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Five-year analysis of isolated pathogens and antibiotic resistance of ocular infections from two large tertiary comprehensive hospitals in east China

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1707-1716页

作者： pan-pan li li li Jun-Fang Zhang Bai Qin li-Hua Kang Min Ji Huai-Jin Guan Suzhou Medical College of Soochow University Suzhou 215123Jiangsu ProvinceChina Department of Ophthalmology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Clinical Laboratory Nantong City No.1 People’s Hospital and Second Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

AIM:To analyze the spectrum of isolated pathogens and antibiotic resistance for ocular infections within 5y at two tertiary hospitals in east ***:Ocular specimen data were collected from January 2019 to October *** pathogen spectrum and positive culture rate for different infection location,such as keratitis,endophthalmitis,and periocular infections,along with antibiotic resistance were ***:We included 2727 specimens,including 827(30.33%)positive cultures.A total of 871 strains were isolated,530(60.85%)bacterial and 341(39.15%)fungal strains were ***-positive cocci(GPC)were the most common ocular *** most common bacterial isolates were Staphylococcus epidermidis(25.03%),Staphylococcus aureus(7.46%),Streptococcus pneumoniae(4.59%),Corynebacterium macginleyi(3.44%),and Pseudomonas aeruginosa(3.33%).The most common fungal genera were Fusarium spp.(12.74%),Aspergillus spp.(6.54%),and Scedosporium spp.(5.74%).Staphylococcus epidermidis strains showed more than 50%resistance to *** pneumoniae and Corynebacterium macginleyi showed more than 90%resistance to *** percentage of bacteria showing multidrug resistance(MDR)significantly decreased(χ^(2)=17.44,P=0.002).CONCLUSION:GPC are the most common ocular *** macginleyi,as the fourth common bacterium,may currently be the local microbiological feature of east *** *** the most common *** than 50%of the GPC are resistant to fluoroquinolones,penicillins,and ***,the proportion of MDR strains has been reduced over time.

关键词： ocular infections bacteria fungus antibiotic resistance multidrug resistance

Orbital pacing and secular evolution of lake-level changes reconstructed by sedimentary noise modeling during the Early Jurassic icehouses-(super)greenhouses

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Science China Earth Sciences 2024年第1期67卷 252-267页

作者： Meng li Xin li Stephen P.HESSELBO Mingjie li Wenjin liU Wei WU Jienan pan Ruizhen GAO School of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China Camborne School of Mines and Environment and Sustainability Institute University of ExeterPenryn TR109FEUnited Kingdom Qinghai No.105 Coal Geological Exploration Team Xining 810000China

Lake-level changes can significantly affect paleoenvironmental evolution,resource occurrence,terrestrial carbon budget,and biodiversity in continental *** is one of the most critical factors controlling lake-level *** of the Early Jurassic has been evidenced by oscillating icehouses to(super)greenhouses with interrupted intermittent extreme climatic events(hyperthermal and cooling),e.g.,the Toarcian oceanic anoxic event(~183 Ma)and the late Pliensbachian cooling event(~185 Ma).Lake-level evolution and hydrologic cycling on Earth’s surface during the Early Jurassic icehouses-to-(super)greenhouses are thus far poorly understood due to a lack of continuous high-resolution nonmarine *** we present a super-long nonmarine lake level record for this pivotal interval from the early Pliensbachian to Toarcian by sedimentary noise modeling,and construct a 16.7-Myr-long astronomical time scale(174.2 Ma to 190.9 Ma)based on cyclostratigraphy analysis of rock color datasets(CIE b*)of the Qaidam *** results document lake-level oscillations on a 5-to 10-million-year(Myr)scale which shows a pronounced correlation with long-term climate variation and extreme climatic events,and 1-to 2.5-Myr-scale lake-level changes that are prominently paced by the 2.4-Myr long-eccentricity forcing and the 1.2-Myr obliquity *** the Pliensbachian Stage,the 1.2-Myr-scale lake-level changes are in phase with the coeval sealevel *** forced growth and decay of the ephemeral or permanent ice sheets in polar regions are interpreted to control the synchronous ups-and-downs of continental lake level and global sea ***,during the Toarcian ice-free greenhouses to(super)greenhouses,the 1.2-Myr-scale lake-level variations show an anti-phase relationship with global sea level,indicating a‘seesaw’interaction between continental reservoirs(lakes and groundwater)and global *** 2.4-Myr longeccentricity cycles mainly regulate variation

关键词： Milankovitch cycles Orbital forcing Sedimentary noise model Lake level Continental basins

Occurrence and vertical distribution of aluminum and rare earths in weathered crust elution-deposited rare earth ore:Effect of soil solution pH and clay minerals

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Journal of Rare Earths 2024年第7期42卷 1394-1402,I0007页

作者： Jiaxin pan Longsheng Zhao Zheng li Xiaowei Huang Zongyu Feng Jun Chen National Engineering Research Center for Rare Earth China GRINM Group Co.Ltd.Beijing100088China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China GRIREM Hi–Tech Co. Ltd.Langfang065201China GRIREM Advanced Materials Co. Ltd.Beijing100088China GRIMAT Engineering Institute Co. Ltd.Beijing101407China

Weathered crust elution-deposited rare earth ore is crucial source of medium and heavy rare earths,with in-situ leaching being the most common mining *** high contents of impurity of aluminum in the leach solution are a significant challenge for the subsequent enrichment process of rare earths.A comprehensive understanding of the occurrences and vertical distribution of aluminum and rare earths within typical vertical profiles can provide valuable insights into entire design of the in-situ *** paper improves a five-step sequential extraction method to analyze the occurrence and vertical distribution of rare earths and aluminum in vertical profiles from Chongzuo and *** results demonstrate that soil solution pH is the main factor affecting the vertical distribution of ionexchangeable rare *** samples have distinct areas of enrichment for ion-exchangeable rare earths or ***-exchangeable rare earths are primary concentrated in the middle and lower parts of the ore layer(4-13 m in Chongzuo,14-22 m in Longyan),while the ion-exchangeable aluminum is mainly enriched in the upper part of the ore layer(1-5 m in Chongzuo,and 2-14 m in Longyan).The vertical distribution of inorganic hydroxy aluminum is likely influenced by the micromorphology and particle size of the clay *** inorganic hydroxy aluminum concentration in Chongzuo samples decreases continuously from 415.65 to 120.95 mg/kg with increasing sampling depth,whereas the concentration in Longyan samples(110.55-171.27 mg/kg)is almost independence with sampling *** results provide direct guidance for the entire design of the injection well depth and the leaching parameters,thereby inhibiting the leaching of impurity of aluminum and lower the consumption of leaching agent.

关键词： Weathered crust elution-deposited rare earth ore Sequential extraction Occurrence Aluminum Rare earth elements

Elevated CO_(2) increases soil redox potential by promoting root radial oxygen loss in paddy field

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Journal of Environmental Sciences 2024年第2期136卷 11-20页

作者： Jie li Han Zhang Wenyi Xie Cheng liu Xiaoyu liu Xuhui Zhang lianqing li Genxing pan Institute of Resource Ecosystem and Environment of AgricultureNanjing Agricultural UniversityNanjing 210095China College of Agriculture Nanjing Agricultural UniversityNanjing 210095China

Soil redox potential(Eh)plays an important role in the biogeochemical cycling of soil *** its effect soil process and nutrients'availability under elevated atmospheric CO_(2) concentration and warming has seldom been ***,in this study,a field experiment was used to elucidate the effect of elevated CO_(2) concentration and warming on soil Eh,redox-sensitive elements and root radial oxygen loss(ROL).We hypothesized elevated CO_(2) and warming could alter soil Eh by promoting or inhibiting *** found that soil Eh in the rhizosphere was significantly higher than that of *** CO_(2) enhanced soil Eh by 11.5%,which corresponded to a significant decrease in soil Fe^(2+)and Mn^(2+)*** elevated CO_(2),the concentration of Fe^(2+)and Mn^(2+)decreased by 14.7%and 13.7%,*** also found that elevated CO_(2) altered rice root aerenchyma structure and promoted rice root *** elevated CO_(2),rice root ROL increased by 79.5%and 112.2%for Yangdao 6 and Changyou 5,*** had no effect on soil Eh and rice root *** warming increased the concentration of Mn^(2+)and SO_(4)^(2-)by 4.9%and 19.3%,*** was a significant interaction between elevated CO_(2) and warming on Fe^(2+)and Mn^(2+).Under elevated CO_(2),warming had no effect on the concentration of Fe^(2+)but decreased Mn^(2+)concentration *** study demonstrated that elevated atmospheric CO_(2) in the future could increase soil Eh by promoting rice root ROL,which will alter some soil nutrients'availability,such as Fe^(2+)and Mn^(2+).

关键词： Atmospheric CO_(2)enrichment Global warming Soil redox potential FACE Rice root aerenchyma

RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells

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Genes & Diseases 2024年第3期11卷 55-58页

作者： Chengyu li Deyuan pan Wan lin Danxia Deng yingxin Zhou Hui Zhao Feng pan liyan Xu Enmin li lin Long The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Institute of Oncologic PathologyShantou University Medical CollegeShantouGuangdong 515041China Institute of Basic Medical Science Cancer Research CenterShantou University Medical CollegeShantouGuangdong 515041China Clinical Research Center Shantou Central HospitalShantouGuangdong 515041China

Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accounting for more than 90%,and the five-year survival rate is less than 10%.Using large-scale genome analysis,many driver mutations and key pathways associated with ESCC have been ***,these genomic signatures have not improved the clinical management of EscC patients,or established effective targeted therapy.^(2)Esophageal cancer still lacks representative molecular markers.

关键词： cancer esophageal Esophageal

STRAP binds to and promotes the repair of N1-methyldeoxyadenosine in DNA

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Chinese Chemical Letters 2024年第3期35卷 204-207页

作者： Meijuan Zhou Qian liu Mengting pan ying Yang Xiaoxia Dai Changjun You State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Provincial Key Laboratory of Biomacromolecular Chemical BiologyMolecular Science and Biomedicine LaboratoryCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

N1-methyladenosine(m1A)is an important RNA modification that functions in various biological processes by interacting with cellular ***,the binding proteins of N1-methyldeoxyadenosine(1mdA)in DNA remain largely ***,we employed a quantitative proteomics strategy to identify the potential binding proteins of 1mdA in human *** results revealed that serine–threonine kinase receptor-associated protein(STRAP)can bind to 1mdA-carrying *** further demonstrated that STRAP participates in alkylating agent-induced DNA damage response and can promote the repair of 1mdA embedded in ***,we investigated the effects of STRAP on 1mdA-induced perturbation in transcription using a shuttle vector-and next-generation sequencing-based assay,and found that STRAP is involved in the transcriptional bypass of 1mdA in human ***,our study revealed STRAP as a novel 1mdA-binding protein in human cells and provided new insight into the biological implications of STRAP and 1mdA modification in human diseases.

关键词： N1-methyldeoxyadenosine 1mdA-binding protein STRAP DNA repair Transcription

Unveiling the secrets of diatom-mediated calcification:Implications for the biological pump

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Science China Earth Sciences 2024年第9期67卷 2895-2909页

作者： Yiwen pan Yifan li Chen-Tung Arthur CHEN Zong-Pei JIANG Wei-Jun CAI Yunwen SHEN Zesheng DING Qixian CHEN Yanan DI Wei FAN Chenba ZHU ying CHEN Ocean College Zhejiang UniversityZhoushan 316021China Hainan Institute of Zhejiang University Sanya 570203China Department of Oceanography Sun Yat-Sen UniversityGaoxiong 80424China School of Marine Science and Policy University of DelawareNewark DE 19716USA Carbon Neutral Innovation Research Center Xiamen UniversityXiamen 361005China

Siliceous diatoms are one of the most prominent actors in the oceans,and they account for approximately 40%of the primary production and particulate organic carbon export *** is believed that changes in carbon flux caused by variations in diatom distribution can lead to significant climate *** the fundamental pathways of diatom-driven carbon sequestration have long been established,there are no reports of CaCO_(3) precipitation induced by marine diatom *** manuscript introduces novel details regarding the enhancement of aragonite precipitation during photosynthesis in Skeletonema costatum in both artificial and natural *** direct measurements of cell surfaces via a pH microelectrode and zeta potential analyzer,it was determined that the diatom-mediated promotion of CaCO_(3) precipitation is achieved through the creation of specific microenvironments with concentrated[CO_(3)^(2-)]and[Ca^(2+)]and/or the dehydrating effect of adsorbed Ca^(2+).Based on this mechanism,it is highly plausible that diatom-mediated calcification could occur in the oceans,an assertion that was supported by the significant deviation of total alkalinity(TA)from the conservative TA-salinity mixing line during a Skeletonema costatum bloom in the East China Sea and other similar *** newly discovered calcification pathway establishes a link between particulate inorganic and organic carbon flux and thus helps in the reassessment of marine carbon export fluxes and CO_(2) sequestration *** discovery may have important ramifications for assessing marine carbon cycling and predicting the potential effects of future ocean acidification.

关键词： Diatom bloom Skeletonema costatum Calcification Biological carbon pump Counter carbonate pump

Amide naphthotubes:Biomimetic macrocycles for selective molecular recognition

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Chinese Chemical Letters 2024年第4期35卷 124-131页

作者： Cheng-Da Zhao Huan Yao Shi-Yao li Fangfang Du li-li Wang liu-pan Yang School of Pharmaceutical Science Postdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Selective molecular recognition in water is routine for bioreceptors,but remains challenging for synthetic *** is principally because noncovalent interactions are usually less efficient in aqueous *** mimicking the cavity feature of bioreceptors,*** Jiang proposed and clarified the concept of“endo-functionalized cavity”.Through situating polar binding sites into a deep hydrophobic cavity,we designed and synthesized several macrocyclic hosts,among which amide naphthotubes are the most *** hosts can selectively recognize various polar molecules including organic micropollutants,drug molecules,and chiral molecules in water by employing the hydrophobic effect and shielded hydrogen *** addition,these biomimetic hosts have been applied in spectroscopic analysis,adsorptive separation and *** this review,we provide an overview of recent advances on amide naphthotubes with special emphasis on the efforts of Jiang's *** are convinced that these biomimetic macrocycles will make further contributions to supramolecular chemistry and beyond.

关键词： Molecular recognition Supramolecular chemistry Amide naphthotube Endo-functionalized cavity Biomimetic macrocycle

Design strategies of high-performance lead-free electroceramics for energy storage applications

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Rare Metals 2024年第3期43卷 853-878页

作者： Biao Guo Fei Jin li li Zi-Zhao pan Xin-Wei Xu Hong Wang Department of Materials Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055China School of Microelectronics and State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China

A greater number of compact and reliable electrostatic capacitors are in demand due to the Internet of Things boom and rapidly growing complex and integrated electronic systems,continuously promoting the development of high-energy-density ceramic-based *** significant successes have been achieved in obtaining high energy densities in lead-based ferroelectric ceramics,the utilization of lead-containing ceramies has been restricted due to environmental and health hazards of ***-free ferroelectric ceramics have garnered tremendous attention and are expected to replace lead-based ceramics in the near ***,the energy density of lead-free ceramics is still lagging behind that of lead-containing ***,severely limiting their *** efforts have been made to enhance the energy storage performance of lead-free ceramics using multi-scale design strategies,and exciting progress has been achieved in the past *** review briefly discusses the energy storage mechanism and fundamental characteristics of a dielectric capacitor,summarizes and compares the state-of-the-art design strategies for high-energy-density lead-free ceramics,and highlights several critical issues and requirements for industrial *** prospects and challenges of lead-free ceramics for energy storage applications are also discussed.

关键词： Dielectric materials Lead-free ceramic Environment friendly Energy storage Design strategy