检索结果-南通市图书馆

Transcriptome sequencing reveals novel biomarkers and immune cell infiltration in esophageal tumorigenesis

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1500-1513页

作者： jian-Rong Sun Dong-Mei Chen Rong Huang Rui-Tao Wang li-qun jia School of Clinical Medicine Beijing University of Chinese MedicineBeijing 100029China Integrated Chinese and Western Medicine Oncology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is one of the most common malignancies worldwide,and its development comprises a multistep process from intraepithelial neoplasia(IN)to carcinoma(CA).However,the critical regulators and underlying molecular mechanisms remain largely *** To explore the genes and infiltrating immune cells in the microenvironment that are associated with the multistage progression of ESCC to facilitate diagnosis and early *** A mouse model mimicking the multistage development of ESCC was established by providing warter containing 4-nitroquinoline 1-oxide(4NQO)to C57BL/6 ***,we established a control group without 4NQO treatment of ***,transcriptome sequencing was performed for esophageal tissues from patients with different pathological statuses,including low-grade IN(LGIN),high-grade IN(HGIN),and CA,and controlled normal tissue(NOR)*** expressed genes(DEGs)were identified in the LGIN,HGIN,and CA groups,and the biological functions of the DEGs were analyzed via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment *** CIBERSORT algorithm was used to detect the pattern of immune cell ***(IHC)was also conducted to validate our ***,the Luminex multiplex cytokine analysis was utilized to measure the serum cytokine levels in the *** Compared with those in the NOR group,a total of 681541,and 840 DEGs were obtained in the LGIN,HGIN,and CA groups,*** the intersection of the three sets of DEGs,we identified 86 genes as key genes involved in the development of *** analysis revealed that these genes were enriched mainly in the keratinization,epidermal cell differentiation,and interleukin(IL)-17 signaling *** analysis revealed that,compared with those in the NOR group,M0 and M1 macrophages in the 4NQO group showed stronger infiltration,which was validated by *** cytok

关键词： Esophageal squamous cell carcinoma Intraepithelial neoplasia Tumorigenesis Transcriptome sequencing Biomarkers Immune cell infiltration 4-nitroquinoline 1-oxid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Professor jia li-qun’s experience in external treatment of tumor complications based on the theory of“use communication as a complement”

引用

Journal of Hainan Medical University 2021年第16期27卷 60-63页

作者： Yan-Ping Wen Shan-Shan Yang Yan-Ni Lou Jing-Yao Luo li-qun jia Beijing University of Chinese Medicine Beijing 100029China Cancer Branch China-Japan Friendship HospitalBeijing 100029China

The external treatment of Traditional Chinese Medicine has a long history of external treatment,with the characteristics of simplicity,convenience,cheapness,and *** also plays an important role in the treatment of malignant tumor *** academic idea of“Use communication as a complement”has existed since ancient times,and it still has great significance in guiding clinical *** on the theory of“Use communication as a complement”,Professor jia liqun used Tongluo powder to treat chemotherapy-induced peripheral neuropathy,Wentong acupoint sticking for external treatment of cancer pain,and digestive tract reaction after chemotherapy,and achieved good clinical *** inspection case is attached to prove it.

关键词： Use communication as a complement Malignant tumor Complication jia li-qun External treatment of Traditional Chinese Medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of pravastatin on endothelial dysfunction in children with medium to giant coronary aneurysms due to Kawasaki disease

引用

World Journal of Pediatrics 2014年第3期10卷 232-237页

作者： Chao Duan Zhong-Dong Du Yu Wang li-qun jia Department of Hematology/Oncology Beijing Children's HospitalCapital Medical UniversityBeijing 100045China Department of Cardiology Beijing Children's HospitalCapital Medical UniversityBeijing 100045China Department of Ultrasonography Beijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background:Ongoing low-grade inflammation and endothelial dysfunction persist in children with coronary lesions diagnosed with Kawasaki disease(KD).Statins,frequently used in the management of high cholesterol,have also shown to improve surrogate markers of infl ammation and endothelial *** study was undertaken to investigate the effi cacy and safety of pravastatin in children with coronary artery aneurysms due to ***:The study enrolled 14 healthy children and 13 male children,aged 2-10 years,with medium-to-giant coronary aneurysms for at least 12 months after the onset of *** was given orally to the KD group at a dose of 5 mg/day for children under 5 and 10 mg/day for children older than 5 *** determine the effects of pravastatin on endothelial function,high-frequency ultrasound was performed before the start of the study and 6 months after pravastatin *** parameters measured were brachial artery flow-mediated dilation(FMD),non-flow mediated dilation(NMD),and carotid artery stiffness index(SI).High sensitive C-reactive protein(hs-CRP)levels,the circulating endothelial progenitor cells(EPCs)number,and serum lipid profiles were also determined at baseline and after 6 months of pravastatin ***:Before treatment,the KD group had significantly decreased FMD(Pline KD group(3.16±6.49 to 10.05±7.74,Pline and that following pra

关键词： coronary aneurysm endothelial function endothelial progenitor cells Kawasaki disease statins

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Propagation form of internal cracks induced by continuous casting soft reduction and control strategy for internal quality

引用

Journal of Iron and Steel Research International 2024年第3期31卷 622-633页

作者： Pu Wang liang Chen qun-wei Tang Wei-tao li Shao-xiang li jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Weifang Special Steel Group Co..Ltd. Weifang 262400ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The propagation form of internal cracks induced by continuous casting soft reduction and the control strategy for enhancing the internal quality of 45 steel through industrial trials and a three-dimensional flow-heat transfer-solidification coupling model were *** results showed that the internal cracks induced by soft reduction exhibited a characteristic of being"coarse in the middle and fine at both ends",and displayed an elliptical arc distribution on the loose side of the strand cross *** cracks originated within the brittle temperature range and propagated inward to the liquid impenetrable temperature and outward to the zero ductility temperature or *** control strategy for enhancing the internal quality of the 45 steel strand through soft reduction is to adjust the casting speed or the reduction zone appropriately,ensuring that the central solid fraction of the reduction zone falls within the range of *** this point,a reasonable reduction amount is allocated to eliminate the center shrinkage cavities and center segregation,even if it results in minor reduction-induced cracks.

关键词： Continuous casting Soft reduction Crack propagation Internal quality Control strategy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Mixed-Mode Fatigue Crack Propagation Model of Piezoelectric Materials Under Electric Fatigue Loading by the Jk-Integral

引用

Acta Mechanica Solida Sinica 2024年第4期37卷 634-641页

作者： Xianghua Chen Chunguang Wang qun li The Institute of Xi’an Aerospace Solid Propulsion Technology Xi’an710025China State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an710049China

The electric fatigue load has a significant effect on the crack propagation behavior and failure life of piezoelectric materials and devices. In this paper, an electrical mixed-mode fatigue crack propagation model for piezoelectric materials is proposed based on the piezoelectric Jk-integral theory. The crack initiation, propagation, and life prediction criteria of piezoelectric materials under electric fatigue loading are given by this model, and the finite element simulation model is established to study the electrical mixed-mode crack propagation behavior of piezoelectric structures. Meanwhile, the electrical mixed-mode fatigue crack propagation model is applied to the fatigue crack propagation behavior of a piezoelectric typical defective structure, the crack–hole interference model. The mixed-mode crack propagation, fatigue life, and the interference behavior between the crack and hole at various hole locations of the crack–hole interference model are well recognized by this model. The crack propagation behavior under different electrical load intensities is also considered. The results show that the hole in front of the crack tip inhibits crack propagation to a certain extent, and the strength of electrical load affects the fatigue life of piezoelectric materials and structures. Therefore, the proposed electrical mixed-mode fatigue crack propagation model provides a reference for predicting the mixed-mode fatigue crack propagation behavior and fatigue life of piezoelectric structures under electric fatigue loading.

关键词： Configurational force J k-integral Piezoelectric Mixed-mode crack propagation life prediction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meta label associated loss for fine-grained visual recognition

引用

Science China(Information Sciences) 2024年第6期67卷 230-247页

作者： Yanchao li Fu XIAO Hao li qun li Shui YU School of Computer Science Nanjing University of Posts and Telecommunications School of Network Engineering Zhoukou Normal University School of Computer Science University of Technology Sydney

Recently, intensive attempts have been made to design robust models for fine-grained visual recognition, most notably are the impressive gains for training with noisy labels by incorporating a reweighting strategy into a meta-learning framework. However, it is limited to up or downweighting the contribution of an instance for label reweighting approaches in the learning process. To solve this issue, a novel noise-tolerant method with auxiliary web data is proposed. Specifically, first, the associations made from embeddings of well-labeled data with those of web data and back at the same class are measured. Next, its association probability is employed as a weighting fusion strategy into angular margin-based loss, which makes the trained model robust to noisy datasets. To reduce the influence of the gap between the well-labeled and noisy web data, a bridge schema is proposed via the corresponding loss that encourages the learned embeddings to be coherent. Lastly, the formulation is encapsulated into the meta-learning framework, which can reduce the overfitting of models and learn the network parameters to be noise-tolerant. Extensive experiments are performed on benchmark datasets, and the results clearly show the superiority of the proposed method over existing state-of-the-art approaches.

关键词： label associated loss weighting noisy samples fine-grained visual recognition noise-tolerant learning meta-learning

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Analysis of the rule of medication of compound Chinese traditional patent medicine for digestive system tumors based on data mining

引用

Journal of Hainan Medical University 2021年第22期27卷 33-38页

作者： Shan-Shan Yang li-qun jia Shao-Dong Hao Beijing University of Chinese Medicine Beijing 100029China Department of oncology of Integrated Traditional Chinese and Western Medicine China-Japan Friendship Hospital of Health MinistryBeijing 100029China

Objective:Based on the data mining method,explore the medication rules of Chinese patent medicines for the treatment of digestive system ***:Based on the"Chinese Traditional Medicine Prescription Database"in https://***/,collect Chinese patent medicines for the treatment of digestive system tumors,establish an Excel table,and use the ancient and modern medical case cloud platform(V2.2.1)to perform frequency statistics,association rules,and drugs on the data Clustering and complex network ***:A total of 36 Chinese patent medicines for the treatment of digestive system tumors were *** medicinal properties were mainly warm and cold,the taste was bitter and sweet,and the meridians were mainly liver and spleen *** frequency Chinese medicine include Astragalus,Scutellaria-barbata,Ginseng,Curcuma,Triangle,Atractylodes,Hedyotis diffusa,*** analysis obtained 17 drug combinations,High-frequency drug pairs include Scutellaria-barbata-Astragalus,Ginseng-Astragalus,Curcuma-Astragalus,Scutellaria-barbata-Curcuma,*** analysis found 3 types of *** core drug network is composed of 27 drugs,and the core compatibility network consists of 3 groups of ***:The Chinese patent compound medicine for the treatment of digestive system tumors has the characteristics of combining cold and warming,replenishing and reducing treatment,and treating the liver and spleen at the same *** medicine is mainly used to replenish qi and invigorate the spleen,promote blood circulation and remove blood stasis,and clear away heat and *** qi,nourish yin,invigorate blood,and detoxify are mainly compatible with each other,reflecting the pathogenesis characteristics of"deficiency,stasis,and toxin"in digestive system *** mining can provide references for the prescription and compatibility of Chinese patent medicines.

关键词： Digestive system tumors Traditional Chinese patent medicine Data mining Core network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data-driven active vibration control for helicopter with trailing-edge flaps using adaptive dynamic programming

引用

Chinese Journal of Aeronautics 2024年第6期37卷 151-166页

作者： Yu CHEN qun ZONG Xiuyun ZHANG Jinna li School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China School of Information and Control Engineering Liaoning Petrochemical UniversityFushun 113001China

The helicopter Trailing-Edge Flaps(TEFs)technology is one of the recent hot topics in morphing wing *** employing controlled deflection,TEFs can effectively reduce the vibration level of ***,designing specific vibration reduction control methods for the helicopters equipped with trailing-edge flaps is of significant practical *** paper studies the optimal control problem for helicopter-vibration systems with TEFs under the framework of adaptive dynamic programming combined with Reinforcement Learning(RL).Time-delay and disturbances,caused by complexity of helicopter dynamics,inevitably deteriorate the control performance of vibration *** solve this problem,a zero-sum game formulation with a linear quadratic form for reducing vibration of helicopter systems is presented with a virtual *** this context,an off-policy reinforcement learning algorithm is developed to determine the optimal control *** algorithm utilizes only vertical vibration load data to achieve a policy that reduces vibration,attains Nash equilibrium,and addresses disturbances while compensating for time-delay without knowledge of the dynamics of the helicopter *** effectiveness of the proposed method is demonstrated in a virtual platform.

关键词： Active control Adaptive dynamic program-ming Helicopter rotor Vibration control Zero-sum game

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Soluble ST2:A Novel Biomarker for Diagnosis and Prognosis of Cardiovascular Disease

引用

Current Medical Science 2024年第4期44卷 669-679页

作者： Yin FENG li-qun HE Department of Cardiology Traditional Chinese and Western Medicine Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

The increasing incidence of cardiovascular disease(CVD)is a significant global health concern,affecting millions of individuals each *** diagnosis of acute CVD poses a formidable challenge,as misdiagnosis can significantly decrease patient survival *** biomarkers have played a vital role in the diagnosis and prognosis of CVDs,but they can be influenced by various factors,such as age,sex,and renal *** ST2(sST2)is a novel biomarker that is closely associated with different *** low reference change value makes it suitable for continuous measurement,unaffected by age,kidney function,and other confounding factors,facilitating risk stratification of ***,the combination of sST2 with other biomarkers can enhance diagnostic accuracy and prognostic *** review aims to provide a comprehensive overview of sST2,focusing on its diagnostic and prognostic value as a myocardial marker for different types of CVDs and discussing the current limitations of sST2.

关键词： soluble ST2 cardiovascular disease combined biomarker diagnosis and prognosis limitations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two-dimensional ballistic transistors for advanced-node integrated circuits

引用

National Science Review 2024年第3期11卷 9-10页

作者： jia li Xidong Duan Hunan Provincial Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University

As the feature size of metal-oxide-semiconductor-field-effect-transistors(MOSFETs) in integrated circuits(ICs)is reduced to sub-10-nm, the traditional channel materials are plagued by enhanced scattering and short-cha... 详细信息

关键词： CONTACT

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：