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神经解剖学杂志 2001年第B7期17卷 103-103页

作者： zhen li and Jun chen Department of Anatomy and K.K.Leung Brain Research Centre, The Fourth Military Medical University, Xi’an, 710032

Aim: To study the roles of spinal cyclooxygenase (COX) -2 in the development of persistent spontaneous nociception and mechanical and thermal hyperalgesia induced by subcutaneous(s.c.) bee venom injection, the effects of intrathecal (i.t.) administration of a selective COX-2 inhibitor, etodolac was evaluated in the conscious rat. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre-and post-application

关键词：大白鼠脊髓环氧化酶2 持续性自发性损伤感受痛觉过敏蜂毒皮下注射

急诊内镜下针状刀切开术治疗十二指肠乳头结石嵌顿导致的急性胆源性胰腺炎

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中华普通外科杂志 2018年第9期33卷 721-724页

作者：郑明伟李宁李伟志陈震王震宇南开医院日间手术中心、微创外科天津300100

目的评价急诊内镜下针状刀切开术治疗十二指肠乳头结石嵌顿导致急性胆源性胰腺炎的应用价值。方法回顾性分析2007年1月至2017年1月因十二指肠乳头结石嵌顿导致急性胆源性胰腺炎人院行急诊内镜下针状刀切开115例患者的临床资料。结果115... 详细信息

目的评价急诊内镜下针状刀切开术治疗十二指肠乳头结石嵌顿导致急性胆源性胰腺炎的应用价值。方法回顾性分析2007年1月至2017年1月因十二指肠乳头结石嵌顿导致急性胆源性胰腺炎人院行急诊内镜下针状刀切开115例患者的临床资料。结果115例患者均行急诊内镜下治疗，成功率100％，针状刀切开平均操作时间（22．5±13．7）min，嵌顿结石总清除率为87．8％（101／115），术后患者胰腺炎症状迅速缓解，白细胞计数、血淀粉酶水平和肝功能均较术前明显好转。并发症发生率5．2％（6／115），包括十二指肠乳头出血3例，急性胆管炎3例，均采用非手术治疗后好转，无治疗相关死亡病例。结论急诊内镜下针状刀预切开术治疗十二指肠乳头结石嵌顿导致急性胆源性胰腺炎安全有效。

关键词：胰腺炎括约肌切开术内窥镜

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen chen Xiaolin Zeng Le Wang Wenwu Zhang Gang li Xing cheng Peiqiang Su Yong Wan Xiang li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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南沙群岛重要珊瑚礁水域鱼类资源数量分布

水产学报 2004年第6期28卷 651-656页

作者：李永振陈丕茂中国水产科学研究院南海水产研究所中国水产科学研究院南海水产研究所广东广州 510300

1998年3-5月和1999年5-6月,采用手钓、延绳钓和流刺网3种作业方式在南沙群岛的渚碧、南薰、东门、美济、赤瓜、永署和华阳等7座珊瑚礁水域进行了2个航次的鱼类资源调查。结果表明,7座珊瑚礁水域不同作业方式的鱼类资源相对丰盛度差别较... 详细信息

1998年3-5月和1999年5-6月,采用手钓、延绳钓和流刺网3种作业方式在南沙群岛的渚碧、南薰、东门、美济、赤瓜、永署和华阳等7座珊瑚礁水域进行了2个航次的鱼类资源调查。结果表明,7座珊瑚礁水域不同作业方式的鱼类资源相对丰盛度差别较大,其中刺网以永暑礁最高,手钓以华阳礁最高,延绳钓以南薰礁最高;同时,刺网和手钓不同水深区域鱼类资源的相对丰盛度也不相同,其中刺网以11～30m区域最高,手钓以10m以浅和51～80m区域较高;分析认为,造成礁区之间鱼类相对丰盛度差异的主要原因不是初级生产力,而是生态环境因素,主要是礁盘形态和大型海藻的数量。另外,各礁区水域的优势类群有明显不同,这主要与洞穴的大小和数量、大型海藻及珊瑚的种类和数量等生物和非生物环境有关。

关键词：数量分布相对丰盛度鱼类资源珊瑚礁南沙群岛

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang li Xuechun chen Wen Zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan chen li liu Fang-zhen lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong liu Xiang chen Jie Peng Yun-Fa Wang Zhi-lin Wang Bin chen De-Le liu Yun liu zheng-zheng li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder

2D phosphides heterostructures on titanium microfiltration membrane for enhanced ampere-level current density overall seawater splitting

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Nano Research 2025年第1期18卷 249-259页

作者： Wenjing Dai Xin Wang Yulong Ma Sisi He Ming chen Zhaohui Yin Shuheng Tian Maolin Wang Shixiang Yu Hang Zhang Yuanzhe Wang Hong Wang Jianxin li Faming Gao Bowen cheng Yun Wang zhen Yin Ding Ma Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization College of Chemical Engineering and Materials ScienceTianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Biobased Fiber Manufacturing Technology Tianjin University of Science and TechnologyTianjin 300457China Haian Institute of High-Tech Research Nanjing UniversityHaian 226600China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Separation Membranes and Membrane Processes Separation Membrane Science and Technology International Joint Research CentreTiangong UniversityTianjin 300387China Centre for Catalysis and Clean Energy School of Environment and ScienceGold Coast CampusGriffith UniversitySouthportQueensland 4222Australia

The advancement of direct seawater electrolysis is a significant step towards sustainable hydrogen production,addressing the critical need for renewable energy sources and efficient resource ***,direct seawater electrolysis has to face several challenges posed by the corrosiveness of highly concentrated chloride and the competitive chlorine evolution reaction(ClER).To overcome these issues,we designed a novel NiP_(2)@CoP electrocatalyst on a porous titanium microfiltration(Ti MF)*** obtained bifunctional NiP_(2)@CoP catalyst outperforms the Pt/C and IrO_(2),as evidenced by its low overpotentials of 192 and 425 mV at a current density of 500 mA·cm^(-2) for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in alkaline seawater(1 M KOH+0.5 M NaCl),***,only 231 and 569 mV overpotentials are required at the current density of 1500 mA·cm^(-2) towards HER and OER in alkaline seawater,*** importantly,no ClER was observed,demonstrating its excellent selectivity to *** selection of porous Ti MF membrane as an electrode substrate further enhances the performance by providing a robust structure that promotes the fast generation and release of gas *** promising outcomes obtained with NiP_(2)@CoP catalysts on Ti MF support,therefore,pave the way for the commercial viability of direct seawater electrolysis technologies at industrial-level current densities.

关键词： direct seawater electrolysis porous titanium microfiltration membrane phosphides heterostructures NiP_(2)@CoP electrocatalyst excellent selectivity to oxygen evolution reaction(OER)

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经复合树脂浸渍的超导磁体应力应变分析

电工电能新技术 2017年第11期36卷 14-20页

作者：李振明陈铮谢凯耿国丽舒航方进丘明中国电力科学研究院储能与电工新技术研究所北京100192 北京交通大学电气工程学院北京100044

采用复合树脂浸渍是提高超导储能磁体机械稳定性的有效手段之一,但是固化工艺条件会产生机械热应力,经复合树脂浸渍的超导磁体在预冷过程和通电运行过程中也会产生机械热应力或电磁力。为了分析储能磁体受力情况,本文通过COMSOL有限元... 详细信息

采用复合树脂浸渍是提高超导储能磁体机械稳定性的有效手段之一,但是固化工艺条件会产生机械热应力,经复合树脂浸渍的超导磁体在预冷过程和通电运行过程中也会产生机械热应力或电磁力。为了分析储能磁体受力情况,本文通过COMSOL有限元软件建立储能磁体模型,研究磁体绕制过程中热应力和运行过程中电磁力对磁体结构应力应变的影响。结果表明,浸渍固化工艺过程中超导带材最大形变为0.23%,热应力没有对超导带材造成不可承受的损伤;在低温预冷过程中复合树脂最大形变2%,可为超导线圈提供一定预应力;在电磁力与热应力耦合作用过程中,超导带材最大形变0.017%,超导磁体的力学稳定性没有被破坏。

关键词：超导储能磁体有限元仿真应力应变环氧树脂

基于电容成像检测技术的带防腐层金属结构缺陷检测

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装备环境工程 2018年第8期15卷 1-9页

作者：李振陈国明谷悦李晨殷晓康中国石油大学(华东)海洋油气装备与安全技术研究中心山东青岛266580

目的同时检测防腐层下金属结构表面缺陷和防腐层缺陷。方法应用电容成像检测技术同时检测防腐层下金属结构表面缺陷和防腐层缺陷,理论分析防腐层下金属表面减薄缺陷、防腐层下金属表面坑状缺陷和防腐层缺陷对电场线的扰动变化规律,仿真... 详细信息

目的同时检测防腐层下金属结构表面缺陷和防腐层缺陷。方法应用电容成像检测技术同时检测防腐层下金属结构表面缺陷和防腐层缺陷,理论分析防腐层下金属表面减薄缺陷、防腐层下金属表面坑状缺陷和防腐层缺陷对电场线的扰动变化规律,仿真分析这三种缺陷对电势线的扰动变化规律,提出电容成像检测技术用于检测防腐层下金属结构表面缺陷和防腐层缺陷的可行性,并搭建电容成像检测系统,利用检测系统检测2 mm和4 mm防腐层下金属表面减薄1 mm和2 mm缺陷、金属表面坑状缺陷、2 mm防腐层下金属结构(防腐层含有通孔缺陷)。结果理论分析和仿真分析显示,电容成像检测技术具有检测防腐层下金属结构表面缺陷和防腐层缺陷的可行性。试验结果表明,电容成像系统能检测2 mm和4 mm防腐层下金属表面减薄1 mm和2 mm缺陷、金属表面坑状缺陷、2 mm防腐层下金属结构(防腐层含有通孔缺陷)。除此之外,在防腐层下金属表面缺陷处的检测结果值呈现上升的趋势,在防腐层缺陷处的检测结果呈现下降的趋势,据此规律可以区分防腐层下金属表面缺陷和防腐层缺陷。结论电容成像检测技术能检测防腐层下金属结构表面减薄缺陷和坑状缺陷,还能同时检测防腐层本身存在的缺陷。根据检测在防腐层下金属结构表面缺陷和防腐层缺陷所呈现的不同结果,可用于区分这两类缺陷,有利于为油气储运设施缺陷维修制定合理的方案。

关键词：电容成像检测技术金属表面缺陷防腐层缺陷检测系统

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect