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Gene mutations in newly diagnosed multiple myeloma patients detected by next-generation sequencing technology

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Cancer Pathogenesis and Therapy 2024年第3期2卷 205-211页

作者： Yutong Wang Mengzhen Wang Bin Chu Minqiu Lu Lei Shi Shan Gao Yuan Chen Qin yan Na Ji li Bao Department of Hematology Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

Background:Multiple myeloma(MM)is a heterogeneous plasma-derived hematopoietic malignancy with complex genetic mutation contributing to the *** gene sequencing has been applied in MM,genetic features from Chinese MM patients are reported *** investigated the genetic mutation of newly diagnosed multiple myeloma(NDMM)patients and explore its correlation with cytogenetic abnormalities detected by fluorescence in situ hybridization(FISH).Methods:A total of 206 patients with NDMM were *** enriching plasma cells with CD138 magnetic beads,92 MM-related target gene mutations were detected by the Illumina sequencing platform,and six common genetic abnormalities were detected by ***:162 cases(78.6%)had at least one gene mutation detected by *** top 5 mutated genes were KRAS,NRAS,TRAF3,BRAF,and *** abnormalities detected by FISH have a certain correlation with gene mutations,t(11;14)translocations are often accompanied by CCND1 and TP53 mutations,KLHL6 in t(4;14),SP140,CDKN1B and PRKD2 in t(14;16)and t(14;20)*** mutation ratio was higher for EGR1,while lower of CCND1 in patients with gain *** TP53 mutation was more likely in patients with 17p *** gene mutation affects the pathway of the RNA process is more frequently occurring in males and age less than 70 years *** International Staging System(ISS)Stage Ⅲ correlated with gene mutations in the NK-κB pathway while Revised ISS(R-ISS)Stage Ⅲ correlated with the DNA damage repair ***:There are various gene mutations in NDMM patients,mainly RAS/MAPK and NF-κB pathway gene pathways.

关键词： Multiple myeloma Next-generation sequencing Genetics mutation

儿童戏剧汲养神话精神的三个维度:象征、身体与狂欢

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四川戏剧 2024年第6期 10-14页

作者：李明真延保全山西师范大学戏剧与影视学院

儿童戏剧与神话在发生学上具有同源性,在想象性建构上也具有相似性。神话想象中的超然性和仪式性、神话身体性中的直观感性和真实性交流,以及神话精神中的狂欢表达,都与儿童戏剧的创作规律有着内在本质上的对应关系。儿童戏剧从神话精... 详细信息

儿童戏剧与神话在发生学上具有同源性,在想象性建构上也具有相似性。神话想象中的超然性和仪式性、神话身体性中的直观感性和真实性交流,以及神话精神中的狂欢表达,都与儿童戏剧的创作规律有着内在本质上的对应关系。儿童戏剧从神话精神的三个维度汲取养分,既为儿童戏剧的创作提供了强大的动力源泉,也对探寻儿童戏剧的艺术精神具有重要意义。

关键词：儿童戏剧神话精神神话象征身体性狂欢性

Flake channels construction of hydroxyapatite/gelatin cryogel with excellent flame retardant properties for enhancing the capturing of iodine

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Collagen and Leather 2024年第1期5卷 101-112页

作者： yanxia Wei Bo Wang liyan Cao Xin Cheng Yuhan Qiao Tao Duan Guiqiang He Pingping Ding yan Zhou Jian Zhou Engineering Research Center of Biomass Materials School of Life Science and EngineeringMinistry of EducationSouthwest University of Science and Technology The Collelge of Nuclear Technology and Automation Engineering Chengdu University of Technology NHC Key Laboratory of Nuclear Technology Medical Transformation Mianyang Central Hospital

Safe and efficient capturing of volatile radioiodine is of extremely important significance in the treatment of spent ***,the flake channels in gelatin-hydroxyapatite（HAP@Ge） cryogel with excellent flame retardant properties were constructed by immobilizing hydroxyapatite nanorods（HAP） on Gelatin（Ge） cryogel for enhancing the capturing of *** immobilization of HAP nanorods enhanced thermal stability,provided low rates of dynamic heat transfer and dissipation,and remarkably improved the flame retardant and smoke suppression properties of the Ge cryogel,which can effectively prevent the occurrence of safety incidents caused by further thermal degradation or combustion of this *** importantly,it was effective in improving the rapid enrichment of iodine,resulting in a high adsorption *** maximum adsorption capacity of HAP@Ge cryogel for iodine vapor reached2693 mg/g at *** high adsorption capacity for iodine was attributed to the multi-scale porous structure in HAP@Ge cryogel,which offered effective channels for iodine diffusion,whereas the numerous complex and irregular flakes provided sufficient number of active sites for iodine *** adsorption process was chemical in nature and involved the-PO43-,-OH,-C=O,and-NHR groups on HAP@Ge ***,the complex porous structure of HAP@Ge cryogel enhanced the physical capturing of *** advantages,such as low-cost raw material,simple preparation method,good flame retardancy,and excellent capturing performance for iodine indicated that HAP@Ge cryogel is a potential candidate for the removal of radioactive iodine in the exhaust gas stream of post-treatment plants.

关键词： Gelatin Hydroxyapatite nanorod Flake channel Flame retardancy Iodine capture

Screening-current-induced magnetic fields and strains in a compact REBCO coil in self field and background field

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Superconductivity 2024年第1期9卷 35-49页

作者： Yufan yan Donghui Jiang Peng Song Jeonghwan Park Seungyong Hahn Yunfei Tan Timing Qu Department of Electrical and Computer Engineering Seoul National UniversitySeoul 08826Republic of Korea State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Wuhan National High Magnetic Field Center Huazhong University of Science and TechnologyWuhan 430074China

REBa_(2)Cu_(3)O_(7−x)(REBCO)coated conductors,owing to its high tensile strength and current‐carrying ability in a background field,are widely regarded a promising candidate in high‐field *** the great potentials,recent studies have highlighted the challenges posed by screening currents,which are featured by a highly nonuniform current distribution in the superconducting *** this paper,we report a comprehensive study on the behaviors of screening currents in a compact REBCO coil,specifically the screeningcurrent‐induced magnetic fields and *** were carried out in the self‐generated magnetic field and a background field,*** the self‐field condition,the full hysteresis of the magnetic field was obtained by applying current sweeps with repeatedly reversed polarity,as the nominal center field reached 9.17 T with a maximum peak current of 350 *** a background field of 23.15 T,the insert coil generated a center field of 4.17 T with an applied current of 170 ***,a total center field of 32.58 T was achieved before *** the sequential model and the coupled model considering the perpendicular field modification due to conductor deformation are *** comparative study shows that,for this coil,the electromagnetic–mechanical coupling plays a trivial role in self‐field conditions up to 9 *** contrast,with a high axial field dominated by the background field,the coupling effect has a stronger influence on the predicted current and strain *** discussions regarding the role of background field on the strains in the insert suggest potential design strategies to maximize the total center field.

关键词： Electromagnetic-mechanical analysis High‐field insert coil REBCO coated conductor Screening‐current‐induced magnetic field Screening‐current‐induced stress

An AI-empowered indoor digital contact tracing system for COVID-19 outbreaks in residential care homes

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Infectious Disease Modelling 2024年第2期9卷 474-482页

作者： Jiahui Meng Justina Yat Wa liu lin yang Man Sing Wong Hilda Tsang Boyu Yu Jincheng Yu Freddy Man-Hin Lam Daihai He Lei yang yan li Gilman Kit-Hang Siu Stefanos Tyrovolas Yao Jie Xie David Man David H.K.Shum School of Nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Research Centre of Textiles for Future Fashion The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Computing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Nutrition and Food Studies George Mason UniversityUSA Tung Wah College Hong Kong Special Administrative RegionChina Mental Health Research Centre The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

An AI-empowered indoor digital contact-tracing system was developed using a centralized architecture and advanced low-energy Bluetooth technologies for indoor positioning,with careful preservation of privacy and data *** analyzed the contact pattern data from two RCHs and investigated a COVID-19 outbreak in one study *** evaluate the effectiveness of the system in containing outbreaks with minimal contacts under quarantine,a simulation study was conducted to compare the impact of different quarantine strategies on outbreak containment within *** significant difference in contact hours between weekdays and weekends was observed for some pairs of RCH residents and staff during the two-week data collection *** significant difference between secondary cases and uninfected contacts was observed in a COVID-19 outbreak in terms of their demographics and contact *** results based on the collected contact data indicated that a threshold of accumulative contact hours one or two days prior to diagnosis of the index case could dramatically increase the efficiency of outbreak containment within RCHs by targeted isolation of the close *** study demonstrated the feasibility and efficiency of employing an AI-empowered system in indoor digital contact tracing of outbreaks in RCHs in the post-pandemic era.

关键词： COVID-19 Indoor contact tracing Contact pattern Outbreak containment Artificial intelligence

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二氧化氯产品危险性分类探讨

化工管理 2024年第9期 159-164页

作者：叶江戎江帆戎霄李亚马茹李叶李洋王燕常州合规思远产品安全技术服务有限公司江苏常州213000

文章探讨了不同浓度二氧化氯产品的危险性,并依据《全球化学品统一分类和标签制度》(以下简称“GHS制度”)第10修订版和《联合国关于危险货物运输的建议书规章范本》(以下简称“TDG法规”)第23修订版,给出了二氧化氯GHS分类和运输危险... 详细信息

文章探讨了不同浓度二氧化氯产品的危险性,并依据《全球化学品统一分类和标签制度》(以下简称“GHS制度”)第10修订版和《联合国关于危险货物运输的建议书规章范本》(以下简称“TDG法规”)第23修订版,给出了二氧化氯GHS分类和运输危险性的建议分类,对常用二氧化氯消毒产品的安全、合规运输具有指导意义。

关键词：二氧化氯 GHS制度 TDG法规

产学研复合系统耦合协调度评价及时空演化研究

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系统科学学报 2024年第2期32卷 126-130页

作者：梁少波宋燕栗继祖太原理工大学经济管理学院山西太原030024 太原理工大学本科生院山西太原030024 太原理工大学求实学院宗复学院山西太原030024

以中国30个省域为研究对象,采用耦合协调度模型、探索性空间数据分析、空间自相关、核密度分析等方法,测算2011—2018年产学研综合发展水平、耦合协调度。研究表明:第一,产学研耦合协调度不断提高,但空间分异显著。第二,省域产学研耦合... 详细信息

以中国30个省域为研究对象,采用耦合协调度模型、探索性空间数据分析、空间自相关、核密度分析等方法,测算2011—2018年产学研综合发展水平、耦合协调度。研究表明:第一,产学研耦合协调度不断提高,但空间分异显著。第二,省域产学研耦合协调度呈现空间正相关关系,但空间相关性较低,空间关联有待加强,省域产学研耦合协调度之间呈现出“空间集聚性”与“空间异质性”并存的特征。第三,省域产学研耦合协调度核密度曲线经历了“向左——向右”的阶段性变化过程,反映出省域产学研耦合协调度整体水平有所提升。

关键词：产学研耦合协调度空间演化

BArcherFuzzer:An Android System Services Fuzzier via Transaction Dependencies of BpBinder

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Intelligent Automation & Soft Computing 2024年第3期39卷 527-544页

作者： Jiawei Qin Hua Zhang Hanbing yan Tian Zhu Song Hu Dingyu yan The State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100080China The National Computer Network Emergency Response Technical Team/Coordination Center of China Beijing100012China

By the analysis of vulnerabilities of Android native system services,we find that some vulnerabilities are caused by inconsistent data transmission and inconsistent data processing logic between client and *** existing research cannot find the above two types of vulnerabilities and the test cases of them face the problem of low *** this paper,we propose an extraction method of test cases based on the native system services of the client and design a case construction method that supports multi-parameter mutation based on genetic algorithm and priority *** on the above method,we implement a detection tool-BArcherFuzzer to detect vulnerabilities of Android native system *** experiment results show that BArcherFuzzer found four vulnerabilities of hundreds of exception messages,all of them were confirmed by Google and one was assigned a Common Vulnerabilities and Exposures(CVE)number(CVE-2020-0363).

关键词： Android OS vulnerability detection binder fuzz testing genetic algorithm

Co-doped BaFe_(2)As_(2) Josephson junction fabricated with a focused helium ion beam

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Chinese Physics B 2024年第4期33卷 181-186页

作者：陈紫雯张焱马平徐中堂李宇龙王越路建明马衍伟甘子钊 Applied Superconductivity Research Center Peking UniversityBeijing 100871China State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Peking UniversityBeijing 100871China Institute of Condensed Matter Physics School of PhysicsPeking UniversityBeijing 100871China yangtze Delta Institute of Optoelectronics Peking UniversityBeijing 100871China Key Laboratory of Applied Superconductivity Institute of Electrical EngineeringChinese Academy of SciencesBeijing 100190China

Josephson junction plays a key role not only in studying the basic physics of unconventional iron-based superconductors but also in realizing practical application of thin-film based devices,therefore the preparation of high-quality iron pnictide Josephson junctions is of great *** this work,we have successfully fabricated Josephson junctions from Co-doped BaFe_(2)As_(2)thin films using a direct junction fabrication technique which utilizes high energy focused helium ion beam(FHIB).The electrical transport properties were investigated for junctions fabricated with various He^(+)irradiation *** junctions show sharp superconducting transition around 24 K with a narrow transition width of 2.5 K,and a dose correlated foot-structure resistance which corresponds to the effective tuning of junction properties by He^(+)*** J_c suppression by more than two orders of magnitude can be achieved by increasing the He^(+)irradiation dose,which is advantageous for the realization of low noise ion pnictide thin film *** Shapiro steps are observed under 10 GHz microwave *** above results demonstrate the successful fabrication of high quality and controllable Co-doped BaFe_(2)As_(2)Josephson junction with high reproducibility using the FHIB technique,laying the foundation for future investigating the mechanism of iron-based superconductors,and also the further implementation in various superconducting electronic devices.

关键词： focused helium ion beam Co doped BaFe_(2)As_(2) Josephson junction