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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： yu-Qin li Wen-Tao Kuai lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han yue-Kui wang lian-Xin Xu li-Ying Ge Yong-Gang liu Shuang li liang Xu yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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硫酸氨基葡萄糖胶囊生物等效性研究基本考虑

中国新药杂志 2018年第6期27卷 634-636页

作者：王玉杨进波贺锐锐李丽王玉珠国家食品药品监督管理总局药品审评中心北京100038

氨基葡萄糖是一种新型骨关节炎治疗药物,其药动学相关的血药浓度研究显得尤为重要,但氨基葡萄糖为人体内源性物质,除了人体内自然存在的氨基葡萄糖以外,还有许多其他内源性糖等物质也存在干扰,且内源性氨基葡萄糖具有浓度低和受试者间... 详细信息

氨基葡萄糖是一种新型骨关节炎治疗药物,其药动学相关的血药浓度研究显得尤为重要,但氨基葡萄糖为人体内源性物质,除了人体内自然存在的氨基葡萄糖以外,还有许多其他内源性糖等物质也存在干扰,且内源性氨基葡萄糖具有浓度低和受试者间变异性较高的特点。因此,若想准确地检测到外源性氨基葡萄糖在血浆中的浓度,在选择使用具有较高灵敏度和选择性的方法的前提下,还需要减去内源性氨基葡萄糖的基线值来排除干扰。

关键词：氨基葡萄糖生物等效性检测方法内源性物质基线干扰

杨树PtROP家族基因的表达分析与功能预测

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林业科学研究 2017年第1期30卷 1-9页

作者：李煜张进王丽娟卢孟柱林木遗传育种国家重点实验室中国林业科学研究院林业研究所北京100091 国家林业局林木培育重点实验室中国林业科学研究院林业研究所北京100091

[目的]为探究ROP基因在林木中的功能。[方法]本研究以杨树为模式,在全基因组水平上对ROP基因的家族成员、基因结构、保守结构域、氨基酸序列相似性及表达模式进行了分析。[结果]显示,杨树PtROP基因家族包含13个成员,不同成员间在进化上... 详细信息

[目的]为探究ROP基因在林木中的功能。[方法]本研究以杨树为模式,在全基因组水平上对ROP基因的家族成员、基因结构、保守结构域、氨基酸序列相似性及表达模式进行了分析。[结果]显示,杨树PtROP基因家族包含13个成员,不同成员间在进化上相对保守,均存在与GTP结合与水解相关的结构域。这些基因在不同组织、不同胁迫条件下的表达具有明显差异,说明它们参与不同的生物学过程。通过构建功能基因网络(functional gene network for poplar)发现PtROP基因主要参与了信号转导过程。[结论]杨树PtROP基因家族包含13个成员参与不同的生物学过程,可能主要参与了信号转导过程。

关键词：杨树 ROP 基因家族基因表达模式

中央与地方教育财政事权与支出责任的划分研究

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清华大学教育研究 2017年第5期38卷 35-43页

作者：李振宇王骏北京师范大学经济与工商管理学院北京100875

探究层级政府间教育财政事权和支出责任,对合理配置和统筹教育财政资源、提高教育财政资金使用和管理效率、保障教育财政投入长效增长、深化和完善教育财政体制具有重要意义。首先,本文从法律法规、政策文件和统计数据等方面对中央和地... 详细信息

探究层级政府间教育财政事权和支出责任,对合理配置和统筹教育财政资源、提高教育财政资金使用和管理效率、保障教育财政投入长效增长、深化和完善教育财政体制具有重要意义。首先,本文从法律法规、政策文件和统计数据等方面对中央和地方各级各类教育的财政事权和支出责任进行实然层面的分析,指出了现有教育财政事权与支出责任划分存在的问题;其次,从教育财政的特殊性出发,提出了合理划分教育财政事权与支出责任的原则,即受益原则、匹配原则、效率原则、中央控制原则、法治原则和动态调整原则;最后,提出了中央与地方教育财政事权与支出责任划分的改革方向,建议逐步建立以省级政府供给为主的基础教育经费制度,强化中央政府在高等教育投入中的责任,调整政府部门间的教育权责关系,建立有效的学校财务治理结构,规范和完善教育转移支付制度,形成教育财政支出公示和问责制度。

关键词：教育财政事权支出责任中央地方

氧化石墨烯水泥浆体流变性能的定量化研究（英文）

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新型炭材料 2016年第6期31卷 574-584页

作者：王琴王健吕春祥崔鑫有李时雨王皙北京建筑大学土木与交通工程学院工程结构与新材料北京市高校工程研究中心绿色建筑与节能技术北京市重点实验室北京100044 中国科学院山西煤炭化学研究所碳纤维制备技术国家工程实验室山西太原030001

采用流变仪和激光共聚焦显微镜对不同氧化石墨烯(GO)掺量的新拌水泥浆体的流变参数以及浆体微观形态进行了定量化研究,并采用Modified-Bingham(M-B)模型和Herschel-Bulkley(H-B)模型对所测数据进行了拟合处理,提出了GO影响新拌水泥浆体... 详细信息

采用流变仪和激光共聚焦显微镜对不同氧化石墨烯(GO)掺量的新拌水泥浆体的流变参数以及浆体微观形态进行了定量化研究,并采用Modified-Bingham(M-B)模型和Herschel-Bulkley(H-B)模型对所测数据进行了拟合处理,提出了GO影响新拌水泥浆体的作用机理。结果表明,GO的掺入可以使新拌浆体中在减水剂作用下分散的水泥颗粒发生再次凝聚,形成重组絮凝结构,且随着GO掺量的增加,重组絮凝结构的数量越多,从而使得浆体流变性发生显著变化。一方面,新拌浆体的塑性粘度、屈服应力以及触变性随GO掺量的提高而显著增加。另一方面,GO的掺入提高了新拌浆体的临界剪切速率,使其在较大剪切速率下的流变行为仍然表现为剪切变稀;降低了浆体的剪切增稠程度,提高了浆体的稳定性。

关键词：氧化石墨烯水泥浆体流变性能絮凝结构

Exposure to crude microcystins via intraperitoneal injection causes hepatotoxicity in ducks

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Exposure to crude microcystins via intraperitoneal injection...

Activity of HDV ribozymes to trans-cleave HCV RNA

中国藻类学会第八次会员大会暨第十六次学术讨论会

作者： Xiao-yu li~*,Chun-yu wang College of life Science,Henan Normal University,Xinxiang,Henan 453007,China

＜正＞There have been reports that duck deaths occur due to the sudden appearance of toxic Microcystis *** recent years,large-scale cyanobacterial blooms have occurred in the fishponds of Dabeinong Fishery Company in ... 详细信息

关键词： Microcystis aeruginosa bloom microcystins duck toxicity

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World Journal of Gastroenterology 2002年第4期8卷 694-698页

作者： yue-Cheng yu Qing Mao Chang-Hai Gu Qi-Fen li yu-Ming wang Institute of Infectious Diseases of Chinese PLA,Southwest Hospital,Third Military Medical University,Chongqing 400038,China Institute of Infectious Diseases of Chinese PLA Southwest Hospital Third Military Medical University Chongqing 400038China. yuechengyu212001@***

AIM: To explore whether HDV ribozymes have the abilityto trans-cleave ***: Three HDV genomic ribozymes weredesigned and named RzC1, RzC2 and RzC3. Thesubstrate RNA contained HCVRNA 5'-noncoding regionand 5'-fragment of C region (5'-NCR-C). All theribozymes and HCV RNA 5'-NCR-C were obtained bytranscription in vibo from their DNA templates, and HCVRNA 5'-NCR-C was radiolabelled at its 5'-end Undercertain pH, temperature, appropriate concentration ofMg2+ and deionized formamide, these ribozymes wererespectively or simultaneously mixed with HCVRNA 5'-NCR-C and reacted for a certain time. The trans-cleavage reaction was stopped at different time points,and the products were separated with polyacrylamidegel electrophoresis (PAGE), displayed byautoradiography. Percentage of trans-deaved productswas measured to indicate the activity of HDV ***: RzC1 and RzC2 could trans-cleave 26 % and21.8 % of HCV RNA 5'-NCR-C under our reactionconditions with 2.5 mol. L-1 deionized formamiderespectively. The percentage of HCV RNA 5'-NCR-Ctrans-cleaved by RzC1, RzC2 or combined usage of thethree ribozymes increased with time, up to 24.9 %, 20.3 %and 37.3 % respectively at 90 min point. Almost noproduct from RzC3 was ***: HDV ribozymes are able to trans-cleavespecifically HCV RNA at certain sites under appropriateconditions, and combination of several ribozymesaiming at different target sites can trans-cleave thesubstrate more efficiently than using only one of them.

关键词：丁型肝炎病毒核酸重组丙型肝炎病毒 RNA活性

Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin Xiao liang Shu-Peng liu Rui-Lan wang Qing-Wei Zhang yu-Feng Shen Xiao-Bo li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Plike cells hyperplasia(OR=3.116,Plike cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

排球运动员肩袖损伤后扣球发力顺序分析及受伤原因探讨

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北京体育大学学报 2017年第5期40卷 59-65页

作者：宋琳于跃王瑶崔立刚廖丽萍李瑜王安利北京体育大学北京100084 北京大学第三医院北京100191

目的:分析肩袖损伤运动员扣球时肌肉发力顺序,探讨肩袖损伤的原因,为运动员纠正错误动作、提高技术水平、预防肩袖损伤提供参考依据。方法:利用MEGAWIN6000表面肌电测试仪对肩袖损伤和肩部无伤的排球运动员疲劳前后的扣球动作进行测试,... 详细信息

目的:分析肩袖损伤运动员扣球时肌肉发力顺序,探讨肩袖损伤的原因,为运动员纠正错误动作、提高技术水平、预防肩袖损伤提供参考依据。方法:利用MEGAWIN6000表面肌电测试仪对肩袖损伤和肩部无伤的排球运动员疲劳前后的扣球动作进行测试,比较发力顺序的异同,分析肩袖损伤对动作控制的影响。结果:1)2组扣球发力各肌肉发力时刻占总动作时间百分比组间比较,疲劳前无伤组斜方肌中束和前锯肌明显大于有伤组,且差异具有非常显著性;2)损伤组组内比较,疲劳前斜方肌下束明显大于疲劳后,且差异具有显著性;3)损伤组仅在疲劳后主动上回旋肩胛骨再引臂,且没有内收预拉长;4)无伤组疲劳前后均会主动上回旋肩胛骨再引臂,且引臂前会内收上臂预拉长肌肉。结论:1)肩袖损伤运动员斜方肌下束激活异常,肩胛骨不稳定且主动运动滞后,肩峰下空间减小,容易引起撞击导致肩袖损伤;2)无伤运动员斜方肌中束和前锯肌激活明显早、贡献大,肩胛骨稳定且主动运动积极,肩峰下空间相对增大,可有效避免撞击损伤,内收预拉长动作有效提高扣球效果;3)肩袖损伤运动员与无伤运动员扣球发力顺序有明显差异,肩袖损伤运动员动作环节过度减少,幅度缩小,影响扣球质量且容易造成损伤。

关键词：排球扣球肩袖损伤发力顺序