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Study on Immunotherapy-related Biomarkers of Small-cell Lung Cancer

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Chinese Journal of Biomedical Engineering(English Edition) 2022年第1期31卷 27-32页

作者： li yu-yan li Shan-shan FAN li ZHANG Bin Jilin Kingmed for Clinical Laboratory Co. Ltd.Changchun Jilin 130000China

The prognosis of small cell lung cancer is *** all patients have a tendency for tumor spreading to the whole body when they are ***,the combination of radiotherapy and chemotherapy is the main treatment,and surgical treatment is only implemented in a small number of limited *** recent years,there has been no obvious breakthrough in the treatment of small cell lung cancer,and the overall poor prognosis has not *** the development of medical technology,immune checkpoint inhibitors are gradually applied to the treatment of small-cell lung cancer,but the overall effect is *** to screen the beneficiary population to further improve the effect of immunotherapy is the key issue in the treatment of small-cell lung cancer.

关键词： immunosuppression biomarkers lung tumor

Decreases of voltage-dependent K~+ currents densities in ventricular myocytes of guinea pigs by chronic oxidant stress

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Acta Pharmacologica Sinica 2004年第6期25卷 49-53页

作者： De-li DONG, yan liU, yu-hong ZHOU,Wei-hua SONG, He WANG, Bao-feng yanG2 Department ofpharmacology, Harbin Medical University, Harbin 150086, China Department of pharmacology Harbin Medical University Harbin 150086

AIM: To determine the changes of delayed rectifier K+ currents (Ik) and inward rectifier K+ currents (Ik1) in the ventricular myocytes of guinea pigs during the gradual apoptotic process by the chronic oxidant stress treatment. METHODS: H2O250 μmol/L (24 h) was used for inducing apoptosis in the cardiomyocytes culture of neonatal rats and to treat the isolated ventricular myocytes of adult guinea pigs in vitro for 24 h. Apoptosis was evaluated by TUNEL methods and voltage-dependent K+ currents were recorded by patch-clamp techniques. RESULTS: H2O2 50 μmol/L (24 h)induced cell apoptosis in the cardiomyocytes culture of neonatal rats. This concentration was used to treat the isolated ventricular myocytes of adult guinea pigs in vitro for 24 h and the voltage-dependent K+ currents densities (Ik, Ik1) were down-regulated. The densities of the delayed rectifier K+ currents (Ik) in 50 μmol/L H2O2 group were 2.52±0.57 pA/pF vs 5.73±1.84 pA/pF in the control group at +50 mV (n=8, P<0.01). The densities of the inward rectifier K+ currents (Ik1) in 50 μmol/L H2O2 group were -13.9± 2.70 pA/pF, 2.52±0.57 pA/pF vs -59.7±11.9 pA/pF, 5.73±1.84 pA/pF in the control group at -120 mV (n=8, P< 0.01) and -40 mV (n=8, P<0.05), respectively. The extent of inward rectifier property of Ik1 was weakened by 50 μmol/L H2O2treatment. CONCLUSION: The densities of Ik, Ik1 in the cardiomyocytes of guinea pigs were down- regulated and the inward rectifier property of Ik1 was weakened during the gradual apoptotic process after 50 μmol/L H2O2 treatment for 24 h.

关键词： hydrogen peroxide potassium apoptosis cardiac myocytes

A Tabletop Nano-CT Image Noise Reduction Network Based on 3-Dimensional Axial Attention Mechanism

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Computers, Materials & Continua 2024年第7期80卷 1711-1725页

作者： Huijuan Fu linlin Zhu ChunhuiWang Xiaoqi Xi yu Han Lei li yanmin Sun Bin yan Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou450000China

Nano-computed tomography(Nano-CT)is an emerging,high-resolution imaging ***,due to their low-light properties,tabletop Nano-CT has to be scanned under long exposure conditions,which the scanning process is *** 3D reconstruction data,this paper proposed a lightweight 3D noise reduction method for desktop-level Nano-CT called AAD-ResNet(Axial Attention DeNoise ResNet).The network is framed by theU-net *** encoder and decoder are incorporated with the proposed 3D axial attention mechanism and residual dense *** layer of the residual dense block can directly access the features of the previous layer,which reduces the redundancy of parameters and improves the efficiency of network *** 3D axial attention mechanism enhances the correlation between 3D information in the training process and captures the long-distance *** can improve the noise reduction effect and avoid the loss of image structure *** results show that the network can effectively improve the image quality of a 0.1-s exposure scan to a level close to a 3-s exposure,significantly shortening the sample scanning time.

关键词： Deep learning tabletop Nano-CT image denoising 3D axial attention mechanism

Tailoring the austenite characteristics via dual nanoparticles to synergistically optimize the strength-ductility in cold rolled medium Mn steel

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Journal of Materials Science & Technology 2024年第2期169卷 158-171页

作者： Qizhe Ye Haokai Dong Qinyi Guo Yishuang yu lijie Qiao yu yan Beijing Advanced Innovation Center for Materials Genome Engineering Corrosion and Protection CenterInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510641China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In this work,we proposed a novel Cu/θdual nanoparticles strategy to tailor the austenite characteris-tics of a medium Mn steel via a tempering-annealing process to optimize the mechanical *** explored the effects of Cu-rich particles and cementite precipitated in the tempering process on the austenite reversion during the subsequent annealing *** experiments and numerical simula-tions verified that the austenite inherited from cementite had a finer size and a higher Mn enrichment compared with the austenite originating from the tempered martensite *** addition,quantitative evaluations revealed that the pinning effect exerted by the Cu-rich particles could significantly hinder theα/γinterface migration and the recrystallized grain growth,thereby further refining the final *** contributions from the effects of dual nanoprecipitates on the austenite reversion,the heterogeneous austenite grains inherited from varying nucleation sites ensured the sustained and gradual deformation-induced martensite and twinning ***,the Cu-added steels subjected to a tempering-annealing process achieved synergetic enhancement of the tensile strength from 1055 MPa to 1250 MPa and elongation from 33%to 45%.This strategy may provide new guidance for the development and alloy design of high-performance medium Mn steels.

关键词： Dual nanoparticles Medium Mn steel Tempering-annealing process Austenite reversion Mechanical properties

Insight into the microbial community of denitrification process using different solid carbon sources: Not only bacteria

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Journal of Environmental Sciences 2024年第10期144卷 87-99页

作者： Congyu li yu ling yanjie Zhang Haiyan Wang Huan Wang Guokai yan Weiyang Dong yang Chang liang Duan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China College of Water Sciences Beijing Normal UniversityBeijing 100875China Research Center of Environmental Pollution Control Technology Chinese Research Academy of Environmental ScienceBeijing 100012China State Environmental Protection Key Laboratory of Estuarine and Coastal Environment Chinese Research Academy of Environmental SciencesBeijing 100012China

There is a lack of understanding about the bacterial,fungal and archaeal communities’composition of solid-phase denitrification(SPD)*** investigated four SPD systems with different carbon sources by analyzing microbial gene sequences based on operational taxonomic unit(OTU)and amplicon sequence variant(ASV).The results showed that the corncob-polyvinyl alcohol sodium alginate-polycaprolactone(CPSP,0.86±0.04 mg NO_(3)^(−)-N/(g·day))and corncob(0.85±0.06 mg NO_(3)^(−)-N/(g·day))had better denitrification efficiency than polycaprolactone(PCL,0.29±0.11 mg NO_(3)^(−)-N/(g·day))and polyvinyl alcoholsodium alginate(PVA-SA,0.24±0.07 mg NO_(3)^(−)-N/(g·day)).The bacterial,fungal and archaeal microbial composition was significantly different among carbon source types such as Proteobacteria in PCL(OTU:83.72%,ASV:82.49%)and Rozellomycota in PVA-SA(OTU:71.99%,ASV:81.30%).ASV methods can read more microbial units than that of OTU and exhibit higher alpha diversity and classify some species that had not been identified by OTU such as Nanoarchaeota phylum,unclassified_f_Xanthobacteraceae genus,etc.,indicating ASV may be more conducive to understand SPD microbial *** co-occurring network showed some correlation between the bacteria fungi and archaea species,indicating different species may collaborate in SPD *** KEGG function prediction results were obtained in two bioinformatic methods generally and some fungi and archaea functions should not be ignored in SPD *** results may be beneficial for understanding microbial communities in SPD systems.

关键词： Solid-phase denitrification Solid carbon source Microbial community ASV analysis OTU analysis

A Selenium Atom Involved Covalent Organic Framework for Window Ledge Photocatalytic Oxidation of Sulfides

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Chinese Journal of Chemistry 2024年第17期42卷 1960-1966页

作者： Fan yang Xia li Hong-yan Qu Jing-Lan Kan yuan Guo yu-Bin Dong College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongKey Laboratory of Molecular and Nano ProbesMinistry of EducationShandong Normal UniversityJinanShandong250014China School of light Industry and Engineering Qilu University of Technology(Shandong Academy of Sciences)JinanShandong 250353China

Covalent organic frameworks(coFs)driven photocatalytic organic transformations especially photooxidation reactions have become a fertile topic and attracted numerous research *** the charge generation and transport process is the key factor for achieving high catalytic *** one of the most effective strategies,the introduction of"heavy atoms"into the long-range ordered conjugated backbones can effectively facilitate the intersystem crossing(isc)process and hence improve the generation of active oxygens,which is beneficial for the *** this work,we designed and synthesized a benzoselenadiazole based covalent organic framework(COF)material,BSe-COF with heavy atom of selenium(Se),and a benzothiadiazole based BT-COF with isomorphic backbone for comparison.

关键词： Covalent organic framework Benzoselenadiazole Density functional theory Heavy atom Photocatalysis Photooxidation Singletoxygen Window ledge reaction

Immune Regulatory Networks and Therapy of yδT Cells in liver Cancer:Recent Trends and Advancements

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 287-297页

作者： Kun-li Yin Kai-Jian Chu Ming li yu-Xin Duan yan-Xi yu Mei-Qing Kang Da Fu Rui liao Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Biliary Surgical Department I the Eastern Hepatobiliary Surgical HospitalNaval Medical UniversityShanghaiChina General Surgery Institute of Pancreatic DiseasesRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

The roles of γδ T cells in liver cancer,especially in the poten-tial function of immunotherapy due to their direct cytotoxic effects on tumor cells and secretion of important cytokines and chemokines,have aroused research *** re-view briefly describes the basic characteristics of γδ T cells,focusing on their diverse effects on liver *** particular,different subtypes of γδ T cells have diverse or even opposite effects on liver *** provide a detailed description of the immune regulatory network of γδ T cells in liver can-cer from two aspects:immune components and nonimmune *** interactions between various components in this immune regulatory network are dynamic and pluralis-tic,ultimately determining the biological effects of γδ T cells in liver *** also integrate the current knowledge of γδ T-cell immunotherapy for liver cancer treatment,emphasiz-ing the potential of these cells in liver cancer immunotherapy.

关键词： liver cancer γδT cells Immunotherapy Tumor microenvironment

Influence of High-Density Bedding Plane Characteristics on Hydraulic Fracture Propagation in Shale Oil Reservoir

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 3051-3071页

作者： Xiao yan Di Wang Haitao yu State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Beijing102206China State Energy Center for Shale Oil Research and Development Beijing102206China Department of Geotechnical Engineering College of Civil Engineering Tongji UniversityShanghai200092China Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Key Laboratory of Deep Earth Science and Engineering(Sichuan University) Ministry of EducationChengdu610065China

The existence of high-density bedding planes is a typical characteristic of shale oil *** the behavior of hydraulic fracturing in high-density laminated rocks is significant for promoting shale oil *** this study,a hydraulic fracturing model considering tensile failure and frictional slip of the bedding planes is established within the framework of the unified pipe-interface element method(UP-IEM).The model developed for simulating the interaction between the hydraulic fracture and the bedding plane is validated by comparison with experimental *** hydraulic fracturing patterns in sealed and unsealed bedding planes are ***,the effects of differential stress,bedding plane permeability,spacing,and the friction coefficient of the bedding plane are *** results showed that a single main fracture crossing the bedding planes is more likely to form in sealed bedding planes under high differential *** decrease in bedding plane permeability and the increase in the friction coefficient also promote the fracture propagating perpendicular to the bedding *** with high-density bedding planes has a poorer fracturing effect than that with low-density bedding planes,as the hydraulic fracture is prone to initiate and propagate along the bedding ***,higher injection pressure is needed to maintain fracture propagation along the *** increase in bedding density will lead to a smaller fracturing *** fluid seepage into the bedding planes slows shale *** is recommended that increasing the injection flow rate,selecting alternative fracturing fluids,and employing multi-well/multi-cluster fracturing may be efficient methods to improve energy production in shale oil reservoirs.

关键词： Hydraulic fracturing bedding planes shale unified pipe-interface element method

Object Helps U-Net Based Change Detectors

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 548-550页

作者： Lan yan Qiang li Kenli li College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,This letter focuses on leveraging the object information in images to improve the performance of the U-Net based change *** detection is fundamental to many computer vision *** existing solutions based on ... 详细信息

关键词： Net computer networks