检索结果-南通市图书馆

Sequential Fluorescent Labeling Observation of Maxillary Sinus Augmentation by a Tissue-engineered Bone Complex in Canine Model

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2009年第1期1卷 39-46页

作者： Xin-quan Jiang Shao-yi Wang Jun Zhao Xiu-li zhang Zhi-yuan zhang Shanghai Research Institute of Stomatology Shanghai Key Laboratory of Stomatolgoy Shanghai Ninth People＇s Hospitalaffiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Aim To evaluate the effects of maxillary sinus floor elevation by a tissue-engineered bone complex of β-tricalcium phosphate （β-TCP） and autologous osteoblasts in dogs. Methodology Autologous osteoblasts from adult Beagle dogs were cultured in vitro. They were further combined with β-TCP to construct the tissue-engineered bone complex. 12 cases of maxillary sinus floor elevation surgery were made bilaterally in 6 animals and randomly repaired with the following 3 groups of materials： Group A （osteoblasts/D-TCP）; Group B （β-TCP）; Group C （autogenous bone）（n=4 per group）. A polychrome sequential fluorescent labeling was performed post-operatively and the animals were sacrificed 24 weeks after operation for histological observation.Results Our results showed that autologous osteoblasts were successfully expanded and the osteoblastic phenol- types were confirmed by ALP and Alizarin red staining. The cells could attach and proliferate well on the surface of the ~3-TCP scaffold. The fluorescent and histological observation showed that the tissue-engineered bone complex had an earlier mineralization and more bone formation inside the scaffold than β-TCP along or even autologous bone. It had also maximally maintained the elevated sinus height than both control groups. Conclusion Porous 13-TCP has served as a good scaffold for autologous osteoblasts seeding. The tissue-engineered bone complex with β-TCP and autologous osteoblasts might be a better alternative to autologous bone for the clinical edentulous maxillary sinus augmentation.

关键词： maxillary sinus augmentation tissue engi-neering β-tricalcium phosphate osteoblasts fluorescentlabeling

New Ideas for an Old Dream

在线全文

学校读者我要写书评

暂无评论

China Today 2012年第9期61卷 32-34页

作者： staff reporters li yuan & zhang HUI

THEY will beat their swords into plowshares and their spears into pruning hooks. Nation will no take up sword against nation nor will they learn war anymore." This quote adorns a stone wall that lies outside the UN headquarters in New York and, though biblical in origin, expresses a universal desire for peace that was the fundamental inspiration for the creation of the UN.

关键词：联合国再学习原产地

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong Mei-ling Xu Jun-Jun zhang Guang-Qiang Chen Zhi-Hui Hong Hong zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao Chen-Yang zhang Rong-Zheng Chen Peng-Fei Xing li-yuan zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

A rare case of arterial thrombosis due to heparin-induced thrombocytopenia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第22期124卷 3830-3833页

作者： li Lei GAO Wei zhang Fu-chun HAN Jiang-li zhang yuan WANG Gui-song SHE Fei GUO li-jun Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

A 78-year-old man presented with an eight-hour history of chest distress. Electrocardiograph and serum cardiac enzymes were suggestive of acute inferior myocardial infarction with right ventricular infarction. The patient, who underwent emergency percutaneous coronary intervention, suffered from thrombocytopenia presenting with cerebral infarction and myocadial reinfarction during haparin exposure. The laboratory test for heparin-induced thrombocytopenia （HIT） specific antibodies （heparin-platelet factor, PF4） was positive. The case was diagnosed as arteries thrombosis due to heparin-induced thrombocytopenia; the patient died after cessation of heparin.

关键词： heparin-induced thrombocytopenia arterial thrombosis

Pharmacology teaching and its reform in China

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第9期 131-136页

作者： Wei-dong li, yuan zhang, Cai-li zhang, Xiu-mei zhangDepartment of Pharmacology, Peking University, Beijing 100083 Department of Pharmacology, Tianjin Medical University, Tianjin 300070 Department of Pharmacology, Shandong University, Ji-nan 250012, China.

The general situation of pharmacology teaching in China was introduced and the educational reform in China in recent decade is summarized. The aim of the article is to provide those who are interested in teaching of pharmacology to be acquainted with the teaching of pharmacology, including the teaching of both principles and practice, in China.

关键词： pharmacology teaching reform principles and practice of teaching

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

一种连续数据保护系统的快照方法

软件学报 2011年第10期22卷 2523-2537页

作者：李虓谭毓安李元章北京理工大学计算机学院北京100081

针对传统连续数据保护技术中使用的快照存储技术难以高效存储足够多快照的问题,提出了一种新的快照存储技术,即基于凸点集合的快照存储技术(convex point SNAPshot,简称CSNAP).在讨论了CSNAP技术使用的数据结构,并引进了在数据结构中加... 详细信息

针对传统连续数据保护技术中使用的快照存储技术难以高效存储足够多快照的问题,提出了一种新的快照存储技术,即基于凸点集合的快照存储技术(convex point SNAPshot,简称CSNAP).在讨论了CSNAP技术使用的数据结构,并引进了在数据结构中加入指针构成的凸点概念的基础上,分析了凸点集合具有的基本性质,并给出了利用凸点集合储存快照的相关算法,同时还给出了一种使用逆行代价改进CSNAP的方法.最后通过在实际工作负载和随机合成工作负载下的模拟实验说明了,在平均情况下,使用改进的CSNAP技术,可以将快照占用的储存空间减少到传统方法的10%以下.

关键词：连续数据保护快照凸点凹点逆行代价

在线全文

学校读者我要写书评

暂无评论

一种块级连续数据保护系统的快速恢复方法

北京理工大学学报 2011年第6期31卷 679-684页

作者：李虓谭毓安李元章北京理工大学计算机学院北京100081

针对传统连续数据保护技术需要遍历连续数据保护(CDP)日志以提供任意时间点磁盘镜像的问题,提出了一种新的快速恢复技术,即基于后向连接的按需快速恢复技术.在讨论了该快速恢复技术使用的基本数据结构,并引进了在基本数据结构中加入指... 详细信息

针对传统连续数据保护技术需要遍历连续数据保护(CDP)日志以提供任意时间点磁盘镜像的问题,提出了一种新的快速恢复技术,即基于后向连接的按需快速恢复技术.在讨论了该快速恢复技术使用的基本数据结构,并引进了在基本数据结构中加入指针构成的后向连接的基础上,给出并分析了利用后向连接实现任意时间点快速恢复的相关算法.通过在实际工作负载下的模拟实验,说明了在恢复时间点距离当前时间点较近的情况下,使用快速恢复方法能够以可接受的响应时间为代价完成快速恢复.

关键词：连续数据保护按需恢复临时磁盘映像

Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 329-355页

作者： Yufeng Xing Ye yuan Gen li Institute of Solid Mechanics Beihang University(BUAA)Beijing100191China

The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical *** taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue ***,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are *** is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.

关键词： Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method

Postoperative recovery from posterior communicating aneurysm complicated by oculomotor palsy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第12期121卷 1065-1067页

作者： YANG Ming-qi WANG Shuo ZHAO yuan-li zhang Dong ZHAO Ji-zong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Oculomotor palsy is a common complication in patients with posterior communicating aneurysm. This study was conducted to investigate the postoperative recovery of patients with posterior communicating aneurysm complicated with oculomotor palsy and to analyze the factors influencing length of recovery.Methods From 2000 to 2006, 148 patients with posterior communicating aneurysm were treated at our hospital, with 74 of them having concurrent unilateral oculomotor palsy. All of the patients underwent craniotomy after the diagnosis by means of whole-brain digital subtraction angiography （DSA）. The patients were divided into two groups for observation of postoperative recovery during the follow-up period. Patients in group A were treated with simple pedicle clipping of the aneurysm while patients in group B were treated with pedicle clipping of the aneurysm and decompression of the oculomotor nerve.Results Of the 40 patients in group A, 20 underwent surgery within 14 days and completely recovered from oculomotor palsy in 10-40 days. Fourteen patients underwent surgery within 14-30 days, of whom 12 completely recovered within 30-90 days and 2 cases recovered incompletely. The remaining six patients underwent surgery after more than 30 days; of these, four patients recovered completely and two recovered incompletely. Of the 34 cases in group B, 15 underwent surgery within 14 days and completely recovered from oculomotor palsy in 10-40 days. Sixteen patients underwent surgery in 14-30 days, of whom 14 completely recovered in 30-90 days and 2 recovered incompletely. The remaining three patients underwent surgery after more than 30 days, of whom two patients recovered completely and one recovered incompletely.Conclusions Early diagnosis and surgical treatment of patients with unilateral oculomotor palsy induced by posterior communicating aneurysm are important to full postoperative recovery of the oculomotor nerve. No correlation was found, however, between d

关键词： oculomotor palsy cerebral angiography intracranial aneurysm