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FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

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Science China life Sciences 2025年

作者： Dake Xiao Haowen Ran lishu chen Yuanyuan li Yan Cai Songyang Zhang Qinghui Qi Huiran Wu cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan li Tao Zhou Fangye li Ailing li Jianghong Man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda Zhang Weimin Yuan Zhixing ling Yong chen Nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu Mingjun liu Xing liu Yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng chen Houlei chen Tianxiang chen Wei chen Yehai chen Yifan chen chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui li Junfei li Longhui li Maoshun li Wei li Zhengda li Tianying lian Congzhan liu Heyang liu Huaqiu liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

Asymptotic Properties of the Maximum likelihood Estimate in Generalized linear Models with Stochastic Regressors

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1679-1686页

作者： Jie li DING Xi ru chen School of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China Graduate School Chinese Academy of Sciences Beijing 100039 P. R. China

For generalized linear models （GLM）, in case the regressors are stochastic and have different distributions, the asymptotic properties of the maximum likelihood estimate （MLE） β^n of the parameters are studied. U... 详细信息

关键词： Generalized linear models Consistency Asymptotic normality

A Cache Replacement Policy Based on Multi-Factors for Named Data Networking

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Computers, Materials & Continua 2020年第10期65卷 321-336页

作者： Meiju Yu ru li Yuwen chen College of Computer Science Inner Mongolia UniversityHohhot020021China Department of Computer Systems Technology New York City College of Technology-The City University of New YorkBrooklynNY 11201USA

Named Data Networking(NDN)is one of the most excellent future Internet architectures and every router in NDN has the capacity of caching contents passing *** greatly reduces network traffic and improves the speed of content distribution and *** order to make full use of the limited caching space in routers,it is an urgent challenge to make an efficient cache replacement ***,the existing cache replacement policies only consider very few factors that affect the cache *** this paper,we present a cache replacement policy based on multi-factors for NDN(CRPM),in which the content with the least cache value is evicted from the caching *** fully analyzes multi-factors that affect the caching performance,puts forward the corresponding calculation methods,and utilize the multi-factors to measure the cache value of ***,a new cache value function is constructed,which makes the content with high value be stored in the router as long as possible,so as to ensure the efficient use of cache *** simulation results show that CPRM can effectively improve cache hit ratio,enhance cache resource utilization,reduce energy consumption and decrease hit distance of content acquisition.

关键词： Cache replacement policy named data networking content popularity freshness energy consumption

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang chengyihan Gu Yinghan chen Wencheng Yan Yong liang Weipeng li chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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胸腹腔镜对比开放Ivor-Lewis术治疗食管中下段癌的疗效分析

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中国现代医学杂志 2018年第35期28卷 53-58页

作者：陈立如谢琛陈梅花林庆柳阳春徐全江西省人民医院胸外科江西南昌330006 江西省人民医院神经内科江西南昌330006

目的探讨胸腹腔镜Ivor-Lewis术在食管中下段癌手术治疗中的临床应用。方法回顾分析2014年3月—2016年5月行Ivor-Lewis术治疗胸中下段食管癌的148例患者的临床资料。按手术方式分为胸腹腔镜Ivor-Lewis组(腔镜组,80例)或开放Ivor-Lewis组... 详细信息

目的探讨胸腹腔镜Ivor-Lewis术在食管中下段癌手术治疗中的临床应用。方法回顾分析2014年3月—2016年5月行Ivor-Lewis术治疗胸中下段食管癌的148例患者的临床资料。按手术方式分为胸腹腔镜Ivor-Lewis组(腔镜组,80例)或开放Ivor-Lewis组(开放组,68例)。两组患者术前一般资料比较,差异无统计学意义(P>0.05)。比较两组患者围手术期情况及2年随访结果。结果与开放组相比,腔镜组淋巴结清扫枚数多、出血量少,术后住院时间缩短,总并发症减少,其中以肺部并发症减少为主;腔镜组总手术时间长,住院费用增加(P 0.05)。结论胸腹腔镜Ivor-Lewis术在肿瘤根治性、术中出血控制、术后恢复等方面具有优势,近期并发症少,且远期效果可靠,值得临床推广。

关键词：食管癌胸腔镜腹腔镜 Ivor-Lewis术外科治疗

Theoretical Investigation of Detailed Thermodynamic Character of Possible Difunctional Adducts Model

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Chinese Journal of Structural Chemistry 2006年第5期25卷 533-542页

作者： CHANG Guan-ru ZHOU li-Xin chen Dong Department of Chemistry Jinan University Guangzhou Guangdong 510632 China

The B3LYP/6-31G^＊ level of theory was used to optimize trans-[Pt（NH3）（Am）G-L], where Am = quinoline or thiazole and L is chosen as the model for functional groups of peptide side chains, and for adenine and guanine sites of DNA as the ultimate target of platinum anticancer drugs. Bond dissociating energy and stability energy of complexes are chosen to study detailedly thermodynamic character of possible difunctional adducts model. In order to investigate the influence of a polarizable environment on the energy of the Pt-L bond formation, we adopt a new bonding energy formula brought forward by lippard and his coworkers： △H（Sol） = △H（SCF）＋ △G（Solv）, which is quite appropriate to compare with what is found in experimental studies. Our calculated results demonstrate that N-containing ligands are more favored in view of thermodynamics both in gas phrase and in solution. However, it is worthly to be noted that addition of solvation free energies result in moderate correction of bonding energy in relative ordering, and the largest ones both present in imidazole ligand, not in guanine ligand. Finally, the nature of bond is analyzed in terms of partial charges distribution based on NBO population.

关键词： nonclassical transplatin antitumor drug difunctional adduct DFT

High Pressure Raman Study of Phase Transitions on Solid Benzene Using Raman Notch Filter Set

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Chinese Physics Letters 1996年第4期13卷 293-296页

作者： XU li-wen WANG ru-ju chen liang-chen Institute of Physics Chinese Academy of SciencesBeijing 100080

A high-throughput Haman notch filter set has been manufactured and used to collect the Raman scattering signals of pressure-hiduced phase transitions of solid benzene in a diamond anvil cell up to 15 GPa at room *** changes in the profiles as well as the frequencies of Raman scattering spectra are observed and enable us to determine the phase transition.

关键词： temperature. transition. Transition

Surface modification of poly(vinyl chloride)by long-distance and direct argon RF plasma

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Chinese Science Bulletin 2006年第5期51卷 615-619页

作者： li ru chen Jierong College of Environmental and Chemical Engineering Xi'an Jiaotong University Xi'an 710049 China College of Environmental and Chemical Engineering Xi'an University of Engineer Science &Technology Xi'an 710048 China

This paper reports the effects of long- distance and direct argon radio frequency (RF) plasma surface treatment on polyvinyl chloride (PVC) films in terms of changes in surface wettability and surface chemistry. The surface properties are char- acterized by the water contact angle measurement, X-ray photoelectron spectroscopy (XPS) and scan- ning electron microscopy (SEM). The mechanism is further analyzed and the role of all kinds of active species, e.g. electrons, ions and free radicals in- volved in plasma surface modification is further evaluated. Results show that the long-distance and direct RF plasma treatments modify the PVC surface in morphology and composition, and both modifica- tions cause surface oxidation of PVC films, in the forming of functional groups enhancing polymer wet- tability. The effect of the long-distance argon RF plasma is more notable. This suggests that long-distance argon RF plasma could restrain the ion and electron eroding effect and enhance free radical reaction.

关键词：聚氯乙烯表面改性远距离射频氩等离子体表面处理 X射线光电子光谱学扫描电子显微术