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Necrotizing fasciitis of cryptoglandular infection treated with multiple incisions and thread-dragging therapy:A case report

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World Journal of Clinical Cases 2021年第28期9卷 8537-8544页

作者： Xiao-Chun Tao De-Chang Hu li-xin yin Chen Wang Jin-Gen Lu Department of Anorectal LongHua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China

BACKGROUND Necrotizing fasciitis is a fulminant necrotizing soft tissue disease with a high fatality *** always starts with impact on the deep fascia rapidly and might result in secondary necrosis of the subcutaneous tissue,fascia,and ***,timely and multiple surgical operations are needed for the ***,the damage of skin and soft tissue caused by multiple surgical operations may require dermatoplasty and other treatments as a *** SUMMARY Here,we report a case of 50-year-old male patient who was admitted to our hospital with symptoms of necrotizing fasciitis caused by cryptoglandular infection in the perianal and perineal *** symptoms of necrotizing fasciitis,also known as the cardinal features,include hyperpyrexia,excruciatingly painful lesions,demonstration gas in the tissue,an obnoxious foul odor and *** results of postoperative pathology met the *** on the premise of complete debridement,multiple incisions combined with thread-dragging therapy(a traditional Chinese medicine therapy)and intensive supportive therapies including comprising antibiotics,nutrition and fluids were *** outcome of the treatment was *** patient recovered quickly and achieved ideal anal function and *** Timely and effective debridement and multiple incisions combined with thread-dragging therapy are an integrated treatment for necrotizing fasciitis.

关键词： Necrotizing fasciitis Cryptoglandular infection Traditional Chinese medicine Multiple incisions and thread-dragging therapy Integrated treatment Case report

Reversal of multidrug resistance in vincristine-resistant human gastric cancer cell line SGC7901/VCR by LY980503

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World Journal of Gastroenterology 2007年第15期13卷 2234-2237页

作者： Da-Long Wu ying Xu li-xin yin Huan-Zhang Lu Department of Pharmacology School of Medicine Jiaxing Colloge Jiaxing 314001 Zhejiang Province China Department of Histology and Embryology School of Medicine Jiaxing College Jiaxing 314001 Zhejiang Province China Department of Chemical Synthesis Institute of Microbiology and Epidemiology Academy of Military Medical Sciences Beijing 100071 China Department of Clinical Pharmacology Affiliated Hospital Academy of Military Medical Sciences Beijing 100039 China

AIM： To investigate the reversal effect of LY980503, a benflumetol derivative, on multidrug resistance in vincristine （VCR） -resistant human gastric carcinoma cell line SGC7901/VCR. METHODS： Cells of a human gastric cancer cell line, SGC7901, and its VCR-resistant variant, SGC7901/VCR, were cultivated with LY980503 and/or doxorubicin （DOX）. The cytotoxicity of drugs in vitro was assayed by M-IF method. Based on the flow cytometric technology, the uptake of DOX was detected in these cells by measuring DOX -associated mean fluorescence intensity （MFI）. RESULTS： SGC7901/VCR cells were 23.5 times more resistant to DOX in comparison with 5GC7901 cells. LY980503 at the concentrations of 2.0 μmol/L -10 μmol/ L had no obvious cytotoxicity to SGC7901 and SGC7901/ VCR cells. After simultaneous treatment with LY980503 at the concentrations of 2.0, 4.0 and 10 μmol/L, the ICso of DOX to SGC7901/VCR cells decreased from 1.6 ± 0.12 μmol/L to 0.55 ± 0.024, 0.25 ± 0.032 and 0.11 ± 0.015 μmol/L, respectively, thus, increasing the DOX sensitivity by 2.9-fold （P 〈 0. 05）, 6.4-fold （P 〈 0. 01） and 14.5-fold （P 〈 0. 01）, respectively. In the uptake study of DOX, simultaneous incubation of SGC7901/VCR cells with LY980503 significantly increased the DOX -associated MFI in SGC7901/VCR cells. No such results were found in parental SGC7901 cells.CONCLUSION： LY980503 at non-cytotoxic concentrations can effectively circumvent resistance of SGC7901/VCR cells to DOX by increasing intracellular DOX accumulation.

关键词： Hultidrug resistance Benflumetol Doxorubicin Gastric cancer Reversal

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大车前体外再生体系的建立和优化

生物工程学报 2005年第6期21卷 916-922页

作者：李平陈华李银心中国科学院植物研究所光合作用与环境分子生理学重点实验室

大车前不仅有很高的药用价值,在生态学研究方面也是重要模式植物。关于大车前的组培,目前报道很少。我们通过不定芽直接再生和愈伤组织诱导两种途径,建立了大车前(PlantagomajorL.‘GiantTurkish.’)的快速高效组培再生系统。完整的成... 详细信息

大车前不仅有很高的药用价值,在生态学研究方面也是重要模式植物。关于大车前的组培,目前报道很少。我们通过不定芽直接再生和愈伤组织诱导两种途径,建立了大车前(PlantagomajorL.‘GiantTurkish.’)的快速高效组培再生系统。完整的成熟种子培养在添加IAA和TDZ的MS培养基中,不经过愈伤的分化阶段,从子叶节的部位产生不定芽,直接不定芽的诱导频率达到100%。在0.2mgliAA和1.0mgLTDZ作用下,培养4～5周后平均每个外植体产生再生芽的数目达到14.6个。对同一个外植体诱导得到的9株再生植株进行的RAPD检测表明,部分植株在DNA水平上发生了变异。以叶片作为外植体,在添加1.0mgLNAA的MS固体培养基中培养3周后,伤口处形成愈伤组织,产生愈伤的频率平均为98%。愈伤组织在添加4.0mgL6BA的MS固体培养基中分化得到再生芽,分化频率为25%,平均每块愈伤产生再生芽2.8个。两种途径得到的再生芽转到12MS培养基上均可生根、长成完整植株,小苗移栽到温室90%能够存活。

关键词：大车前(Plantago major L.'Giant Turkish.’) 愈伤诱导植株再生不定芽

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药蒲公英再生体系的建立和优化

生物工程学报 2005年第2期21卷 244-249页

作者：陈华李平刘晶李银心中国科学院植物研究所光合作用与环境分子生理学重点实验室

通过愈伤组织诱导和直接不定芽再生途径 ,建立了药蒲公英的快速高效再生系统。叶片外植体在含 0 2mg liAA和1mg LTDZ的MS培养基中培养 2周后便产生大量的丛生芽 ,在含有 0 5mg L 2 ,4 D和 2mg L 6 BA的MS培养基中培养 30d后 ,形成... 详细信息

通过愈伤组织诱导和直接不定芽再生途径 ,建立了药蒲公英的快速高效再生系统。叶片外植体在含 0 2mg liAA和1mg LTDZ的MS培养基中培养 2周后便产生大量的丛生芽 ,在含有 0 5mg L 2 ,4 D和 2mg L 6 BA的MS培养基中培养 30d后 ,形成明显的愈伤组织 ,愈伤组织块在含 1 0mg L 6 BA的MS培养基中成功再生。对 9株再生植株进行RAPD检测表明 ,部分植株在DNA水平上发生了变异。与对照相比 ,再生植株的主要抗氧化成分无明显变化 ,保证了有效成分的稳定。

关键词：药蒲公英愈伤组织培养器官发生 RAPD

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异面结构GaAs光导开关耐压特性研究

传感器与微系统 2009年第6期28卷 16-17,21页

作者：李寅鑫苏伟刘娟中国工程物理研究院电子工程研究所四川绵阳621900

光导开关用于产生高功率脉冲,提高光导开关的耐压能力可有效提高器件的输出功率。用SILVACO软件对共面和异面电极结构的GaAs光导开关进行了仿真分析,比较了两者的击穿电压,指出异面开关耐压性能优于共面开关。对设计制作的3mm间隙宽度的... 详细信息

光导开关用于产生高功率脉冲,提高光导开关的耐压能力可有效提高器件的输出功率。用SILVACO软件对共面和异面电极结构的GaAs光导开关进行了仿真分析,比较了两者的击穿电压,指出异面开关耐压性能优于共面开关。对设计制作的3mm间隙宽度的GaAs光导开关进行了耐压特性试验,并结合模拟结果进行分析。模拟结果和试验结果表明:和共面电极结构相比,异面结构的光导开关具有更高的耐压能力,击穿电场可达7.67 kV/mm。

关键词：光导开关异面开关 SILVACO模拟耐压特性

LEARNING OF HOST-INFESTED PLANT VOLATILES AFFECTS PREFERENCE OF LARVAL PARASITOIDS OF DIAMONDBACK MOTH IN HOST FORAGING TOWARDS DIFFERENT PLANTS

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LEARNING OF HOST-INFESTED PLANT VOLATILES AFFECTS PREFERENCE...

Research on Site Selection Model of Distribution Center of Agricultural Products

The ⅩⅤth International Plant Protection Congress

作者： liU Shu-sheng JIANG li-hui li xin and liU yin-quan Institute of Applied Entomology Zhejiang University Hangzhou 310029 China

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Asian Agricultural Research 2011年第4期3卷 132-134页

作者： li Yong-xin,yin Chun-wu,HUI Xiao-jian Department of Basic Courses,Xijing University,Xi’an 710123,China Department of Basic Courses Xijing University

In the light of the practical situation of logistics distribution of agricultural products,we primarily select transportation factor,economic factor,environment factor,and other factors,to establish evaluation index system of site selection of distribution center of agricultural *** then we adopt the analytic hierarchy process method to calculate weight of site selection of distribution center of agricultural *** the circumstance that the evaluation information is interval number,we use uncertain and multiple attribute decision making method to establish site selection model of distribution center of agricultural ***,taking one city as an example,we discuss the application of this model in site selection of distribution center of agricultural *** results of empirical analysis show that the model we established fully considers the randomness and uncertainty in the process of evaluation,so as to make the results of evaluation more objective,in line with *** the effect of evaluation is better as against the former real number evaluation calibration.

关键词： Distribution center of agricultural products Model

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基于光纤传导的青光眼快速筛选分析仪

光电工程 2011年第9期38卷 88-92页

作者：杨基春刘铁根李迎新天津大学精仪学院光电信息工程系天津300072 天津市中国医学科学院生物医学工程研究所天津300070

青光眼的筛查应遵循简易、快捷、有效的原则,本文研发一种高精度快速视野筛选分析仪以满足青光眼大规模筛查需要。该分析仪各个刺激点亮度均匀度好,采用光纤传导分光技术,使得视野刺激点之间亮度差小于5%;刺激点亮度精度高,采用单片机... 详细信息

青光眼的筛查应遵循简易、快捷、有效的原则,本文研发一种高精度快速视野筛选分析仪以满足青光眼大规模筛查需要。该分析仪各个刺激点亮度均匀度好,采用光纤传导分光技术,使得视野刺激点之间亮度差小于5%;刺激点亮度精度高,采用单片机脉宽调制方式,使得亮度精度达到0.001Nit,结合四点视野筛查理论,可进行快速视野检测,完成对青光眼的早期诊断。

关键词：青光眼分析仪脉宽调试光纤传导

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions