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磁化水对6月龄肉牛生产性能及血清指标的影响

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饲料研究 2024年第6期47卷 12-15页

作者：邵丽玮孙凤莉郭建军刘嫣然王珏符乐李艳荣王晓芳河北省畜牧兽医研究所河北保定071000 承德市农林科学院河北承德067000 沧县农业农村局河北沧州061000

试验旨在研究磁化水对6月龄肉牛生产性能及血清指标的影响。将同一批6月龄左右、体重约300 kg的西门塔尔架子牛212头,随机分为2组。对照组(110头牛)饮用普通水,试验组(102头牛)饮用磁化水。试验期87 d。结果显示,与普通水相比,磁化水的p... 详细信息

试验旨在研究磁化水对6月龄肉牛生产性能及血清指标的影响。将同一批6月龄左右、体重约300 kg的西门塔尔架子牛212头,随机分为2组。对照组(110头牛)饮用普通水,试验组(102头牛)饮用磁化水。试验期87 d。结果显示,与普通水相比,磁化水的pH值提高了7.91%,总硬度和耗氧量降低了0.36%和13.70%,磁化前后水的菌落总数和大肠杆菌数均为0。与对照组相比,试验组10 d的平均日采食量和平均日增重分别增加了4.41%和5.36%(P>0.05)。与对照组相比,试验组血清超氧化物歧化酶和过氧化氢酶活性分别提高了32.82%(P<0.05)和73.36%(P<0.01),丙二醛含量降低,免疫球蛋白A、免疫球蛋白G和免疫球蛋白M含量分别提高了13.85%、3.21%和5.99%,血清尿素氮含量增加了30%(P<0.05),总蛋白含量降低了34.53%(P<0.01),血清胰岛素、生长激素和促生长激素释放激素水平分别提高了10.73%、13.00%和5.04%。研究表明,水被磁化后水质有所改变,磁化水能够增加肉牛采食量和体重,增强血清抗氧化水平、免疫力和生长相关激素水平。

关键词：磁化水肉牛生产性能血清指标

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不同含水率状态下黄土崩塌地质灾害声发射响应特征模型试验

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科学技术与工程 2024年第22期24卷 9293-9301页

作者：杨孝宇李彦荣孙晓慧王智斌太原理工大学矿业工程学院太原030024

为有效解决黄土崩塌灾害孕灾周期短、隐蔽性强、前兆信息难以捕捉的问题,深入研究黄土崩塌监测新方法具有重要的工程与科学意义。目前声发射技术在岩质边坡的监测预警中已取得较好的应用,但将其应用于黄土崩塌监测尚缺乏可靠依据。为此... 详细信息

为有效解决黄土崩塌灾害孕灾周期短、隐蔽性强、前兆信息难以捕捉的问题,深入研究黄土崩塌监测新方法具有重要的工程与科学意义。目前声发射技术在岩质边坡的监测预警中已取得较好的应用,但将其应用于黄土崩塌监测尚缺乏可靠依据。为此,采用含水率分别为3%、7%、10%的单面连接型黄土崩塌模型开展试验,结合有源波导方式进行实时声发射监测,探索不同含水率下黄土崩塌过程中的声发射响应特征,分析黄土崩塌的破坏形式与变形破坏过程中声发射振铃计数的时序演化特征。结果表明:含水率为3%、10%的黄土崩塌破坏模式以小块黄土的局部崩落为主,7%的黄土崩塌破坏模式以大块黄土的整体崩塌为主。随着黄土崩塌变形破坏加剧,声发射振铃计数大小也随着增加,且在黄土崩塌破坏前,声发射振铃计数数值会快速上升,可将振铃计数开始“突增”作为黄土崩塌的破坏前兆信息。

关键词：黄土崩塌含水率声发射响应模型试验

左乙拉西坦血药浓度监测结果分析及在重症患者中的应用

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中国药物应用与监测 2024年第1期21卷 73-75页

作者：王蓉蓉蔡乐李荣艳陈孟莉王天琳解放军总医院医疗保障中心药剂科北京100853

目的分析左乙拉西坦治疗药物监测(therapeutic drug monitoring,TDM)结果,为重症患者临床合理用药提供参考。方法收集2021年3月—2022年8月左乙拉西坦TDM数据和病历资料,分析左乙拉西坦治疗方案及谷浓度、峰浓度达标情况,探讨左乙拉西... 详细信息

目的分析左乙拉西坦治疗药物监测(therapeutic drug monitoring,TDM)结果,为重症患者临床合理用药提供参考。方法收集2021年3月—2022年8月左乙拉西坦TDM数据和病历资料,分析左乙拉西坦治疗方案及谷浓度、峰浓度达标情况,探讨左乙拉西坦的血药浓度影响因素。结果共收集64例次左乙拉西坦TDM数据,包括36例谷浓度和28例峰浓度,仅有36.1%患者的谷浓度达标。进行左乙拉西坦TDM的重症患者占52.8%,其中76.9%的重症患者存在肾功能亢进(augmented renal clearance,ARC)现象。1.5每12 h 1次未达标组的重症患者可能存在更加严重的ARC。结论左乙拉西坦的临床血药浓度达标率偏低。对于重症患者,应注意识别ARC,并根据TDM和肌酐清除率(creatinine clearance,Ccr)适当调整左乙拉西坦用药剂量。

关键词：左乙拉西坦治疗药物监测重症肾功能亢进

Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

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World Journal of Pediatrics 2024年第5期20卷 525-531页

作者： yan li Yu-rong Piao Tong-Xin Han Hua-Wei Mao Department of Immunology Ministry of Education Key Laboratory of Major Diseases in ChildrenBeijing Key Laboratory for Genetics of Birth DefectsNational Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan Li Shi LuBeijing100045China

Splenic infarction(SI)is a rare clinical phenomenon that occurs when the blood supply to the spleen is interrupted,resulting in tissue ischemia and necrosis[1].There are many causes of SI;in adult patients,cardioembolism,hematological malignancy,and infectious disease are the most common[2].Rheumatic diseases,especially systemic lupus erythematosus(SLE)and granulomatosis with polyangitis,can also lead to SI[3];however,only a few cases have been *** are currently no statistically meaningful data on the etiology of SI in *** most patients with SI can recover after conservative treatment,a small number of patients develop complications,such as splenic abscess,splenic rupture,splenic hemorrhage,and hemoperitoneum,and may even undergo splenectomy in severe cases.

关键词： erythematosus lupus treatment

High-precision parallel computing model of solute transport based on GPU acceleration

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Journal of Hydrodynamics 2024年第1期36卷 202-212页

作者： Shang-hong Zhang rong-qi Zhang Wen-da li Xi-yan yang yang Zhou School of Water Resources and Hydropower Engineering North China Electric Power UniversityBeijing102206China Hubei Key Laboratory of Intelligent yangtze and Hydroelectric Science China Yangtze Power Co.Ltd.Yichang443133China

The scenario simulation analysis of water environmental emergencies is very important for risk prevention and control,and emergency *** quickly and accurately simulate the transport and diffusion process of high-intensity pollutants during sudden environmental water pollution events,in this study,a high-precision pollution transport and diffusion model for unstructured grids based on Compute Unified Device Architecture(CUDA)is *** finite volume method of a total variation diminishing limiter with the Kong proposed r-factor is used to reduce numerical diffusion and oscillation errors in the simulation of pollutants under sharp concentration conditions,and graphics processing unit acceleration technology is used to improve computational *** advection diffusion process of the model is verified numerically using two benchmark cases,and the efficiency of the model is evaluated using an engineering *** results demonstrate that the model perform well in the simulation of material transport in the presence of sharp ***,it has high computational *** acceleration ratio is 46 times the single-thread acceleration effect of the original *** efficiency of the accelerated model meet the requirements of an engineering application,and the rapid early warning and assessment of water pollution accidents is achieved.

关键词： Pollution transport and diffusion model parallel computing Compute Unified Device Architecture(CUDA) pollution event

Machine learning and neural network supported state of health simulation and forecasting model for lithium-ion battery

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Frontiers in Energy 2024年第2期18卷 223-240页

作者： Nan QI Kang yan Yajuan YU Rui li rong HUANG Lai CHEN Yuefeng SU Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China Department of Energy and Environmental Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Electric Vehicle Co. Ltd.Beijing 100176China

As the intersection of disciplines deepens,the field of battery modeling is increasingly employing various artificial intelligence(AI)approaches to improve the efficiency of battery management and enhance the stability and reliability of battery *** paper reviews the value of AI methods in lithium-ion battery health management and in particular analyses the application of machine learning(ML),one of the many branches of AI,to lithium-ion battery state of health(SOH),focusing on the advantages and strengths of neural network(NN)methods in ML for lithium-ion battery SOH simulation and *** is one of the important branches of ML,in which the application of NNs such as backpropagation NN,convolutional NN,and long short-term memory NN in SOH estimation of lithium-ion batteries has received wide *** so far have shown that the utilization of NN to model the SOH of lithium-ion batteries has the advantages of high efficiency,low energy consumption,high robustness,and scalable *** the future,NN can make a greater contribution to lithium-ion battery management by,first,utilizing more field data to play a more practical role in health feature screening and model building,and second,by enhancing the intelligent screening and combination of battery parameters to characterize the actual lithium-ion battery SOH to a greater *** in-depth application of NN in lithium-ion battery SOH will certainly further enhance the science,reliability,stability,and robustness of lithium-ion battery management.

关键词： machine learning lithium-ion battery state of health neural network artificial intelligence

Empirical likelihood for spatial cross-sectional data models with matrix exponential spatial specification

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 125-139页

作者： liU yan rong Jian-rong QIN Yong-song Nanning University Nanning 530200China Center for Applied Mathematics of Guangxi and College of Mathematics and Statistics Guangxi Normal UniversityGuilin 541004China

In this paper,we study spatial cross-sectional data models in the form of matrix exponential spatial specification(MESS),where MESS appears in both dependent and error *** empirical likelihood(EL)ratio statistics are established for the parameters of the MESS *** is shown that the limiting distributions of EL ratio statistics follow chi-square distributions,which are used to construct the confidence regions of model *** experiments are conducted to compare the performances of confidence regions based on EL method and normal approximation method.

关键词： MESS empirical likelihood con dence region

Wuzi yanzong Pill Plays A Neuroprotective Role in Parkinson’s Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress

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Chinese Journal of Integrative Medicine 2023年第1期29卷 19-27页

作者： li yan-rong FAN Hui-jie SUN Rui-rui JIA Lu yanG li-yang ZHANG Hai-fei JIN Xiao-ming XIAO Bao-guo MA Cun-gen CHAI Zhi The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine Shanxi University of Chinese MedicineJinzhongShanxi Province030619China Institute of Brain Science Department Neurology of First Affiliated HospitalShanxi Datong UniversityDatongShanxi Province037009China Department of Anatomy and Cell Biology Department of Neurological SurgerySpinal Cord and Brain Injury Research GroupStark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisIN46202USA Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai200025China

Objective:To investigate the protective effects and its possible mechanism of Wuzi yanzong Pill(WYP) on Parkinson’s disease(PD) model ***:Thirty-six C57BL/6 male mice were randomly assigned to 3 groups including normal,PD,and PD+WYP groups,12 mice in each *** week of intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) was used to establish the classical PD model in ***,mice in the PD+WYP group were administrated with 16 g/kg WYP,twice daily by *** 14 days of administration,gait test,open field test and pole test were measured to evaluate the movement *** hydroxylase(TH) neurons in substantia nigra of midbrain and binding immunoglobulin heavy chain protein(GRP78) in striatum and cortex were observed by *** levels of TH,GRP78,p-PERK,p-elF2α,ATF4,p-IRE1α,XBP1,ATF6,CHOP,ASK1,p-JNK,Caspase-12,-9 and-3 in brain were detected by Western ***:Compared with the PD group,WYP treatment ameliorated gait balance ability in PD mice(Pliorated motor symptoms and pathological lesion of PD mice,which may be related to the regulation of unfolded protein response-mediated signaling pathway and inhibiting the endoplasmic reticulum stress-mediated neuronal apoptosis pathway.

关键词： Wuzi yanzong Pill Parkinson’s disease dopaminergic neurons endoplasmic reticulum stress apoptosis

Activation of catalase activity by a peroxisome-localized small heat shock protein Hsp17.6CⅡ

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Journal of Genetics and Genomics 2017年第8期44卷 395-404页

作者： guannan li jing li rong hao yan guo college of biological sciences China agricultural universityBeijing 100193China

Plant catalases are important antioxidant enzymes and are indispensable for plant to cope with adverse environmental stresses. However, little is known how catalase activity is regulated especially at an organelle level. In this study, we identified that small heat shock protein Hsp17.6Cll （AT5GI2020） in- teracts with and activates catalases in the peroxisome of Arabidopsis thaliana. Although Hsp17.6Cll is classified into the cytosol-located small heat shock protein subfamily, we found that Hsp17.6Cli is located in the peroxisome. Moreover, Hsp17.6Cli contains a novel non-canonical peroxisome targeting signal 1 （PTS1）, QKL, 16 amino acids upstream from the C-terminus. The QKL signal peptide can partially locate GFP to peroxisome, and mutations in the tripeptide lead to the abolishment of this activity. In vitro catalase activity assay and holdase activity assay showed that Hsp17.6Cli increases CAT2 activity and prevents it from thermal aggregation. These results indicate that Hspl7.6Cli is a peroxisome-localized catalase chaperone. Overexpression of HsplK6II conferred enhanced catalase activity and tolerance to abiotic stresses in grabidopsis. Interestingly, overexpression of HspI7.6CII in catalase-deficient mutants, ncal-3 and cat2 cat3, failed to rescue their stress-sensitive phenotypes and catalase activity, suggesting that HsplT.6Cll-mediated stress response is dependent on NCA1 and catalase activity. Overall, we identified a novel peroxisome-located catalase chaperone that is involved in plant abiotic stress resis- tance by activating catalase activity.

关键词： ChaperoneHsp17.6CIIPTS1PeroxisomeCatalaseAbiotic stress tolerance