检索结果-南通市图书馆

Serum cholinesterase: a potential assistant biomarker for hand, foot, and mouth disease caused by enterovirus 71 infection

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2016年第1期5卷 249-253页

作者： Bang-Ning Cheng Yu-lian Jin Bi-Quan Chen li-yan zhu Zi-Cheng Xu Tao Shen Clinical Laboratory Center Anhui Provincial Children’s HospitalHefei 230051China Department of Infectious Diseases Anhui Provincial Children’s HospitalHefei 230051China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking UniversityBeijing 100191China

Background:Hand,foot,and mouth disease(HFMD)caused by enterovirus 71(EV71)is a potentially life-threatening infectious disease that commonly occurs in *** of HFMD caused by EV71 largely depends on clinical manifestations and rare serological biomarkers used to identify children suffering from *** cholinesterase(SChE)activity has frequently been reported as a potential biomarker for solid central nervous system tumors,chronic heart failure,and liver ***,its potential value in the diagnosis of neurotropic virus infections,such as HFMD caused by EV71,remains to be ***:In our study,220 children hospitalized with HFMD caused by EV71,34 inpatients infected with coxsackievirus A16(CVA16),and 43 undefined enterovirus-infected HFMD inpatients were recruited at the Anhui Provincial Children’s Hospital between January 2011 and December *** activity was *** non-parametric Mann–Whitney U test showed that SChE activity in children diagnosed with HFMD caused by EV71 was significantly higher than in healthy controls(plitis(p0.05).An important finding was that SChE activity declined in the recovery phase of HFMD caused by EV71 compared to the acute phase(p<0.001).Conclusions:Elevated SChE activity was observed in patients with severe HFMD caused by ***,SChE might be a potential assistant biomarker for the diagnosis of HFMD caused by EV71 in children.

关键词： Serum cholinesterase Hand foot and mouth disease Enterovirus 71 Coxsackievirus A16 Children Biochemical marker

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao Sun Jiamin zhu Justin zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

Nanostructural evolution of Zn by dry roller vibration milling at room temperature

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2006年第4期16卷 441-444页

作者： WANG Shulin, li Shengjuan, DU yanchen, XU Bo, li Laiqiang and zhu yan Department of Power Engineering Department of Medical Apparatus, University of Shanghai for Science and Technology, Shanghai 200093, China [a]Department of Power Engineering University of Shanghai for Science and Technology Shanghai China [b]Department of Medical Apparatus University of Shanghai for Science and Technology Shanghai China

It remains open to date to produce stable nanostructures of single element by dry mechanical method at room temperature on a large scale. Here we report nanostructural evolution of zinc by dry roller vibration milling at room temperature, which leads to structurally near perfect zinc flakes sized 3-5 nm in diameter. The synthesized nanostructures are single crystalline, transparent, uniform, randomly oriented, almost equiaxed, and mostly free from defects. The evolution seems to open a way to optimize zinc nanostructures by the mechanical method, offer valuable references to prepare nanostructures of other metals optimally, and shed light on how to lower the size limit by mechanical milling. Single elemental metal nanostructures with excellent properties give rise to new opportunities in scientific research and development of nanotechnology.

关键词： nanoparticles nanostructures vibration milling.

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

CRYSTAL STRUCTURE OF 1-METHYL-6-(E-ETHOXYCAR-BONYLVINYL)-8-BENZOYL-2, 3-DIHYDRO-1H-IMIDAZO[1, 2-a] PYRIDIN-5-ONE

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 1993年第4期12卷 293-296页

作者： li yan zhu Nai-Jue Wang Mei-Xiang Huang Zhi-Tang Institute of Chemistry,Academia Sinica,Beijing,China 中科院化学所北京

The title compound C20H20N2O4(Mr=352.39)belongs to mono-clinic space group C2/c with a=9.208(4),b=11.714(3),c=32.336(8)A,β=100.83(2)°,V=7146.2(6)A3,Z=16,Dc=1.35 g/cm3,μ(Moka)=1.03 cm-1 and final R=0.06 for 1781 reflections with F≥2.5(F).There are two independent molecules in an asymmetric *** pyridinone nor phenyl ring is coplanar with the ketonic carbonyl group in the molecule.

关键词： E-ETHOXYCAR-BONYLVINYL DIHYDRO-1H-IMIDAZO[1 PYRIDIN-5-ONE CRYSTAL STRUCTURE OF 1-METHYL-6 BENZOYL-2

Inhibition of connective tissue growth factor overexpression decreases growth of hepatocellular carcinoma cells in vitro and in vivo

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2011年第22期124卷 3794-3799页

作者： JIA Xiao-qin CHENG Hai-qing li Hong zhu yan li Yu-hua FENG Zhen-qing ZHANG Jian-ping Department of Pathology School of Medicine Yangzhou University Yangzhou Jiangsu 225500 China

Background We have previously found that connective tissue growth factor （CTGF） is highly expressed in a rat model of liver cancer. Here, we examined expression of CTGF in human hepatocellular carcinoma （HCC） cells and its effect on celt growth. Methods Real-time PCR was used to observe expression of CTGF in human HCC cell lines HepG2, SMMC-7721, MHCC-97H and LO2. siRNA for the CTGFgene was designed, synthesized and cloned into a PIk0.1-GFP-SP6 vector to construct a lentivirus-mediated shRNA/CTGF. CTGF mRNA and protein expression in HepG2 cells treated by CTGF-specific shRNA was evaluated by real-time PCR and Western blotting. 3-（4,5-dimethylthiazol-2-yl）- 2,5-diphenyltetrazolium bromide （MTT） assay was utilized to evaluate the growth effect, and a colony formation assay was used for observing clonogenic growth. In vivo, tumor cell proliferation was evaluated in a nude mouse model of xenotransplantation. Statistical significance was determined by t test for comparison between two groups, or analysis of variance （ANOVA） for multiple groups. Results Immunohistochemical staining of CTGF was seen in 35 of 40 HCC samples （87.5%）. CTGF was overexpressed 5-fold in 20 HCC tissues, compared with surrounding non-tumor liver tissue. CTGF mRNA level was 5-8-fold higher in HepG2, SMMC-7721 and MHCC-97H than in LO2 cells. This indicated that the inhibition rate of cell growth was 43% after knockdown of CTGF expression （P 〈0.05）. Soft agar colony formation assay showed that siRNA mediated knockdown of CTGF inhibited colony formation in soft agar of HepG2 cells （P 〈0.05）. The volume of tumors from CTGF-shRNA-expressing cells only accounted for 35% of the tumors from the scrambled control-infected HepG2 cells （P 〈0.05）. Conclusions CTGF was overexpressed in human HCC cells and downregulation of CTGF inhibited HCC growth in vitro and in vivo. Knockdown of CTGFmay be a potential therapeutic strategy for treatment of HCC.

关键词： hepatocellular carcinoma connective tissue growth factor siRNA cell proliferation

微观公平感的形成机制:基于职业群体的双重比较理论

在线全文

学校读者我要写书评

暂无评论

华中科技大学学报（社会科学版） 2017年第1期31卷 37-45页

作者：李煜朱妍复旦大学社会学系上海200433 上海社会科学院社会学研究所上海200020

微观公平感指的是人们评价自己的收入所得是否公平合理。既有研究提出了"参照群体理论",认为人们会参照他人来形成对自己收入是否公平的判断,却未能澄清人们如何选择参照群体,以及相应的微观公平感形成机制。本文基于新涂尔干主义的社... 详细信息

微观公平感指的是人们评价自己的收入所得是否公平合理。既有研究提出了"参照群体理论",认为人们会参照他人来形成对自己收入是否公平的判断,却未能澄清人们如何选择参照群体,以及相应的微观公平感形成机制。本文基于新涂尔干主义的社会分层理论提出"职业群体参照理论",强调"职业"构成了群内与群际比较的参照边界。具体而言,人们通过双重比较过程形成自己的微观公平感判断,一方面将自己与同职业的其他从业者进行比较,形成"个体利益受损与否"的判断;另一方面则会将本职业群体与其他职业群体进行比较,形成"群体利益受损与否"的判断,进而整合为个体的微观公平感认知。而且,当人们判断个体利益与本职业群体利益均受损时,会产生加乘效应,加剧恶化人们的微观公平感。

关键词：微观公平感个体利益受损群体利益受损

Preliminary assessing no-surgical treatment response in bronchogenic carcinoma with changes in enhancement pattern

在线全文

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2012年第9期11卷 508-512页

作者： Shenjiang li Changcheng li Feng zhu yan zhu Xuefeng Cui Debin liu Wenjie liang Department of Imageology The Eighty-eighth Military Hospital Tai'an 271000 China

Objective： The aim of this study was to evaluate the efficacy of changes in enhancement pattern in assessing no-surgical treatment response in bronchogenic carcinoma preliminarily. Methods Thirty-three patients with bronchogenic carcinoma underwent two-phase contrast material-enhanced computed tomography prior to and after stopping no-surgical treatment more than one-month respectively. Two spiral CT scans were obtained at 25 and 90 s respectively after nonionic contrast material was administrated via the antecubital vein at a rate of 3 mL/s by using an autoinjector. The sum of the tumor longest diameters （LD） prior to treatment, after treatment and the sum of the post-treatment tumor enhancement area LD on the images obtained at 90 s after injection of contrast medium were recorded, Precontrast and postcontrast attenuation on every scan was recorded and peak height was calculated. The significance of the difference among groups was analyzed by means of ANOVA, student t test and chi-square test. Results： The sum of the tumor LD prior to treatment, that of after treatment and the sum of the post-treatment tumor enhancement area LD on the images obtained at 90 s after injection of contrast medium were （4.49 ± 1.32）, （4.05 ± 1.63）, （3.36 ± 1.22） cm respectively and there were statistically significant dif- ferences among them （f= 5.467, P = 0.006）. The sum of the tumor LD prior to treatment was significantly higher than that of the post-treatment tumor enhancement area （P = 0.001）. No statistically significant difference in the sum of the tumor LD was found between the pre- treatment and the post-treatment （P = 0.207）. There was no statistically significant difference between the sum of the tumors LD and that of tumor enhancement area after treatment （P = 0.086）. The response rate （RR）（21.21%） according to changes in sum of the tumor LD was significantly lower than that （30.30%） according to changes in the sum of the post-treatment tumor enhancement area LD （x2 = 15.1

关键词： tomography X-ray computed lung neoplasms image enhancement evaluation of therapeutic effect angio-genesis

在线全文

学校读者我要写书评

暂无评论

列车-桥梁耦合系统非线性随机振动分析

铁道学报 2017年第9期39卷 109-116页

作者：晋智斌李小珍朱艳强士中西南交通大学土木工程学院四川成都610031

在轨道不平顺激励下,列车过桥时发生车-桥耦合振动。由于轨道不平顺激励源是随机过程,而轮轨接触关系又是非线性的,因此,车-桥耦合振动属于非线性随机振动问题。用统计线性化方法分析车-桥非线性随机振动。轮轨接触几何关系用5个非线性... 详细信息

在轨道不平顺激励下,列车过桥时发生车-桥耦合振动。由于轨道不平顺激励源是随机过程,而轮轨接触关系又是非线性的,因此,车-桥耦合振动属于非线性随机振动问题。用统计线性化方法分析车-桥非线性随机振动。轮轨接触几何关系用5个非线性函数描述,推导车-桥系统非线性振动方程。对车-桥非线性振动方程中的非线性函数进行统计线性化,得到时变的线性车-桥耦合振动方程。用虚拟激励法求解线性车-桥系统的随机响应,提出一种"显式"统计线性化方法,该法在每个时间步均无需作统计线性化迭代。最后,用Monte Carlo法验证了车-桥统计线性化随机振动分析方法具有较高的精度。算例表明,轮轨非线性接触对车辆和桥梁的随机响应影响很大,车-桥随机振动分析应合理考虑轮轨非线性接触。

关键词：列车-桥梁耦合系统非线性随机振动轮轨接触统计线性化