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Brain functional network connectivity based on a visual task: visual information processing-related brain regions are significantly activated in the task state

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Neural Regeneration Research 2015年第2期10卷 298-307页

作者： yan-li yang Hong-xia Deng Gui-yang Xing Xiao-luan Xia Hai-fang li School of Computer Science and Technology Taiyuan University of Technology

It is not clear whether the method used in functional brain-network related research can be applied to explore the feature binding mechanism of visual perception. In this study, we inves-tigated feature binding of color and shape in visual perception. Functional magnetic resonance imaging data were collected from 38 healthy volunteers at rest and while performing a visual perception task to construct brain networks active during resting and task states. Results showed that brain regions involved in visual information processing were obviously activated during the task. The components were partitioned using a greedy algorithm, indicating the visual network existed during the resting state.Z-values in the vision-related brain regions were calculated, conifrming the dynamic balance of the brain network. Connectivity between brain regions was determined, and the result showed that occipital and lingual gyri were stable brain regions in the visual system network, the parietal lobe played a very important role in the binding process of color features and shape features, and the fusiform and inferior temporal gyri were crucial for processing color and shape information. Experimental ifndings indicate that understanding visual feature binding and cognitive processes will help establish computational models of vision, improve image recognition technology, and provide a new theoretical mechanism for feature binding in visual perception.

关键词： nerve regeneration functional magnetic resonance imaging resting state task state brain network module division feature binding Fisher’s Z transform connectivity visual stimuli NSFC grants neural regeneration

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Novel modified pectin for heavy metal adsorption

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Chinese Chemical Letters 2007年第3期18卷 325-328页

作者： Feng Ting li Hong yang yan Zhao Ran Xu State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and Engineering Tongji University Shanghai 200092 China

Modified pectin cross-linked with adipic acid, was synthesized and used for heavy metal removal from wastewater. SEM and FTIR were used to investigate its structure and morphology. The modified pectin had a rough, porous phase covered with carboxy groups, resulting a high adsorption capacity. And at the room temperature, the saturated loading capacity for Pb^2＋, Cu^2＋ and Zn^2＋ reached 1.82 retool/g, 1.794 mmol/g and 0.964 retool/g, respectively. The results proved its potential application to remove of the heavy metal.

关键词： Modified pectin Adsorption Heavy metal

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Rapid progression of atherosclerosis in a patient with acute coronary syndrome and ANCA-associated vasculitis:split or confluence?

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Journal of Geriatric Cardiology 2022年第5期19卷 403-408页

作者： Ya-Chao li Meng-Jie LEI yan-li yang Zeng-Ming XUE Department of Cardiology Langfang People’s HospitalHebei Medical UniversityLangfang Core Laboratory of Precision Treatment of CADLangfangHebei ProvinceChina

A59-year-old female patient was admitted to our hospital on 9 March 2021,due to recurrent chest *** underwent percutaneous coronary intervention,with a focus on the proximal segment of the left anterior descending(LAD)artery,six months prior to *** patient had a long-term history of hyperlipidaemia and obstructive sleep apnoea syndrome(OSAS).She also had rheumatoid arthritis and ANCA-associated vasculitis that lasted for more than 10 years and a 9-year history of concomitant *** was on long-term oral leflunomide and intermittent oral *** patient underwent a computed tomography angiogram(CTA)six years ago(2015),which showed minor atherosclerotic plaque build-up in the LAD artery and the right coronary artery(RCA)(Figure 1).

关键词： coronary patient admitted

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Manufacture the conducting polymer with light

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Science China Chemistry 2025年第1期68卷 8-9页

作者： yang li Tianyu li yan Ji Baoguang liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

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NUMERICAL SIMULATION OF UPliFT FORCES ON SLAB IN PLUNGE POOL

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Journal of Hydrodynamics 2002年第3期14卷 91-96页

作者： li, yan-ling yang, Yong-Quan Zhang, Jian-Min Hydraulics Lab. of High Speed Flows Sichuan Univ. Chengdu 610065 China

The mechanism of the fluid-solid coupled vibration is analyzed as the fluctuating pressure acts on the inlet and the outlet slits of a slab. The parameter multinomial method was exploited to calculate the pressure field within the joints of the slabs by solving the basic equations of the oscillation flow. The calculated result shows that the time-averaged uplift increases with the increase of the length of the slab and is large in the middle and is small in both sides. The time-averaged uplift reduces with the increase of water depth, and the fluctuating uplift reduces rapidly with the increase of the thickness of the slit. The calculated result is in agreement with the experimental results.

关键词： Energy dissipators Flow of fluids Numerical analysis Uplift pressure Vibrations (mechanical)

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Novel conservative treatment for peritoneal dialysis-related hydrothorax:Two case reports

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World Journal of Clinical Cases 2020年第24期8卷 6437-6443页

作者： Bin-Bin Dai Bei-Duo lin li-yan yang Jian-Xin Wan yang-Bin Pan Department of Nephrology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Nephrology Shanghai Pudong HospitalShanghai 201399China

BACKGROUND Peritoneal dialysis (PD) is an important renal replacement therapy for patientswith end-stage renal disease. PD-related hydrothorax is a rare but seriouscomplication in PD patients, produced by the movement of peritoneal dialysatethrough pleuroperitoneal fistulas. In previous reports, patients with hydrothoraxsecondary to PD were usually recommended to discontinue PD and transfer tohemodialysis (HD). Herein, we describe another method of managing thiscomplication—with an adjusted PD prescription and continuous drainage ofpleural effusion, patients could continue PD without recurrence of *** SUMMARY In this report, we present the medical records of 2 patients with hydrothoraxsecondary to PD. We recommended intermittent PD with continuous drainage ofpleural effusion. A type 18Ga soft catheter was placed to drain pleural ***-guided thoracentesis was performed, and the soft catheter was placedin the pleural cavity for a long period (3 mo and 2 mo, respectively). The pleuralcatheter was removed when no fluid was drained from the pleural cavity. Afterseveral months, pleuroperitoneal fistulas were closed in both patients and PD wascontinued. These patients did not transfer to HD, had no recurrence ofhydrothorax and were still treated with PD after 1 *** These 2 case reports show that continuous drainage of pleural effusion with an18Ga soft catheter is a useful method for hydrothorax secondary to PD.

关键词： Peritoneal dialysis End-stage renal disease Hydrothorax Treatment Conservative Case report

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Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

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Infectious Diseases of Poverty 2021年第1期10卷 95-96页

作者： Justus Amuche Nweze Florence N.Mbaoji yan-Ming li li-yan yang Shu-Shi Huang Vincent N.Chigor Emmanuel A.Eze li-Xia Pan Ting Zhang Deng-Feng yang Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry National Engineering Research Center of Non-Food Biorefi neryState Key Laboratory of Non-Food Biomass and Enzyme TechnologyGuangxi Academy of SciencesNanning 530007GuangxiPeople's Republic of China Nation al Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Center for Tropical DiseasesNatio nal Center for Inter national Research on Tropical DiseasesKey Laboratory of Parasite and Vector Biology of the Chinese Ministry of HealthShanghai 200025People's Republic of China Full list of author information is available at the end of the article

Background:Malaria and neglected communicable protozoa parasitic diseases,such as leishmaniasis,and trypanosomiasis,are among the otherwise called diseases for neglected communities,which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa,Asia,and the *** of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period,which have encouraged *** have prompted many researchers to focus on fin ding new drugs that are safe,effective,and affordable from marine environ *** aim of this review was to show the diversity,structural scaffolds,in-vitro or in-vivo efficacy,and recent progress made in the discovery/isolation of marine natural products(MNPs)with potent bioactivity against malaria,leishmaniasis,and *** text:We searched PubMed and Google scholar using Boolean Operators(AND,OR,and NOT)and the combination of related terms for articles on marine natural products(MNPs)discovery published only in English language from January 2016 to June *** nine articles reported the isolation,identification and antiparasitic activity of the isolated compounds from marine environment.A total of 125 compounds were reported to have been isolated,out of which 45 were newly isolated *** compounds were all isolated from bacteria,a fungus,sponges,algae,a bryozoan,cnidarians and soft *** recent years,great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent ***,some of these promising antikinetoplastid MNPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal ***,very few of these MNPs have a pharmaceutical destiny due to lack of the following:sustainable production of the bioactive compounds,stan da rd efficient screening methods,knowledge of the me

关键词： Marine natural products Neglected tropical diseases Anti-trypanosoma Anti-leishmania Anti-plasmodia Protozoa parasites

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sPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of Idiopathic Membranous Nephropathy

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Current Medical Science 2020年第4期40卷 683-690页

作者： li-yan yang Yuan-sheng WU Bin-bin DAI Song-hua liN Hong CHEN Guo-ping li Xuan TAO Jian-xin WAN yang-bin PAN Department of Nephrology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China Shanghai Pudong Hospital Fudan University Pudong Medical CenterShanghai 201399China Department of Cardiology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China Department of Pathology the First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China

Summary:Recent studies suggested that serum secretory phospholipase A2 group IB(sPLA2-IB)was increased in idiopathic membranous nephropathy(IMN).However,the interference of high lipemia on the sPL.A2-IB levels was not taken into account in these *** present study aimed to investigate the correlation between sPLA2-IB and lipemia,and the clinical merit of sPLA2-IB in the prediction of prognosis of IMN patients.A total of 64 IMN patients,39 immunoglobulin A nephropathy(IgAN)patients and 64 healthy controls were included in the *** levels of serum sPLA2-IB,lipemia and proteinuria were *** IMN patients were followed up for 6 *** stages were made for all IgAN and IMN *** results showed that the levels of serum sPLA2-IB,cholesterol and low-density lipoprotein cholesterol(LDL-C)were significantly higher,and the levels of albumin and high-density lipoprotein cholesterol(HDL-C)were significantly lower in IMN patients than in healthy controls and IgAN *** sPLA2-IB levels were also found to be higher in IgAN patients than in heathy controls,but the association of serum sPLA2-IB levels with proteinuria,cholesterol and albumin was only shown in IMN *** against M-type receptor for secretory phospholipase A2(PLA2R1)was positive in 813%IMN *** sPLA2-IB deposition,podocyte fused processes,and density deposition on thickened basement membrane were seen in IMN patients,but not in IgAN *** patients with lower sPLA2-IB and proteinuria levels were found to have better outcome after the 6-month *** IMN patients,sPLA2-IB levels were significantly increased in both serum and renal *** conclusion,serum sPLA2-IB was closely correlated with proteinuria,albumin and cholesterol,and IMN patients with lower sPLA2-IB levels were more likely to achieve a better outcome.

关键词： sPLA2-IB lipemia idiopathic membranous nephropathy prognosis

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Positive reverse transcription-polymerase chain reaction assay results in patients recovered from COVID-19: Report of two cases

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World Journal of Clinical Cases 2021年第12期9卷 2816-2822页

作者： Ke-Xin Huang Cheng He yan-li yang Di Huang Zhi-Xia Jiang Bang-Guo li Heng liu Department of Radiology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Nursing Guizhou Jiangjunshan HospitalGuiyang 563000Guizhou ProvinceChina

BACKGROUND Coronavirus disease 2019(COVID-19)has spread around the *** February 28,2020,the World Health Organization adjusted the risk of spread and impact of COVID-19 to“very high”at the global *** have mainly focused on the etiology,epidemiology,and treatment of COVID-19 to limit further spread and the negative impact of the disease,while less attention has been devoted to the follow-up and reexamination of patients who recovered from COVID-19 or were released from *** SUMMARY This study reports two cases where patients who had negative reverse transcription-polymerase chain reaction(RT-PCR)test results and met the criteria for discharge subsequently had positive RT-PCR test *** clinical manifestations and computed tomography(CT)findings of these patients were *** conversion of RT-PCR test results in these two patients may be related to false-negative and false-positive outcomes of the *** images helped track improvement of pulmonary *** The timing of discharge of COVID-19 patients should be determined by comprehensive analysis of CT images and RT-PCR test results.

关键词： COVID-19 False negative Recovery Reverse transcription-polymerase chain reaction SARS-CoV-2 Case report

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Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus

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Biomedical and Environmental Sciences 2009年第5期22卷 359-368页

作者： yan-li yang RUO-LAN XIANG CHANG yang XIAO-JUN liU WEN-JUN SHEN JIN ZUO YONG-SHENG CHANG Fu-DE FANG Department of Internal Medicine Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100730 China Department of Physiology and Pathophysiology Peking University Health Science Center BeiJing 100083 China National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100005 China Division of Endocrinology Stanford University and VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto CA 94304 USA

Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus （T2DM） patients and healthy subjects using DNA microarray analysis, Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to anaIyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds, These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured.

关键词： Type 2 diabetes mellitus (T2DM) Microacray technology Skeletal muscle Adipose tissue

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