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基于CiteSpace中医药治疗脑出血科学知识图谱分析

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中医药通报 2024年第3期23卷 45-50页

作者：廖远生廖吉连张胜唐佳茜高丽丽吴成翰福建中医药大学附属第二人民医院脑病科福建福州350003

目的:基于CiteSpace对中医药治疗脑出血的相关文献进行可视化分析,探讨中医药在治疗脑出血领域的现状、热点及未来发展趋势。方法:检索2011年1月1日—2021年12月31日中国知网数据库(CNKI)中收录的中医药治疗脑出血相关文献,运用CiteSpac... 详细信息

目的:基于CiteSpace对中医药治疗脑出血的相关文献进行可视化分析,探讨中医药在治疗脑出血领域的现状、热点及未来发展趋势。方法:检索2011年1月1日—2021年12月31日中国知网数据库(CNKI)中收录的中医药治疗脑出血相关文献,运用CiteSpace软件对文献的作者、机构及关键词进行共现分析、突现分析及聚类分析,绘制相关科学知识图谱。结果:共纳入文献493篇,该领域文献的年发文量总体呈上升趋势,主要核心研究团队有刘远新团队、兰志刚团队、刘旭团队及赵海滨团队等,研究机构主要以陕西中医药大学、长春中医药大学附属医院及南京中医药大学等为核心。关键词分析显示,高频关键词有针灸、中药治疗、康复、临床疗效、活血化瘀等,成为目前研究热点;生活质量、针灸康复及安全性是未来研究趋势。结论:中医药治疗脑出血研究领域发展良好,但影响力不足,针灸、中药治疗、康复及生活质量是现阶段研究的热点与前沿。

关键词：脑出血中医药可视化分析 CiteSpace

Explicit Meromorphic Solutions of a Certain Briot-Bouquet Differential Equations

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Chinese Annals of Mathematics,Series B 2020年第3期41卷 383-396页

作者： Xujie SHI liangwen liao Song ZHANG Department of Mathematics Nanjing UniversityNanjing 210093China

This paper deals with the Briot-Bouquet differential equations with degree three. The previous result shows that all the meromorphic solutions belong to W. Here,by applying the Kowalevski-Gambier method, the authors give all the possible explicit meromorphic solutions. The result is more applicable. Also, this method can be used to deal with the more general Briot-Bouquet differential equations.

关键词： Movable poles Differential equations Meromorphic solutions

Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-inhibitory activity

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Science China Chemistry 2012年第12期55卷 2537-2547页

作者： WANG Meng MA liYan LOU YangTong BIAN Chao ZHOU TingTing ZHOU HaiBin liao HongZe MA Zhao YIN DongSheng CHEN AiZhong WANG ShaoZhong YANG ZhenYu SUN bing YAO ZhuJun State Key Laboratory of Coordination Chemistry and Nanjing National Laboratory of Microstructures Institute of Chemical Biology and Drug InnovationSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes of BiologicalSciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Inhibitory effect on tumor necrosis factor-c~ （TNF-c0 production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl sub- stituent have been found to exhibit much more potent TNF-a inhibitory activity than natural sinomenine and other derivatives.

关键词： sinomenine druggability heterocycle tumor necrosis factor-m inhibition

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基于事件流数据世系的网络渗透攻击防御方法

计算机仿真 2024年第3期41卷 406-409,430页

作者：廖西樊洁馨电子科技大学成都学院四川成都611731 成都信息工程大学网络空间安全学院四川成都610225

为了保证网络通信安全,降低网络攻击风险,提出基于事件流数据世系的网络渗透攻击防御方法。通过构建网络攻击信号模型,对时间尺度实行划分,完成数据采集与信号拟合;利用主元分析提取网络动态特征,剔除全部的攻击变量共线性,令网络中的... 详细信息

为了保证网络通信安全,降低网络攻击风险,提出基于事件流数据世系的网络渗透攻击防御方法。通过构建网络攻击信号模型,对时间尺度实行划分,完成数据采集与信号拟合;利用主元分析提取网络动态特征,剔除全部的攻击变量共线性,令网络中的隐藏信息显现出来;将网络信息流分割为各种数据世系,按照类似接近程度对备选数据世系实行排序,识别产生信息关联异常事件,防御攻击数据,保障网络安全。通过实验,证明所提方法能够防御网络渗透攻击,且所用时间较短,具有可应用价值。

关键词：事件流数据世系网络渗透攻击网络攻击防御特征提取信息熵

Connecting past and present:single-cell lineage tracing

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Protein & Cell 2022年第11期13卷 790-807页

作者： Cheng Chen Yuanxin liao Guangdun Peng Center for Cell lineage and Development CAS Key Laboratory of Regenerative BiologyGuangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research CentreGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Center for Cell lineage and Atlas Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)Guangzhou 510005China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Central to the core principle of cell theory,depicting cells'history,state and fate is a fundamental goal in modern *** leveraging clonal analysis and sin-gle-cell RNA-seq technologies,single-cell lineage trac-ing provides new opportunities to interrogate both cell states and lineage *** the past few years,many strategies to achieve lineage tracing at single-cell resolution have been developed,and three of them(in-tegration barcodes,polylox barcodes,and CRISPR barcodes)are noteworthy as they are amenable in experimentally tractable *** the above strategies have been demonstrated in animal develop-ment and stem cell research,much care and effort are still required to implement these *** we review the development of single-cell lineage tracing,major characteristics of the cell barcoding strategies,applications,as well as technical considerations and limitations,providing a guide to choose or improve the single-cell barcoding lineage tracing.

关键词： single-cell lineage tracing integration barcodes polylox barcodes CRISPR barcodes

Changes in HIV-1 Subtypes/Sub-Subtypes,and Transmitted Drug Resistance Among ART-Naïve HIV-Infected Individuals—China,2004–2022

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China CDC weekly 2023年第30期5卷 664-671,I0010-I0012页

作者： Xiu liu Dong Wang Jing Hu Chang Song lingjie liao Yi Feng Dan li Hui Xing Yuhua Ruan State Key Laboratory of Infectious Disease Prevention and Control(SKliD) National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:The efficacy of treatment and clinical outcomes may be jeopardized by factors such as transmitted drug resistance(TDR)and the genetic diversity of the human immunodeficiency virus type 1(HIV-1).This comprehensive study aims to examine the alterations in HIV-1 subtypes or sub-subtypes and TDR among Chinese individuals,who have been diagnosed with HIV infection and are previously untreated with antiretroviral therapy(ART),across the span of 2004 to ***:Sequences of the HIV-1 pol gene region were obtained from ART-naïve HIV-positive individuals across 31 provincial-level administrative divisions between 2004 and *** predict susceptibility to 12 antiretroviral drugs,the research utilized the Stanford HIV Drug Resistance *** Cochran-Armitage trend test facilitated the analysis of changes in HIV-1 subtype/sub-subtype prevalence and *** analysis was conducted in alignment with the progression of the National Free Antiretroviral Treatment Program’s stages between 2004 and ***:Among the 57,902 ART-naïve individuals infected with HIV,there was a notable decline in the prevalence of CRF01_AE,B,and C from 37.3%,24.1%,and 1.3%respectively in 2004–2007 to 29.4%,7.3%,and 0.2%respectively in 2020–***,a significant increase was observed in the proportions of CRF07_BC,CRF08_BC,CRF55_01B,other CRFs,and URFs,from 24.1%,11.5%,0.1%,0.4%,and 0.9%respectively in 2004–2007 to 40.8%,11.5%,3.8%,3.7%,and 2.8%respectively in 2020–2022(all P<0.001 for trend).The prevalence of TDR to overall,non-nucleoside reverse transcriptase inhibitor(NNRTI),efavirenz,and nevirapine also significantly increased from 2.6%,1.8%,1.6%,and 1.8%respectively in 2004–2007 to 7.8%,6.7%,6.3%,and 6.7%respectively in 2020–2022(all P<0.001 for trend).However,there were no meaningful changes in the TDR prevalence of nucleoside reverse transcriptase inhibitor and protease ***,in 2020–2022,the overall TDR prevalence exceeded 15%in ***

关键词： prevalence alterations drugs

An E-band CMOS frequency quadrupler with 1.7-dBm output power and 45-dB fundamental suppression

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Journal of Semiconductors 2022年第9期43卷 46-52页

作者： Xiaofei liao Dixian Zhao Xiaohu You National Mobile Communication Research Laboratory Southeast UniversityNanjing 211189China Purple Mountain Laboratories Nanjing 211111China

This paper presents an E-band frequency quadrupler in 40-nm CMOS *** circuit employs two push-push frequency doublers and two single-stage neutralized *** pseudo-differential class-B biased cascode topo-logy is adopted for the frequency doubler,which improves the reverse isolation and the conversion *** tech-nique is applied to increase the stability and the power gain of the amplifiers *** stacked transformers are used for single-ended-to-differential transformation as well as output bandpass *** output bandpass filter enhances the 4th-harmonic output power,while rejecting the undesired harmonics,especially the 2nd *** core chip is 0.23 mm^(2)in size and consumes 34 *** measured 4th harmonic achieves a maximum output power of 1.7 dBm with a peak conversion gain of 3.4 dB at 76 *** fundamental and 2nd-harmonic suppressions of over 45 and 20 dB are achieved for the spectrum from 74 to 82 GHz,respectively.

关键词： capacitor neutralization CMOS E-band frequency doubler frequency quadrupler push-push

活性炭对CFC-113加氢脱氯Cu-Pd催化剂反应性能的影响

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应用化工 2024年第1期53卷 82-87,93页

作者：申宝林廖湘洲施云海华东理工大学化学工程研究所上海200237 上海化工研究院有限公司上海200062

以木制炭AC-1、沥青炭AC-2为载体,制备负载Cu-Pd双组分催化剂,用于三氟三氯乙烷(CFC-113)加氢脱氯制备三氟氯乙烯(CTFE),发现两种载体催化剂均表现出较高的初始活性,但AC-2催化剂在短时间内迅速失活。化学吸附和XRD表明,AC-1催化剂具有... 详细信息

以木制炭AC-1、沥青炭AC-2为载体,制备负载Cu-Pd双组分催化剂,用于三氟三氯乙烷(CFC-113)加氢脱氯制备三氟氯乙烯(CTFE),发现两种载体催化剂均表现出较高的初始活性,但AC-2催化剂在短时间内迅速失活。化学吸附和XRD表明,AC-1催化剂具有更高的Pd分散度,Cu晶粒尺寸相对较大;XPS和TPR分析表明,AC-2催化剂表面金属还原温度低于AC-1,但后者表现出更集中的Cu物种分布。载体表面官能团的不同会导致催化剂反应性能的差异,AC-2表面较高的羧基浓度有利于Cu的吸附和分散,但Cu在反应过程中易受HCl的作用而产生物种以及价态的变化,而木制炭催化剂稳定性优于沥青炭可能与其表面较为单一、集中分布的Cu物种有关。

关键词：活性炭载体铜钯催化剂加氢脱氯

慢性心力衰竭患者30天内非计划再入院的研究进展

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天津护理 2024年第3期32卷 367-371页

作者：吴嘉慧廖喜琳王金涛李雨航广西中医药大学广西南宁530001 广西中医药大学附设中医学校

对慢性心力衰竭患者30天非计划再入院的相关概念、现状、影响因素、干预措施、风险预测模型进行综述,以期为临床识别和评估患者病情,制定干预决策提供科学依据。

关键词：慢性心力衰竭非计划再入院影响因素风险预测模型综述