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钢桥面板U肋-盖板焊缝疲劳裂纹萌生仿真

交通运输工程学报 2024年第1期24卷 131-145页

作者：赵秋唐琨李英豪邓俊逸福州大学土木工程学院福建福州350116 西南交通大学土木工程学院四川成都610031

为建立适用于钢桥面板U肋-盖板焊缝疲劳裂纹萌生分析方法,以Roe-Siegmund循环内聚力模型为基础,考虑混合加载模式下的内聚力参数转换,对ABAQUS进行二次开发,形成反映疲劳累计损伤的VUMAT子程序;通过试验数据获得了Q345钢材对应的焊接区... 详细信息

为建立适用于钢桥面板U肋-盖板焊缝疲劳裂纹萌生分析方法,以Roe-Siegmund循环内聚力模型为基础,考虑混合加载模式下的内聚力参数转换,对ABAQUS进行二次开发,形成反映疲劳累计损伤的VUMAT子程序;通过试验数据获得了Q345钢材对应的焊接区域材料内聚力参数,基于Voronoi图法、焊接区域晶粒微观形态与力学特性建立了U肋-盖板焊缝焊趾处微观晶粒组织,并与宏观二维平面应变模型合并,模拟了多尺度疲劳裂纹萌生;结合等效结构应力法和线弹性断裂力学裂纹扩展理论,考虑初始缺陷形态和疲劳断裂临界标准反推了不同应力水平下的累积内聚力长度,进而得到疲劳裂纹萌生寿命的计算方法。分析结果表明:采用提出的方法模拟U肋-盖板焊缝焊趾裂纹萌生行为时,裂纹在焊趾处萌生并垂直于顶板表面进行扩展,形成了穿晶断裂模式,微观晶粒组织应力分布随裂纹萌生及短裂纹扩展而不断变化,且随着微观晶粒组织分布和力学特性的随机性变化,仿真结果中的短裂纹扩展路径细节与临界循环次数均不相同;反推得到的累积内聚力长度随初始缺陷形状比、长裂纹扩展临界深度、微观晶粒组织分布及其力学特性以及所处应力幅值的不同产生变化,考虑上述因素获取的累积内聚力长度-等效结构应力幅拟合曲线能够获取对应的裂纹萌生寿命。由此可知,建立的多尺度疲劳裂纹萌生仿真分析方法可为钢桥面板疲劳裂纹萌生寿命的获取提供新的解决路径。

关键词：桥梁工程钢桥面板循环内聚力模型 Voronoi图法断裂力学等效结构应力法

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ERE铺装钢桥面板疲劳扩展与疲劳寿命研究

公路交通科技 2024年第6期41卷 130-137页

作者：王奎吴文明卢超何蕾李英豪湖北联合交通投资开发有限公司湖北武汉430048 北京公科固桥技术有限公司北京100088 福州大学土木工程学院福建福州350108

为研究ERE铺装对正交异性钢桥面板U肋与顶板焊接处疲劳细节的影响,针对某悬索桥实际的正交异性钢桥面板构造细节,利用等效结构应力理论研究其疲劳性能,并利用线弹性断裂力学理论进一步分析其疲劳裂纹扩展行为。首先,采用Abaqus软件分别... 详细信息

为研究ERE铺装对正交异性钢桥面板U肋与顶板焊接处疲劳细节的影响,针对某悬索桥实际的正交异性钢桥面板构造细节,利用等效结构应力理论研究其疲劳性能,并利用线弹性断裂力学理论进一步分析其疲劳裂纹扩展行为。首先,采用Abaqus软件分别建立原铺装和ERE铺装的正交异性钢桥面板节段有限元模型,基于等效结构应力法分析其疲劳细节疲劳性能以及在不同荷载位置下的等效结构应力;随后在此基础上运用FRANC.3D与Abaqus软件建立具有相同等效结构应力幅的三维顶板-U肋构造细节等效模型,并植入裂纹,对其结构局部模型的裂纹扩展性能进行对比分析。结果表明:该桥某跨跨中截面开裂模式以C.3开裂模式为主导,通过等效结构应力计算得疲劳寿命最短为427.1万次;对于采用ERE铺装加固后C.1,C.2裂纹开裂模式,在相同的裂纹扩展深度上,其应力强度因子都有着不同程度的降低,其平均寿命增加幅度为138.22%;当裂纹深度大于2 mm时原铺装结构C.3开裂模式的裂纹应力强度因子迅速增加,而采用ERE铺装加固后其应力强度因子幅值均低于原铺装结构且数值较为稳定,其平均寿命增加幅度为99.26%;ERE铺装加固后裂纹扩展寿命提升在75.13%~163.51%,平均增加幅度为125.23%。通过疲劳裂纹扩展寿命对比,可以认为ERE铺装能有效降低裂纹处的等效应力强度因子幅值,抑制裂纹的增长速率,从而提高构件的疲劳寿命。

关键词：桥梁工程疲劳性能等效结构应力应力强度因子正交异性钢桥面板 ERE铺装

Nonreciprocal generation of Schrodinger cat state induced by topology

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 23-30页

作者： Zi-hao li li-li Zheng ying Wu Xin-You Lü School of Physics and Institute for Quantum Science and Engineering Huazhong University of Science and Technologyand Wuhan Institute of Quantum TechnologyWuhan 430074China Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education Jianghan UniversityWuhan 430074China

The Schrodinger cat state produced differently in two directions is anticipated to be a critical quantum resource in quantum information *** exploring the interplay between quantum nonreciprocity and topology in a one-dimensional microcavity array,we obtain the Schrodinger cat state(a pure quantum state)in a chosen direction at the edge cavity,whereas a classical state in the other *** nonreciprocal generation of the cat state originates from the topologically protected chiralitymode excitation in the nontrivial phase,but in the trivial phase,the nonreciprocal generation of cat state ***,our proposal is switchable by tuning the parameters so that a topological phase transition ***,the obtained cat state has nonreciprocal high fidelity,nonclassicality,and quantum coherence,which are sufficient to be used in various one-way quantum technologies,e.g.,invisible quantum sensing,noise-tolerant quantum computing,and chiral quantum *** work provides a general approach to control quantum nonreciprocities with the topological effect,which substantially broadens the fields of nonreciprocal photonics and topological physics.

关键词： Schr?dinger cat state nonreciprocity topology

Eu掺杂ZnO多孔片状材料的制备及其降解印刷染料RhB

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当代化工 2024年第4期53卷 764-768页

作者：吴娟王晶王刚李丹婷李英豪王健俐哈尔滨商业大学基础科学学院黑龙江哈尔滨150028 哈尔滨商业大学轻工学院黑龙江哈尔滨150028

采用常温络合-水解法构筑Eu掺杂Zn O多孔片状材料。通过SEM、TEM、XRD、EDS等表征手段证明稀土元素Eu成功掺杂到Zn O之中,Eu-Zn O的形貌为多孔片状结构。研究了Eu-Zn O多孔片状材料对染料的光催化性能。结果表明:该材料对Rh B具有较好... 详细信息

采用常温络合-水解法构筑Eu掺杂Zn O多孔片状材料。通过SEM、TEM、XRD、EDS等表征手段证明稀土元素Eu成功掺杂到Zn O之中,Eu-Zn O的形貌为多孔片状结构。研究了Eu-Zn O多孔片状材料对染料的光催化性能。结果表明:该材料对Rh B具有较好的降解效率,降解效率高达99.2%,循环稳定性能高达98.3%,远大于商用Zn O的76.2%的降解效率和82.3%的循环稳定性能,由以上数据说明Eu-Zn O具有很好的光催化降解效率和循环稳定性能。其优异的光催化性能归因于稀土元素Eu掺杂和多孔片状结构。

关键词： Eu-Zn O Rh B 常温络合-水解法光催化

A deoxidation thermodynamic model for 304 stainless steel considering multiple-components coupled reactions

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Journal of Iron and Steel Research(International) 2024年第1期31卷 74-91页

作者： Yan Yan Guang-hao Shang li-ping Zhang Shao-ying li Han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Henan Jinhui Stainless Steel Industry Group Co. Ltd.Xuchang461500HenanChina Changge Jinhui Recycling Metal R&D Co. Ltd.Xuchang461500HenanChina

A thermodynamic model for predicting the equilibrium oxygens of 304 stainless steel was developed based on the theory of slag-steel equilibrium,the law of mass conservation,and the ion and molecule coexistence *** the developed model,the Fe-Cr-Mn-Si-Al-S-O-melts reaction system and CaO-MgO-CaF_(2)-FeO-MnO-Al_(2)O_(3)-SiO_(2)-Cr2O_(3)slags were *** oxygen contents calculated by the model are in good agreement with experimental results and reference *** equilibrium oxygen contents in 304 stainless steel mainly decrease with increasing binary basicity(w(CaO)/w(SiO_(2)),where w(i)is the mass percentage of component i)and decreasing *** binary basicity at 2.0 while maintaining temperatures lower than 1823 K will keep the oxygen contents in the 304 stainless steel lower than 15×10^(-6).The equilibrium oxygen contents may also be decreased with increasing content of MgO in slags,which is more significant at lower binary ***,a small amount of FeO,MnO,and Al_(2)O_(3)(about 0-2.5 wt.%)in slags has little effect on equilibrium oxygen ***,it is found that the[C]-[O]reaction may occur during refining process but will not significantly affect the equilibrium oxygen contents.

关键词： Complex deoxidation Thermodynamic model Ion and molecule coexistence theory 304 stainless steel Slag-steel reaction

Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions

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World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： hao li Chang liu ying Cui Panpan Chang Wei Chong Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of China Beijing 100871China

BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone deacetylase 6(HDAC6)-specific inhibitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macrophages under hypoxia/reoxygenation(H/R)***:The viability of RAW264.7 cells subjected to H/R after treatment with different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with RAW264.7 cells under H/R ***264.7 cells were divided into three groups,namely the control,H/R,and TubA *** levels of reactive oxygen species(ROS)in the cells were detected using fluorescence *** protein expression of HDAC6,heat shock protein 90(Hsp90),inducible nitric oxide synthase(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in the supernatants were detected using enzyme-linked immunosorbent assay(EliSA).RESULTS:HDAC6,Hsp90,and iNOS expression levels were significantly higher(P<0.01)in the H/R group than in the control group,but lower in the TubA group than in the H/R group(P<0.05).When comparing the H/R group to the control group,ROS levels were significantly higher(P<0.01),but significantly reduced in the TubA group(P<0.05).The H/R group had higher NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels than the control group(P<0.05),however,the TubA group had significantly lower expression levels than the H/R group(P<0.05).IL-1βand IL-18 levels in the supernatants were significantly higher in the H/R group compared to the control group(P<0.01),but significantly lower in the TubA group compared to the H/R group(P<0.01).CONCLUSION:TubA inhibited the expression of HDAC6,Hsp90,and iNOS in macrophages

关键词： Hemorrhagic shock Hypoxia/reoxygenation Macrophage NLRP3 Tubastatin A

Colon signet-ring cell carcinoma with chylous ascites caused by immunosuppressants following liver transplantation:A case report

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2343-2350页

作者： ying li Yang Tai hao Wu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Chylous ascites is caused by disruption of the lymphatic system,which is characterized by the accumulation of a turbid fluid containing high levels of triglycerides within the abdominal *** two most common causes are cirrhosis and tuberculosis,and colon signer ring cell carcinoma(SRCC)due to the use of immunosuppressants is extremely rare in cirrhotic patients after liver transplantation,making it prone to misdiagnosis and missed *** SUMMARY A 52-year-old man who underwent liver transplantation and was administered with immunosuppressants for 8 months was admitted with a 3-month history of progressive abdominal ***,based on lymphoscintigraphy and lymphangiography,lymphatic obstruction was considered,and cystellar chyli decompression with band lysis and external membrane stripping of the lymphatic duct was ***,his abdominal distention was persistent without *** paracentesis revealed allogenic cells in the ascites,and immunohistochemistry analysis revealed adenocarcinoma cells with phenotypic features suggestive of a gastrointestinal *** endoscopy was performed,and biopsy showed atypical signet ring cells in the ileocecal *** patient eventually died after a three-month follow-up due to progression of the *** Colon SRCC,caused by immunosuppressants,is an unusual but un-neglected cause of chylous ascites.

关键词： Colonic signer ring cell carcinoma Immunosuppressant Chylous ascites Cirrhosis liver transplantation Case report

Non-contact and full-field online monitoring of curing temperature during the in-situ heating process based on deep learning

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Advances in Manufacturing 2024年第1期12卷 167-176页

作者： Qiang-Qiang liu Shu-Ting liu ying-Guang li Xu liu Xiao-Zhong hao College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing211816People’s Republic of China

Online monitoring of the curing temperature field is essential to improving the quality and efficiency of the manufacturing process of composite *** embedded sensor-based technologies have difficulty monitoring the full temperature field or have to introduce heterogeneous items that could have an undesired impact on the *** this paper,a non-contact,full-field monitoring method based on deep learning that predicts the internal temperature field of composite parts in real time using surface temperature measurements of auxiliary materials is *** the proposed method,an average temperature monitoring accuracy of 97%is achieved in various heating *** addition,this method also demonstrates satisfying feasibility when a stronger thermal barrier covers the *** method was experimentally validated during the self-resistance electric heating process,in which the monitoring accuracy reached 93.1%.This method can potentially be applied to automated manufacturing and process control in the composites industry.

关键词： Online monitoring Curing temperature field Deep learning(DL) In-situ heating

Harnessing innate immune pathways for therapeutic advancement in cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu li Sun hao lin Yuheng liao Hui Yang ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate