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The impact of broad glutamine metabolism inhibition on the tumor microenvironment

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Genes & Diseases 2024年第3期11卷 2-4页

作者： tianhe li Yun-Ta Chuang tian-li wang Departments of Pathology Oncologyand Gynecology and ObstetricsThe Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21231USA

Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and *** also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox *** cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.

关键词： metabolism tumor microenvironment

A Novel High-Entropy Amorphous Thin Film with High Electrical Resistivity and Outstanding Corrosion Resistance

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Acta Metallurgica Sinica(English Letters) 2021年第11期34卷 1537-1545页

作者： Chuang-Shi Feng tian-Wei Lu tian-li wang Man-Zhen lin Junhua Hou Wenjun Lu Wei-Bing liao College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China

This study explores a novel WNbMoTaV high-entropy thin film(HETF)in amorphous structure via pulsed laser deposition *** formation of amorphous structure of this high-entropy alloy is ascribed to the high cooling rate during the deposition *** HETF shows a smooth surface with a height fl uctuation of less than 13 *** film has a high electrical resistivity of~320.6μΩ·cm and a low corrosion current density of 0.088μA/cm *** corrosion resistance of the HETF at ambient temperature is superior to the conventional AISI 316 L stainless *** high electrical resistivity and excellent corrosion resistance of the HETF are mainly attributed to its chemical disorder,cocktail effect and homogeneous amorphous *** experimental phenomenon not only provides a basis for the preparation of amorphous alloy films with low glass forming ability by pulsed laser deposition system,also promotes the potential application of WNbMoTaV HETF in the microelectronic components as resistivity sensors.

关键词： High-entropy alloys Thin films Electrical resistivity Microstructures Corrosion behaviors

Warm Deformation Behavior of Steels Containing Carbon of 0.45% to 1.26% With Martensite Starting Structure

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Journal of Iron and Steel Research International 2010年第5期17卷 34-37页

作者： li Qun wang tian-sheng li Hong-biao GAO Yu-wei liNing JING tian-fu State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004 Hebei China

Warm deformation was investigated for steels containing carbon of 0. 45%,0. 79%, and 1. 26% respeetively with martensite starting structure, using Gleeble 3500 thermomechanical simulator at the temperature ranging from 873 K to 973 K and the strain rate ranging from 0.1 s^-1 to 0. 001 s^-1. The effect of carbon content on the deformation activation energy, Z value and the deformation resistance was analyzed, The results showed that the deformation resistance decreased with increasing carbon content. The peak stress of the steel containing earbon of 1.26% was decreased by 16.2% compared to the steel containing carbon of 0.45% under the same condition. This may be attributed to the weakening effect of solid solution strengthening which outweighs the precipitation strengthening of cementite.

关键词： carbon steel martensite starting structure warm deformation deformation resistance

Expression and Clinical Significance of REGy in Gastric Cancer Tissue and Variously Differentiated Gastric Cancer Cell lines

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Clinical oncology and cancer researeh 2009年第3期6卷 208-213页

作者： Jia li tian tian Xiaoyi wang Fan li Guosheng Ren Department of General Surgery the First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China

OBJECTIVE To evaluate the REGγ expression in gastric cancer tissue and gastric cancer cell lines of various differentiation levels and its clinical significance. METHODS Immunohistochemistry was used to detect the expression of REGγ protein in 70 specimens of gastric cancer and 30 specimens of normal gastric mucosa. The relationship between the expression of REGγ protein and the biological behaviors of gastric cancer was analyzed. RT-PCR and Western blot were used to detect the mRNA level and the protein expression of REGγ in normal gastric cell line GES-1, well differentiated gastric cancer cell line MKN-28, moderately differentiated gastric cancer cell line SGC-7901 and poorly differentiated gastric cancer cell line BGC-823. RESULTS The expression rate of REGγ protein in gastric cancer tissue （52/70, 74.29%） was significantly higher than that in normal gastric tissue （12/30, 40%）（P 〈 0.01）. The expression rate of REGγ was correlated with tumor size （P 〈 0.01）, lymph node metastasis （P 〈 0.05）, differentiation degree （P 〈 0.01）, infiltration depth （P 〈 0.01） and distant metastasis （P 〈 0.05）. RT-PCR analysis showed that the expression of REGγ mRNA was 0.459 ± 0.079 in the normal gastric mucosa cell ling 0.588 ±0.118 in the well differentiated gastric cancer cell line, 0.715±0.066 in the moderately differentiated gastric cancer cell line, and 0.873 ± 0.099 in the poorly differentiated gastric cancer cell line, showing a negative correlation between REGγ mRNA expression and differentiation level （P 〈 0.05）. Western blot analysis showed that the expression of REGγ protein was 0.712±0.065 in the normal gastric mucosa cell line, 1.176±0.185 in the well differentiated gastric cancer cell line, 1.533 ± 0.127 in the moderately differentiated gastric cancer cell line, and 2.061± 0.398 in the poorly differentiated gastric cancer cell line, showing a negative correlation between REGγ protein expression and differentiation level （P 〈 0.05）. CONCLUSION REGγ is expressed in gas

关键词： gastric tumor REGy immunohistochemistry gene protein.

Growth of Nano-Sb_2O_3 on Mica Substrates and Flame Retardant Properties

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Journal of China University of Mining and Technology 2006年第3期16卷 266-269页

作者： FENG li liU Jiong-tian wang Bing-guo SONG Shuo-jiang School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

In this paper, the Sb2O3 nanoparticles prepared with SbCl3 by the alky hydrolysis, processed with the surfactants, were assembled on mica substrates. The morphology and the assembled behavior of the nano-Sb2O3 on the mica were analyzed by means of TEM. The flame retardant properties of nano-Sb2O3 and Sb2O3/mica complex were studied by combustion test and thermal analysis. The results show that the Sb2O3 nanoparticles are assembled uniformly on the mica substrates. The nano-Sb2O3 was characterized with small size, narrow size distribution, uniform crystal and monodispersed particles. Compared with nano-Sb2O3, the Sb2O3/mica complexes have been achieved the same coordinated effects with Chlorinated Paraffin(CP) and excellent flame retardant properties.

关键词： Sb2O3 nanoparticle mica flame retardant chlorinated-paraffin

Fecal microbiota in pouchitis and ulcerative colitis

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World Journal of Gastroenterology 2016年第40期22卷 8929-8939页

作者： Kai-Yu li Jian-lin wang Jiang-Peng Wei Sen-Yang Gao Ying-Ying Zhang li-tian wang Gang liu Department of General Surgery Tianjin Medical University General Hospital Department of General Surgery Tianjin NanKai Hospital

AIM To investigate the changes in microbiota in feces of patients with ulcerative colitis(UC) and pouchitis using genomic *** Fecal samples were obtained from UC patients with or without an ileal pouch-anal anastomosis(IPAA) procedure, as well as healthy controls. The touchdown polymerase chain reaction technique was used to amplify the whole V3 region of the 16 S r RNA gene, which was transcribed from DNA extracted from fecal samples. Denaturing gradient gel electrophoresis was used to separate the amplicons. The band profiles and similarity indices were analyzed digitally. The predominant microbiota in different groups was confirmed by sequencing the 16 S rR NA gene. RESULTS Microbial biodiversity in the healthy controls was significantly higher compared with the UC groups(P libacterium prausnitzii and Eubacterium rectale, were reduced in UC. Patients with pouchitis had an altered microbiota composition compared with UC patients. The microbiota from pouchitis patients was less diverse than that from severely active UC patients. Sequencing results showed that similar microbiota, such as Clostridium perfringens, were shared in both UC and *** Less diverse fecal microbiota was present in patients with UC and pouchitis. Increased C. perfringens in feces suggest its role in the exacerbation of UC and pouchitis.

关键词： Pouchitis Intestinal flora Ulcerative colitis Disease activity index Ileal pouch-anal anastomosis

Submerged culture of Magnetospirillum gryphiswaldense under N_2-fixing condition and regulation of activity of nitrogen fixation

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Chinese Science Bulletin 2002年第24期47卷 2095-2099页

作者： JIANG Wei, ZHAO Dehua, li Ying, tian Jiesheng, wang Zhenfang & li JilunDepartment of Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100094, China Department of Microbiology College of Biological Sciences China Agricultural University Beijing China

A submerged culture technique for Magneto-spirillum gryphiswaldense under the nitrogen-fixing condition (microaerobic and N-limited) was set up. In N-limited medium with Na-lactate as a sole carbon source, the optical density (A600 nm) and activity of nitrogen fixation of cells were 1.3 and 217 nmol of ethylene produced per hour per A600nm respectively within 21 h by three times of feeds. The pH and temperature were controlled at 7.2 and 30℃ respectively, and the oxygen concentration was controlled by sparging with N2 containing 0.4%-0.8% of O2. The activity of nitrogen fixation of cells was obviously inhibited by oxygen and ammonium. It indicated that the posttranslational regulation of nitrogenase existed in M. gryphiswaldense.

关键词： M. gryphiswaldense submerged culture nitrogen fixation regulation of nitrogenase activity.

Surgical treatment of posttraumatic foreign bodies in the heart or great vessels

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Chinese Medical Journal 2006年第23期119卷 2018-2020页

作者： JIANG Chun-li GU tian-xiang wang Chun Department of Cardiac Surgery First Hospital of China MedicalUniversity Shenyang 110001 China

Posttraumatic foreign bodies in the heart or great vessels is rare, which may cause cardiac tamponade, bleeding, shock, infection, embolism, arrhythmia, valve dysfunction, etc.13 The foreign bodies can be removed by surgery or percutaneous intervention.4 In this report we reviewed our experience in managing posttraumatic foreign bodies in 13 patients at our institution from 1992 to 2002.

关键词： thoracic injuries heart injuries foreign bodies blood vessels vascular surgical procedures

Hydrogen sulfide donor regulates alveolar epithelial cell apoptosis in rats with acute lung injury

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Chinese Medical Journal 2013年第3期126卷 494-499页

作者： liU Wen-li liU Zhi-wei li tian-shui wang Cong ZHAO Bin Department of Emergency Medicine Beijing Jishuitan Hospital Beijing 100035 China

Background Acute lung injury （Ali） is a common syndrome associated with high morbidity and mortality in emergency medicine. Cell apoptosis plays a key role in the pathogenesis of ALl. Hydrogen sulfide （H2S） plays a protective role during acute lung injury. We designed this study to examine the role of H2S in the lung alveolar epithelial cell apoptosis in rats with ALl. Methods Sixty-nine male Sprague Dawley rats were used. Ali was induced by intra-tail vein injection of oleic acid （OA）. NariS solution was injected intraperitonally 30 minutes before OA injection as the NariS pretreatment group. Single sodium hydrosulfide pretreatment group and control group were designed. Index of quantitative assessment （IQA）, wet/dry weight （W/D） ratio and the percentage of polymorphonuclear leukocyte （PMN） cells in the bronchoalveolar lavage fluid （BALF） were determined. H2S level in lung tissue was measured by a sensitive sulphur electrode. Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling （TUNEL） staining and Fas protein was measured by immunohistochemical staining. Results The level of endogenous H2S in lung tissue decreased with the development of ALl induced by OA injection. Apoptosis and Fas protein in alveolar epithelial cells increased in the ALl of rats but NariS lessened apoptosis and Fas protein expression in alveolar epithelial cells of rats with ALl. Conclusion Endogenous H2S protects rats from oleic acid-induced ALl, probably by inhibiting cell apoptosis.

关键词： hydrogen sulfide acute lung injury cell apoptosis