检索结果-南通市图书馆

Bayesian mapping of neural tube defects prevalence in Heshun County, Shanxi Province, China during 1998～2001

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第6期8卷 921-925页

作者： CHI Wen-xue WANG Jin-feng li xin-hu ZHENG Xiao-ying liAO Yi-lan China University of Geosciences Beijing 100083 China Institute of Geographical Sciences and Nature Resources Research Chinese Academy of Sciences Beo＇ing 100101 China Institute of Population Research Peking University Beijing 100871 China

Objective: To estimate the prevalence rates of neural tube defects (NTDs) in Heshun County, Shanxi Province, China by Bayesian smoothing technique. Methods: A total of 80 infants in the study area who were diagnosed with NTDs were analyzed. Two mapping techniques were then used. Firstly, the GIS software ArcGIS was used to map the crude prevalence rates. Secondly, the data were smoothed by the method of empirical Bayes estimation. Results: The classical statistical approach produced an extremely dishomogeneous map, while the Bayesian map was much smoother and more interpretable. The maps produced by the Bayesian technique indicate the tendency of villages in the southeastern region to produce higher prevalence or risk values. Conclusions: The Bayesian smoothing technique addresses the issue of heterogeneity in the population at risk and it is therefore recommended for use in explorative mapping of birth defects. This approach provides procedures to identify spatial health risk levels and assists in generating hypothesis that will be investigated in further detail.

关键词： Birth defects Neural tube defects (NTDs) Disease map Spatial analysis Bayesian smoothing China

Laminar Flame Instability of n-Hexane,n-Octane,and n-Decane in Spherical Expanding Flames

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第3期33卷 1189-1199页

作者： YIN Geyuan hu Erjiang li Xiaotian LV xin huANG Zuohua State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China United Automotive Electronic Systems Co. LtdShanghai201206China Chongqing Changan Automobile Co. Ltd.Chongqing401120China

This paper focuses on the laminar flame instability of three high molecular weight n-alkanes,namely n-hexane,n-octane,and *** experiment was carried out in a constant volume combustion bomb to get the flame *** critical radius under different conditions was extracted using the image processing *** with the existing critical Peclet number theory,the dominant factors of flame instability under current conditions for three n-alkanes can be figured ***,the average cell size(equivalent cell radius,R_(cell))was extracted to provide quantitative analysis of the flame cellular structure,based on the method developed in this *** theoretical R_(cell)were also calculated and compared with the experimental results to validate the proposed method.

关键词： cellular instability equivalent cell radius critical Peclet number spherical flame

Improving the value of molecular testing:current status and opportunities in colorectal cancer precision medicine

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第1期21卷 21-28页

作者： Haiyun li linwei Guo Chenchen Wang xin hu Ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Precision Cancer Medical Center Affiliated with Fudan University Shanghai Cancer Center Shanghai 201315China

Colorectal cancer(CRC)is the second leading cause of cancer-related deaths *** radical resection with adjuvant chemotherapy remains the primary treatment choice for CRC,but the 5-year postoperative survival rate is only approximately 60%,and approximately one-third of patients with CRC experience recurrence within 2 years of ***,the transformation of high-throughput sequencing has accelerated the development of precision *** example,KRAS mutations indicate resistance to anti-epidermal growth factor receptor(EGFR)-targeted therapies in ***,molecular-guided individualized therapy has brought new promise in major clinical areas and challenges,such as novel biomarkers predicting sensitivity and resistance to immunotherapy for microsatellite stable(MSS)CRC.

关键词： cancer chemotherapy colorectal

Drinking water quality & health risk assessment of secondary water supply systems in residential neighborhoods

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第2期18卷 47-62页

作者： Yating Wei Dong hu Chengsong Ye Heng Zhang Haoran li xin Yu College of the Environment&Ecology Xiamen UniversityXiamen 361102China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Secondary water supply systems(SWSSs)are important components of the water supply infrastructure that ensure residents’drinking water *** are characterized by long detention time,warm temperature,and unreasonable management,which may trigger the deterioration of water quality and increase *** this study,drinking water quality index(DWQI)and health risk assessment(HRA)were selected and modified to quantitatively assess the water quality and health risks of SWSSs in residential *** total,121 seasonal water samples were *** was observed that the water quality was excellent with the DWQI of 0.14±0.04,excluding one sample,which was extremely poor owing to its excessive total bacterial *** HRA results revealed that the health risks were low:negligible non-carcinogenic risk for any population;negligible and acceptable carcinogenic risk for children aged 6–17 and ***,samples revealed higher carcinogenic risk(7.63×10−5±3.29×10−6)for children aged 0–5,and arsenic was the major *** samples had poor water quality and higher health risks,which called for *** further investigate the water quality and health risks of SWSSs,monthly sampling was conducted during *** 24 water samples were qualified in Chinese standard(GB 5749-2022)and characterized as excellent *** HRA results were consistent with the seasonal samples’and the health risks were mainly concentrated in ***,our study provides a suitable framework for water quality security,advice for managers,and references for administrators in other cities.

关键词： Drinking water quality Water quality index Health risk assessment Secondary water supply systems Heavy metals

Exploring the ultrahigh rolling contact fatigue life of M50 bearing steel by adjusting the cryogenic sequence

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第2期169卷 243-250页

作者： xin Cai Xiaoqiang hu xingyu Lu Hongwei liu Yanfei Cao Dianzhong li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The influence of different cryogenic sequences on the rolling contact fatigue(RCF)life of M50-bearing steel has been *** results show that direct cryogenic treatment after quenching can effectively improve RCF *** L_(10)life is strikingly 5 times longer than that with cryogenic treatment after *** is caused by the distinct lattice construction of martensite and the transformation of retained *** secondary nanocarbides and fine twins are formed via cryogenic treatment before tem-pering compared with cryogenic treatment after *** improvement in the RCF life of the steel is attributed to the joint effects of the secondary nanocarbides and twin boundaries with a width of 5-13 nm,which delays significantly crack initiation and *** study highlights a common method to improve the service life of high-carbon and high-alloy steels by adjusting the cryogenic se-quence.

关键词： M50 steel Cryogenic treatment Rolling contact fatigue life Carbide Twin

Risk Factors Asscociated with Hypokalemia during Postanesthesia Recovery and Its Impact on Outcomes in Gynecological Patients:A Propensity Score Matching Study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第2期44卷 441-449页

作者： Bei-bei WANG li hu xin-yue hu Dong HAN Jing WU Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute of Anesthesia and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Anesthesiology and Resuscitation(huazhong University of Science and Technology) Ministry of EducationWuhan430022China

Objective:This study aimed to explore the risk factors and outcomes of hypokalemia during the recovery period from anesthesia in the gynecological ***:This retrospective cohort study included 208 patients who underwent gynecological surgery at our institution between January 2021 and March *** were collected for each patient,including demographics,disease status,surgical data,and clinical *** bowel preparation,postoperative gastrointestinal function,and electrolyte levels were compared between the two groups using propensity score matching(PSM).Results:The incidence of hypokalemia(serum potassium levellinical outcomes,including postoperative gastrointestinal function,postoperative complications,and length of hospital stay.

关键词： hypokalemia gynecological surgery postanesthesia recovery perioperative electrolyte disturbances postoperative recovery

Functions and mechanisms of cytosolic phospholipase A_(2)in central nervous system trauma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第2期18卷 258-266页

作者： Hao-Jie Zhang Yi-Tuo Chen xin-li hu Wan-Ta Cai Xiang-Yang Wang Wen-Fei Ni Kai-liang Zhou Department of Orthopedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Zhejiang Provincial Key Laboratory of Orthopedics WenzhouZhejiang ProvinceChina The Second Clinical Medical College of Wenzhou Medical University WenzhouZhejiang ProvinceChina

Central nervous system(CNS)trauma,including traumatic brain injury and spinal cord injury,has a high rate of disability and mortality,and effective treatment is currently *** studies have revealed that neural inflammation plays a vital role in CNS *** the initial enzyme in neuroinflammation,cytosolic phospholipase A_(2)(cPLA2)can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release lysophospholipids andω3-polyunsaturated fatty acid dominated by arachidonic acid,thereby inducing secondary *** there is substantial fresh knowledge pertaining to cPLA2,in-depth comprehension of how cPLA2 participates in CNS trauma and the potential methods to amelio rate the clinical res ults after CNS trauma are still *** present review summarizes the latest understanding of how cPLA2 participates in CNS trauma,highlighting novel findings pertaining to how cPLA2 activation initiates the potential mechanisms specifically,neuroinflammation,lysosome membrane functions,and autophagy activity,that damage the CNS after ***,we focused on testing a variety of drugs capable of inhibiting cPLA2 or the upstream pathway,and we explored how those agents might be utilized as treatments to improve the results following CNS *** review aimed to effectively understand the mechanism of cPLA2 activation and its role in the pathophysiological processes of CNS trauma and provide clarification and a new referential framework for future research.

关键词： autophagy cytosolic phospholipase A_(2) drugs lysosome membrane permeability mitogen-activated protein kinase neuroinflammation spinal cord injury traumatic brain injury

BIO-inspired intelligent navigation: from methodology, system theory, to behavioural science

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第9期67卷 333-335页

作者： Wenshuo li xin liU Pengwei hu Jian YANG Xiang YU Lei GUO Hangzhou Innovation Institute of Beihang University School of Automation Science and Electrical Engineering Beihang University School of Instrumentation and Optoelectronic Engineering Beihang University

It is crucial for unmanned systems to determine their motion information accurately, reliably, and in real time. This function is accomplished by the autonomous navigation module of the unmanned systems. By analogy to the animals,the autonomous navigation module can be regarded as the“sensory nerve center” of an unmanned system.

关键词：

Fermented Lentinus edodes extract containingα-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and human Wellness 2024年第4期13卷 2102-2115页

作者： xin hu Dan Cheng Yingxia Zhang Po li Xiaoping Wu Junsheng Fu College of life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China Mycological Research Center Fujian Agriculture and Forestry UniversityFuzhou 350002China Shanghai lithy One-Health Group Technology Co. Ltd.Shanghai 200235China

Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease that threatens human health *** aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containingα-glucan(FLA),in a concanavalin A(Con A)-induced AIH mouse model and to determine the underlying liver-protective *** results showed that compared with the model group,the level of proinflammatory cytokines in serum of FLA pretreated mice was significantly decreased,and the degree of inflammatory cell infiltration in liver,thymus and spleen was significantly *** polymerase chain reaction,immunohistochemistry,and Western blotting showed that FLA pre-treatment inhibited the Con A-induced apoptosis of hepatocytes by down-regulating the expression of BAX and up-regulating the expression of *** research found that FLA may improve liver injury in mice by activating NRF2 signaling pathway and inhibiting TRAF6/NF-κB signaling ***,FLA may improve liver injury in mice by shifting gut microbial composition to reduce the release of inflammatory cytokines in the serum and prevent the necrosis of ***-regulation of NRF2 signaling pathway,down-regulation of TRAF6/NF-κB signaling pathway,and an increase in the relative abundance of Lactobacillus_johnsonii and ligilactobacillus_murinus play a protective role in liver.

关键词： Autoimmune hepatitis Concanavalin A Lentinus edodes TRAF6/NF-κB NRF2