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Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying liu Shuai ye Xin-Ni li Wei-Guang li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

A ratiometric optical thermometer with dual-color emission based on Eu^(2+)-doped CsCu_(2)I_(3) microcrystals

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Journal of Rare Earths 2024年第8期42卷 1429-1436,I0001页

作者： Xiaorong li Ge Gao Kaiyu Wang Zhaoqiong Chen Zejiang Gao Qingyong Qin li Chen Bingsuo zou State Key Laboratory of Featured Metal Materials and life-cycle Safety for Composite Structures School of Physical Science and TechnologyGuangxi UniversityNanning530004China School of Resources Environments and MaterialsGuangxi UniversityNanning530004China

With the increasing demand for non-co ntact fluorescence intensity ratio-based optical thermometry,novel phosphor materials with high-efficiency,dual-emitting centers,and differentiable temperature sensitivity are highly desired,In this wo rk,rare earth Eu^(2+) ions were incorporated Wnto CsCu_(2)I_(3) microcrystals by solidstate reaction,Under a single UV excitation,the as-synthesized samples exhibit two emissions:452 nm blue emission from the 5d→4f transition of Eu^(2+)and 582 nm yellow emission from self-trapped exciton e mission of CsCu_(2)I_(3).The photoluminescence quantum yield reaches to 50%,The dual-band emission of Eu^(2+)-doped CsCu_(2)I_(3) shows different temperature responses in the range of 260-360 *** on fluorescence intensity ratio technology,the maximum absolute sensitivity and re Iative sensitivity are 0.091 K^(-1)(at 360 K) and 2.60%/K(at 260 K),*** results suggest that Eu^(2+)-doped GsCu_(2)I_(3) could be a good candidate for highly sensitive optical thermometer.

关键词： CsCu_(2)I_(3) Eu^(2+)-doping Fluorescence intensity ratio Optical thermometer Rare earths

Research on virtual coupling technology in rail transit train collision protection

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Transportation Safety and Environment 2024年第1期6卷 40-46页

作者： Gaosong li Jinbai zou Weijie Ma Meng Lan School of Railway Transportation Shanghai Institute of TechnologyShanghai 201418China Shanghai Metro First Operation Co. LtdShanghai 201418China

In the research on the new generation of intelligent rail transit system,the prevention of train collision accidents is still a *** coupling technology controls the running speed and interval distance of two or more trains cooperatively through Trainto-Train(T2T)direct communication *** aim is to form a coordinated logical system and jointly complete the train control and *** this paper,a virtual coupling train formation control method based on the model predictive control(MPC)framework is *** the establishment of the virtual coupling system,the construction of an MPC model and decoupling method,how to integrate virtual coupling technology into the rail transit train collision protection is *** safety and reliability of the system are calculated through fault tree and the method of constructing reliability *** research shows that if virtual coupling technology is used for train collision protection,the overall safety and reliability of the train control system is improved.

关键词： virtual coupling model predictive control collision protection

Analysing free way diverging risks using high-resolution trajectory data based on conflict prediction models

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Transportation Safety and Environment 2024年第1期6卷 8-21页

作者： ye li Sani Dalhatu Chen Yuan School of Traffic and Transportation Engineering Central South UniversityChangshaHunan 410075P.R.China Department of Computer Science City University of Hong KongKowloonHong Kong 999077P.R.China.

This study aims to develop a reliable safety evaluation model for diverging vehicles and investigates the impact of the surrounding traffic environment on freeway diverging ***-resolution trajectory data from three sites in the Netherlands(Delft,Ter-Heide and Zonzeel)were employed for the risk *** regression(LR),support vector machine(SVM),random forest(RF),extreme randomize trees(ET),adaptive boosting(Adaboost),extreme gradient boosting(XGboost)and multilayer perceptron(MLP),were developed for safety *** result showed that MLP outperforms the other models for diverging risk prediction over all the indicators,conflict thresholds and *** matrix,shapely addictive explanation(SHAP),and LR algorithms were further adopted to interpret the influence of the surrounding *** indicates that an increase in traffic density,subject vehicle(SV)lateral speed,the distance of SV from ramp nose and SV length would increase the diverging *** the same time,an increase in leading vehicle speed and space headway would decrease diverging ***,spatial analysis was also conducted to explore the stability of identified traffic features regarding the impact on the diverging risk across the sites.

关键词： diverging risk,machine learning shapely addictive explanation(SHAP) linear regression(LR) extended time-to-collision(TET) time-integrated time-to-collision(TIT)

The role of lipid metabolism in osteoporosis:Clinical implication and cellular mechanism

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Genes & Diseases 2024年第4期11卷 220-233页

作者： Jing Zhang Wenhui Hu Zhi zou Yuheng li Fei Kang Jianmei li Shiwu Dong College of Bioengineering Chongqing UniversityChongqing 400044China Department of Biomedical Materials Science College of Biomedical EngineeringArmy Medical University(Third Military Medical University)Chongqing 400038China State Key Laboratory of Trauma and Chemical Poisoning Army Medical University(Third Military Medical University)Chongqing 400038China

In recent years,researchers have become focused on the relationship between lipids and bone metabolism ***,many diseases related to lipid metabolism dis-orders,such as nonalcoholic fatty liver disease,atherosclerosis,obesity,and menopause,are associated with osteoporotic *** has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone ***,similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal *** lipid metabolism(such as increased oxidized lipids and elevated plasma cholesterol)affects bone microenvironment ho-meostasis via cross-organ communication,promoting differentiation of mesenchymal stem cells to adipocytes,and inhibiting commitment towards ***,disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cyto-kines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of ***,this review addresses the possible link be-tween lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism *** also summarize the possible approaches and prospects of intervening lipid meta-bolismforosteoporosistreatment.

关键词： Bone homeostasis Cross-organ communication lipid metabolism Osteoclast Osteoporosis

Post-disaster spatial reconstruction from the perspective of a rural settlement niche in the upper reaches of the Minjiang River

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Journal of Mountain Science 2024年第5期21卷 1630-1646页

作者： liU Yanguo WANG li zou Qiang li Jingji LU Yafeng li lin XU Binni WANG lihui Tianfu Institute of Research and Innovation Southwest University of Science and TechnologyChengdu 610299China Mianyang Science and Technology City Division the National Remote Sensing Center of ChinaSouthwest University of Science and TechnologyMianyang 621010China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610299China State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection(Chengdu University of Technology) Chengdu 610059China Tianfu New Area Park City Construction Bureau Chengdu Municipal Bureau of Planning and Nature ResourcesChengdu 610218China

Post-disaster recovery and reconstruction provide an effective way to reduce the disaster vulnerability of, and promote leapfrog development in, an affected area. To date, studies that have used administrative boundaries to investigate the reconstruction of settlement space have not been able to clearly define the real boundaries of land use changes or quantify the degree of response to the ‘Build-Back-Better’ initiative, and have lacked any consideration of the fourth reconstruction stage–development period(10 years). This study constructed a mountain settlement niche and analyzed the characteristics, spatial reconstruction, and drivers of rural settlements during 2009–2019 in the upper reaches of the Minjiang River, southwest China. The results showed the following:(1) Natural factors were the basis for the formation and development of mountain settlement niches. The scale of the settlement niche and its land use structure depended on the physical geography features and the ethnic farming and grazing traditions. The settlement niche provided a realistic boundary for the spatial reconstruction.(2) The layout of residential land around cropland was the common feature of the mountain settlement niche. Of all the land use types, the roads and rural residential lands showed the most change over the 10 years;13,860 residential patches increased in size and 4,742 patches were abandoned.(3) The area of orchards, planted to reconstruct the economy in the mountains, increased by nearly 2.5 times.(4) Collapses, landslides, and debris flow disasters and the ecological red line influenced the spatial reconstruction. While the main focus of post-disaster recovery is spatial reconstruction, initiatives should include economic and spiritual recovery, and should also achieve sustainable development of the region.

关键词： Rural settlements Spatial reconstruction Settlement niche Post-Wenchuan Earthquake Reconstruction Southwest China

Coated sodium butyrate ameliorates high‑energy and low‑protein diet induced hepatic dysfunction via modulating mitochondrial dynamics, autophagy and apoptosis in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1190-1206页

作者： Sasa Miao Tianming Mu Ru li Yan li Wenyan Zhao Jiankui li Xinyang Dong Xiaoting zou Key Laboratory of Animal Feed and Nutrition of Zhejiang Province Key Laboratory of Animal Nutrition and Feed Science(Eastern of China)Ministry of Agriculture and Rural AffairsThe Key Laboratory of Molecular Animal NutritionMinistry of EducationCollege of Animal SciencesZhejiang UniversityHangzhou 310058China.

Background Fatty liver hemorrhagic syndrome(FLHS),a fatty liver disease in laying hens,poses a grave threat to the layer industry,stemming from its ability to trigger an alarming plummet in egg production and usher in acute mortality among laying *** evidence suggests that the onset and progression of fatty liver was closely related to mitochondria *** butyrate was demonstrated to modulate hepatic lipid metabolism,alle-viate oxidative stress and improve mitochondrial dysfunction in vitro and mice ***,there is limited existing research on coated sodium butyrate(CSB)to prevent FLHS in laying hens,and whether and how CSB exerts the anti-FLHS effect still needs to be *** this experiment,the FLHS model was induced by administering a high-energy low-protein(HELP)diet in laying *** objective was to investigate the effects of CSB on alleviating FLHS with a focus on the role of CSB in modulating mitochondrial *** A total of 288 healthy 28-week-old Huafeng laying hens were arbitrarily allocated into 4 groups with 6 replicates each,namely,the CON group(normal diet),HELP group(HELP diet),CH500 group(500 mg/kg CSB added to HELP diet)and CH750 group(750 mg/kg CSB added to HELP diet).The duration of the trial encompassed a period of 10 *** The result revealed that CSB ameliorated the HELP-induced FLHS by improving hepatic steatosis and patho-logical damage,reducing the gene levels of fatty acid synthesis,and promoting the mRNA levels of key enzymes of fatty acid *** reduced oxidative stress induced by the HELP diet,upregulated the activity of GSH-Px and SOD,and decreased the content of MDA and *** also mitigated the HELP diet-induced inflammatory response by blocking TNF-α,IL-1β,and F4/*** addition,dietary CSB supplementation attenuated HELP-induced activation of the mitochondrial unfolded protein response(UPRmt),mitochondrial damage,and decline of ATPase *** diet decreased th

关键词： Autophagy Coated sodium butyrate Laying hens lipid metabolism Mitochondria

Two-stage Scheduling for Island CPHH IES Considering Plateau Climate

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1775-1786页

作者： Yuchen Pu Qi li Yibin Qiu Xueli zou Weirong Chen School of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China

In this paper,an island integrated energy system(IES)combining power,heat and hydrogen(CPHH)is built,and optimal power-heat-hydrogen scheduling is studied under actual plateau meteorological *** the comprehensive demands of residents,an IES including renewable energy sources(RESs),fuel cell,electrolyzer,electric boiler,thermal energy storage device and new energy vehicles is established and *** the first stage of operation,according to the prediction of RESs and demands,day-ahead optimization is carried out which aims to minimize operation cost,while electric vehicles(EVs)are considered as special demand response(DR)*** the second stage of operation,ultra-short-term prediction is implemented to provide prediction data for model predictive control(MPC),realizing real-time *** as a CPHH system,the fuel cell and electrolyzer collaborate to meet various needs of the plateau residential area with high *** addition,the method and IES structure proposed in this paper is compared with other options.

关键词： CPHH feul cell hydrogen island IES scheduling

Parameter sensitivity analysis of the axial stability for a marine flexible pipe

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Petroleum 2024年第3期10卷 548-556页

作者： liping Tang Jiaxin zou Kenan Song Yongheng Shi li liu School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500China School of Engineering University of AberdeenAberdeenAB243UEUK Oil&Gas Control Center National Petroleum and Natural Gas Pipeline Network Group Co.Ltd.Beijing100020China

Marine unbonded flexible pipes serve as the most essential equipment in offshore oil and gas exploration and *** compressive loads during installation or in service in the complex marine environment usually lead to buckling failure.A flexible pipe is a composite structure with multiple functional layers,of which the tensile armor layer plays a key role with regard to the response of the pipe subjected to axial *** this paper,a simplified three-dimensional finite element model is developed,focusing on the tensile layer and replacing the carcass layer,pressure sheath layer,and pressure armor layer by a cylindrical rigid body to reduce computational *** using this model,the buckling failure modes of the tensile armor layer(in particular the birdcaging phenomenon)are *** key parameters that affect the stability of the flexible pipe under axial compression and torsion are emphasized,and their effects on its axial and torsional stiffness are compared and *** results show that both the lay angle of the steel wires and the interlayer friction coefficient have a significant influence on the axial and torsional stiffness of the pipe,whereas the damaged length of the outer sheath has virtually no effect.

关键词： Flexible pipe Tensile armor Buckling failure Key parameters Stiffness