency at the First Affiliated Hospital of Guangdong Pharmaceutical University from 2017 to 2018 were included and divided into a WMT or PPI group treated with PPI with/without *** endpoint was NERD symptom frequency evaluated 1 mo after WMT using reflux disease questionnaire(RDQ)and GERD questionnaire(GERDQ)scores,remission time,PPI dose,and the examination of intestinal mucosal barrier *** In the WMT(n=15)and PPI(n=12)groups,the total remission rate at 1 mo after treatment was 93.3%vs 41.7%.Compared with the PPI group,the WMT group showed better results in GERDQ(P=0.004)and RDQ(P=0.003)and in remission months(8 vs 2,P=0.002).The PPI dose was reduced to some extent for 80%of patients in the WMT group and 33.3%in the PPI *** 24 patients,intestinal mucosal barrier function was examined before treatment,and changes in the degree of damage were observed in 13 of these patients after *** one of the 15 patients had minor side effects,including a mushy stool two or three times a day,which resolved on their own after 1 *** This study is the first to demonstrate that WMT may be safe and effective for relieving NERD symptoms and reducing PPI dependency and recurrence.

关键词： Nonerosive reflux disease Washed microbiota transplantation Proton pump inhibitor dependency Intestinal bacteria lipopolysaccharide Small intestinal bacterial overgrowth

Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling li Xiaoyao Yu Yingjie Zhou Yao lin Ying wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration