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TwinNet: Twin Structured Knowledge Transfer Network for Weakly Supervised Action Localization

Machine Intelligence Research 2022年第3期19卷 227-246页

作者： Xiao-Yu Zhang Hai-Chao Shi Chang-Sheng li li-xin duan Institute of Information Engineering Chinese Academy of SciencesBeijing 100093China School of Computer Science Beijing Institute of TechnologyBeijing 100081China School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Action recognition and localization in untrimmed videos is important for many applications and have attracted a lot of attention. Since full supervision with frame-level annotation places an overwhelming burden on manual labeling effort, learning with weak video-level supervision becomes a potential solution. In this paper, we propose a novel weakly supervised framework to recognize actions and locate the corresponding frames in untrimmed videos simultaneously. Considering that there are abundant trimmed videos publicly available and well-segmented with semantic descriptions, the instructive knowledge learned on trimmed videos can be fully leveraged to analyze untrimmed videos. We present an effective knowledge transfer strategy based on inter-class semantic relevance. We also take advantage of the self-attention mechanism to obtain a compact video representation, such that the influence of background frames can be effectively eliminated. A learning architecture is designed with twin networks for trimmed and untrimmed videos, to facilitate transferable self-attentive representation learning. Extensive experiments are conducted on three untrimmed benchmark datasets (i.e., THUMOS14, ActivityNet1.3, and MEXaction2), and the experimental results clearly corroborate the efficacy of our method. It is especially encouraging to see that the proposed weakly supervised method even achieves comparable results to some fully supervised methods.

关键词： Knowledge transfer weakly supervised learning self-attention mechanism representation learning action localization

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Integration of artificial intelligence and multi-omics in kidney diseases

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Fundamental Research 2023年第1期3卷 126-148页

作者： Xu-Jie Zhou Xu-Hui Zhong li-xin duan Renal Division Peking University First HospitalBeijing 100034China Kidney Genetics Center Peking University Institute of NephrologyBeijing 100034China Key Laboratory of Renal Disease Ministry of Health of ChinaBeijing 100034China Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University) Ministry of EducationBeijing 100034China Department of Pediatrics Peking University First HospitalBeijingChina The Big Data Research Center University of Electronic Science and Technology of ChinaNo.2006Xiyuan AveWest Hi-Tech ZoneChengdu 611731China

Kidney disease is a leading cause of death ***,the diagnosis of kidney diseases and the grading of their severity are mainly based on clinical features,which do not reveal the underlying molecular *** recent surge of∼omics studies has greatly catalyzed disease *** advent of artificial intelligence(AI)has opened the avenue for the efficient integration and interpretation of big datasets for discovering clinically actionable *** review discusses how AI and multi-omics can be applied and integrated,to offer opportunities to develop novel diagnostic and therapeutic means in kidney *** combination of new technology and novel analysis pipelines can lead to breakthroughs in expanding our understanding of disease pathogenesis,shedding new light on biomarkers and disease classification,as well as providing possibilities of precise treatment.

关键词： Artificial intelligence Kidney diseases Multi-omics Network Pathway Precision medicine

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Two new secolignans from the roots of Urtica mairei Levi.

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Chinese Chemical Letters 2008年第10期19卷 1212-1214页

作者： Wei Wang xing Guo Yan li xin duan Yuan Zhou ling Tang Yong Qi Wang Bao Min Feng College of Bioengineering Dalian University Economic and Development Zone Dalian 116622 China Center for Signal Transduction and Metabolomics Institute of Botany Chinese Academy of Sciences Beijing 10093 China liaoning Key Laboratory of Bioorganic Chemistry Dalian University Economic and Development Zone Dalian 116622 China

Two new secolignans （1 and 2） were isolated from the roots of Urtica mairei Levi. The structures of these two compounds were determined on the basis of extensive spectroscopic methods including HR-EI-MS, 1D and 2D N... 详细信息

关键词： Urtica mairei Levi. Secolignans Urticaceae

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Effects of heat treatment on magnetic properties of Co-Fe-plated hollow ceramic microspheres

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Progress in Natural Science:Materials International 2011年第5期21卷 392-400页

作者： Xiang li,Yue-xin duan,Yan ZHAO,Lei ZHU School of Materials Science and Engineering,Beijing University of Aeronautics and Astronautics, Beijing 100191,China School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100191 China

Functional hollow ceramic microspheres plated with Co-Fe were obtained through electroless plating technique for the application of lightweight microwave *** were treated at different temperatures by vacuum annealing *** surface-coated hollow microspheres were characterized by scanning electron microscopy(SEM) and X-ray diffraction analysis (XRD).The microwave electromagnetic loss and absorbing properties of hollow microspheres plated with Co-Fe were tested by network vector *** magnetic properties were tested by vibrating sample magnetometer(VSM).The results show that the annealing treatment changed the crystal phase of Co from HCP to FCC,simultaneously increased the crystallinity and crystal size of Co and Fe in coating ***,after annealing at 800℃or 1 000℃,the microwave absorbing properties and soft magnetic properties of hollow microspheres plated with Co-Fe were further improved.

关键词： electroless plating hollow ceramic microspheres magnetic properties heat treatment Co-Fe

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Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi

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Molecular Plant 2012年第2期5卷 376-386页

作者： li-xin duan Tian-Lu Chen Ming li Min Chen Ye-Qing Zhou Guang-Hong Cui Ai-Hua Zhao Wei Jia Lu-Qi Huang Xiaoquan Qi The Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences20 Nanxincun Xiangshan RoadBeijing 100093China Shanghai Center for Systems Biomedicine(Ministry of Education Key Laboratory of Systems Biomedicine) Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Institute of Chinese Materia Medica Chinese Academy of Chinese Medical Sciences16 Nanxiao RoadBeijing 100700China School of Pharmacy Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

Integration of the genetic and metabolic fingerprinting can provide a new approach to differentiate similar Traditional Chinese Medical （TCM） materials. Two leguminous plants, Mojia Huangqi and Menggu Huangqi, are important medical herbs and share great similarities in morphology, chemical constituent, and genomic DNA sequence. The taxonomy of Mojia Huangqi and Menggu Huangqi has been debated for more than 50 years and discrimination of TCM materials directly affects the pharmacological and clinical effects. AFLP based genetic fingerprinting and GC-TOF/MS-based meta- bolic fingerprinting were used to successfully discriminate the two species. The results of AFLP supported the opinion that Menggu Huangqi was a variant of Mojia Huangqi. The metabolic fingerprinting showed growth locations have greater impacts on the metabolite composition and quantity than the genotypes （cultivated versus wild） in Menggu Huangqi. The difference of some soluble sugars, fatty acids, proline, and polyamine reflected plant adaptation to different growth environments. Using multivariate and univariate statistical analysis, three AFLP markers and eight metabolites were identified as candidate DNA and metabolic markers to distinguish the two herb materials. The correlation network between AFLP markers and metabolites revealed a complex correlation network, which indicated the special metabolic pathways and the regulation networks of Huangqi.

关键词： Astragalus membranaceus metabolic fingerprinting amplified fragment length polymorphisms gas chromatography time-of-flight mass spectrometry.

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Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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大学学院治理研究的本土化认知与反思

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黑龙江高教研究 2018年第10期36卷 70-74页

作者：余利川段鑫星中国矿业大学江苏徐州221116

学院治理是国内大学治理研究领域的前沿点,研究历程久远、成果颇丰。立足学院治理的"真语境""真问题",通过文献计量分析,依据"治理研究历程—谁参与治理—治理什么"的主要逻辑,反思学院治理的本土化研究,解读学院制、学院治理主体与治... 详细信息

学院治理是国内大学治理研究领域的前沿点,研究历程久远、成果颇丰。立足学院治理的"真语境""真问题",通过文献计量分析,依据"治理研究历程—谁参与治理—治理什么"的主要逻辑,反思学院治理的本土化研究,解读学院制、学院治理主体与治理内容。从宏观国际、中观政策、微观组织视野审视学院治理改革,正视新旧"行政化"的双重挑战,同现代大学制度建设相对接,平衡行政权力与学术权力。

关键词：文献计量分析学院治理本土化

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Cloning and Expression of HBV X Protein Gene

Cloning and Expression of HBV X Protein Gene

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第九次全国生物物理大会学术会议

作者： li Xuemei, Pang Hai, An Jianli, li Shentao, duan xin, Wu Hao, Wu xin, Zhang Xiaoxue, Rao Zihe (MOE Laboratory of Protein Science & Laboratory of Structural Biology, Department of Biological Science and Biotechnology, Tsinghua University, Beijing, 100084)

＜正＞ 0ver 250 million people world-wide are persistently infected by HBV andchronic infection is associated with diverse and liver diseases includingchronic hepatitis, cirrhosis and primary HCC.

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan li Peng Hao Hongmei duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong duan Jiaxin Han Jinrong Chen Ning Sun Yuan li Tifei Yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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