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Preparation, characterization, and adsorption-photocatalytic activity of nano TiO_2 embedded in diatomite synthesis materials

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Rare Metals 2017年第12期36卷 987-991页

作者： ya-li zhang Jing yang Xian-Jin Yu School of Chemical-Engineering Shandong University of Technology Zibo 255049 China

Nano TiOembedded in diatomite(NTED)synthesis materials were prepared by a sol-gel method in absolute ethyl alcohol suspension. NTED synthesis materials have a higher specific surface area and larger pore volume using micromeritics ASAP 2020. The result of characterization was measured by X-ray diffraction(XRD),Fourier transform infrared(FT-IR) spectroscopy, scanning electron microscope(SEM), and energy dispersive spectroscopy(EDS). The cyanide wastewater was employed to evaluate the adsorption capacity and photocatalytic activity of prepared NTED synthesis materials. The better photocatalytic activity and adsorption capacity of NTED synthesis materials are attributed to their high surface area and higher UV absorption intensity for the cyanide wastewater.

关键词： Nano TiO_2 Diatomite(NTED) Embedded Adsorption Photocatalysis

Effect of microcystin-LR on protein phosphatase 2A and its function in human amniotic epithelial cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 951-960页

作者： Jing liANG Fan li ya-li zhang Zong-lou GUO li-hong XU Department of Biochemistry and Genetics School of Medicine Zhejiang University Hangzhou 310058 China Department of Biosystem Engineering College of Biosystem Engineering and Food Science Zhejiang University Hangzhou 310058 China

Due to their toxicity,the increased distribution of microcystins(MCs) has become an important worldwide *** have been recognized as inhibitors of protein phosphatase 2A(PP2A) through their binding to the PP2A catalytic ***,the exact mechanism of MC toxicity has not been elucidated,especially concerning the cellular response and its *** further dissect the role of PP2A in MC-induced toxicity,the present study was undertaken to determine the response of PP2A in human amniotic epithelial(FL) cells treated with microcystin-LR(MCLR),one of the MC *** results show that a low-dose treatment of MCLR in FL cells for 6 h induced an increase in PP2A activity,and a high-dose treatment of MCLR for 24 h decreased the activity of PP2A,as *** increased mRNA and protein levels of the PP2A C subunit may explain the increased activity of ***,MCLR altered microtubule post-translational modifications through *** results further clarify the underlying mechanism how MCLR affects PP2A and may be helpful for elucidating the complex toxicity of MCLR.

关键词： Microcystin-LR Protein phosphatase 2A Phosphatase activity Hormesis Tubulin B55α

PRODUCTION AND CHARACTERIZATION OF POLY(3-HYDROXYBUTYRATE-co-3-HYDROXYHEXANOATE)-POLY(ETHYLENE GLYCOL) HYBIRD COPOLYMER WITH ADJUSTABLE MOLECULAR WEIGHT

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Chinese Journal of Polymer Science 2012年第1期30卷 101-111页

作者： ya—li zhang Xiao-yun Lu Qian-qian liu Ming-chuan li Zhi-qian yang Jian-gang Ma Department of Biological Science and Bioengineering Key Laboratory of Biomedicai Information Engineering of Ministry of Education School of Life Science and Technology Xi ＇an Jiaotong University Xi ＇an 710049 China

A novel natural-synthetic hybrid block copolymer was synthesized by Aeromonas hydrophila 4AK4 in poly（ethylene glycol）（PEG,M_n=200） modified *** hybrid biomaterial consists of the natural hydrophobic polymer poly（3-hydroxybutyrat-co-3-hydroxyhexanoate）（PHBHHx） end-capped with hydrophilic PEG,which has the increased flexibility as well as the improved thermal *** of diethylene glycol（DEG） and ethylene glycol could not result in the accumulation of hybrid block *** and ethylene glycol,together with PEG-200,could cause a reduction of molar mass of PHBHHx,resulting in a series of low molecular weight polymer and the reduction of the polymer yield as well as the cellular *** vitro degradation of PHBHHx and PHBHHx-PEG with different molecular weight showed that the decrease of molecular weight accelerated the degradation of copolymers,but PEG modification has little effect on its degradation *** results in this study provided a convenient and direct method to produce a series of PHBHHx and PHBHHx-PEG materials with adjustable molecular weight and broad molecular weight distribution which will be very useful for the biomedical applications.

关键词： Biopolyester Biodegradable Molecular weight Polyhydroxyalkanoates Polyethylene glycol

Del(5q) and inv(3) in myelodysplastic syndrome: A rare case report

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World Journal of Clinical Cases 2022年第11期10卷 3601-3608页

作者： Hai-Ping liang Xing-Chun Luo ya-li zhang Bei liu The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Hematology The First Affiliated HospitalLanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Del(5q)is the most common molecular event in myelodysplastic syndrome(MDS),accounting for 10%-15%of ***(3)is an adverse cytogenetic abnormality observed in less than 1%of MDS *** studies have reported the coexistence of del(5q)and inv(3)in ***,the pathological mechanism,treatment strategy and prognosis of this subtype need to be *** SUMMARY A 66-year-old woman was admitted to the hospital due to chest tightness and shortness of *** clinical assessments with laboratory examinations,the patient was diagnosed with MDS containing both del(5q)and inv(3).Considering the deletion of chromosome 5q,we first treated the patient with *** drug resistance arose,we tried azacitidine,and the patient had a short ***,the patient refused treatment with haematopoietic stem cell transplantation and died of severe infection four months *** MDS patients with del(5)and inv(3)have a poor *** may achieve short-term remission for such patients.

关键词： Myelodysplastic syndrome Del(5q) Inv(3) Lenalidomide Azacitidine Case report

Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells

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World Journal of Gastroenterology 2020年第48期26卷 7593-7602页

作者： Xiong Sun yao Huang ya-li zhang Dan Qiao yan-Cheng Dai Department of Gastroenterology Shanghai PuTuo District People's Hospital Affiliated to Tongji UniversityTongji University School of MedicineShanghai 200060China Department of Digestive Diseases Jing'an District Central HospitalFudan UniversityShanghai 200040China Institute of Digestive Diseases LongHua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China

Ulcerative colitis(UC)is a chronic relapsed intestinal disease with an increasing incidence around the *** pathophysiology of UC remains ***,the role of the interaction between the enteric nervous system and the immune system in the pathogenesis of UC has been the focus of attention and has become a research *** intestinal peptide(VIP)is a kind of endogenous neuropeptide with regulatory activity on intestinal *** has been shown to regulate immune disorders in animal and human experiments and has become an effective anti-inflammatory and immune modulator that affects the innate immune system and adaptive immune *** B cells(Bregs)are a new group of B cells that negatively regulate the immunity and have received extensive attention in immune *** can regulate immune tolerance by producing interleukin(IL)-10,IL-35,and transforming growth factor-β,suppressing autoimmune diseases or excessive inflammatory *** secretion of IL-10 by Bregs induces the development of T helper(Th)0 and Th2 *** also induces Th2 cytokines and inhibits Th1 cytokines,thereby inhibiting Th1 cells and the Th1/Th2 *** further clarity on the mechanism of the regulation of IL-10 expression by VIP in Bregs in colitis patients,we believe that Bregs can provide a novel strategy for the clinical treatment of ***,we aim to review the current literature on this evolving topic.

关键词： Vasoactive intestinal peptide Ulcerative colitis Interleukin-10 Bregs Pathogenesis

Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis

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World Journal of Gastroenterology 2018年第13期24卷 1398-1409页

作者： You-Lan Chen ya-li zhang yan-Cheng Dai Zhi-Peng Tang Institute of Digestive Disease Longhua Hospital Shanghai University of Traditional Chinese Medicine Department of Gastroenterology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

AIM To investigate the protective effects of Ampelopsis grossedentata(AMP) on dextran sulfate sodium(DSS)-induced colitis in mice based on systems pharmacology *** Systems pharmacology approach was used to predict the active ingredients, candidate targets and the efficacy of AMP on ulcerative colitis(UC) using a holistic process of active compound screening, target fishing, network construction and analysis. A DSSinduced colitis model in C57 BL/6 mice(n = 10/group) was constructed and treated with 5-aminosalicylic acid(100 mg/kg/d) and AMP(400 mg/kg/d) to confirm the underlying mechanisms and effects of AMP on UC with western blot analyses, polymerase chain reaction, histological staining and *** The therapeutic effects of AMP against DSS-induced colitis were determined in the beginning, and the results showed that AMP significantly improved the disease in general observations and histopathology analysis. Subsequent systems pharmacology predicted 89 corresponding targets for the four candidate compounds of AMP, as well as 123 candidate targets of UC, and protein-protein interaction networks were constructed for the interaction of putative targets of AMP against UC. Enrichment analyses on TNF-α and RANKL/RANK, a receptor activator of NF-κB signaling pathways, were then carried out. Experimental validation revealed that inflammation-related signaling pathways were activated in the DSS group, and AMP significantly suppressed DSS-induced high expression of IRAK1, TRAF6, IκB and NF-κB, and inhibited the elevated expression levels of TNF-α, IL-1β, IL-6 and *** AMP could exert protective effects on UC via suppressing the IRAK1/TRAF6/NF-κB-mediated inflammatory signaling pathways.

关键词： Ulcerative colitis Ampelopsis grossedentata Traditional Chinese medicine Systems pharmacology Inflammation

GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells

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World Journal of Gastroenterology 2014年第42期20卷 15727-15735页

作者： Xiao-Min Xin Mu-Xiao Zhong Gong-li yang yao Peng ya-li zhang Wei Zhu Guangdong Provincial Key Laboratory of Gastroenterology Department of Gastroenterology Nanfang Hospital Southern Medical University Department of Gastroenterology Anyang People’s Hospital Department of Gastroenterology Taihe Hospital Hubei University of Medicine

AIM: To investigate the effect of GW4064 on the expression of adipokines and their receptors during differentiation of 3T3-L1 preadipocytes and in HepG2 cells.

关键词： Farnesoid X receptor Adipokines Adipokine receptors 3T3-L1 cells HepG2 cells Nonalcoholic fatty liver disease

Safety and clinical efficacy of linezolid in children:a systematic review and meta-analysis

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World Journal of Pediatrics 2023年第2期19卷 129-138页

作者： Yi Shi Hai-Lan Wu Yu-Hang Wu Shuang li li-ya zhang Shan-Shan Xu He-Yu Huang Chun-Hong zhang Xu-Ben Yu Kang Cai Jing zhang li-Su Huang Department of Infectious Disease Xinhua Children’s HospitalXinhua HospitalShanghai Jiao Tong University School of MedicineShanghai200092China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou310052China Institute of Antibiotics Huashan HospitalFudan UniversityShanghai200040China Department of Pharmacy the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China

Background We aimed to evaluate the tolerability and efficacy of linezolid in children for treating suspected and diagnosed Gram-positive bacterial *** A systematic literature search was conducted up to April 23,2021,using linezolid and its synonyms as search *** reviewers independently identified and extracted relevant randomized controlled trials and prospective cohort *** extracted studies were included in a single-rate meta-analysis of adverse events and clinical outcomes using random-effects *** A total of 1082 articles were identified,and nine studies involving 758 children were included in the *** overall proportion of adverse events was 8.91%[95%confidence interval(CI)=1.64%–36.52%],with diarrhea(2.24%),vomiting(2.05%),and rash(1.72%)being the most *** incidences of thrombocytopenia and anemia were 0.68%and 0.16%,*** specific adverse events,including rash and gastrointestinal events,were more frequent in the oral administration *** terms of efficacy,the overall proportion of clinical improvement was 88.80%(95%CI=81.31%–93.52%).Children with a history of specific bacteriological diagnosis or concomitant antibiotic therapy had a 1.13-fold higher clinical improvement than children without such *** proportion of microbial eradication was 92.68%(95%CI=84.66%–96.68%).The proportion of all-cause mortality was 0.16%(95%CI=0.00%–7.75%).Conclusions linezolid was well-tolerated in pediatric patients and was associated with a low frequency of adverse events,such as anemia,thrombocytopenia,and ***,linezolid was effective in children with diagnosed and suspected Gram-positive infections.

关键词： Children Efficacy linezolid Meta-analysis Safety

Microsatellite instability,MMR gene expression and proliferation kinetics in colorectal cancer with famillial predisposition

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World Journal of Gastroenterology 2000年第6期6卷 902-905页

作者： Bao Ping Wu ya li zhang Dian Yuan Zhou Chun Fang Gao Zhuo Sheng Lai Institute for Digestive Medicine Nanfang HospitalGuangzhou 510515Guangdong ProvinceChina Department of Surgery of Colon and Rectum 150 Central HospitalLuoyang 471031Henan ProvinceChina

INTRODUCTIONGenetic instability is a conunon property of manyhuman cancers,including those of HNPCC.A novel form of genetic instability involving somaticalterations,such as deletions and insertions insimple repeated s... 详细信息

关键词： colorectal neoplasms microsatellite instability gene expression familial predisposition proliferation kinetics immunohistochemistry polymerase chain reaction flow cytometry