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Forecasting supernova observations with the CSST:*** samples

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 164-177页

作者： Chengqi liu Youhua xu Xianmin Meng xin Zhang Shi-Yu li Yuming Fu Xiaofeng Wang Shufei liu Zun Luo Guanghuan Wang Hu Zhan Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Beijing Planetarium Beijing Academy of Science and TechnologyBeijing 100044China Leiden Observatory Leiden UniversityNL-2300 RA LeidenThe Netherlands Kapteyn Astronomical Institute University of GroningenNL-9700 AV GroningenThe Netherlands Physics Department Tsinghua UniversityBeijing 100084China School of Astronomy and Space Science University of ChineseAcademy of SciencesBeijing 100049China

The China Space Station Telescope(CSST,also known as xuntian)is a serviceable two-meter-aperture wide-field telescope operating in the same orbit as the China Space *** CSST plans to survey a sky area of 17,500 deg^(2)of the medium-to-high Galactic latitude to a depth of 25-26 AB mag in at least 6 photometric bands over 255-1,000 *** such a large sky area,slitless spectra will also be taken over the same wavelength range as the imaging *** though the CSST survey is not dedicated to time-domain studies,it would still detect a large number of transients,such as supernovae(SNe).In this paper,we simulate photometric SN observations based on a strawman survey plan using the Sncosmo *** its 10-year survey,the CSST is expected to observe about 5 million SNe of various *** quality cuts,we obtain a“gold”sample that comprises roughly 7,400 SNe Ia,2,200 SNe Ibc,and 6,500 SNeⅡcandidates with correctly classified percentages reaching 91%,63%,and 93%(formally defined as classification precision),*** same survey can also trigger alerts for the detection of about 15,500 SNe Ia(precision 61%)and 2,100 SNeⅡ(precision 49%)candidates at least two days before the light ***,the near-ultraviolet observations of the CSST will be able to catch hundreds of shock-cooling events serendipitously every *** results demonstrate that the CSST can make a potentially significant contribution to SN studies.

关键词： space-based ultraviolet optical and infrared telescopes supernovae data analysis

Quantum support vector machine for multi classification

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Communications in Theoretical Physics 2024年第7期76卷 57-62页

作者： li xu Xiao-yu Zhang Ming li Shu-qian Shen College of Science China University of PetroleumQingdao 266580China

Classical machine learning algorithms seem to be totally incapable of processing tremendous data,while quantum machine learning algorithms could deal with big data unhurriedly and provide exponential acceleration over classical *** this paper,we propose two quantum support vector machine algorithms for multi *** is the quantum version of the directed acyclic graph support vector *** other one is to use the Grover search algorithm before measurement,which amplifies the amplitude of the phase storing of the classification *** k classification,the former provides quadratic reduction in computational complexity when *** latter accelerates the training speed significantly and more importantly,the classification result can be read out with a probability of at least 50%using only one *** conduct numerical simulations on two algorithms,and their classification success rates are 96%and 88.7%,respectively.

关键词： quantum support vector machine quantum feature mapping Grover search algorithm

Spatiotemporal changes in sunshine duration and its influential factors in Chongqing,China from 1961 to 2020

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Journal of Mountain Science 2024年第6期21卷 2005-2024页

作者： li Jun XIA Hongxuan JIANG Jinge xu Weifeng WEN Di xu Junfeng College of Geography and Tourism Chongqing Normal UniversityChongqing 401331China Key Laboratory of GIS Application of Chongqing Chongqing 401331China Chongqing Key Laboratory of Earth Surface Processes and Environmental Remote Sensing in Three Gorges Reservoir area Chongqing 401331China Institute of Remote Sensing and Earth Sciences School of Institute of Remote Sensing and Earth SciencesSchool of ScienceHangzhou Normal UniversityHangzhou 311121China

The surface solar radiation in most parts of the world has undergone a phenomenon known as global dimming and brightening,characterized by an initial decrease followed by an *** a result,the sunshine duration(SD)has decreased in the past 60 *** the backdrop of global dimming and brightening,SD has decreased to varying degrees in many regions of *** the observed data of SD,cloud amount(total cloud amount and low cloud amount,abbreviated as TCA and LCA),precipitation,and relative humidity(RH)from 34 meteorological stations in Chongqing during the period of 1961-2020,along with a digital elevation model(DEM)with a resolution of 90 m,this study analyzed the spatiotemporal variations and influencing factors of *** analysis employed methods such as linear regression,Mann-Kendall test,wavelet transformation,and DEM-based possible SD distributed *** results showed that the annual SD in Chongqing has significantly decreased over the last 60 years,with a decreasing interannual trend rate(ITR)of 40.4 h/*** for no obvious trend in spring,SD decreased significantly in summer,autumn and winter at the ITR of 21.1 h/10a,8.5 h/10a and 7.5 h/10a,*** abrupt decrease in the annual SD was found in *** difference before and after the abrupt decrease was 177.7 *** difference before and after the abrupt decrease was 177.7 *** annual SD possessed the oscillation period of *** spatial heterogeneity of the mean annual SD during the last 60 years was *** distribution of SD in Chongqing is high in the northeast and low in the *** addition,about 73%of the total area in Chongqing showed a significant and very significant decreasing *** regions with significant changes are mainly concentrated in the regions with altitudes of 200~1000 *** increasing LCA was the main cause of the decrease of the annual SD in the regions with 200-400 m altitude decreased the most and changed the *** LCA is the prim

关键词： Sunshine duration Spatiotemporal changes Mann-Kendall test Wavelet analysis Geodetector model

Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning

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Neural Regeneration Research 2024年第12期19卷 2723-2734页

作者： Xiaolu li Ye Yang Senming xu Yuchang Gui Jianmin Chen Jianwen xu Department of Rehabilitation Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Rehabilitation Medicine Guilin People’s HospitalGuilinGuangxi Zhuang Autonomous RegionChina Department of Rehabilitation Medicine The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina

Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd *** can greatly affect nerve regeneration and functional ***,there is still limited understanding of the peripheral immune inflammato ry response in spinal cord inju *** this *** obtained microRNA expression profiles from the peripheral blood of patients with spinal co rd injury using high-throughput *** also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus(GEO)database(GSE151371).We identified 54 differentially expressed microRNAs and 1656 diffe rentially expressed genes using bioinformatics *** enrichment analysis revealed that various common immune and inflammation-related signaling pathways,such as neutrophil extracellular trap formation pathway,T cell receptor signaling pathway,and nuclear factor-κB signal pathway,we re abnormally activated or inhibited in spinal cord inju ry patient *** applied an integrated strategy that combines weighted gene co-expression network analysis,LASSO logistic regression,and SVM-RFE algorithm and identified three biomarke rs associated with spinal cord injury:ANO10,BST1,and *** verified the expression levels and diagnostic perfo rmance of these three genes in the original training dataset and clinical samples through the receiver operating characteristic *** polymerase chain reaction results showed that ANO20 and BST1 mRNA levels were increased and ZFP36L2 mRNA was decreased in the peripheral blood of spinal cord injury *** also constructed a small RNA-mRNA interaction network using ***,we evaluated the proportion of 22 types of immune cells in the peripheral blood of spinal co rd injury patients using the CIBERSORT *** proportions of naive B cells,plasma cells,monocytes,and neutrophils were increased while the proportions of memory B cells,C

关键词： bioinformatics analysis biomarker CIBERSORT GEO dataset LASSO miRNA-mRNA network RNA sequencing spinal cord injury SVM-RFE weighted gene co-expression network analysis

Underwater RGB-D imaging system with millimetric precision

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Science China(Information Sciences) 2024年第10期67卷 383-385页

作者： Yajun GAO Yang CONG xu TANG Mingxue li State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences University of Chinese Academy of Sciences College of Automation Science and Engineering South China University of Technology

In recent years, underwater fine three-dimensional reconstruction technology has emerged as a focal point in research, exhibiting extensive potential applications, particularly in underwater archaeology and resource e... 详细信息

关键词： SINGLE CAMERA

Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1027-1034页

作者： GUO Fan HAN Xiao YOU Yue xu Shu-juan ZHANG Ye-hao CHEN Yuan-yuan xin Gao-jie liU Zi-xin REN Jun-guo CAO Ce li ling-mei FU Jian-hua Institute of Basic Medical Sciences of Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing Key Laboratory of Chinese Materia Pharmacology Department of Central Laboratory Kunshan Hospital of Chinese Medicine

Objective: To observe the protective effect and mechanism of hydroxyl safflower yellow A(HSYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs). Methods:HUVECs were treated with oxygen-glucose deprivation reperfusion(OGD/R) to simulate the ischemia reperfusion model, and cell counting kit-8 was used to detect the protective effect of different concentrations(1.25–160 μmol/L)of HSYA on HUVECs after OGD/R. HSYA 80 μmol/L was used for follow-up experiments. The contents of inflammatory cytokines interleukin(IL)-18, IL-1β, monocyte chemotactic protein 1(MCP-1), tumor necrosis factor α(TNF-α) and IL-6 before and after administration were measured by enzyme-linked immunosorbent assay. The protein expressions of toll-like receptor, NOD-like receptor containing pyrin domain 3(NLRP3), gasdermin D(GSDMD) and GSDMD-N-terminal domain(GSDMD-N) before and after administration were detected by Western blot. NLRP3 inflammasome inhibitor cytokine release inhibitory drug 3 sodium salt(CRID3 sodium salt, also known as MCC950) and agonist were added, and the changes of NLRP3, cysteine-aspartic acid protease 1(Caspase-1), GSDMD and GSDMD-N protein expressions were detected by Western blot. Results: HSYA inhibited OGD/R-induced inflammation and significantly decreased the contents of inflammatory cytokines IL-18,IL-1β, MCP-1, TNF-α and IL-6(P<0.01 or P<0.05). At the same time, by inhibiting NLRP3/Caspase-1/GSDMD pathway, HSYA can reduce the occurrence of pyroptosis after OGD/R and reduce the expression of NLRP3,Caspase-1, GSDMD and GSDMD-N proteins(P<0.01). Conclusions: The protective effect of HSYA on HUVECs after OGD/R is related to down-regulating the expression of NLRP3 inflammasome and inhibiting pyroptosis.

关键词： Chinese medicine NLRP3 inflammasome human umbilical vein endothelial cells hydroxysafflor yellow A myocardial reperfusion injury oxygen-glucose deprivation reperfusion pyroptosis

Research progress on simulation of multiscale mass transfer processes in gas-solid system by computational mass transfer

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Particuology 2024年第7期90卷 478-492页

作者： xu li Yaohui Wang Leifu li Runye Zhang Hailun Ren Wenbin li Zhongli Tang Donghui Zhang The Research Center of Chemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China The Department of Chemical Engineering Tianjin Renai CollegeTianjin 301636China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Particle-fluid system is one of the most popular systems in chemical *** to complex interface structure and high-velocity turbulence,the momentum and mass transfer exhibit nonlinear characteristics,which pose a great challenge for further study and *** solve this problem,computational mass transfer(CMT)emerged and has been proved to be effective in deeply exploring the mass transfer behavior of particle-fluid ***,this paper reviews recent gas-solid numerical studies of turbulence issues from empirical to theoretical,then discusses interphase mass transfer rate models and the interfacial interaction ***,the present study particularly reviews researches on mass transfer process of fixed and fluidized regime by CMT,providing reliable analysis of turbulent anisotropy diffusivity as well as multiscale structure and presenting theoretical instruction for the industrial optimization of mass transfer processes in chemical engineering.

关键词： Fixed bed Fluidized bed Computational mass transfer Turbulent mass diffusion Multiscale Anisotropy

Imaging, pathology, and diagnosis of solitary fibrous tumor of the pancreas: A case report and review of literature

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World Journal of Clinical Cases 2024年第5期12卷 995-1003页

作者： Wen-Wen Wang Shu-Ping Zhou Xiang Wu Luo-Luo Wang Yi Ruan Jun Lu Hai-li li xu-ling Ni li-li Qiu xin-Hua Zhou Department of Hepatobiliary and Pancreatic Surgery The Affiliated Li Huili HospitalNingbo University School of MedicineNingbo 315000Zhejiang ProvinceChina Ningbo College of Health Sciences Ningbo College of Health SciencesNingbo 315000Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou310006Zhejiang ProvinceChina Department of Diagnosis Ningbo Diagnostic Pathology CenterNingbo 315000Zhejiang ProvinceChina

BACKGROUND A solitary fibrous tumor(SFT)is often located in the pleura,while SFT of the pancreas is extremely ***,we report a case of SFT of the pancreas and discuss imaging,histopathology,and immunohistochemistry for accurate diagnosis and *** SUMMARY A 54-year-old man presented to our hospital with pancreatic occupancy for over a *** were no previous complaints of *** blood pressure was *** glucose,tumor markers,and enhanced computed tomography(CT)suggested a malignant *** the CT appearance of pancreatic cancer varies,we could not confirm the diagnosis;therefore,we performed endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB).Pathology and immunohistochemistry were consistent with SFT of the *** posto-perative pathology and immunohistochemistry were consistent with the puncture *** patient presented for a follow-up examination one month after discharge with no adverse *** Other diseases must be excluded in patients with a pancreatic mass that cannot be *** and pathological histology have diagnostic value for pancreatic *** puncture biopsy under ultrasound can help diagnose pancreatic masses that cannot be diagnosed *** is an effective treatment for SFT of the pancreas;however,long-term follow-up is strongly recommended because of the possibility of malignant transformation of the tumor.

关键词： Pancreas Neoplasm fibrous tumor Endoscopic ultrasound-guided fine-needle biopsy Treatment Case report

Long way up:rethink diseases in light of phase separation and phase transition

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Protein & Cell 2024年第7期15卷 475-492页

作者： Mingrui Ding Weifan xu Gaofeng Pei Pilong li State Key Laboratory of Membrane Biology&Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for life Sciences Beijing 100084China NuPhase Therapeutics Beijing 100083China

Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular dysfunction and physiological disorders. As ongoing research endeavors wholeheartedly embrace this newly acknowledged principle, a transformative shift is occurring in our comprehension of disease. Consequently, significant strides have been made in unraveling the profound relevance and potential causal connections between abnormal phase separation and various diseases. This comprehensive review presents compelling recent evidence that highlight the intricate associations between aberrant phase separation and neurodegenerative diseases, cancers, and infectious diseases. Additionally, we provide a succinct summary of current efforts and propose innovative solutions for the development of potential therapeutics to combat the pathological consequences attributed to aberrant phase separation.

关键词： multivalency compartments aberant phase separation therapeutics gain or loss of phase separation diseases