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Radiation combined high doses IA chemotherapy against advanced head and neck malignant tumor

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中国口腔颌面外科杂志 2008年第B5期6卷 158-159页

作者： Cai Yi li xin Dong fan lin Zhang Department of Oral and Maxillofacial Surgery Ninth People's Hospital Shanghai Jiao Tong University Shanghai 200011 China

Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?

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Nano-Micro Letters 2025年第1期17卷 135-159页

作者： Zhengqing fan Ruimin li xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage ***,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical *** engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for *** this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further ***,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are *** applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also ***,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described.

关键词： Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration

Risk factors of severe ischemic biliary complications after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 374-379页

作者： Ming-Feng Wang,Zhong-Kui Jin,Da-Zhi Chen,Xian-liang li,xin Zhao and Hua fan Department of Hepatobiliary and Pancreaticosplenic Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China Department of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

BACKGROUND:Ischemia-related biliary tract complications remain high after orthotopic liver *** ischemic biliary complications often involve the hepatic duct bifurcation and left hepatic duct,resulting finally in obstructive *** and management of such complications remain a challenge for transplant ***:All 160 patients were followed up for at least 180 days after ***-way analysis of variance (ANOVA) and comparative univariate analysis were made using 3 groups (no complications;mild complications;severe complications),to analyze risk factors associated with biliary *** logistic regression and linear regression analysis were used to analyze independent risk factors for severe ischemic biliary complications,after excluding other confounding ***:By ANOVA and comparative univariate analysis,the risk factors associated with biliary complications were preoperative bilirubin level (P=0.007) and T-tube stenting of the anastomosis (P=0.016).Multiple logistic regression analysis showed that the use of T-tube and preoperative serum bilirubin were not independent risk factors for severe ischemic biliary complications after orthotopic liver ***-square analysis indicated that in the incidence of severe ischemic biliary lesions,bile duct second warm ischemic time longer than 60 minutes was a significant risk *** regression demonstrated a negative correlation between cold preservation time and warm ischemia ***:Preoperative serum bilirubin level and the use of T-tube stenting of the anastomosis were independent risk factors for biliary complications after liver transplantation,but not for severe ischemic biliary *** second warm ischemia time of bile duct longer than 60minutes and prolonged bile duct second warm ischemia time combined with cold preservation time were significant risk factors for severe ischemic biliary complications after

关键词： liver transplantation ischemic biliary complications warm ischemia cold preservation

Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

开放式创新视角下企业推动技术转移转化策略研究

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中国电子科学研究院学报 2017年第3期12卷 312-316页

作者：李欣欣魏凡刘从中国电子科学研究院北京100041

开放式创新环境下对企业技术创新的速度和质量都提出了越来越高的要求,本文通过对开放式创新环境下技术转移转化的特点分析,提出技术转移转化已经渗透到技术创新全链条,并按照研究、开发和商业化三个阶段分析企业推动技术转移转化的主... 详细信息

开放式创新环境下对企业技术创新的速度和质量都提出了越来越高的要求,本文通过对开放式创新环境下技术转移转化的特点分析,提出技术转移转化已经渗透到技术创新全链条,并按照研究、开发和商业化三个阶段分析企业推动技术转移转化的主要策略以及保障措施。

关键词：开放式创新技术转移技术转化创新链

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang fan Yang Jian-Qin liu Jie Chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Organocatalytic One-Pot Tandem Reaction for the Synthesis of Optically Active 2-Amino-2-Chromene Derivatives

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Organocatalytic One-Pot Tandem Reaction for the Synthesis of...

Efficient Kinetic Resolution of Racemic 3-Nitro-2H-Chromene Derivatives Catalyzed by Takemoto’s Organocatalyst

中国化学会第27届学术年会

作者： li-Ping fan, xin-Sheng li, Dong-Cheng Xu, Jian-Wu Xie* Department of Chemistry and life Science, Zhejiang Normal University, Jinhua,321004

＜正＞Chromene derivatives are an important class of heterocycles, widely present in plants, including edible vegetables and fruits. And they are of considerable interest as they possess a wide range

关键词： 2-amino-2-chromene One-Pot Tandem Reaction Michael addition

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Efficient Kinetic Resolution of Racemic 3-Nitro-2H-Chromene ...

考虑齿面摩擦的机车齿轮传动系统参数振动稳定性（英文）

中国化学会第27届学术年会

作者： li-Ping fan, xin-Sheng li, Dong-Cheng Xu, Jian-Wu Xie* Department of Chemistry and life Science, Zhejiang Normal University, Jinhua, 321004

＜正＞The 3-nitro-2H-chromene is very important unit which is recognized due to their biological activity and their importance as precursors of flavonols, amines, and other important targets.

关键词： kinetic resolution chromenes organocatalyst

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交通运输工程学报 2017年第2期17卷 52-63页

作者：王燕刘建新李奕璠虞大联谢鸣西南交通大学机械工程学院四川成都610031 西南交通大学牵引动力国家重点实验室四川成都610031 中车青岛四方机车车辆股份有限公司山东青岛266111

针对机车齿轮传动系统的参数振动问题,建立了考虑齿面摩擦时机车齿轮传动系统的动力学模型,基于势能原理获得了齿轮时变啮合刚度,并利用傅里叶级数展开,利用多尺度法进行求解,获得了系统参数振动稳定的边界条件。最后开展实例分析,研究... 详细信息

针对机车齿轮传动系统的参数振动问题,建立了考虑齿面摩擦时机车齿轮传动系统的动力学模型,基于势能原理获得了齿轮时变啮合刚度,并利用傅里叶级数展开,利用多尺度法进行求解,获得了系统参数振动稳定的边界条件。最后开展实例分析,研究了齿面摩擦因数对机车齿轮传动系统参数振动稳定性的影响。分析结果表明:不计齿面摩擦时,当机车速度约为119.02/j km·h^(-1)(j是谐波项)时,系统会产生参数共振,摩擦因数越大,对应的参数共振速度越大;在参数共振速度附近存在系统振动不稳定区域,当系统阻尼系数和摩擦因数均为0,谐波项分别为1、2、3、4时,相对于参数共振速度的波动值分别为9.16、1.46、0.53、0.55km·h^(-1),系统振动不稳定;当阻尼系数为0时,在对应谐波项下,与摩擦因数为0时相比,齿面摩擦因数分别为0.1、0.2时,系统振动不稳定区域内相对于参数共振速度的波动值分别增加了约4.88%、9.54%;当阻尼系数为0.01时,随着摩擦因数的增大,在系统振动不稳定区域内相对于参数共振速度的波动值不一定增加;摩擦因数越大,系统稳定所需的阻尼系数越小。

关键词：机车工程齿轮传动系统齿面摩擦参数振动稳定性