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Senegenin suppresses hepatocellular carcinoma by regulating O-GlcNAcylation

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3994-4005页

作者： Xiang Zhang li-qiong wang Zhi-Yong liu Department of Traditional Chinese Medicine Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China Department of Hepatology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China

BACKGROUND Based on current knowledge,hepatocellular carcinoma(HCC)is a condition with numerous etiologies and risk ***,the pathogenesis of HCC remains *** To investigate the roles of senegenin and O-GlcNAcylation in the growth and metastasis of *** The levels of O-linked N-acetylglucosamine transferase(OGT)and O-GlcNAcylation in HCC cells and tissues were detected using western blot *** effects of senegenin and O-GlcNAcylation on the proliferation of HCC cells were investigated in vitro using cell counting kit-8 and clonogenic *** potential effects of senegenin and O-GlcNAcylation on HCC metastasis were examined using the transwell migration assay.O-GlcNAcylation levels were altered via drug treatment and lentiviral infection,and western blot analysis was used to detect proteins involved in various *** Western blot analysis revealed that OGT and O-GlcNAcylation levels were significantly elevated in HCC tissues and cells.O-GlcNAcylation levels in HCC cells were significantly altered by drug treatment and lentiviral *** increase in the glycosylation level was linked to enhanced proliferation,invasiveness,clonogenicity,and metastatic potential of cancer cells.O-GlcNAcylation induced by senegenin was found to slow the proliferation and migration of HCC *** levels of proteins involved in nuclear factor-kappa B(NF-κB)and c-Jun N-terminal kinase(JNK)pathways,which are associated with endoplasmic reticulum stress,were *** Senegenin lowers O-GlcNAcylation levels,decreases OGT expression,and inhibits cancer cell growth and metastasis by regulating proteins involved in NF-κB and JNK pathways.

关键词： Senegenin O-GlcNAcylation liver cancer Pathogenesis Metastasis

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Cationic Conjugated Oligomers for Efficient and Rapid Antibacterial Photodynamic Therapy via Both Type Ⅰ and Type Ⅱ Pathways

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Chinese Journal of Chemistry 2024年第1期42卷 61-66页

作者： Huan wang Shuwen Guo qiong Yuan Meiqi li Yanli Tang Country Key Laboratory of Analytical Chemistry for life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'anShaanxi 710119China

Recently,photodynamic therapy(PDT)has attracted wide attention due to its less susceptibility to drug resistance,broad-spectrum biocidal activity and biosafety in normal ***,the traditional photosensitizers(Ps)face the disadvantage of poor therapeutic efficacy due to the requirement of an aerobic environment to generate ^(1)O_(2) through Type Ⅱ ***,we designed and synthesized a novel cationic conjugated oligomer oligo(phenylene vinylene)(OPV)and studied its antibacterial photodynamic activity against both Gram-negative Escherichia coli(***)and Gram-positive bacteria methicillin-resistant Staphylococcus aureus(MRSA).Importantly,the OpV can rapidly produce reactive oxygen species(ROs)through double pathways,Type Ⅰ and Ⅱ mechanism under white light irradiation,and efficiently kill *** and MRSA at a nanomolar *** dual type photosensitizing capability makes OPV promising for enhanced PDT to treat pathogens and tumors in complex environments.

关键词： Conjugated oligomers Antibacterial photodynamic therapy Oligo(phenylene vinylene) Reactive oxygen species Typelandll pathways

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Deep tectonics and seismogenic mechanisms of the seismic source zone of the Jishishan M_(s)6.2 earthquake on December 18,2023,at the northeast margin of the Tibetan Plateau

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Earth and Planetary Physics 2024年第3期8卷 514-521页

作者： qiong wang ShuYu li XinYi li Yue Wu PanPan Zhao Yuan Gao Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,*** earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China *** this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and *** discovered that the location of the earthquake was related to changes in the crustal *** results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave *** epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity ***,the source area is flanked by two high-velocity anomalies from the east and *** principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this *** some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal *** features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic *** NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension *** presence

关键词： Jishishan M_(s)6.2 earthquake crustal structure anisotropy stress and strain seismogenic mechanism northeast margin of the Tibetan Plateau

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The MtRGF6 Peptide Differentially Regulates Root Development and Symbiotic Nodulation of Medicago truncatula and Lotus japonicus

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1237-1248页

作者： Junhui Yan Yawen wang qiong li Yu Zhou Xu wang li Luo School of life Sciences Shanghai Key Laboratory of Bio-Energy CropsShanghai UniversityShanghai200444China College of life Science State Key Laboratory of Tea Plant Biology and UtilizationAnhui Agricultural UniversityHefei230036China

Rhizobia induces nitrogen-ﬁxing nodules in legumes used in agricultural production,providing a direct source of combined nitrogen to leguminous *** peptides,such as CLAVATA3/EMBRYO SURROUNDING REGION peptides(CLE),are known to regulate the formation and development of nitrogen-ﬁxing nodules in *** meristem growth factor(RGF)peptides from Medicago truncatula not only regulate root develop-ment but also modulate nodulation symbiosis with Sinorhizobium ***,the impact of RGF peptides from one leguminous species on the others remains *** this study,we investigate the effects of the RGF family peptide MtRGF6p from *** on nodulation symbiosis and root development in Lotus *** MtRGF6 gene is predominantly expressed in the root nodules of *** and shows low identity with RGF homologous genes from *** gene promoter is active in the primordia of root nodules and lat-eral roots,as well as in young nodules and roots,and the meristem,infection,and nitrogen-ﬁxing regions of the mature *** synthesized MtRGF6p promoted primary root growth in *** but sup-pressed the growth of *** primary *** peptide negatively affected the initiation of nodule primor-dia,the formation of infection threads,and nodulation in both legumes,with a low dosage showing effects on *** compared to *** results suggest that the MtRGF6 peptide from *** may serve as an inter-species signal affecting the root organ development of ***.

关键词： Peptide RGF legume symbiotic nodulation lateral root

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Boosting High-Voltage Practical lithium Metal Batteries with Tailored Additives

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Nano-Micro Letters 2024年第12期16卷 23-41页

作者： Jinhai You qiong wang Runhong Wei li Deng Yiyang Hu li Niu Jingkai wang Xiaomei Zheng Junwei li Yao Zhou Jun-Tao li College of Energy Xiamen UniversityXiamen 361005People’s Republic of China Magnetism Key Laboratory of Zhejiang Province College of Materials and ChemistryChina Jiliang UniversityHangzhou 310018People’s Republic of China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium State Key Lab of Physical Chemistry of Solid Surface College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Department of Chemical Engineering KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070GansuPeople’s Republic of China

The lithium(li)metal anode is widely regarded as an ideal anode material for high-energy-density ***,uncontrolled li dendrite growth often leads to unfavorable interfaces and low Coulombic efficiency(CE),limiting its broader ***,an ether-based electrolyte(termed FGN-182)is formulated,exhibiting ultra-stable li metal anodes through the incorporation of liFSI and liNO3 as dual *** synergistic effect of the dual salts facilitates the formation of a highly robust SEI film with fast li+transport ***,li||Cu half cells exhibit an average CE reaching up to 99.56%.In particular,pouch cells equipped with high-loading lithium cobalt oxide(LCO,3 mAh cm^(-2))cathodes,ultrathin li chips(25μm),and lean electrolytes(5 g Ah-1)demonstrate outstanding cycling performance,retaining 80%capacity after 125 *** address the gas issue in the cathode under high voltage,cathode additives 1,3,6-tricyanohexane is incorporated with FGN-182;the resulting high-voltage LCO||li(4.4 V)pouch cells can cycle steadily over 93 *** study demonstrates that,even with the use of ether-based electrolytes,it is possible to simultaneously achieve significant improvements in both high li utilization and electrolyte tolerance to high voltage by exploring appropriate functional additives for both the cathode and anode.

关键词： li metal anode li dendrites liNO_(3) 1,3,6-tricyanohexane Pouch cells

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Sedimentary-tectonic interaction on the growth sequence architecture within the intraslope basins of deep-water Niger Delta Basin

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Journal of Palaeogeography 2023年第1期12卷 107-128页

作者： Jia-Jia Zhang Sheng-He Wu Guang-Yi Hu Da-li Yue Cheng Chen Mei Chen Ji-Tao Yu Qi-Cong Xiong li-qiong wang College of Geosciences State Key Laboratory of Petroleum Resource and ProspectingChina University of Petroleum(Beijing)Beijing 102249China Research Institute China National Offshore Oil CorporationBeijing 100028China The Fourth Gas Production Plant Changqing Oilfield CompanyPetroChinaOrdos 017300Inner Mongolia Autonomous RegionChina

This paper presents a 3D seismic-based case study from the deep-water Niger Delta Basin to investigate sedimentary-tectonic interaction on growth sequence architecture within the thrust-related intraslope or piggyback basins. Gravitational contraction in the lower continental slope had yielded a series of thrust faults and associated folds in the study area, which formed several piggyback basins. These basins were filled by a suite of growth sequences with varying stratigraphic architecture. Analysis of the 3D seismic data recognized three primary seismic facies types respectively as: convergent, draping and chaotic, which contain seven subtypes. These facies types are combined to form different filling successions for convergent or chaotic growth sequences. The convergent growth sequences mainly occur in the deep section of basin fills during strong gravitational deformation, and always began with convergent-baselapping strata succeeded by convergent-thinning strata, representing pond-to-bypass transition in the ponded-basin accommodation space. The chaotic growth sequences mainly occur in the shallow section of basin fills in response to weak gravitational deformation, and usually began with debris-flow deposits succeeded by channel-levee complexes, reflecting dominant erosion-bypass processes in the slope accommodation space. A dynamic fill-andspill model considering relationship between episodic sedimentation rate and structural growth rate is proposed to explain the formative mechanisms of growth strata units and associated successions. Interaction between glaciation or deglaciation and sea-level change and gravitational deformation history are suggested to be the factor which resulted in the complex stratal stacking patterns, including progradational or retrogradational stacking patterns within convergent growth sequences, and progradational stacking patterns within chaotic growth sequences.

关键词： Intraslope basin Gravitational deformation Growth sequence Stratigraphic architecture Niger Delta Basin

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Simulation study on the security of consensus algorithms in DAG-based distributed ledger

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Frontiers of Computer Science 2024年第3期18卷 171-182页

作者： Shuzhe li Hongwei XU qiong li Qi HAN Faculty of Computing Harbin Institute of TechnologyHarbin 150001China

Due to the advantages of high volume of transactions and low resource consumption,Directed Acyclic Graph(DAG)-based Distributed Ledger Technology(DLT)has been considered a possible next-generation alternative to ***,the security of the DAG-based system has yet to be comprehensively *** at verifying and evaluating the security of DAG-based DLT,we develop a Multi-Agent based IOTA Simulation platform called *** MAIOTASim,we model honest and malicious nodes and simulate the configurable network environment,including network topology and *** double-spending attack is a particular security issue related to *** perform the security verification of the consensus algorithms under multiple double-spending attack *** simulations show that the consensus algorithms can resist the parasite chain attack and partially resist the splitting attack,but they are ineffective under the large weight *** take the cumulative weight difference of transactions as the evaluation criterion and analyze the effect of different consensus algorithms with parameters under each attack ***,MAIOTASim enables users to perform largescale simulations with multiple nodes and tens of thousands of transactions more efficiently than state-of-the-art ones.

关键词： distributed ledger IOTA Multi-Agent system simulation

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Frost Resistance of Pervious Concrete Mixed with Waste Glass Powder

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1325-1336页

作者： AN Baofeng li qiong QIAO Hongxia SU Rui wang Xi wang Chaoqun JIAO Daowei School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China Gansu Advanced Civil Engineering Materials Engineering Research Center Lanzhou 730050China China Construction First Group The Fifth Construction Co.Ltd Beijing 100000China

The contents of waste glass powder(WGP)(0%,10%,15%,20%,25%)and water-binder ratio(W/C)(0.24,0.26,0.28)were used as influencing factors,and the quality loss rate(Δm)and compressive strength loss rate(Δfc)were used as characterization *** Ca/Si ratio and main element contents of C-S-H gels with different WGP content were investigated by energy dispersive spectrometry(EDS).The pore structure evolution characteristics of WGP composite cementing materials were investigated by low field nuclear magnetic resonance(NMR).UsingΔfc as the index of frost resistance degradation and Weibull function,the frost resistance degradation of glass doped pervious concrete(WGP-PC)was *** results show that,with WGP,for the same number of cycles,Δm andΔfc decrease and increase with the increase of *** the same WGP content,Δm andΔfc decrease first and then increase with the increase of W/*** 100 freeze-thaw cycles,the samples with WGP content of 20%and W/C of 0.26 have the best *** tests show that with the increase of WGP content,the Ca/Si ratio of C-S-H gel decreases at first and then increases with the increase of WGP *** extreme value of Ca/Si is 2.36 when WGP is added by 20%.The pore volume of hardened paste with 20%WGP content decreased by 18.6%compared with that of cement system without *** overall compactness of the specimen was *** the basis of the test data,a life prediction model was established according to Weibull *** experiment showed thatΔfc could be used as a durability degradation index,and the slope of the reliability curve became gentle after WGP was added,which reduced the damage degradation rate of PC.W/C was ***'s about 5000 hours.

关键词： pervious concrete glass powder frost resistance energy dispersive analysis test low field nuclear magnetic resonance instrument life prediction

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BLUPmrMLM:A Fast mrMLM Algorithm in Genome-wide Association Studies

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 55-67页

作者： Hong-Fu li Jing-Tian wang qiong Zhao Yuan-Ming Zhang College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China

Multilocus genome-wide association study has become the state-of-the-art tool for dissecting the genetic architecture of complex and multiomic ***,most existing multilocus methods require relatively long computational time when analyzing large *** address this issue,in this study,we proposed a fast mrMLM method,namely,best linear unbiased prediction multilocus random-SNP-effect mixed linear model(BLUPmrMLM).First,genome-wide single-marker scanning in mrMLM was replaced by vectorized Wald tests based on the best linear unbiased prediction(BLUP)values of marker effects and their variances in ***,adaptive best subset selection(ABESS)was used to identify potentially associated markers on each chromosome to reduce computational time when estimating marker effects via empirical ***,shared memory and parallel computing schemes were used to reduce the computational *** simulation studies,BLUPmrMLM outperformed GEMMA,EMMAX,mrMLM,and FarmCPU as well as the control method(BLUPmrMLM with ABESS removed),in terms of computational time,power,accuracy for estimating quantitative trait nucleotide positions and effects,false positive rate,false discovery rate,false negative rate,and F1 *** the reanalysis of two large rice datasets,BLUPmrMLM significantly reduced the computational time and identified more previously reported genes,compared with the aforementioned *** study provides an excellent multilocus model method for the analysis of large-scale and multiomic *** software mrMLM v5.1 is available at BioCode(https://***/biocode/tool/BT007388)or GitHub(https://***/YuanmingZhang65/mrMLM).

关键词： Genome-wide association study BLUP Multilocus model mrMLM Large-scale dataset

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NLRP3 and autophagy in retinal ganglion cell inflammation in age-related macular degeneration:potential therapeutic implications

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1531-1544页

作者： Xiao-li wang Yun-Xia Gao qiong-Zhen Yuan Ming Zhang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Retinal degenerative diseases were a large group of diseases characterized by the primary death of retinal ganglion cells(RGCs).Recent studies had shown an interaction between autophagy and nucleotide-binding oligomerization domain-like receptor 3(NLRP3)inflammasomes,which may affect RGCs in retinal degenerative *** NLRP3 inflammasome was a protein complex that,upon activation,produces caspase-1,mediating the apoptosis of retinal cells and promoting the occurrence and development of retinal degenerative *** autophagy could inhibit NLRP3 inflammasome activation,while inhibited autophagy can promote NLRP3 inflammasome activation,which leaded to the accelerated emergence of drusen and lipofuscin deposition under the neurosensory *** activated NLRP3 inflammasome could further inhibit autophagy,thus forming a vicious cycle that accelerated the damage and death of *** review discussed the relationship between NLRP3 inflammasome and autophagy and its effects on RGCs in age-related macular degeneration,providing a new perspective and direction for the treatment of retinal diseases.

关键词： autophagy age-related macular degeneration NLRP3 inflammasome retinal degeneration retinal ganglion cells

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