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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 897-900页

作者： li-xiao zhou Yu Zhu Department of Ophthalmology First Affiliated Hospital of Zhengzhou University

Objective:To explore the influence of extract of Ginkgo biloba（EGB） on the proliferation, apoptosis of ACC-2 cell and Survivin gene expression in adenoid cystic carcinoma（ACC） of lacrimal ***:ACC-2 cell in human with ACC of lacrimal gland was in vitro cultured. MTT method was used for cell proliferation *** V/PI double-staining flow cytometer was used to detect cell apoptosis and cell *** gene expression was analyzed by RT-PCR and Western ***:EGB had inhibitory effect on the proliferation of ACC-2 cell with significant dose-effect relationship,and there was statistical difference when compared with the control group（P50) is 88 mg/L. The flow cytometer test indicated that CGB can gradually increase ACC-2 cell in G0-G1 stage and decrease it in G2-M and S *** the increase of dose,the apoptosis rate of ACC-2 cell was obviously increased（Pliferation.

关键词： Ginkgo biloba extract ACC-2 cell Proliferation Apoptosis Survivin gene

Solid Phase Extraction Chemiluminescence Determination of Methamidaphos on Vegetables

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Chemical Research in Chinese Universities 2006年第1期22卷 21-24页

作者： li xiao-zhou GUAN Ting-ting zhou Chi YIN Ji-qiu ZHANG Yi-hua College of Chemistry Jilin University Changchun 130012 P.R. China College of lnspection Dalian Medical University Dalian 116031 P.R. China

The determination of the methamidaphos pesticide residue on vegetables with a simple solid phase extract（SPE） flow injection（FI） -chemiluminescence（CL） method is described. The method is based on the enhancing effect of methamidaphos on the CL reaction of luminol with hydrogen peroxide in an alkaline solution. Under the optimal conditions, the CL intensity is linear to the methamidaphos mass concentration in a range of 0. 2-13μg/mL （ r= 0. 9992）. The detection limit（3σ） is 0. 047μg/mL. The relative standard deviations for the analysis of three samples are 1.8%, 2.5% and 3.7% （ n = 5 ）, respectively. The recovery is in a range of 90%-109% by the method. In this work, this method was successfully applied to the determination of the methamidaphos residue on some vegetable samples.

关键词： Chemiluminescence Flow injection Solid phase extraction Methamidaphos

Characteristics of rapidly intensifying tropical cyclones in the South China Sea,1980–2016

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Advances in Climate Change Research 2022年第3期13卷 333-343页

作者： Lei YANG Xi LUO Sheng CHEN xiao-li zhou Wei-Qiang WANG Dong-xiao WANG State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory Guangzhou 511458China School of Marine Science Sun Yat-sen UniversityZhuhai 519082China Institute of Deep-Sea Science and Engineering Chinese Academic ScienceSanya 572099China

The differences in the characteristics of the rapid intensification(RI)during the TCs that form in the SCS(referred as local TCs)and that enter the SCS from the western North Pacific(WNP;referred as entering TCs)have not been well studied,which could contribute the inaccuracy of current TC intensity forecast in the *** this study,we used TC observations,reanalysis data and model experiments to analyze the RI occurrences during local TCs and entering TCs in *** found that the significant interannual and interdecadal variations in RI occurrences during local eastward-moving TCs were related to the strong intraseasonal oscillation(ISO)over the SCS and the WNP under La Niña *** during local westward-moving TCs showed insignificant variations as a result of the complex interactions among the monsoon trough,ISO and the large-scale *** during entering TCs showed strong interdecadal variations,with increased RI after 1997,even though the total number of entering TCs has decreased since 1997,which is a result of a higher number of entering TCs in the northwestern quadrant of the WNP,a stronger ISO and weak vertical windshear over the SCS and east of the Philippines under negative phase of Pacific Decadal *** different variations and related mechanisms of RI indicates that distinct forecasting factors should be considered for intensity prediction during local eastward-and westward-moving TCs and entering TCs.

关键词： Tropical cyclones Rapid intensification Intraseasonal oscillation Pacific Decadal Oscillation South China Sea Western North Pacific

Low Temperature Reduction Degradation Characteristics of Sinter,Pellet and Lump Ore

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Journal of Iron and Steel Research International 2011年第8期18卷 20-24页

作者： WU Sheng-li liU xiao-qin zhou Qi XU Jian liU Cheng-song School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China

The reduction degradation characteristics of typical sinter, pellet and lump ore were tested with the reducing gas conditions simulating two kinds of irowmaking processes. The results show that, in the same condition of gas composition and temperature, the reduction degradation degree （RDI〈3.15mm） of sinter is high, RDI〈3.15mm of lump ore is low and RDI〈3.15 mm of pellet is in the middle level. With two kinds of gas composition simulating different iron-making processes, the reduction degradation indices （RDI） of three kinds of iron ores all present the tenden- cy of ＂inverted V-shape＂ in the temperature range from 450 to 650℃, and the RDI reach the maximum value at 550℃. The reduction degradation degrees of iron ores are extended when mixing the gas with hydrogen to increase the re duction potential, and the influence extent is discrepant for different iron ores. Colligating the increase amplitude of grains in small size fraction, the influence of reducing gas on lump ore is the greatest, the influence on sinter is the second, and the sensitivity of pellet on the reducing gas properties change is relatively small. As for the degradation form, lump ore and sinter both present the degradation ,of cracking, and the distribution of small grains generated from the cracking is in the range from 03 5 to 6. 3 mm uniformly. The lump ore presents surface cracking, while sin- ter presents integral cracking. The pellet presents the degradation of surface stripping, and the proportion of grains smaller than 0.5 mm is the highest, which is up to 90% in the grains smaller than 3.15 mm.

关键词： sinter pellet lump ore low temperature reduction degradation characteristic gas property

THE VOID FRACTION DISTRIBUTION IN TWO-DIMENSIONAL GAS-liQUID TWO PHASE FLOW USING IMAGE PROCESS METHOD

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Journal of Hydrodynamics 2006年第2期18卷 127-134页

作者： ZHAO Ke-yu CHENG Wen liAO Wei-li zhou xiao-de College of Water Resource and Architectural Engineering Northwest Agriculture and Forestry University Xi＇an 712100 China Environment Research Institute Xi＇ an University of Technology Xi＇an 710048 China

An image processing method for measuring the instantaneous two-dimensional （2D） local void fraction at high bubble number density was proposed. It was based on computing a correlation between the locally averaged brightness of the bubble plume images and the real void fraction. The method was tested using the 2D distribution of local void fraction from visualized image, where a correlation between the locally averaged brightness and the projection void fraction was derived by introducing an ideal of overlapping probability of the bubble-images under various conditions. This research was used to study the behavior of the bubbly flows with aspect ratio of 1.0,1.5, and 2.0. The present method was applied to the instantaneous measurement. The void fraction for bubble plumes of three different aspect ratios with three different bubble generating flow rates were measured for the clarification of the effect of the bubble on the behavior of the bubbly flows. Dependency of the void fraction on the gas flow rate was measured and compared to other results from the literature. In the range of our experiments, it was observed that not only does an aspect ratio of the tank affect the structure of the plume, but also the gas flow rate in the tank affects the structure of the plume.

关键词： local void fraction gas-liquid two-phase flow,brightness aspect ratio the projection void fraction

Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 563-570页

作者： Yu-Qing Cheng Geng-Fang Wang xiao-li zhou Min lin Xin-Wen Zhang Qin Huang Department of Pathology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Gastroenterology Center The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhou 213164Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA 02215United States

BACKGROUND Early adenocarcinoma mixed with a neuroendocrine carcinoma(NEC)component arising in the gastroesophageal junctional(GEJ)region is rare and even rarer in young ***,we report such a case in a 29-year-old Chinese *** SUMMARY This patient presented to our hospital with a 3-mo history of dysphagia and *** endoscopy revealed an elevated nodule in the distal esophagus 1.6 cm above the GEJ line,without Barrett’s esophagus or involvement of the gastric *** nodule was completely resected by endoscopic submu-cosal dissection(ESD).Pathological examination confirmed diagnosis of intra-mucosal adenocarcinoma mixed with an NEC component,measuring 1.5 ***,both adenocarcinoma and NEC components were positive for P53 with a Ki67 index of 90%;NEC was positive for synaptophysin and ***-generation sequencing of 196 genes demonstrated a novel germline mutation of the ERCC3 gene in the DNA repair pathway and a germline mutation of the RNF43 gene,a common gastric cancer driver gene,in addition to pathogenic somatic mutations in P53 and CHEK2 *** patient was alive without evidence of the disease 36 mo after *** Early adenocarcinoma with an NEC component arising in the distal esophageal side of the GEJ region showed evidence of gastric origin.

关键词： Adenocarcinoma Neuroendocrine carcinoma Gastroesophageal junction Next generation sequencing Case report

Triple Z^(0)-Boson Production in a Large Extra Dimensions Model at the International linear Collider

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Chinese Physics Letters 2012年第11期29卷 31-35页

作者： JIANG Ruo-Cheng li xiao-zhou MA Wen-Gan GUO Lei ZHANG Ren-You Department of Modern Physics University of Science and Technology of ChinaHefei 230026

We investigate the effects induced by the interactions of the Kaluza–Klein graviton with the standard model(SM)particles on the triple Z^(0)-boson production process at the International linear Collider in the framework of the large extra dimension(LED)*** present the dependence of the integrated cross sections on the electron-positron colliding energy√s,and various kinematic distributions of final Z^(0) bosons and their subsequential decay products in both the SM and the LED *** also provide the relationship between the integrated cross section and the fundamental scale MS by taking the number of the extra dimensions(d)as 3,4,5,and 6,*** numerical results show that the LED effect can induce an observable relative discrepancy for the integrated cross section(δ_(LED)).We find that the relative discrepancy of the LED effect can even reach a few dozen percent in the high transverse momentum area or the central rapidity region of the final Z^(0)-bosons and muons.

关键词： dimensions momentum subsequent

Dynamic effects of high-pressure pulsed water jet in low-permeability coal seams

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Journal of Coal Science & Engineering(China) 2009年第3期15卷 284-288页

作者： li xiao-hong zhou Dong-ping LU Yi-yu KANG Yong ZHAO Yu WANG xiao-chuan Key Lab for the Exploitation of Southwestern Resources ＆ Environmental Disaster Control Engineering Chongqing University Chongqing 400030 China

Mine gas extraction in China is difficult due to the characteristics such as micro-porosity,low-permeability and high adsorption of coal *** pulsed mechanismof a high-pressure pulsed water jet was studied through theoretical analysis,experimentand field *** results show that high-pressure pulsed water jet has threedynamic ***'s more,the three dynamic effects can be found in low-permeabilitycoal seams.A new pulsed water jet with 200-1 000 Hz oscillation frequency andpeak pressure 2.5 times than average pressure was *** bubble collapsing,sound vibration and instantaneous high pressures over 100 MPa enhanced the cuttingability of the high-pressure *** high-pressure pulsed water jet drilling and slotting,the exposure area of coal bodies was greatly enlarged and pressure of the coal seamsrapidly ***,the permeability of coal seams was improved and gas absorptionrate also *** results show that gas adsorption rate decreasedby 30%-40%and the penetrability coefficient increased 100 *** proves that high-pressurepulsed water is more efficient than other conventional methods.

关键词： high-pressure pulsed water jet gas desorption penetrability dynamic effects

Genome-Wide Analysis Regulatory Network of Photomorphogenesis Revealed the Complex Brassinosteroid Effects in

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Molecular Plant 2009年第4期2卷 755-772页

作者： li Song xiao-Yi zhou li li liang-Jiao Xue Xi Yang Hong-Wei Xue National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road 200032 Shanghai China

light and brassinosteroids （BRs） have been proved to be crucial in regulating plant growth and development; however, the mechanism of how they synergistically function is still largely unknown. To explore the underlying mechanisms in photomorphogenesis, genome-wide analyses were carried out through examining the gene expressions of the dark-grown WT or BR biosynthesis-defective mutant det2 seedlings in the presence of light stimuli or exogenous Brassinolide （BL）. Results showed that BR deficiency stimulates, while BL treatment suppresses, the expressions of lightresponsive genes and photomorphogenesis, confirming the negative effects of BR in photomorphogenesis. This is consistent with the specific effects of BR on the expression of genes involved in cell wall modification, cellular metabolism and energy utilization during dark-light transition. Further analysis revealed that hormone biosynthesis and signaling-related genes, especially those of auxin, were altered under BL treatment or light stimuli, indicating that BR may modulate photomorphogenesis through synergetic regulation with other hormones. Additionally, suppressed ubiquitin-cycle pathway during light-dark transition hinted the presence of a complicated network among light, hormone, and protein degradation. The study provides the direct evidence of BR effects in photomorphogenesis and identified the genes involved in BR and light signaling pathway, which will help to elucidate the molecular mechanism of plant photomorphogenesis.

关键词： brassinosteroid light photomorphogenesis hormone interplay ubiquitin.

Research progress in immunotherapy of pancreatic cancer

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TMR Integrative Medicine 2017年第1期1卷 2-8页

作者： Yong Tang Hong-Yin Zhang xiao-li zhou Department of Pancreatic Oncology Tianjin Medical University Cancer Institute and Hospital National ClinicalCenter for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin 300060 China The ThirdDepartment of General Surgery Tianjin Xi-Qing Hospital Department of Toxicology Tianjin Center for DiseaseControl and Prevention

Pancreatic cancer is among the most lethal malignancies resistant to conventional therapies. The urgent need fornew therapies has turned the spotlights on immunotherapy. In recent years, a growing body of evidence has alreadybeen gathered regarding the efficacy of genetic engineering modified T-cells, checkpoint inhibitors of T-cells, killercells induced by dendritic cells and cytokine in patients with pancreatic cancer. Cryoimmunotherapy in situ andextra-tumor and immunotherapy combined with chemotherapy could also increase the effectiveness. Research ofpancreatic cancer vaccine has made some progress. The immunity enhancing function of some traditional herbshave been reported, such as Ginsenoside Rg3, which could enhance T-cell subsets and NK cell activity inpancreatic cancer patients with chemotherapy.

关键词： Pancreatic cancer Modified T-cells Checkpoint inhibitors Killer cells Immunotherapy plus cryotherapy Immunotherapy combined with chemotherapy Traditional herbal medicine