检索结果-南通市图书馆

Effect of silencing of high mobility group A2 gene on gastric cancer MKN-45 cells

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第8期19卷 1239-1246页

作者： Chun-Hui wei li-xiu wei Ming-Yu Lai Jia-Zhuang Chen Xi-Jing Mo Department of Geriatric Gastroenterology the First Affiliated Hospital of Guangxi Medical University Department of Gastroenterology the First Affiliated Hospital of Guangxi Chinese Medical University

AIM:To investigate the effect of high mobility group A2(HMGA2) gene silencing on gastric cancer MKN-45 cells in ***:HMGA2 short hairpin RNA(shRNA) expression plasmids were constructed,including a pair of random scrambled *** gastric cancer cell line MKN-45 cells were divided into three groups:blank control group(non-transfected cells),transfected group(cells transfected with HMGA2 shRNA recombinant plasmid) and scrambled sequence group(transfected with random scrambled plasmid).Cells were transfected with HMGA2 shRNA recombinant plasmids and scrambled plasmid in vitro,and the cells transfection efficiency was assayed by fluorescence *** HMGA2 messenger RNA(mRNA) expression was detected by reverse transcription polymerase chain reaction,gastric cancer cells apoptosis was detected by flow cytometry,cell proliferation was detected by methyl thiazol tetrazolium,and the protein expression of phosphatidylinositol 3-kinase(PI3K),protein kinase B(Akt),P27,caspase-9 and B-cell leukemia/lymphoma-2(Bcl-2) were analyzed by Western ***:Compared with the blank control group and the scrambled sequence group,the levels of HMGA2 mRNA and protein expression in the transfected group were significantly reduced(P < 0.05).The relative HMGA2 mRNA expression levels of the blank control group,transfected group and scrambled sequence group were 0.674 ± 0.129,0.374 ± 0.048 and 0.689 ± 0.124,*** relative HMGA2 protein expression levels of the blank control group,transfected group and scrambled sequence group were 0.554 ± 0.082,0.113 ± 0.032 and 0.484 ± 0.123,***,transfection with the scrambled sequence had no effect on the expression of *** being transfected with shRNA for 24,48 and 72 h,the cell apoptotic rates of the transfected group were 21.65% ± 0.28%,39.98% ± 1.82% and 24.51% ± 0.93%,respectively,which significantly higher than those of blank control group(4.72% ± 1.34%,5.83% ± 0.13% and 5.22% ± 1.07%) a

关键词： Gastric cancer cells RNA interference High mobility group A2 Proliferation Apoptosis

Task-specific Part Discovery for Fine-grained Few-shot Classification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine Intelligence Research 2024年第5期21卷 954-965页

作者： Yongxian wei xiu-Shen wei School of Computer Science and Technology Nanjing University of Science and TechnologyNanjing210094China

Localizing discriminative object parts(e.g.,bird head)is crucial for fine-grained classification tasks,especially for the more challenging fine-grained few-shot *** work always relies on the learned object parts in a unified manner,where they attend the same object parts(even with common attention weights)for different few-shot episodic *** this paper,we propose that it should adaptively capture the task-specific object parts that require attention for each few-shot task,since the parts that can distinguish different tasks are naturally *** for a few-shot task,after obtaining part-level deep features,we learn a task-specific part-based dictionary for both aligning and reweighting part features in an ***,part-level categorical prototypes are generated based on the part features of support data,which are later employed by calculating distances to classify query data for *** retain the discriminative ability of the part-level representations(i.e.,part features and part prototypes),we design an optimal transport solution that also utilizes query data in a transductive way to optimize the aforementioned distance calculation for the final *** experiments on five fine-grained benchmarks show the superiority of our method,especially for the 1-shot setting,gaining 0.12%,8.56%and 5.87%improvements over state-of-the-art methods on CUB,Stanford Dogs,and Stanford Cars,respectively.

关键词： Fine-grained image recognition few-shot learning transductive learning visual dictionary part feature discovery

黄河流域乡村文旅融合赋能乡村振兴发展研究 ——以泰安东平县为例

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

安徽农业科学 2024年第11期52卷 125-129页

作者：问荣荣孟欣慧李秀伟王步勇菏泽学院山东菏泽274015

东平是黄河流域一个重要的地区,地理位置重要,生态功能突出,地方文化资源丰富,黄河流域生态保护和高质量发展和乡村振兴战略双重背景下,东平县大力发展文旅融合,加强农业产业建设,以期促进两者协同互惠。在深入分析东平文旅融合发展推... 详细信息

东平是黄河流域一个重要的地区,地理位置重要,生态功能突出,地方文化资源丰富,黄河流域生态保护和高质量发展和乡村振兴战略双重背景下,东平县大力发展文旅融合,加强农业产业建设,以期促进两者协同互惠。在深入分析东平文旅融合发展推动乡村振兴阶段性成果的现状基础上,深刻挖掘困境背后的原因,并从基础设施建设、人才培养、体验项目、文创产品开发方面提出了可行的对策建议,推动东平县乡村振兴战略的实施。

关键词：地方文化文旅融合乡村旅游乡村振兴黄河流域

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

植物保护专业硕士主干课课程思政建设与实践

安徽农业科学 2024年第6期52卷 255-257,260页

作者：李修伟田宏哲秦培文祁之秋梁亚萍沈阳农业大学植物保护学院辽宁沈阳110866

课程思政是将思想政治教育与学科教学结合起来,构建常态化思想政治教育的新模式。植物保护专业硕士主干课程是核心基础课,是学习专业技能、掌握专业知识的主要阵地,也是思政育人的主要载体。以植物保护专业硕士主干课程为例,阐述了课程... 详细信息

课程思政是将思想政治教育与学科教学结合起来,构建常态化思想政治教育的新模式。植物保护专业硕士主干课程是核心基础课,是学习专业技能、掌握专业知识的主要阵地,也是思政育人的主要载体。以植物保护专业硕士主干课程为例,阐述了课程思政建设的重要性、建设现状、建设途径和建设实践,旨在促进专业教学与思政教育的有机融合,提高植物保护专业硕士课堂育人的成效。

关键词：植物保护硕士主干课课程思政思政建设

Backstepping Adaptive Controller of Electro-Hydraulic Servo System of Continuous Rotary Motor

在线全文

学校读者我要写书评

暂无评论

Journal of Harbin Institute of Technology(New Series) 2014年第3期21卷 111-116页

作者： Xiao-Jing Wang Chang-Fu Xian Cao-Lei Wan Jin-Bao Zhao li-wei xiu An-Cai Yu School of Mechanical and Power Engineering Harbin University of Science and Technology School of Mechanical and Electrical Engineering Harbin Institute of Technology Tianjin Research Institute of Construction Machinery

In order to consider the influence of the continuous rotary motor electro-hydraulic servo system parameters change on its performance,the design method of backstepping adaptive controller is put *** mathematical model of electro-hydraulic servo system of continuous rotary motor is established,and the whole system is decomposed into several lower order subsystems,and the virtual control signal is designed for each subsystem from the final subsystem with motor angular displacement to the subsystem with system control input voltage. Based on Lyapunov method and the backstepping theory,an adaptive backstepping controller is designed with the changed parameters adaptive law. It is proved that the system reaches the global asymptotic stability,and the system tracking error asymptotically tends to zero. The simulation results show that the backstepping adaptive controller based on the adaptive law of the changed parameters can improve the performance of continuous rotary motor,and the proposed control strategy is feasible.

关键词： continuous rotary motor low speed performance backstepping adaptive control

Maternal weight and its association with risk of overweight in offspring:a trajectory analysis from a birth cohort in China

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第5期20卷 496-505页

作者： Rui Deng wei-Qin li Xing-xiu li liu-Mei wei Jie Hu Jun-Hong Leng Bin Dong Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterNo.38 Xueyuan RdHaidian DistrictBeijing100191China Tianjin Women and Children’s Health Center No.96 Guizhou RdHeping DistrictTianjin300070China Menzies Health Institute Queensland Griffith UniversityNathanQLD4111Australia

Background Most studies on the association of maternal pregnancy weight with offspring weight trajectory have a short follow-up *** study aimed to explore the associations of maternal prepregnancy body mass index(BMI)and gestational weight gain(GWG)with childhood weight trajectories in a 7-year birth *** A total of 946 mother–child pairs(467 boys and 479 girls)from a longitudinal birth cohort in Tianjin City,China,were included in this study,ranging from pregnancy to offspring at 7 *** outcome variable was defined as overweight or not overweight in offspring at the last round.A group-based trajectory model was applied to identify childhood BMI trajectory *** Five discrete BMI trajectory groups were identified and characterized as constant underweight(25.2%),constant normal weight(42.8%),and high or increasing trajectory[at risk of overweight(16.9%),progressive overweight(11.0%)and progressive obesity(4.1%)].Maternal prepregnancy overweight was associated with 1.72(95%CI 1.14–2.60,P=0.01)to 4.02(95%CI 1.94–8.36,Pweight[relative risk ratio(RRR)2.09,95%CI 1.27–3.46,P=0.004]and progressive obesity(RRR 3.33,95%CI 1.13–9.79,P=0.029).Children in all high or increasing trajectory groups were associated with greater overweight risk at the last round[risk ratios(RRs)ranged from 3.54(95%CI 2.53–4.95,Pweight and excessive gestational weight gain were associated with increasing or high-level childhood body mass index trajectories as well as a greater risk of overweight at 7 years.

关键词： Body-weight trajectory Child Gestational weight gain Overweight Pregnancy

Tunable VO_(2) cavity enables multispectral manipulation from visible to microwave frequencies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

light(Science & Applications) 2024年第3期13卷 510-518页

作者： Hang wei Jinxin Gu Tao Zhao Zhiyuan Yan He-xiu Xu Shuliang Dou Cheng-wei Qiu Yao li Center for Composite Materials and Structure Harbin Institute of TechnologyHarbin 150001China National University of Singapore Department of Electrical&Computer EngineeringSingapore 117583Singapore School of Chemical Engineering and Technology Harbin Institute of TechnologyHarbin 150001China Suzhou Laboratory Suzhou 215123China

Optical materials capable of dynamically manipulating electromagnetic waves are an emerging field in memories,optical modulators,and thermal ***,their multispectral design preliminarily attracts much attention,aiming to enhance their efficiency and integration of ***,the multispectral manipulation based on these materials is challenging due to their ubiquitous wavelength dependence restricting their capacity to narrow *** this article,we cascade multiple tunable optical cavities with selective-transparent layers,enabling a universal approach to overcoming wavelength dependence and establishing a multispectral platform with highly integrated *** on it,we demonstrate the multispectral(ranging from 400 nm to 3 cm),fast response speed(0.9 s),and reversible manipulation based on a typical phase change material,vanadium *** platform involves tandem VO_(2)-based Fabry–Pérot(F-P)cavities enabling the customization of optical responses at target bands *** can achieve broadband color-changing capacity in the visible region(a shift of~60 nm in resonant wavelength)and is capable of freely switching between three typical optical models(transmittance,reflectance,and absorptance)in the infrared to microwave regions with drastic amplitude tunability exceeding *** work represents a state-of-art advance in multispectral optics and material science,providing a critical approach for expanding the multispectral manipulation ability of optical systems.

关键词： spectral microwave visible

Dynamic Analysis of A Deepwater Drilling Riser with A New Hang-off System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第1期38卷 29-41页

作者： li Yan-wei liU xiu-quan WANG Jin-long CHEN Guo-ming CHANG Yuan-jiang SHENG Lei-xiang Centre for Offshore Engineering and Safety Technology China University of PetroleumQingdao 266580China National Engineering Laboratory of Offshore Geophysical and Exploration Equipment China University of PetroleumQingdao 266580China China CNOOC Research Institute Co. Ltd.Beijing 100028China

The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of *** approach leads to a challenging problem:coupling the dynamics of risers with a new hang-off system combined with multiple structures and complex *** accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the Newmarkβ*** analysis program is also developed in MATLAB for dynamic *** simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation *** bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and *** platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.

关键词： deepwater drilling riser new hang-off system dynamic analysis finite element method penalty function method

Effect of universal salt iodization on antithyroid drugs

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2006年第13期119卷 1108-1112页

作者： DAI wei-xin liAN Xiao-lan LU lin li Su-mei li Shu-hua li xiu-wei Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100730 China National Iodide-Deficiency Reference Laboratory of China Beijing102206 China

Iodine deficiency disease （IDD） is common in China. An universal salt iodization （USl） program has been implemented by the Chinese government since 1996. As a result, the goiter rate in 8- to 10-year old children decreased from 20.4% in 1995 to 5.8% in 2002.1 But the adverse effects of iodine excess such as iodine-induced hyperthyroidism, iodine-induced goiters, iodine-induced hypothyroidism, etc. have become a great concern to healthcare professionals as well as the general population. The impact of USI on antithyroid drugs （ATDs） might become a potential challenge to address. With a special grant from the Department of Disease Control, the Health Ministry of China, we conducted a prospective study on the effects of USI on ATDs at the thyroid section of the Endocrinology Clinic of Peking Union Medical College Hospital （PUMCH）, Beijing.

关键词： iodine deficiency disease universal salt iodization antithyroid drugs