检索结果-南通市图书馆

维普期刊数据库博看期刊

A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第7期19卷 505-520页

作者： MI li li Yu-chen SUN Meng-ru ZHANG Pei-lin li Yi YANG Hua State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

The tubers and roots of Aconitum(Ranunculaceae)are widely used as heart medicine or analgesic agents for the treatment of coronary heart disease,chronic heart failure,rheumatoid arthritis and neuropathic pain since ancient *** a type of natural products mainly extracted from Aconitum plants,Aconitum alkaloids have complex chemical structures and exert remarkable biological activity,which are mainly responsible for significant effects of Aconitum *** present review is to summarize the progress of the pharmacological,toxicological,and pharmacokinetic studies of Aconitum alkaloids,so as to provide evidence for better clinical *** data concerning pharmacological,toxicological and pharmacokinetic studies of Aconitum alkaloids were collected from different scientific databases(PubMed,CNKI,Google Scholar,Baidu Scholar,and Web of Science)using the phrase Aconitum alkaloids,as well as generic *** alkaloids are both bioactive compounds and toxic ingredients in Aconitum *** produce a wide range of pharmacological activities,including protecting the cardiovascular system,nervous system,and immune system and anti-cancer ***,Aconitum alkaloids also exert strong cardiac toxicity,neurotoxicity and liver toxicity,which are supported by clinical ***,pharmacokinetic studies indicated that cytochrome P450 proteins(CYPs)and efflux transporters(ETs)are closely related to the low bioavailability of Aconitum alkaloids and play an important role in their metabolism and detoxification in vivo.

关键词： Aconitum alkaloids Pharmacological activities Toxicity Pharmacokinetics

A new method for the stability analysis of geosynthetic-reinforced slopes

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2016年第11期13卷 2069-2078页

作者： SONG Fei chen ru-yi MA li-qiu CAO Geng-ren Institute of Geotechnical Engineering School of Highway EngineeringChang'an UniversityXi'an 710064China Guizhou Electricity Engineering Construction Supervise Company Guiyang 550005China Merchants Chongqing Communications Research and Design Institute Co. Ltd.Chongqing 400067China

This paper is concerned with the stability analysis of reinforced slopes.A new approach based on the limit equilibrium principle is proposed to evaluate the stability of the reinforced *** effect of reinforcement is modeled as an equivalent restoring force acting the bottom of the slice and added into the general limit equilibrium(GLE) *** equations of force and moment equilibrium of the slice are derived and corresponding iterative solution methods are *** new method can satisfy both the force and the moment equilibrium and be applicable to the critical failure surface of arbitrary ***,the results predicted by the proposed method are compared with the calculation examples of other researchers and the centrifuge model test results to validate its correctness and effectiveness.

关键词： Reinforced slope Stability analysis limit equilibrium General limit equilibrium method Centrifuge model test

在线全文

学校读者我要写书评

暂无评论

用吸附法从察尔汗盐湖卤水中提取锂

湿法冶金 2003年第3期22卷 118-128页

作者：何力陈儒庆徐运海蔡炳荃核工业北京化工冶金研究院北京101149

研究了用两步吸附法从察尔汗高镁低锂盐湖卤水中提取锂。将卤水用水稀释并用盐酸调整pH至4～6之间,先用自制的锂吸附剂吸附锂、镁,用水淋洗负载吸附剂,获得含锂、镁溶液,再用阳离子交换树脂吸附锂、镁,之后用1mol/LHCl或60g/LNaCl溶液... 详细信息

研究了用两步吸附法从察尔汗高镁低锂盐湖卤水中提取锂。将卤水用水稀释并用盐酸调整pH至4～6之间,先用自制的锂吸附剂吸附锂、镁,用水淋洗负载吸附剂,获得含锂、镁溶液,再用阳离子交换树脂吸附锂、镁,之后用1mol/LHCl或60g/LNaCl溶液淋洗锂,用3mol/LHCl或150g/LNaCl溶液淋洗镁。含锂淋洗液用Na2CO3沉淀可获得li2CO3产品。该方法简单,易行,无环境污染,经济效益明显。

关键词：锂两步吸附法卤水青海察尔汗盐湖沉淀法离子交换法溶剂萃取法提取

Circumventing brittleness of 3D-printed Al_(2)O_(3)cellular ceramic structures via compositing with polyurea

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第11期43卷 5994-6005页

作者： Xue-Qin Zhang ru-Yue Su Xiong Gao Jing-Yi chen Guo liu ru-Jie He Ying li Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China Department of Mechanical Engineering City University of Hong KongHongKong999077China

Benefiting from excellent mechanical properties and low density,cellular ceramic structures(CCSs)are competitive candidates as structural ***,inherent brittleness from strong chemical bonds among atoms extremely impeded CCSs'*** materials occupied outstanding strength and toughness simultaneously due to the dual-phase interpenetrated *** by natural materials,it was proposed to fabricate coating covered and fulfilled polyurea/CCS interpenetrated composites(C/CCSs and B/CCSs)to circumvent the brittleness of 3D-printed Al_(2)O_(3)*** was demonstrated that polyurea coating had less effect on the compressive strength of C/CCSs but tremendously improved their energy-absorbing *** energy-absorbing ability of C/CCSs was improved from26.48-52.57 kJ·m^(-3)of CCSs to 1.04-1.89 MJ·m^(-3)because of the extended plateau ***,compressive strength and energy-absorbing ability of B/CCSs were strengthened to 1.33-1.36 and 2.84-4.61 times of C/CCSs,***,failure mode of C/CCSs changed from localized deformation to fracturing entirely with the increase in relative density of CCSs inside,which was the same as that of ***,with the help of polyurea coating,C/CCSs were still intact at strains up to60%,which would neve r fail catastrophically as CCSs at low strains.B/CCSs tended to fracture as a whole,which was not influenced by relative density of pristine *** was believed that this work provided a creative way to circumvent the brittleness of CCSs and improve their mechanical performances.

关键词： Cellular ceramic structures Dual-phase interpenetrated composites Energy-absorbing ability Compressive strength 3D printing

Quantum Remote State Preparation Based on Quantum Network Coding

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第10期73卷 119-132页

作者： Zhen-Zhen li Zi-chen li Yi-ru Sun Haseeb Ahmad Gang Xu Xiu-Bo chen School of Information Engineering Beijing Institute of Graphic CommunicationBeijing102600China School of Computer Science and Information Engineering Zhejiang Gongshang UniversityHangzhou310018China Information Security Center State key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Department of Computer Science National Textile UniversityFaisalabad37610Pakistan School of Information Science and Technology North China University of TechnologyBeijing100144China Advanced Cryptography and System Security Key Laboratory of Sichuan Province China

As an innovative theory and technology,quantum network coding has become the research hotspot in quantum network *** this paper,a quantum remote state preparation scheme based on quantum network coding is *** with the general quantum remote state preparation schemes,our proposed scheme brings an arbitrary unknown quantum state finally prepared remotely through the quantum network,by designing the appropriate encoding and decoding steps for quantum network *** is worth mentioning,from the network model,this scheme is built on the quantum k-pair network which is the expansion of the typical bottleneck network—butterfly ***,it can be treated as an efficient quantum network preparation scheme due to the characteristics of network coding,and it also makes the proposed scheme more applicable to the large-scale quantum *** addition,the fact of an arbitrary unknown quantum state remotely prepared means that the senders do not need to know the desired quantum ***,the security of the proposed scheme is ***,this scheme can always achieve the success probability of 1 and 1-max flow of value ***,the communication efficiency of the proposed scheme is ***,the proposed scheme turns out to be practicable,secure and efficient,which helps to effectively enrich the theory of quantum remote state preparation.

关键词： Quantum remote state preparation quantum network coding quantum k-pair network

Effects of long-term phosphorus fertilization and straw incorporation on phosphorus fractions in subtropical paddy soil

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2015年第2期14卷 365-373页

作者： li Yu-yuan YANG rui GAO ru WEI Hong-an chen An-lei li Yong Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences School of Environmental and Municipal Engineering Xi'an University of Architecture and Technology

Study on soil phosphorus（P） fraction is an important aspect in probing the mechanisms of soil P accumulation in farmland and mitigating its losing risk to the environment. We used a sequential extraction method to evaluate the impacts of long-term fertilization and straw incorporation on inorganic, organic, and residual P（Pi, Po, and Pre） fractions in the plow layer（0–20 cm） of acidic paddy soil in southern China. The experiment comprised of six treatments：（i） no fertilizer control（CK）;（ii） straw incorporation and green manure（SG）;（iii） nitrogen and P fertilizer（NP）;（iv） NP＋SG;（v） NP＋K fertilizer（NPK）; and（vi） NPK＋SG. The results showed that, compared to the initial total soil P content（TSP, 600 mg kg^–1 in 1990）, long-term（20 years） combined continuous P fertilizer and SG significantly increased P accumulation（by 13–20%） while single fertilization（39.3 kg P ha^–1 yr^–1） could maintain soil P status at the most. The average soil P fractions comprised of extractable Pi, Po, and Pre by 51.7, 33.4, and 14.9% in total soil P, respectively. With comparison of no fertilizer addition（CK）, long-term single fertilization significantly（P〈0.05） increased the accumulation of Na HCO3^–, Na OH^–, and HCl^– extractable Pi fractions accounting for two- to three-fold, while SG increased the accumulation of Na HCO3^– and Na OH^– extractable Piand Po accounting for 12–60%. Though the mobilization of Pre fractions was not significant（P〉0.05）, our data indicate that SG may partially substitute for fertilizer P input and minimizing soil P accumulation and subsequent environmental risk in the subtropical paddy soil.

关键词： soil organic P soil inorganic P sequential extraction method soil P accumulation soil P mobilization manure application

丹酚酸B调控脂质代谢改善非酒精性脂肪肝实验研究

在线全文

学校读者我要写书评

暂无评论

中国药理学通报 2025年第1期41卷 107-115页

作者：张佳健郭梦茹梅金玉陈明安徽医科大学基础医学院药理学教研室安徽合肥230032 安徽医科大学第二附属医院耳鼻喉科安徽合肥230601

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低... 详细信息

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低剂量为15 mg·kg^(-1)·d^(-1),高剂量为30 mg·kg^(-1)·d^(-1),对照组和模型组用等剂量生理盐水灌胃。肝脏转录组测序结果揭示模型组和SalB组的差异表达基因,HE染色、油红O染色观察肝组织的病理变化,试剂盒检测血清和肝组织的脂质、氧化应激和炎症指标,RT-qPCR检测Lcn2、SREBP-1C以及脂质合成相关酶的mRNA水平。体外实验,用棕榈酸(PA)诱导L02和LX-2细胞24 h建立NAFLD模型,用SalB(30μmol·L^(-1))和PA(0.2 mmol·L^(-1))共孵育检测SalB体外改善NAFLD的情况。试剂盒检测L02细胞TC、TG的含量,细胞油红O染色试剂盒检测L02细胞的脂质积累,RT-qPCR检测LX-2细胞Lcn2、SREBP-1C以及脂质合成相关酶基因的mRNA水平。结果模型组血清、肝脏的生化指标异常,肝组织脂质、炎症和氧化应激水平升高,出现大面积脂肪空泡和大量的脂质沉积,PA诱导的L02细胞也出现大量的脂质积累,在SalB干预后均有明显改善。转录组测序结果表明SalB可以调控肝脏脂质代谢和炎症。肝脏和LX-2细胞mRNA水平显示模型组Lcn2、SREBP-1C以及脂质合成相关酶基因表达明显上调,SalB干预后均能降低这些基因的表达。结论丹酚酸B可以明显改善非酒精性脂肪肝,其机制可能是通过下调Lcn2、SREBP-1C和脂质合成酶的表达。

关键词： SalB 非酒精性脂肪肝脂质代谢 Lcn2 SREBP-1C 脂质合成相关酶

Probing granular inhomogeneity of a particle-emitting source by imaging two-pion Bose–Einstein correlations

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2021年第2期32卷 81-89页

作者： li-Ya li Peng ru Ying Hu School of Mathematics and Economics Hubei University of EducationWuhan 430205HubeiChina Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China

Using the source imaging technique in two-pion interferometry,we study the image of the hydrodynamic particle-emitting source with the HIJING initial conditions for relativistic heavy-ion collisions on an event-by-event *** is shown that the initial-state fluctuations may give rise to bumpy structures of the medium during hydrodynamical evolution,which affects the two-pion emission space and leads to a visible two-tiered shape in the source function imaged using the two-pion Bose–Einstein *** two-tiered shape can be understood within a similar but more analytic granular source model and is found to be closely related to the introduced quantity n,which characterizes the granular inhomogeneity of the *** fitting the imaged source function with a granular source parametrization,we extract the granular inhomogeneity of the hydrodynamic source,which is found to be sensitive to both the Gaussian smearing width of the HIJING initial condition and the centrality of the collisions.

关键词： Heavy-ion collision Bose-Einstein correlations Imaging technique

Experimental and numerical study of thermal fatigue behavior under variable amplitude induced by pulsed laser

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2018年第10期61卷 88-91页

作者： SiNing Pan Gang Yu Xiuli He ShaoXia li ru chen Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Thermal fatigue is the typical failure mode of high-temperature combustion chamber components used in power plants and in the aerospace and transportation industries [1-3]. With growing demand for good performance and high reliability, thermal fatigue is becoming a serious problem. The thermal working conditions of combustion chamber components include start-stop cycles and routine working cycles simultaneously [4,5]. The former refer to large temperature changes, with the amplitude of 200℃-500℃ and time period of several hundred seconds that are responsible for low-cycle fatigue （LCF） damage. The latter correspond to low temperature amplitudes of 20℃-60℃, with time period of milliseconds, and are responsible for high-cycle fatigue （HCF） damages.

关键词：疲劳行为振幅试验性工作周期可变光导学习交通工业