检索结果-南通市图书馆

Recent Strategies and Advances in Hydrogel-Based Delivery Platforms for Bone Regeneration

NANO-MICRO LETTERS 2025年第1期17卷 1-51页

作者： Wang, Xiao Zeng, Jia gan, Donglin ling, Kun He, Mingfang li, Jianshu Lu, Yongping Guangyuan Cent Hosp Sci & Technol Innovat Ctr Biomed Mat & Clin Res Guangyuan Key Lab Multifunct Med Hydrogel Guangyuan 628000 Peoples R China Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab Biofunct Mat Nanjing 210023 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China

Recent advances in the combined delivery platform that integrate nano-/microscale carriers and with 3D hydrogel network for bone regeneration are *** strategies for bioactive molecules delivery involving nanoparticles, nanosheets, and microspheres, along with extra stimuli such as near-infrared light, temperature changes, ultrasonication, and inflammatory conditions, are *** prospects and challenges for the clinical translation and the development of nano-/microscale incorporated hydrogel-based delivery platform are discussed. Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics for bone regeneration. However, the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in vivo. Hydrogels have emerged as ideal carriers to address these challenges, offering the potential to prolong retention times at lesion sites, extend half-lives in vivo and mitigate side effects, avoid burst release, and promote adsorption under physiological conditions. This review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration, encompassing applications in cranial defect repair, femoral defect repair, periodontal bone regeneration, and bone regeneration with underlying diseases. Additionally, this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery, carrier-assisted delivery, and sequential delivery. Finally, this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

疼痛护理干预对创伤骨科患者疼痛影响的meta分析

引用

中国伤残医学 2018年第19期26卷 98-99页

作者：冯淑芬李淑影甘红广东省广州中医药大学第一附属医院骨科广东广州510405

目的：通过Meta分析评价综合护理对疼痛护理干预对创伤骨科患者疼痛的影响.方法：通过检索CNKI、万方、CBM中比较是否使用综合护理干预创伤骨科患者疼痛效果的随机对照实验和回顾性队列研究文献,并追查已纳入文献的参考文献,做独立的文... 详细信息

目的：通过Meta分析评价综合护理对疼痛护理干预对创伤骨科患者疼痛的影响.方法：通过检索CNKI、万方、CBM中比较是否使用综合护理干预创伤骨科患者疼痛效果的随机对照实验和回顾性队列研究文献,并追查已纳入文献的参考文献,做独立的文献筛查、资料提取和质量评价.所得数据通过Stata 12.0统计软件完成Meta分析,比较综合护理干预后的VAS评分,患者满意度.结果：本研究共纳入了14篇文献中的1901例创伤骨科的病人.结果显示综合护理干预下的病人疼痛评分更低（P〈0.001）,满意度更高（P〈0.0001）,对比具有统计学意义.结论：在创伤骨科疼痛患者的护理中,疼痛综合护理干预可以提高患者满意度,降低患者疼痛.疼痛护理干预仍有待进一步的挖掘,用于其他疾病的护理当中.

关键词：疼痛护理干预创伤骨科 meta

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low limit of detection of the Algan/gan-based sensor by the Kelvin connection detection technique

引用

Microsystems & Nanoengineering 2021年第4期7卷 35-44页

作者： Hanyuan Zhang ying gan Shu Yang Kuang Sheng Ping Wang College of Electrical Engineering Zhejiang University310027 HangzhouChina Biosensor National Special Laboratory Department of Biomedical EngineeringZhejiang University310027 HangzhouChina Hangzhou Global Scientific and Technological Innovation Center Zhejiang University310027 HangzhouChina

The Algan/gan-based sensor is a promising POCT(point-of-care-testing)device featuring miniaturization,low cost,and high *** is an effective protein biomarker for the early diagnosis of HF(heart failure).In this work,a novel Algan/gan device with the Kelvin connection structure and the corresponding detection technique was *** technique can effectively suppress the background noise and improve the SNR(signal-to-noise ratio).A BNP detection experiment was carried out to verify the effectiveness of this *** is shown that compared with that of the traditional detection method,the LOD(limit of detection)was improved from 0.47 ng/mL to 1.29 pg/*** BNP detection experiment was also carried out with a traditional electrochemical Au-electrode sensor with the same surface functionalization *** Algan/gan sensor showed a better LOD than the Au-electrode ***,the influence of Algan/gan sensor package on background noise was investigated with the mechanism of the noise source ***,based on the optimized package,the optimal SNR quiescent operating point of the Algan/gan sensor was *** biasing the sensor at the optimal quiescent operating point and immobilizing the magnetic beads with anti-BNP on the gate of the Algan/gan sensor,the LOD for BNP detection was further improved to 0.097 pg/mL.

关键词： Algan/gan limit noise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cervical spine infection arising from chronic paronychia:A case report and review of literature

引用

World Journal of Orthopedics 2024年第12期15卷 1214-1225页

作者： Dan Zhang li-ying gan Wen-Jie Zhang Ming Shi liang Zhang Yong Zhang Ming-Wei liu Department of Orthopedics and Spine Surgery Guangxi University of Traditional Chinese Medicine Affiliated International Zhuang HospitalNanning 530201Guangxi Zhuang Autonomous RegionChina Department of Clinical Laboratory Guangxi University of Traditional Chinese Medicine Affiliated International Zhuang HospitalNanning 530201Guangxi Zhuang Autonomous RegionChina Department of Orthopedics and Spine Guangxi University of Traditional Chinese Medicine Affiliated International Zhuang HospitalNanning 530201Guangxi Zhuang Autonomous RegionChina Department of Orthopedics Clinical Medical CollegeYangzhou UniversityYangzhou 225001Jiangsu ProvinceChina

BACKGROUND Cervical spine pyogenic infection(CSPI)is a rare and challenging form of spinal infection that is typically caused by pyogenic bacteria and primarily affects the cervical vertebral bodies and surrounding *** its nonspecific symptoms,such as fever and neck pain,early diagnosis is crucial to prevent severe complications,including spinal cord *** report a previously unreported case of acute CSPI arising from chronic paronychia,exploring its diagnostic and therapeutic challenges through a review of the current *** SUMMARY The presented case involved a 15-year-old man with CSPI caused by Staphylococcus aureus,which led to complications including bacteremia and a paronychiaassociated *** pyogenic infection was initially diagnosed by typical symptoms and blood *** improved after antibiotic treatment while developing progressive limbs *** days after admission,the patient underwent anterior cervical debridement+autogenous iliac bone graft fusion+plate internal fixation and received 12 weeks of antibiotic treatment after the ***-examination 3 years postoperatively showed that the patient had stable cervical fixation,no significant neck pain or upper limb abnormalities,and normal urinary *** Early imaging findings,laboratory markers,and timely antibiotic treatment are crucial for CSPI management,preventing complications and facilitating recovery.

关键词： Cervical spine Pyogenic infection Paronychia Surgery Antibacterial treatment Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital twin-enabled adaptive scheduling strategy based on deep reinforcement learning

引用

Science China(Technological Sciences) 2023年第7期66卷 1937-1951页

作者： gan XueMei ZUO ying ZHANG AnSi li ShaoBo TAO Fei School of Mechanical Engineering Guizhou UniversityGuiyang 550025China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang 550025China

The modern complicated manufacturing industry and smart manufacturing tendency have imposed new requirements on the scheduling method,such as self-regulation and self-learning *** traditional scheduling methods cannot meet these needs due to their ***-learning is an inherent ability of reinforcement learning(RL) algorithm inhered from its continuous learning and trial-and-error ***-regulation of scheduling could be enabled by the emerging digital twin(DT) technology because of its virtual-real mapping and mutual control *** paper proposed a DT-enabled adaptive scheduling based on the improved proximal policy optimization RL algorithm,which was called explicit exploration and asynchronous update proximal policy optimization algorithm(E2APPO).Firstly,the DT-enabled scheduling system framework was designed to enhance the interaction between the virtual and the physical job shops,strengthening the self-regulation of the scheduling ***,an innovative action selection strategy and an asynchronous update mechanism were proposed to improve the optimization algorithm to strengthen the self-learning ability of the scheduling ***,the proposed scheduling model was extensively tested in comparison with heuristic and meta-heuristic algorithms,such as wellknown scheduling rules and genetic algorithms,as well as other existing scheduling methods based on reinforcement *** comparisons have proved both the effectiveness and advancement of the proposed DT-enabled adaptive scheduling strategy.

关键词： agent reinforcement learning digital twin adaptive scheduling generalization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioleaching of vanadium from barren stone coal and its effect on the transition of vanadium speciation and mineral phase

引用

International Journal of Minerals,Metallurgy and Materials 2018年第3期25卷 253-261页

作者： Xin Wang Hai lin ying-bo Dong gan-yu li School of Civil and Resource Engineering University of Science and Technology Beijing Beijing 100083 China School of Energy and Environmental Engineering University of Science and Technology Beijing Beijing 100083 China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083 China

This study determined the optimal conditions required to obtain maximum vanadium extraction and examined the transition of mineral phases and vanadium speciation during the bioleaching process. Parameters including the initial p H value, initial Fe^(2+) concentration, solid load, and inoculum quantity were examined. The results revealed that 48.92 wt% of the vanadium was extracted through bioleaching under optimal conditions. Comparatively, the chemical leaching yield(H_2SO_4, pH 2.0) showed a slower and milder increase in vanadium yield. The vanadium bioleaching yield was 35.11 wt% greater than the chemical leaching yield. The Community Bureau of Reference(BCR) sequential extraction results revealed that 88.62 wt% of vanadium existed in the residual fraction. The bacteria substantially changed the distribution of the vanadium speciation during the leaching process, and the residual fraction decreased to 48.44 wt%. The X-ray diffraction(XRD) and Fourier transform infrared(FTIR) results provided evidence that the crystal lattice structure of muscovite was destroyed by the bacteria.

关键词： bioleaching stone coal BCR-sequential extraction vanadium speciation mineral phase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Free control of far-field scattering angle of transmission terahertz wave using multilayer split-ring resonators'metasurfaces

引用

Frontiers of physics 2020年第6期15卷 125-132页

作者： ying Tian Xufeng Jing Haiyong gan Chenxia li Zhi Hong Institute of Optoelectronic Technology China Jiliang UniversityHangzhou 310018China National Institute of Metrology Beijing 102200China

To enhance transmission eficiency of Pancharatnam Berry(PB)phase metasurfaces,multilayer split-ring resonators were proposed to develop encoding *** per the generalized Snell's law,the deflection angle of the PB phase encoding metasurfaces depends on the metasurface period's ***,it is impossible to design an infinitesimal metasurface unit;consequently,the continuous transmission scattering angle cannot be *** digital signal processing,this study introduces the Fourier convolution principle on encoding metasurface sequences to freely control the trausmitted scattering *** addition and subtraction operations between two diferent encoding sequences were then performed to achieve the continuous variation of the scattering ***,we established that the Fourier convolution principle can be applied to the checkerboard coded metasur-faces.

关键词： metamaterial metasurface scattering Fourier convolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Altered cerebral activities and functional connectivity in depression:a systematic review of fMRI studies

引用

Quantitative Biology 2022年第4期10卷 366-380页

作者： Xue-ying li Xiao Chen Chao-gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101400China Sino-Danish Center for Education and Research Beijing 101400China CFIN and PET Center Aarhus UniversityNørrebrogade 448000 AarhusDenmark Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China

Background:As one of the leading causes of global disability,major depressive disorder(MDD)places a noticeable burden on individuals and *** the great expectation on finding accurate biomarkers and effective treatment targets of MDD,studies in applying functional magnetic resonance imaging(fMRI)are still faced with challenges,including the representational ambiguity,small sample size,low statistical power,relatively high false positive rates,***,reviewing studies with solid methodology may help achieve a consensus on the pathology of ***:In this systematic review,we screened fMRI studies on MDD through strict criteria to focus on reliable studies with sufficient sample size,adequate control of head motion,and a proper multiple comparison control ***:We found consistent evidence regarding the dysfunction within and among the default mode network(DMN),the frontoparietal network(FPN),and other brain ***,controversy remains,probably due to the heterogeneity of participants and data processing ***:Future studies are recommended to apply a comprehensive set of neuro-behavioral measurements,consider the heterogeneity of MDD patients and other potentially confounding factors,apply surface-based neuroscientific network fMRI approaches,and advance research transparency and open science by applying state-ofthe-art pipelines along with open data sharing.

关键词： depression resting-state fMRI task-based fMRI default mode network frontoparietal network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly N/O co-doped ultramicroporous carbons derived from nonporous metal-organic framework for high performance supercapacitors

引用

Chinese Chemical Letters 2021年第4期32卷 1491-1496页

作者： Yangyi Gu ling Miao ying Yin Mingxian liu lihua gan liangchun li Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghai 200092China

A new nonporous Zn-based metal-organic framework(NPMOF) synthesized from a high nitrogencontaining rigid ligand was converted into porous carbon materials by direct carbonization without adding additional carbon sources.A series of NPMOF-derived porous carbons with very high N/O contents(24.1% for NPMOF-700,20.2% for NPMOF-800,15.1% for NPMOF-900) were prepared by adjusting the pyrolysis *** NPMOF-800 fabrica ted electrode exhibits a high capacitance of220 F/g and extremely large surface area normalized capacitance of 57.7 μF/cm~2 compared to other reported MOF-derived porous carbon electrodes,which could be attributed to the abundant ultramicroporosity and high N/O *** importantly,symmetric supercapacitor assembled with the MOF-derived carbon manifests prominent stability,i.e.,99.1 % capacitance retention after 10,000 cycles at 1.0 A/*** simple preparation of MOF-derived porous carbon materials not only finds an application direction for a variety of porous or even nonporous MOFs,but also opens a way for the production of porous carbon materials for superior energy storage.

关键词： N/O co-doped Ultramicroporous Metal-organic frameworks Porous carbons Supercapacitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physical modeling of multiphase flow via lattice Boltzmann method： Numerical effects, equation of state and boundary conditions

引用

Frontiers of physics 2012年第4期7卷 481-490页

作者： Yan-Biao gan Ai-Guo Xu Guang-Cai Zhang ying-Jun li North China Institute of Aerospace Engineering Langfang 065000 China National Key Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics P. O. Box 8009-26 Beijing 100088 China State Key Laboratory for GeoMechanics and Deep Underground Engineering SMCEChina University of Mining and Technology (Beijing) Beijing 100083 China

The aims of the present paper are threefold. First, we further study the fast Fourier transform thermal lattice Boltzmann （FFT-TLB） model for van der Waals （VDW） fluids proposed in Phys. Rev. E, 2011, 84（4）： 046715. We analyze the merits of the FFT approach over the traditional finite difference scheme and investigate the effects of smoothing factors on accuracy and stability in detail. Second, we incorporate the VDW equation of state with flexible parameters into the FFT- TLB model. As a result, the revised model may be used to handle multiphase flows with various critical densities and temperatures. Third, we design appropriate boundary conditions for systems with solid walls. These improvements, from the views of numerics and physics, significantly extend the application scope of the model in science and engineering.

关键词： van der Waals fluids lattice Boltzmann method FFT equation of state

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：