检索结果-南通市图书馆

Regulatory effects of evodiamine on glucose metabolism-related factors in CT26 colorectal carcinoma-bearing mice

Precision Medicine Research 2022年第4期4卷 12-17页

作者： Jiang-Yue Yu Kui Chen Ruo-Qin Zhao li-qun wang Chao Gong Shen-Zhou Huang Yun-Juan Zheng Pei-Wen Zhu Xin-Ran Song Fang-Hua Wu General Surgery Fujian Medical University Affiliated Fuzhou First HospitalFuzhou 350009China College of Forestry Shanxi Agricultural UniversityJinzhong 030801China School of Bioengineering Tianjin Modern Vocational Technology CollegeTianjin 300350China

Objective:To investigate the therapeutic effect of evodiamine(EVO)on the expression of hexokinase(HK),lactate dehydrogenase A(LDHA),and pyruvate kinase M(PKM),key enzymes of glycolysis,in the tumor-bearing mice after modeling mouse colon cancer cells(CT26).Methods:A tumor-bearing mouse model was generated by administering axillary injection of CT26 and intraperitoneally injecting different doses of *** therapeutic effects of EVO on CT26 tumor-bearing mice were evaluated by measuring the thymus and spleen indices,tumor volume,tumor suppression rate,and other related indicators in the tumor tissues of mice in each group after the administration of EVO,in addition,histopathological changes in the tumor tissues of the mice in the groups were studied by hematoxylin and eosin *** expression levels of HK,LDHA,and PKM in the tumor tissues of each group of mice were measured by performing Western blot to investigate the mechanism of EVO treatment in CT26 tumor-bearing ***:EVO inhibited the growth of tumors in CT26-bearing mice and enhanced their splenic and thymic *** blot results showed that EVO reduced the expression levels of HK,LDHA,and PKM proteins in the tumor tissues of CT26 tumor-bearing ***:EVO has a therapeutic effect on CT26 tumor-bearing mice,and its mechanism of action may be related to the low expression of key enzymes HK,LDHA and PKM of glycolysis in tumor tissues.

关键词： evodiamine mouse colon cancer cells tumor-bearing mice glycolysis hexokinase lactate dehydrogenase A pyruvate kinase M

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on the mechanism of the anti-tumor effects of matrine via regulation of lipid metabolism mediated by SREBP signaling pathway

引用

Cancer Advances 2023年第12期6卷 1-5页

作者： Fang-Hua Wu Fei Huang Yan Chen Kui Chen Chao Gong Shen-Zhou Huang Jiang-Yue Yu Ruo-Qin Zhao Pei-Wen Zhu li-qun wang Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical University Fujian 350009China Forestry Institute Shanxi Agricultural UniversityShanxi 030801China

Objective:To investigate the therapeutic effects of matrine on CT26 tumor-bearing mice and its effect on the sterol regulatory element binding protein(SREBP)signaling ***:A CT26 tumor-bearing mouse model was established using CT26 *** doses of matrine were orally administered to mice,and the tumor size and weight in each group of mice before and after administration were measured to calculate the tumor inhibition rate of ***,tumor tissues were subjected to hematoxylin and eosin(HE)staining to observe morphological changes in tumor tissue,and quantitative polymerase chain reaction(qPCR)was performed to detect the expression of the genes of the lipid metabolism-related enzymes sterol regulatory element binding transcription factor 1(Srebf1),ATP citrate lyase(Acly),acetyl-Coenzyme A carboxylase alpha(Acc),and fatty acid synthase(Fasn)in tumor tissues before and after matrine ***:Compared to those in the model group,tumor-bearing mice in both the low and high-dose matrine groups showed significantly reduced tumor *** staining showed that matrine significantly inhibited tumor cell proliferation in both the low and high-dose *** qPCR results showed that,compared with the model group,the expression levels of the genes of lipid metabolism-related enzymes Srebf1,Acly,Acc,and Fasn in tumor tissues were significantly downregulated in both the low and high-dose matrine ***:Matrine modulates the lipid metabolism pathway,affects tumor cell lipid metabolism,and exerts antitumor effects.

关键词： Matrine CT26 tumor lipid metabolism SREBP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

厚层水泥稳定碎石基层分层连续施工技术研究

引用

公路 2017年第7期62卷 51-55页

作者：李洋洋谢立炳胡力群王军长安大学特殊地区公路工程教育部重点实验室西安市710064 杭州萧山路桥工程处杭州市311200

为研究厚层水泥稳定碎石基层分层连续摊铺整体成型技术,设计了一次整体成型、分层连续成型、分层间断成型3种层间状态的成型方式,成型不同方式的水泥稳定碎石试件,对其抗剪强度、抗压强度、抗弯拉强度、疲劳性能进行测试及分析。试验结... 详细信息

为研究厚层水泥稳定碎石基层分层连续摊铺整体成型技术,设计了一次整体成型、分层连续成型、分层间断成型3种层间状态的成型方式,成型不同方式的水泥稳定碎石试件,对其抗剪强度、抗压强度、抗弯拉强度、疲劳性能进行测试及分析。试验结果表明一次整体成型和分层连续成型的试件各项性能优于分层间断成型,提出了厚层水泥稳定碎石基层分层连续摊铺碾压施工的关键技术,并通过现场铺筑试验路验证了厚层水泥稳定碎石基层分层连续摊铺整体成型技术的可行性。

关键词：道路工程厚层水泥稳定碎石基层分层连续施工技术层间黏结力学性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Involvement of glycogen synthase kinase-3 in tau hyperphosphorylation and β-amyloid generation in cells expressing amyloid precursor protein

Involvement of glycogen synthase kinase-3 in tau hyperphosph...

引用

湖北省暨武汉市病理生理学会第十二届学术年会

作者： Ze-Fen wang, Hua-Xi Xu, Xia-Chun li, Hong-lian li, Qi Zhang,qun wang, Jian-Zhi wang Institute of Neuroscience, Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R.China

Deposition of β-amyloid (Aβ) and accumulation of hyperphosphorylated tau are hallmark lesions in the brain of Alzheimer disease (AD) patients. To study the intracellular link of Aβ and tau, we examine

关键词： β-amyloid tau phosphorylation glycogen synthase kinase-3 cyclin-dependent kinase-5

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

引用

Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu wang Xiao Ding Huang Yunyi Yiyu liu Jia li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Copper homeostasis and neurodegenerative diseases

引用

Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan wang Daidi li Kaifei Xu Guoqing wang Feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： lin Peng Yu Bai Hang li Meixiu Qu Zhenhua wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

lithium-sulfur （li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （liPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes li2S dissolution and nucleation ***,the li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： lithium sulfur batteries

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng li Meifeng Cai Shengjun Miao Yuan li Yu wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用酸敏感超支化聚缩醛制备聚乳酸多孔微球

引用

高分子学报 2014年第6期24卷 802-807页

作者：陈蕊罗军卢毅於麟涂克华蒋宏亮王利群浙江大学高分子科学与工程学系教育部高分子合成与功能构造重点实验室杭州310027

通过缩醛转移聚合合成了一种具有酸敏感特性的超支化聚缩醛(HBPAs),对该聚合物降解行为的研究表明,该聚合物具有很强的酸敏感特性,在pH为5.0时,短时间内可发生迅速的降解,而在pH为7.4时,该聚合物基本不发生降解.利用该聚合物的酸敏感特... 详细信息

通过缩醛转移聚合合成了一种具有酸敏感特性的超支化聚缩醛(HBPAs),对该聚合物降解行为的研究表明,该聚合物具有很强的酸敏感特性,在pH为5.0时,短时间内可发生迅速的降解,而在pH为7.4时,该聚合物基本不发生降解.利用该聚合物的酸敏感特性,其在弱酸性条件下降解速率远远超过PLA的降解速率,制备了多孔PLA微球.进一步研究发现,通过调控超支化聚缩醛(HBPAs)与PLA的投料比,可以线性调控PLA多孔微球的孔径尺寸,并拟合得到了线性方程.DSC结果以及对微球降解过程的观察表明,在共混微球内部,HBPAs与PLA会发生一定的相分离,使得在酸降解的过程中,更有利于微球内部的HBPAs组分发生降解.

关键词：超支化聚缩醛酸敏感致孔剂多孔微球

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Controlled cationic ring-opening polymerization of L-lactide by organic ion pair: novel approach to isotactic-rich and crystalline polylactide

引用

Science China Chemistry 2025年第1期 394-402页

作者： Zhiqiang Ding Mingqian wang Zijing Zhou Bin wang Yuesheng li Tianjin Key Laboratory of Composite & Functional Materials School of Materials Science and Engineering Tianjin University

living/controlled cationic ring-opening polymerization （ROP） of L-lactide is a promising approach to isotactic-rich and crystalline poly（L-lactide）.In contrast with the unsubstituted lactones,L-LA can not be polymerized by organic Lewis acids or carbenium ions,and the state of the art in this field is the cationic ROP of L-LA catalyzed by Br?nsted acid/alcohol system via activated monomer ***,we reported the first example of controlled cationic ROP of L-LA by using Meerweintype ion pair[Me3O]+[B（C6F5）4]-as the catalyst.[Me3O]+[B（C6F5）4]-promoted rapid L-LA cationic polymerization in the absence of alcohol,producing isotactic-rich and crystalline PLLA without transesterification and epimerization side *** activated chain end mechanism,involving twice SN2 substitution and configuration-inversion （S→R→S） with the assistance of released Me2O,was proposed and further verified by density functional theory and control *** work expands the catalytic toolbox of isotactic-rich and crystalline polylactide *** represents a unique example of cationic-controlled polymerization of L-LA catalyzed by an organic ion pair.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：