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Identification of a new target region on the long arm of chromosome 7 in gastric carcinoma by loss of heterozygosity

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World Journal of Gastroenterology 2006年第15期12卷 2437-2440页

作者： De-Sheng Weng Jin-Tian li Shi-Juan Mai Zhi-Zhong Pan Bing-Jian Feng Qi-Sheng Feng li-xi huang Qi-Jing Wang Yong-Qiang li xing-Juan Yu Shi-Ping Chen Jia He Jian-Chuan xia Research Section of Oncopathology State Key Laboratory of Oncology in Southern china Cancer CenterZhongshan University Guangzhou 510064 Guangdong ProvinceChina

AIM： To define the common deleted region on the long arm of haman chromosome 7q linked to primary gastric carcinomas in Chinese by loss of heterozygosity （LOH） and its clinical significance. METHODS： Nine microsatellite markers distributed over chromosome 7q with an average marker density of 10cM were used to examine 70 primary gastric carcinomas for LOH by PCR amplification. The PCR products were separated by electrophoresis on polyacrylamide gel. Genescan and Genotyper softwares were used to analyze LOH. RESULTS： LOH with at least one marker on 7q occurred in 34.3% （12/50） of the tumors. Among them, LOH at D7S486 and D7S798 was higher in 24.0% （24/70） and 29.2% （5/26）, respectively. By statistical analysis we also observed an obvious genotype-phenotype correlation on 7q （P〈0.05）. The frequency of LOH at D7S486 in patients with lymph node metastasis was significantly higher than that in those without lymph node metastasis （P=0.015）. CONCLUSION： The high incidence of LOH at D7S486 and its correlation with poorer prognosis suggest that there might be putative tumor suppressor genes in this region involved in the tumorigenesis and progression of gastric carcinoma.

关键词： LOH Chromosome 7 Gastric cancer

Stent-grafting for unfavorable abdominal aortic aneurysm： a practical challenge

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Chinese Medical Journal 2009年第7期122卷 787-792页

作者： HU Zuo-jun CHANG Guang-qi li xiao-xi huang Xue-ling YIN Heng-hui WANG Shen-ming Department of Vascular Surgery First Affiliated Hospital of SunYat-sen University Guangzhou Guangdong 510080 China

Background The endovascular treatment of abdominal aortic aneurysm （AAA） has improved greatly in the last 15 years. The present study aimed to evaluate the endografting experience for the treatment of unfavorable abdominal aortic aneurysm （uAAA）. Methods During December 2001 and December 2007, 41 patients with uAAA were treated with endografting using concomitant techniques. Patients were followed up for 1 to 48 months （mean 20.5 months）. Results Technical success rate was 97.6% （40/41） with 1 failure converted to open surgery for an unaccessed iliac stenosis. Nine （22.5%） type Ⅰ endoleaks （5 proximal and 4 distal） were observed on the completion angiograms and successfully corrected with aortic cuffs and iliac extensions during the procedure. Twenty-two of the planed adjunctive procedures were concomitantly performed just before endograft-implantation. There were 2 （5.0%） type Ⅰ endoleaks at 30 days; one type Ⅰ patient was treated by open conversion, another type Ⅰ patient died from a rupture before treatment in the ward, causing a 2.5% of initial mortality. The two type Ⅱ endoleaks were observed without aneurismal expansion. No buttock or leg claudication or ischemic colitis occured. During late follow-up, one additional death occurred from stroke. One new type Ⅰ endoleak was encountered from thrombocytopenia, which caused a 2.6% secondary endoleak that converted to an open surgery in the third month after a failed transabdominal banding of the aortic neck in the second month. All type Ⅱ endoleaks had disappeared in the third and sixth month. The Endografts did not present signs of material fatigue and no other type of endoleak formed. One patient presented with left limb ischemia, which underwent percutaneous transluminat angioplasty. There was no additional aneurysm rupture or any endograft imgration. Conclusion The endografting with concomitant procedures is a feasible and efficient alternative for managing unfavorable AAAs, achieving low morbidity and mort

关键词： aortic aneurysm, abdominal endovascular repair stent-grafi concomitant intervention outcome analysis

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波形钢腹板组合槽形梁抗扭性能试验研究

工程力学 2017年第3期34卷 108-114页

作者：陈卓异李传习黄侨贺君长沙理工大学省部共建桥梁工程安全控制教育部重点实验室长沙410114 东南大学交通学院南京210096

为了研究新型结构预应力波形钢腹板组合槽形梁的抗扭性能,基于约束扭转理论,推导了波形钢腹板组合槽形梁的约束扭转翘曲应力表达式和扇形惯性矩;考虑了波形钢腹板的褶皱效应对纵向刚度的影响,计入波形钢腹板的剪切变形对约束扭转刚度的... 详细信息

为了研究新型结构预应力波形钢腹板组合槽形梁的抗扭性能,基于约束扭转理论,推导了波形钢腹板组合槽形梁的约束扭转翘曲应力表达式和扇形惯性矩;考虑了波形钢腹板的褶皱效应对纵向刚度的影响,计入波形钢腹板的剪切变形对约束扭转刚度的降低,得到了扇形惯性矩修正公式;最终建立了集中扭矩作用下的扭转角计算公式。完成了2片波形钢腹板组合槽形试验梁的偏载试验和3片相同梁的对称加载试验,试验表明:90 k N以内的偏载作用下,试验梁的荷载-位移曲线基本呈线性;试验梁两侧竖向位移的平均值与对称荷载作用下的竖向位移基本相同;试验梁的偏载系数位于1.2~1.3,比波形钢腹板组合箱梁增大10%左右。理论计算、试验测试和有限元分析表明:该文建立的扭转角计算公式采用修正过的扇形惯性矩进行计算,具有良好的精度。

关键词：组合梁波形钢腹板槽形梁抗扭性能偏载试验

榴莲壳粉-聚偏氟乙烯复合膜对次甲基蓝吸附的研究

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环境工程 2018年第2期36卷 54-59页

作者：黄晓东李茜黄雅丽闽江学院化学与化学工程系福州350108

采用溶解-相转化法制备榴莲壳粉-聚偏氟乙烯(PVDF)复合膜吸附剂,通过扫描电镜(SEM)和红外光谱(FTIR)对吸附剂进行表征,同时考察了榴莲壳粉/PVDF质量比、溶液pH值、吸附剂用量和吸附时间的影响。结果表明:复合膜对次甲基蓝的吸附的最佳... 详细信息

采用溶解-相转化法制备榴莲壳粉-聚偏氟乙烯(PVDF)复合膜吸附剂,通过扫描电镜(SEM)和红外光谱(FTIR)对吸附剂进行表征,同时考察了榴莲壳粉/PVDF质量比、溶液pH值、吸附剂用量和吸附时间的影响。结果表明:复合膜对次甲基蓝的吸附的最佳条件为:榴莲壳粉/PVDF质量比为0.75∶1,溶液pH值为7,吸附剂用量为0.4 g,吸附时间为90 min。吸附遵循准二级动力学方程和Langmuir方程,吸附剂经5次重复使用,对次甲基蓝去除率为81.25%。

关键词：聚偏氟乙烯榴莲壳复合膜次甲基蓝吸附

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu li Mu xi Xu Tianyi huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

BIFURCATIONS OF TRAVELliNG WAVE SOLUTIONS TO A COUPLED NONliNEAR WAVE SYSTEM

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Annals of Differential Equations 2008年第3期24卷 270-282页

作者： li Ming (Dept. of Math., Qujing Normal Institute, Qujing 655000, Yunnan) li xi, huang Yan (Center for Nonlinear Science Studies, Kunming University of Science and Technology, Kunming 650093, Yunnan)

Employ theory of bifurcations of dynamical systems to a system of coupled nonlin-ear equations, the existence of solitary wave solutions, kink wave solutions, anti-kink wave solutions and periodic wave solutions is obtained. Under different parametric conditions, various sufficient conditions to guarantee the existence of the above so-lutions are given. Some exact explicit parametric representations of travelling wave solutions are derived.

关键词： solitary wave solution kink wave solution anti-kink wave solution

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang xiao Ding huang Yunyi Yiyu liu Jia li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

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基于FRFT的强时频干扰抑制方法

舰船科学技术 2017年第6期39卷 83-87页

作者：李希友黄福锦大连测控技术研究所辽宁大连116013

混响是影响双基地或多基地声呐对水中目标探测识别的最主要干扰,提高抗混响能力对识别水中目标有极其重要意义。本文针对混响对目标回波的强时频干扰特性,基于分数阶傅里叶变换所具有的时频耦合分离特性,研究一种基于分数阶傅里叶变换... 详细信息

混响是影响双基地或多基地声呐对水中目标探测识别的最主要干扰,提高抗混响能力对识别水中目标有极其重要意义。本文针对混响对目标回波的强时频干扰特性,基于分数阶傅里叶变换所具有的时频耦合分离特性,研究一种基于分数阶傅里叶变换的强混响抑制方法,并进行模拟仿真和水池测试研究,研究结果验证算法的有效性。本算法适用于信号形式为线性调频的宽带信号抗混响干扰,将脉冲信号在分数阶变换域进行尺度压缩,进而将目标信号和干扰信号在变换域中进行分离,有效达到抗混响的目的。

关键词：混响分数阶傅里叶变换干扰抑制

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao Yuan li xi liu Wenping liang Yu li liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor