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World Journal of Clinical Oncology 2025年第2期16卷 130-143页

作者： Wei-Wu Chen Yue-Hong Kong li-yuan zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Bone is a major site of metastasis in nasopharyngeal carcinoma(NPC).Recently,nuclear factor kappa-beta ligand(RANKL)inhibitors have garnered attention for their ability to inhibit osteoclast formation and bone resorption,as well as their potential to modulate immune functions and thereby enhance the efficacy of programmed cell death protein 1(PD-1)inhibitor *** SUMMARY We present a case of a patient with NPC who developed sternal stalk metastasis and multiple bone metastases with soft tissue invasion following radical chemoradiotherapy and targeted *** to chemotherapy,the patient experienced severe bone marrow suppression and opted out of further chemotherapy ***,the patient received combination therapy,including RANKL inhibitors(denosumab)alongside PD-1,radiotherapy,and granulocyte-macrophage colonystimulating factor(PRaG)therapy(NCT05435768),and achieved 16 months of progression-free survival and more than 35 months of overall survival,without encountering any grade 2 or higher treatment-related adverse *** Denosumab combined with PRaG therapy could be a new therapeutic approach for the second-line treatment in patients with bone metastases.

关键词： Nasopharyngeal carcinoma Bone metastasis Radiotherapy Programmed cell death protein 1 inhibitors Denosumab Case report

Low-thermal-conductivity thermal barrier coatings with a multi-scale pore design and sintering resistance following thermal exposure

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Rare Metals 2020年第4期39卷 352-367页

作者： Wei-Wei zhang Zhi-yuan Wei li-yuan zhang Ya-Zhe Xing Qiang zhang School of Materials Science and Engineering Chang'an UniversityXi'an 710064China State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi'an 710049China College of Chemistry and Chemical Engineering Neijiang Normal UniversityNeijiang 641112China AECC Beijing Institute of Aeronautical Material Beijing 100095China

High-insulation,long-life thermal barrier coatings(TBCs)decrease the service temperature of superalloys and improve the service life of gas *** in the thermal insulation properties of the coating mainly depends on the optimization of the TBC *** important challenge for TBCs is maintaining a high performance during thermal exposure without degradation,as the pore-rich structure of the topcoat would inevitably be transformed by sintering.A low-thermalconductivity anti-sintering coating can overcome the tradeoff between thermal insulation and sinter *** this review,the design,preparation,and serviceability evaluation of a low-thermal-conductivity anti-sintering coating will be ***,directions for potential development are *** paper provides a comprehensive understanding of the structured tailoring of TBCs for better thermal insulation and anti-sintering performance.

关键词： Thermal barrier coatings Multi-scale pore Sintering resistance Low thermal conductivity

Rapid and nondestructive layer number identification of two-dimensional layered transition metal dichalcogenides

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Rare Metals 2017年第9期36卷 698-703页

作者： Jia-Peng Wu Le Wang li-yuan zhang Department of Physics Renmin University of ChinaBeijing 100872China Beijing Key Laboratory of Opto-Electronic Functional Materials&Micro-Nano Devices Renmin University of ChinaBeijing 100872China Department of Physics South University of Science and Technology of ChinaShenzhen 518055China

MoS2, MoSe2 and WSe2 thin flakes were fabricated by the standard micromechanical cleavage procedures. The thickness and the optical contrast of the atomic thin dichalcogenide flakes on SiO2/Si substrates were measured by atomic force microscopy（AFM） and spectroscopic ellipsometer. A rapid and nondestructive method by using reflection spectra was proposed to identify the layer number of 2D layered transition metal dichalcogenides on SiO2（275 nm）/Si substrates. The contrast spectra of 2D nanosheets with different layer numbers are in agreement with theoretical calculations based on Fresnel＇s law, indicating that this method provides an unambiguous and nondestructive contrast spectra fingerprint for identifying single-and few-layered transition metal dichalcogenides. The results will greatly help in fundamental research and application.

关键词： Transition metal dichalcogenides Opticalcontrast Layer number identification

Aperture shape optimization in intensity-modulated radiation therapy planning

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Nuclear Science and Techniques 2023年第9期34卷 106-117页

作者： li-yuan zhang Zhi-Guo Gui Peng-Cheng zhang Jie Yang Shanxi Provincial Key Laboratory for Biomedical Imaging and Big Data North University of ChinaTaiyuan 030051China School of Medicine Management Shanxi University of Chinese MedicineTaiyuan 030619China

The gradient element of the aperture gradient map is utilized directly to generate the aperture shape without *** process can be likened to choosing the direction of negative gradient descent for the generic aperture shape *** negative gradient descent direction is more suitable under local conditions and has a slow convergence *** overcome these limitations,this study introduced conjugate gradients into aperture shape optimization based on gradient ***,the aperture gradient map of the current beam was obtained for the proposed aperture shape optimiza-tion method,and the gradients of the aperture gradient map were modulated using conjugate gradients to form a modulated gradient *** aperture shape was generated based on the modulated gradient *** proposed optimization method does not change the optimal solution of the original optimization problem,but changes the iterative search direction when generating the aperture *** performance of the proposed method was verified using cases of head and neck cancer,and prostate *** optimization results indicate that the proposed optimization method better protects the organs at risk and rapidly reduces the objective function value by ensuring a similar dose distribution to the planning target *** to the contrasting methods,the normal tissue complication probability obtained by the proposed optimization method decreased by up to 4.61%,and the optimization time of the proposed method decreased by 5.26%on average for ten cancer *** effectiveness and acceleration of the proposed method were verified through comparative *** to the comparative experiments,the results indicate that the proposed optimization method is more suitable for clinical *** is feasible for the aperture shape optimization involving the proposed method.

关键词： Aperture shape Column generation Conjugate gradient Gradient modulation Direct aperture optimization

Enhanced spin diffusion length by suppressing spin-flip scattering in lateral spin valves

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Rare Metals 2015年第3期34卷 156-159页

作者： lin-Jing Pan Le Wang li-yuan zhang Department of Physics Renmin University of China Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of China

The spin transport was investigated in permally （Py）/MgO/Ag junction with lateral spin valve structure. Non-local lateral spin valves measurement was carried out to determin, the apin accumulignal in Ag strip, and the spin dif u^sion - length in Ag of the lateral spin valves was extracted from devices with the different distances between injector and detector. The experimental results are found that spin accumulation and spin diffusion length （2s） could be significantly enhanced in Ag strip with MgO capping layer, and those effects may be attributed to the low-surface spin scattering rate in Ag with an MgO cap- ping layer.

关键词： Spin accumulation Spin diffusion length Lateral spin valve Spin scattering

Probing the influence of secondary fracture connectivity on fracturing fluid flowback efficiency

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Petroleum Science 2023年第2期20卷 973-981页

作者： Yi-Ning Wu li-Sha Tang yuan li li-yuan zhang Xu Jin Ming-Wei Zhao Xiang Feng Cai-li Dai School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Research Institute of Petroleum Exploration&Development PetroChinaBeijing 100083China College of Chemistry and Chemical Engineering China University of Petroleum(East China)Qingdao266580ShandongChina

A deep understanding of the geometric impacts of fracture on fracturing fluid flowback efficiency is essential for unconventional oil development. Using nuclear magnetic resonance and 2.5-dimensional matrix-fracture visualization microfluidic models, qualitative and quantitative descriptions of the influences of connectivity between primary fracture and secondary fracture on flowback were given from core scale to pore network scale. The flow patterns of oil-gel breaking fluid two-phase flow during flowback under different fracture connectivity were analyzed. We found some counterintuitive results that non-connected secondary fracture (NCSF, not connect with artificial primary fracture and embedded in the matrix) is detrimental to flowbackefficiency. The NCSF accelerates the formation of oil channeling during flowback, resulting in a large amount of fracturing fluid trapped in the matrix, which is not beneficial for flowback. Whereas the connected secondary fracture (CSF, connected with the artificial primary fracture) is conducive to flowback. The walls of CSF become part of primary fracture, which expands the drainage area with low resistance, and delays the formation of the oil flow channel. Thus, CSF increases the high-speed flowback stage duration, thereby enhancing the flowback efficiency. The fracturing fluid flowback efficiency investigated here follows the sequence of the connected secondary fracture model (72%) > the matrix model (66%) > the non-connected secondary fracture model (38%). Our results contribute to hydraulic fracturing design and the prediction of flowback efficiency.

关键词： Fracturing fluid Secondary fracture connectivity Flowback efficiency Dual media Microfluidic model

Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives

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Chinese Chemical Letters 2016年第1期27卷 163-167页

作者： li-yuan zhang Bao-Lei Wang Yi-Zhou Zhan Yan zhang Xiao zhang Zheng-Ming li State Key Laboratory of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering Nankai University

A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR,~1H NMR,^（13）C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 mg/m L.

关键词： Triazole thione derivatives Fluorine Piperazine Mannich base Biological activity

Synthesis and characterization of a novel hydroxypolyether blocked polydimethylsiloxane PEO-b-PDMS-b-PEO

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Chinese Chemical Letters 2008年第10期19卷 1209-1211页

作者： Wei Hu li Xing yuan zhang Jia Bing Dai CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 China

A novel hydroxypolyether blocked polydimethylsiloxane, poly（ethylene oxide） propyl-b-polydimethylsiloxane-b-propyl poly（ethylene oxide）（PEO-b-PDMS-b-PEO） was synthesized by simple hydrosilation reaction of poly（ethylene glycol） monoallyl ether with α,ω-dihydrogen terminated PDMS （HPDMS）. Fourier transform infrared spectroscopy （FTIR） and IH NMR were used to identify the structure of PEO-b-PDMS-b-PEO and intermediate product HPDMS. Based on the effect investigations of temperature, reactant molar ratio, catalyst and time on the hydrosilation, it was found that the conversion of Si-H bond to SiC bond increased with the increase of catalyst and time, and the reaction completed when the content of catalyst was 22μg/g and the time was 5 h, respectively. Urethane reaction of OH and NCO group confirms that PEO-b-PDMS-b-PEO is more reactive toward to diisocyanate than α,ω-dihydroxylbutyl terminated PDMS.

关键词： Synthesis Polydimethylsiloxane Hydrosilation reaction Reactivity

Synthesis and characterization of fluorinated PEO-b-PDMS-b-fluorinated PEO by free radical addition

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Chinese Chemical Letters 2009年第9期20卷 1127-1130页

Fluorinated poly（ethylene oxide） propyl-b-polydimethylsiloxane-b-propyl fluorinated poly（ethylene oxide）（FPEO-b-PDMS-b- FPEO） was synthesized by a free radical addition of carbon-hydrogen of polyether segments of poly（ethylene oxide） propyl-b- polydimethylsiloxane-b-propyl poty（ethylene oxide）（PEO-b-PDMS-b-PEO） to hexafluoropropylene （HFP） using tert-butyl peroxypivalate as an initiator. In order to reduce the possibility of side reaction, the protection and deprotection via silylation were used for the end-hydroxyls in PEO-b-PDMS-b-PEO chain. The structure of Intermediates and FPEO-b-PDMS-b-FPEO was confirmed by means of Fourier transform infrared and 1H NMR spectroscopy. The effects of amount of initiator, reaction temperature and time on free radical addition were investigated in detail. 2009 Xing yuan zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Fluorinated Hexafluoropropylene Polydimethylsiloxane Free radical addition Silylation

Dynamics-based optimization of rolling schedule aiming at dual goals of chatter suppression and speed increase for a 5-stand cold tandem rolling mill

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Journal of Iron and Steel Research International 2021年第2期28卷 168-180页

作者： Zhi-ying Gao Bo Tian Yang liu li-yuan zhang Mao-lin liao School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

In the process of cold tandem rolling,chatter instability leads to serious impacts on enhancing rolling speed,improving product quality,reducing production cost and realizing *** occurs with the rolling speed up to a certain threshold value,but the critical speed is determined by both product specifications and rolling schedules.A 5-stand cold tandem rolling mill whose first three stands and subsequent two stands,respectively,have four and six rolls was investigated by formulating its dynamic equations with the corresponding structure-process *** applying the stability-based calculation model about the critical rolling speed in each stand,the system dynamic responses around the critical rolling speed were simulated,and the system eigenvalues which represent instability and characteristic frequencies were figured ***,via combining the critical rolling speeds with the system dynamic behavior,a dynamics-based optimization model of rolling schedule for the 5-stand cold tandem system was proposed for the purposes of both the chatter suppression and rolling speed *** the optimization model,eight rolling technique parameters(four strip thicknesses and four tensions between the upstream and downstream stands)were taken as design variables,and the constraint conditions were set as no chatter instability in all five stands,and the optimization goal was to maximize the outlet speed of the final *** pattern search method was introduced to solve the optimization *** applying such a dynamics-based optimization model for the 5-stand cold tandem rolling process,the chatter instability was suppressed effectively and the rolling efficiency was improved considerably;therefore,such an optimization model is expected to be valuable for intelligent manufacturing of rolling process.

关键词： Cold tandem rolling Chatter Critical rolling speed Rolling schedule Dynamics-based optimization Stability