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Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

Science China(life Sciences) 2025年第1期68卷 189-203页

作者： Wenjie li Wenyi Mei Hewei Jiang Jie Wang Xiaoli li lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang lin Fangfang liu Kangdong liu Mingliang Ye Zhenjiang Zhao Yajun duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao lili Zhu Honglin li Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&TechnologyShanghai 200237China Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan UniversityKunming650500China CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Medicine University of Massachusetts Chan Medical SchoolWorcester MA 01655USA Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou UniversityZhengzhou 450001China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China lingang Laboratory Shanghai 200031China

Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for ***,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling *** exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling ***,we identify SHP-2 as the direct molecular target of PA for inhibiting the PD-1 signaling ***,mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM recognition site of SHP-2,inhibiting the recruitment of SHP-2 by *** together,our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop PD-1 signaling *** addition,our success in target recognition provides a paradigm of target identification and confirmation for natural products.

关键词： pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition

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干燥工艺对红薯叶冠突散囊菌发酵茶品质的影响

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食品与发酵工业 2025年第1期51卷 124-135页

作者：汪俊领易军鹏李欣刘文超段续李璐瑶高炎河南科技大学食品与生物工程学院河南洛阳471000 漯河职业技术学院河南漯河462000 中原食品实验室河南漯河462000 河南科技大学化学化工学院河南洛阳471000

为探讨干燥工艺对红薯叶冠突散囊菌发酵茶品质的影响,探寻红薯叶冠突散囊菌发酵茶最适干燥工艺。采用不同温度(60、70、80℃)热风干燥(hot air drying, HAD)、60℃热泵干燥(heat pump drying, HPD)、真空冷冻干燥(vacuum freeze drying,... 详细信息

为探讨干燥工艺对红薯叶冠突散囊菌发酵茶品质的影响,探寻红薯叶冠突散囊菌发酵茶最适干燥工艺。采用不同温度(60、70、80℃)热风干燥(hot air drying, HAD)、60℃热泵干燥(heat pump drying, HPD)、真空冷冻干燥(vacuum freeze drying, FD)5种不同的干燥工艺对红薯叶冠突散囊菌发酵茶进行脱水处理,并对干茶样品进行感官评价同时检测分析了干茶中的主要成分及风味物质。结果表明,在HAD中,随着干燥温度的升高,茶叶总酚、总黄酮含量下降,可溶糖含量升高,单宁含量没有变化;HAD 80℃干茶中,引发茶汤涩味的酚类物质和黄酮含量低,茶汤色及香气感官评分高,香气组分最多且综合品质最好;HAD 60℃干茶总酚、总黄酮和苦味氨基酸含量均高,苦涩味较重;FD干茶外形评价最好且单宁含量最低,但其总酚和总黄酮最高,且青草香气重,这与其挥发性物质中愈创木酚含量高有关,使其感官评分较低。所有干茶样品的香气成分中,1-辛烯-3-醇、愈创木酚和β-紫罗兰酮的OAV值均高于100,是红薯叶冠突散囊菌发酵茶干茶中的关键香气成分。该研究为红薯叶冠突散囊菌发酵茶风味的形成及加工工艺优化提供了指导。

关键词：红薯叶茶冠突散囊菌发酵干燥工艺品质分析香气成分

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Influence of acetic acid on the morphology of indium oxide nanocrystals and the associated plasmonic properties

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Science China Materials 2025年第2期68卷 432-440页

作者： Jiangtong Su Peixian li Zhe liu Zifeng liu Xiaoqi Hou Junli duan Ning Dai Yang li School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Chemistry and Material Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China University of Chinese Academy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China

Synthetic control of metal oxide nanocrystals with precise size and morphology is of great importance for promising optoelectronic applications due to their unique size-and shape-dependent optical/optoelectronic ***,the understanding of the mechanism for size and morphology control of metal oxide nanocrystals are less ***,we demonstrate that acetic acid,the byproduct of the initial chemical reaction of precursors,plays a dominant role in determining the morphology of indium oxide(In_(2)O_(3))nanocrystals by influencing the nucleation of the nanocrystals *** acetic acid would induce anisotropic growth,leading to the generation of nanoflowers,while limited existence of acetic acid results in sphere-shaped ***,the effects of geometries of In_(2)O_(3) nanocrystals on their plasmonic properties are *** resulting plasmonic In_(2)O_(3) nanocrystals show size-tunable plasmon resonance peaks in the near-infrared to mid-infrared regime and outstanding air/thermal *** work shall give an in-depth understanding of the mechanism for geometry control of nanocrystals and offer more opportunities in potential optoelectronic and photothermal applications based on plasmonic metal oxide nanocrystals.

关键词： colloidal semiconductor nanocrystals metal oxide nanocrystals localized surface plasmon resonance surface ligands geometry control

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The Impairment Attention Capture by Topological Change in Children With Autism Spectrum Disorder

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生物化学与生物物理进展 2025年第1期52卷 223-232页

作者： XU Hui-lin XI Huan-Jun duan Tao li Jing li Dan-Dan WANG Kai ZHU Chun-Yan School of Mental Health and Psychological Sciences Anhui Medical UniversityHefei 230032China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China Anhui Provincial Institute of Translational Medicine Hefei 230032China Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefei 230032China Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders Anhui Medical UniversityHefei 230032China Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health Anhui Medical UniversityHefei 230032China

Objective Autism spectrum disorder(ASD)is a neurodevelopmental condition characterized by difficulties with communication and social interaction,restricted and repetitive *** studies have indicated that individuals with ASD exhibit early and lifelong attention deficits,which are closely related to the core symptoms of *** visual attention processes may provide a critical foundation for their social communication and interaction ***,this study explores the behavior of children with ASD in capturing attention to changes in topological *** Our study recruited twenty-seven ASD children diagnosed by professional clinicians according to DSM-5 and twenty-eight typically developing(TD)age-matched *** an attention capture task,we recorded the saccadic behaviors of children with ASD and TD in response to topological change(TC)and non-topological change(nTC)*** reaction time(SRT),visual search time(VS),and first fixation dwell time(FFDT)were used as indicators of attentional *** correlation tests between the clinical assessment scales and attentional bias were *** This study found that TD children had significantly faster SRT(Pli compared to the nTC stimuli,while the children with ASD did not exhibit significant differences in either measure(P>0.05).Additionally,ASD children demonstrated significantly less attention towards the TC targets(measured by FFDT),in comparison to TD children(Plinear correlation between their attentional bias(measured by VS)and their scores on the compulsive subscale(P<0.05).Conclusion The results suggest that children with ASD have difficulty shifting their attention to objects with topological changes during change *** atypical attention may affect the child’s cognitive and behavioral development,thereby impacting their social communication and

关键词： attention autism spectrum disorder perceptual object topological perception

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神经介入放射学的发展现状及未来展望

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中华神经医学杂志 2025年第1期24卷 2-7页

作者：段传志李铁林南方医科大学珠江医院神经外科中心脑血管病外科国家临床重点专科脑血管病诊断与治疗教育部工程研究中心广东省普通高校脑功能修复与再生重点实验室广州

近20年来, 随着新设备、新材料、人工智能等前沿科技的不断融入, 神经介入放射学发展迅速, 在颅内动脉瘤、脑动静脉畸形、硬脑(脊)膜动静脉瘘、急性大血管闭塞性脑卒中、颅内动脉粥样硬化性狭窄等脑血管疾病中的治疗效果不断提升, 适应... 详细信息

近20年来, 随着新设备、新材料、人工智能等前沿科技的不断融入, 神经介入放射学发展迅速, 在颅内动脉瘤、脑动静脉畸形、硬脑(脊)膜动静脉瘘、急性大血管闭塞性脑卒中、颅内动脉粥样硬化性狭窄等脑血管疾病中的治疗效果不断提升, 适应证逐渐扩大, 成为部分疾病一线甚至首选治疗方式。本文就神经介入放射学的临床应用现状及可能的发展趋势做一述评, 以期为临床实践提供参考。

关键词：神经介入放射学临床应用发展趋势

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地理知识图谱推理研究进展与展望

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地球信息科学学报 2025年第1期27卷 41-59页

作者：段雨希陈碧宇李岩张雪英林黎武汉大学测绘遥感信息工程国家重点实验室武汉430079 武汉大学社会地理计算联合研究中心武汉430079 南京师范大学地理科学院南京210023 南京师范大学虚拟地理环境教育部重点实验室南京210023 江苏省地理信息资源开发与利用协同创新中心南京210023

【目的】随着知识图谱技术在GIS领域应用和发展,地理知识图谱(GeoKG)近年来逐渐成为GIS领域的重要研究方向。GeoKG往往无法确保涵盖所有知识,知识的缺失和不一致性严重影响应用性能,需要采用GeoKG推理技术来自动补全缺失知识、识别矛盾... 详细信息

【目的】随着知识图谱技术在GIS领域应用和发展,地理知识图谱(GeoKG)近年来逐渐成为GIS领域的重要研究方向。GeoKG往往无法确保涵盖所有知识,知识的缺失和不一致性严重影响应用性能,需要采用GeoKG推理技术来自动补全缺失知识、识别矛盾知识、预测地理现象未来发展趋势。区别于通用知识图谱推理技术,GeoKG推理技术需要着重考虑地理知识的复杂时空特性。本文对近年来GeoKG的推理工作进行了全面介绍和总结。【分析】首先,介绍了GeoKG推理的相关概念与问题描述;其次,本文分析了GeoKG推理的二大核心任务:①面向知识补全的推理模型,主要用于填补图谱中的空白,确保知识的完整性;②面向预测任务的推理模型,旨在通过已有地理数据预测未来的趋势。两类模型各自针对不同的应用场景进行优化,并在地理数据的处理中各有侧重。【展望】展望了GeoKG推理的未来发展趋势,指出未来GeoKG推理技术的发展将更加关注时空数据的复杂关系处理、多尺度地理知识的推理、多模态数据的融合,以及提高推理模型的可解释性与智能化。此外,GeoKG与大规模预训练模型的结合也将成为关键方向。

关键词：地理知识图谱地理知识推理研究进展地理知识表达时空数据推理

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Evaluation of tool wear and cutting performance based on FEM simulation

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Chinese Journal of Aeronautics 2021年第4期34卷 140-152页

作者： Zhenyu SHI xin li Ningmin duan Qibiao YANG Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationShandong UniversityJinan 250061China School of Mechanical Engineering Shandong UniversityJinan 250061China School of Mechanical Engineering Hubei University of TechnologyWuhan 430000China

An accurate estimation of tool wear morphology can provide the opportunity to investigate the influence of tool wear on cutting performance as well as reduce the overall production ***,tool wear prediction is still a very challenging research *** this paper,a novel method for simulating the actual chip formation and wear evolution thorough the 3 D finite element model has been carried *** order to improve the accuracy of simulation results,the influence of worn tool,stress and temperature distribution on wear rate are *** cutting experiment has been conducted by turning AISI1045 with uncoated carbide tools to validate the accuracy of the proposed *** comparison between experimental and simulation results show good agreement which proves the ability of the proposed model in forecasting the tool *** validated finite element model has been further utilized studying how the worn tool affects the cutting performance including actual cutting rake,stress distribution,cutting force and *** results of this paper not only provide a clear understanding of wear evolution between tool rake face and chip,but also are meaningful to optimize tool design and cutting parameters.

关键词： Finite element method Friction model Machining Stress distribution Wear

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YOLOX-SwinT algorithm improves the accuracy of AO/OTA classification of intertrochanteric fractures by orthopedic trauma surgeons

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Chinese Journal of Traumatology 2025年第1期28卷 69-75页

作者： Xue-Si liu Rui Nie Ao-Wen duan li Yang Xiang li Le-Tian Zhang Guang-Kuo Guo Qing-Shan Guo Dong-Chu Zhao Yang li He-Hua Zhang Department of Medical Engineering Daping HospitalArmy Medical UniversityChongqing400042China Department of Information Southwest HospitalArmy Medical UniversityChongqing400038China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Division of Trauma and War Injury Daping HospitalArmy Medical University of PLAState Key Laboratory of Trauma and Chemical PoisoningChongqing400042China

Purpose:Intertrochanteric fracture(ITF)classification is crucial for surgical ***,orthopedic trauma surgeons have shown lower accuracy in ITF classification than *** objective of this study was to utilize an artificial intelligence(AI)method to improve the accuracy of ITF ***:We trained a network called YOLOX-SwinT,which is based on the You Only Look Once X(YOLOX)object detection network with Swin Transformer(SwinT)as the backbone architecture,using 762 radiographic ITF examinations as the training ***,we recruited 5 senior orthopedic trauma surgeons(SOTS)and 5 junior orthopedic trauma surgeons(JOTS)to classify the 85 original images in the test set,as well as the images with the prediction results of the network model in *** analysis was performed using the SPSS 20.0(IBM Corp.,Armonk,NY,USA)to compare the differences among the SOTS,JOTS,SOTS+AI,JOTS+AI,SOTS+JOTS,and SOTS+JOTS+AI *** images were classified according to the AO/OTA 2018 classification system by 2 experienced trauma surgeons and verified by another expert in this *** on the actual clinical needs,after discussion,we integrated 8 subgroups into 5 new subgroups,and the dataset was divided into training,validation,and test sets by the ratio of 8:1:***:The mean average precision at the intersection over union(IoU)of 0.5(mAP50)for subgroup detection reached 90.29%.The classification accuracy values of SOTS,JOTS,SOTS+AI,and JOTS+AI groups were 56.24%±4.02%,35.29%±18.07%,79.53%±7.14%,and 71.53%±5.22%,*** paired t-test results showed that the difference between the SOTS and SOTS+AI groups was statistically significant,as well as the difference between the JOTS and JOTS+AI groups,and the SOTS+JOTS and SOTS+JOTS+AI ***,the difference between the SOTS+JOTS and SOTS+JOTS+AI groups in each subgroup was statistically significant,with all p<*** independent samples t-test results showed that

关键词： Artificial intelligence Intertrochanteric fracture Fracture classification Assist diagnosis YOLOX Swin transformer

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花生水剂法制油工艺中蛋白质的结构特征研究

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中国油脂 2025年第2期50卷 63-70页

作者：贾琪琪章绍兵李端河南工业大学粮油食品学院郑州450001

为降低花生水剂法制油过程中固相的残油率与残蛋白率,以河南省主要花生栽培品种(豫花37、豫花9326和远杂6号)为研究对象进行水剂法制油,通过分析亚基组成、内源荧光光谱、表面疏水性、粒径、Zeta电位、三相接触角与聚集作用力等表征固... 详细信息

为降低花生水剂法制油过程中固相的残油率与残蛋白率,以河南省主要花生栽培品种(豫花37、豫花9326和远杂6号)为研究对象进行水剂法制油,通过分析亚基组成、内源荧光光谱、表面疏水性、粒径、Zeta电位、三相接触角与聚集作用力等表征固相和水相中花生蛋白的结构特征。结果表明:在pH10条件下,未脱皮花生豫花37的总固相残油率最低(5.73%),而残蛋白率(15.37%)与其他2个品种无显著差异;水剂法所得固相中含有较多可溶性蛋白,其亚基组成和水相蛋白相似,但前者的内源荧光强度、表面疏水性和三相接触角显著高于后者,表明固相可溶性蛋白结合油脂的能力更强;与水相蛋白相比,固相可溶性蛋白的平均粒径和Zeta电位绝对值更低;针对固相可溶性蛋白结合油脂能力强和携带电荷少的结构特点,进一步提高提取体系pH,发现当pH为11.0时,脱皮豫花37的总固相残油率和残蛋白率分别降至3.44%和11.86%。综上,可通过提高提取体系pH降低花生水剂法制油的固相残油率和残蛋白率。

关键词：水剂法花生蛋白制油分子结构

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临汾市臭氧污染时期VOCs来源解析研究

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中国环境科学 2025年第1期45卷 78-92页

作者：段丽琴吴雨彤刘保双山西省临汾生态环境监测中心山西临汾041000 南开大学环境科学与工程学院国家环境保护城市空气颗粒物污染防治重点实验室中国气象局-南开大学大气环境与健康研究联合实验室天津300350

本文通过基于光化学年龄的参数方法,估算了山西临汾市2021年4月18日~7月31日在线监测的VOCs初始体积分数数据,矫正其光化学损耗影响;然后利用正定矩阵因子分解(PMF)模型进行了其来源解析.结果表明,研究期间临汾市环境总VOCs(TVOCs)的平... 详细信息

本文通过基于光化学年龄的参数方法,估算了山西临汾市2021年4月18日~7月31日在线监测的VOCs初始体积分数数据,矫正其光化学损耗影响;然后利用正定矩阵因子分解(PMF)模型进行了其来源解析.结果表明,研究期间临汾市环境总VOCs(TVOCs)的平均体积分数为17.1×10^(-9);其中白天TVOCs的平均初始体积分数为27.2×10^(-9),其化学损耗达到10.6×10^(-9),化学损耗率约为39.0%.相比与其它VOCs类别,烯烃化学损耗率最高(66.0%),其中异戊二烯(3.16×10^(-9))、1,3-丁二烯(1.27×10^(-9))和乙烯(1.19×10^(-9))的化学损耗明显高于其它物种.臭氧污染时期TVOCs化学损耗达到15.1×10^(-9),是非臭氧污染时期的1.6倍.臭氧污染时期烯烃的化学损耗率最高(81.7%),其中异戊二烯、1,3-丁二烯、反-2-丁烯和反-2-戊烯的化学损耗分别达到5.05×10^(-9)、1.85×10^(-9)、1.59×10^(-9)和1.10×10^(-9),显著高于其它物种.基于初始体积分数的PMF来源解析(IC-PMF)结果发现,石化相关企业排放(36.4%)、天然气(17.2%)、柴油车排放和溶剂使用混合源(12.9%)、汽油车排放(9.6%)、液化石油气(8.6%)、植物排放(8.6%)和燃烧源(6.7%)是研究期间临汾市环境VOCs的主要贡献源类.相比于基于观测体积分数的PMF解析结果(OC-PMF),植物排放贡献被低估了83.3%,其被低估量明显高于其它源类;其次是柴油车排放和溶剂使用混合源以及石化相关企业排放,分别被低估了22.2%和19.7%.同时,IC-PMF结果表明臭氧污染期间贡献较高的源类是石化相关企业排放和植物排放,分别达到24.1%和21.7%.基于IC-PMF的解析结果,利用臭氧生成潜势(OFP)模型的估算结果表明,石化相关企业排放是臭氧生成潜势(OFP)最高的贡献源类,其对总OFP贡献率达到50.7%,其次为植物排放以及柴油车排放和溶剂使用混合源,其对总OFP的贡献率分别达到24.8%和10.4%;其中臭氧污染期间对于OFP的贡献较高的源类为植物排放和石化相关企业排放,分别达到52.6%和27.8%.

关键词：临汾挥发性有机化合物光化学损耗初始体积分数源解析

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