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Science China life Sciences 2025年第1期 300-302页

作者： Ze-Min lin Mai Xiang Wen-Hui Wei Shu-Hui fan li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui zhen Bo-Cheng li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

Fibrous Separator with Surface Modification and Micro-Nano Fibers Lamination Enabling Fast Ion Transport for lithium-Ion Batteries

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Chinese Journal of Polymer Science 2023年第2期41卷 222-232页

作者： Yi-Ge Zhou li fan He-Qin li Yu-Jia Cui Shu-Fa Yu zhen-zhen Wei Yan Zhao College of Textile and Clothing Engineering National Engineering Laboratory for Modern SilkSoochow UniversitySuzhou215123China Jiangsu Yingyang Nonwoven Machinery Co. LTD.Changshu215500China

Appropriate materials collaborated with reasonable structure can significantly increase the separator performance for lithium-ion *** this work,taking the advantages of microfibrous and nanofibrous membranes and compensating for their defects,we developed a composited separator(GOPPH)with excellent overall performance by first wetting-modifying the polyethylene terephthalate microfibers and then laminating a polyvinylidene fluoride-hexafluoropropylene nanofiber *** a combination not only offers the GOPPH separator,from the perspective of structure,with high porosity and hierarchical structure in terms of fiber diameter and pore size,but also provides satisfactory features including wettability,mechanical strength and thermal shutdown function that benefit from the selected ***,as determined by experimental and theoretical approaches,the obtained GOPPH separator exhibits considerably enhanced lithium ion transport ability with a high lithium ion transference number and transport rate,which thereby endowing the cell with superior cycling stability with a capacity retention of 93%after 200 cycles at 1 ***,considering battery safety and performance,the GOPPH fibrous membrane could be a promising separator candidate for lithium-ion batteries.

关键词： Fibrous separator Surface modification Micro-nano fiber lamination Ion transport lithium-ion batteries

An Inexact Affine Scaling Levenberg-Marquardt Method Under Local Error Bound Conditions

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 830-844页

作者： Zhu-jun WANG li CAI Yi-fan SU zhen PENG School of Computational Science and Electronics Hunan Institute of Engineering Xiangtan 411104 China Shanghai Research Institute of Microwave Equipment Shanghai 200063 China School of Mathematics and Computational Science Xiangtan University Xiangtan 411104 China

We propose an inexact affine scaling Levenberg-Marquardt method for solving bound-constrained semismooth equations under the local error bound assumption which is much weaker than the standard nonsingularity condition. The affine scaling Levenberg-Marquardt equation is based on a minimization of the squared Euclidean norm of linearized model adding a quadratic affine scaling matrix to find a solution which belongs to the bounded constraints on variable. The global convergence and the superlinear convergence rate are *** results show that the new algorithm is efficient.

关键词： semismooth equation Levenberg-Marquardt method inexact method affine scaling local error bounds

Modulating effect of adenosine deaminase on function of adenosine A1 receptors

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Acta Pharmacologica Sinica 2005年第2期26卷 160-165页

作者： Wan-chun SUN,Yan CAO,Lei JIN,li-zhen WANG,fan MENG~2,Xing-zu ZHU~3Department of Pharmacology,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 201203,China ~2Department of Psychiatry,University of Michigan,The Psychiatry/MHRI Microarray Laboratory,205 Zina Pitcher Place,Ann Arbor,MI 48109-0720,USA Department of Pharmacology Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China

Aim:To study the modulating effect of adenosine deaminase（ADA）on yheadenosine A1receptor（A1R）in HEK293 cells stably expressing the human ***:cDNA was amplified by RT-PCR using total RNA from human embryobrain tissue as the *** PCR products were subcloned into the plasmidpcDNA3 and cloned into the plasmid *** cloned A1R cDNA wassequenced and stably expressed in HEK293 *** modulating effect of ad-enosine deaminase on A1R was studied by using[3H]DPCPX binding assay andan intracellular calcium ***:HEK293 cells stably expressing humanA1R were *** studies showed that the KDvalue and Bmaxvalueof[3H]DPCPX were 1.6±0.2 nmol/L and 1.819±0.215 nmol/g of protein respectively,in the absence of ecto-ADA respectively,and 1.3±0.2 nmol/L and 1.992±0.130nmol/g of protein in the presence of ecto-ADA respectively,suggesting that theKDvalue and Bmaxvalue of[3H]DPCPX were unaffected by *** the caseof[3H]DPCPX competition curves obtained from intact cells or membranes,A1Ragonist CCPA/[3H]DPCPX competition curve could be fitted well to a one-sitemodel in the absence of ecto-ADA and a two-site model in the presence of ecto-ADA with a KHvalue of 0.74（0.11-4.8）nmol/L（intact cells）or 1.8（0.25-10）nmol/L（membrane）and a KLvalue of 0.94（0.62-1.41）μmol/L（intact cells）or 0.77（0.29-0.99）μmol/L（membrane）.The KLvalue is not significantly different from the IC50value of 0.84（0.57-1.23）μmol/L（intact cells）or 0.84（0.63-1.12）μmol/L（membrane）obtained in the absence of *** results were obtained from theCPA/[3H]DPCPX competition curve in the absence or presence of ecto-ADA onintact cells or *** calcium assay demonstrated that the EC50value of CPA were 10（5-29）nmol/L and 94（38-229）nmol/L in the presence orabsence of ecto-ADA,***:A1R stably expressed in theHEK293 cells display a low affinity for agonists in the absence of ADA and highand low affinities for agonists in the presence of *** pr

关键词： adenosine deaminase adenosine A1 receptor radioligand assay calcium fluorescence diagnosis

Metastable state of gas hydrate during decomposition: A novel phenomenon

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Chinese Journal of Chemical Engineering 2020年第4期28卷 949-954页

作者： Ronghui Sun zhen fan Lei Yang Yuanping li Xin Lü Yang Miao Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of TechnologyDalian 116023China School of Chemistry University of GlasgowGlasgow G128QQUnited Kingdom 3 Institute of Science and TechnologyShenzhen BranchChina National Offshore Oil CorporationGuangzhou 510420China CNOOC Research Institute Co.Ltd Beijing 100028China Xingang Shipbuilding Heavy Industry Co. Ltd.Tianjin 300452China

Natural gas hydrates are solid compounds with cage-like structures formed by gas and *** intriguing phenomenon that gas hydrates can dissociate at a low rate below the ice freezing point has been viewed as the metastability of *** mechanisms of hydrate metastability have been widely studied,and many mechanisms were proposed involving the self-preservation effect,supercooled water-gas-hydrate metastable equilibrium,and supersaturated liquid-gas-hydrate system *** metastable state of hydrate could be of crucial significance in the kinetics of hydrate formation and decomposition,heat and mass transfer during gas production processes,and the application of hydrate-based technique involving desalination,energy storage and transportation,and gas separation and *** researches have systematically considered this phenomenon,and its mechanism remains *** this work,various mechanisms and hypothesis explaining the metastable state of gas hydrates were introduced and *** studies are still required to reveal the intrinsic nature of this metastable state of gas hydrate,and this work could give some implications on the existing theory and current status of relevant efforts.

关键词： Hydrates Dissociation Metastability Self-preservation Supersaturation

FDNet: Fourier transform guided dual-channel underwater image enhancement diffusion network

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Science China Technological Sciences 2025年第1期 62-78页

作者： zhen ZHU Xiaobo li Qianwen MA Jingsheng ZHAI Haofeng HU School of Marine Science and Technology Tianjin University College of Mechanical Engineering and Automation Fuzhou University

Due to the scattering and absorption of light, underwater imaging yields suboptimal results characterized by low brightness, diminished image contrast, and the loss of details. Current learning-based underwater image enhancement(UIE)methods mainly focus on addressing these issues in the spatial domain, with limited attention to the Fourier frequency *** propose the Fourier transform guided dual-channel underwater image enhancement diffusion network(FDNet), aiming to fully leverage frequency domain information and the characteristics of a diffusion-based generation model. The amplitude-phase dualchannel not only effectively provides feedback on the energy distribution of the image but also incorporates crucial image structure and texture information. Capitalizing on these advantages, we first introduce a Fourier transform-based amplitude-phase dualchannel enhancement front-end network for UIE. This network significantly improves the quality of the network's image input,including brightness and contrast, by incorporating phase congruency edge enhancement and prior-driven amplitude mapping strategies. The preceding network mitigates the overall training challenges caused by poor input image quality. Simultaneously,the application of denoising networks based on lightweight transformers effectively improves the computational time required for each iteration during model training. The results indicate that FDNet outperforms many current learning-based UIE algorithms in restoring images across multiple real underwater image datasets, demonstrating more robust generalization capabilities in degraded underwater scenarios. The competitive performance advantage achieved in enhancing visual quality underscores the effectiveness of our method.

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Translocation time of a polymer chain through an energy gradient nanopore

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Frontiers of physics 2017年第3期12卷 157-165页

作者： Meng-Bo Luo Shuang Zhang fan Wu li-zhen Sun Department of Physics Zhejiang University Hangzhou 310027 China College of Science Qinzhou University Qinzhou 535011 China Department of Applied Physics Zhejiang University of Technology Hangzhou 310023 China

The translocation time of a polymer chain through an interaction energy gradient nanopore was studied by Monte Carlo simulations and the Fokker-Planck equation with double-absorbing boundary condi- tions. Both the simulation and calculation revealed three different behaviors for polymer translocation. These behaviors can be explained qualitatively from free-energy landscapes obtained for polymer translocation at different parameters. Results show that the translocation time of a polymer chain through a nanopore can be tuned by suitably designing the interaction energy gradient.

关键词： polymer chain translocation time nanopore Monte Carlo simulation Fokker-Planck equation

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris Zhou fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu Mingjun liu Xing liu Yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo zhenqing Jia Bowen Jiang Ge Jin Chengkui li Junfei li Longhui li Maoshun li Wei li zhengda li Tianying lian Congzhan liu Heyang liu Huaqiu liu fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang zhen Zhang zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

Low Cycle Fatigue Behavior and Cyclic Softening of P92 Ferritic-martensitic Steel

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Journal of Iron and Steel Research International 2015年第6期22卷 534-542页

作者： zhen ZHANG zheng-fei HU li-kun fan Bin WANG School of Materials Science and Engineering Tongji University Shanghai Key Laboratory for Engineering Materials Application Evaluation Shanghai Research Institute of Materials

The low cycle fatigue （LCF） behavior of P92 martensitic steel was investigated under different controlled strain amplitudes at room and high temperatures （873 K）. The cyclic stress responses at all temperatures and strain amplitudes exhibited obviously rapid softening behavior at the early stage of fatigue life, and there was no saturated stage at high temperature. The fracture surfaces of the fatigue samples were observed by scanning electron microsco py （SEM） and optical microscopy. It was shown that crack initiation and propagation occurred transgranularly at both testing temperatures. A typical character was the high density crack branches or secondary cracks along fatigue striations at high temperature, which initiated from the oxidized inclusions and grain boundaries. Further investiga- tion by transmission electron microscopy （TEM） showed that the softening behavior was attributed to the micro- structure evolution during fatigue life, such as annihilation of dislocations and migration of martensite laths as well as carbide coarsening, especially for samples tested at high temperature.

关键词： low cycle fatigue P92 steel oxidative damage cyclic softening