检索结果-南通市图书馆

Contralateral C7 transfer combined with acellular nerve allografts seeded with differentiated adipose stem cells for repairing upper brachial plexus injury in rats

引用

Neural Regeneration Research 2019年第11期14卷 1932-1940页

作者： Jian-Tao Yang Jin-Tao Fang liang li Gang Chen Ben-Gang Qin li-qiang gu Department of Microsurgery & Orthopedic Trauma the First Affiliated Hospital of Sun Yat-sen University

Nerve grafting has always been necessary when the contralateral C7 nerve root is transferred to treat brachial plexus injury. Acellular nerve allograft is a promising alternative for the treatment of nerve defects, and results were improved by grafts laden with differentiated adipose stem cells. However, use of these tissue-engineered nerve grafts has not been reported for the treatment of brachial plexus injury. The aim of the present study was to evaluate the outcome of acellular nerve allografts seeded with differentiated adipose stem cells to improve nerve regeneration in a rat model in which the contralateral C7 nerve was transferred to repair an upper brachial plexus injury. Differentiated adipose stem cells were obtained from Sprague-Dawley rats and transdifferentiated into a Schwann cell-like phenotype. Acellular nerve allografts were prepared from 15-mm bilateral sections of rat sciatic nerves. Rats were randomly divided into three groups: acellular nerve allograft, acellular nerve allograft + differentiated adipose stem cells, and autograft. The upper brachial plexus injury model was established by traction applied away from the intervertebral foramen with micro-hemostat forceps. Acellular nerve allografts with or without seeded cells were used to bridge the gap between the contralateral C7 nerve root and C5–6 nerve. Histological staining, electrophysiology, and neurological function tests were used to evaluate the effect of nerve repair 16 weeks after surgery. Results showed that the onset of discernible functional recovery occurred earlier in the autograft group first, followed by the acellular nerve allograft + differentiated adipose stem cells group, and then the acellular nerve allograft group;moreover, there was a significant difference between autograft and acellular nerve allograft groups. Compared with the acellular nerve allograft group, compound muscle action potential, motor conduction velocity, positivity for neurofilament and S100, diameter of regenerating axons, myelin sheath thickness, a

关键词： nerve regeneration peripheral nerve injury brachial plexus injury contralateral C7 nerve root acellular nerve adipose stem cells Schwann cells tissue engineering nerve nerve grafting nerve defect neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison between direct repair and humana cellular nerve allografting during contralateral C7 transfer to the upper trunk for restoration of shoulder abduction and elbow flexion

引用

Neural Regeneration Research 2019年第12期14卷 2132-2140页

作者： liang li Wen-Ting He Ben-Gang Qin Xiao-lin liu Jian-Tao Yang li-qiang gu Department of Orthopedic Trauma and Microsurgery the First Affiliated Hospital of Sun Yat-sen University

Direct coaptation of contralateral C7 to the upper trunk could avoid the interposition of nerve grafts. We have successfully shortened the gap and graft lengths, and even achieved direct coaptation. However, direct repair can only be performed in some selected cases, and partial procedures still require autografts, which are the gold standard for repairing neurologic defects. As symptoms often occur after autografting, human acellular nerve allografts have been used to avoid concomitant symptoms. This study investigated the quality of shoulder abduction and elbow flexion following direct repair and acellular allografting to evaluate issues requiring attention for brachial plexus injury repair. Fifty-one brachial plexus injury patients in the surgical database were eligible for this retrospective study. Patients were divided into two groups according to different surgical methods. Direct repair was performed in 27 patients, while acellular nerve allografts were used to bridge the gap between the contralateral C7 nerve root and upper trunk in 24 patients. The length of the harvested contralateral C7 nerve root was measured intraoperatively. Deltoid and biceps muscle strength, and degrees of shoulder abduction and elbow flexion were examined according to the British Medical Research Council scoring system;meaningful recovery was defined as M3–M5. Lengths of anterior and posterior divisions of the contralateral C7 in the direct repair group were 7.64 ± 0.69 mm and 7.55 ± 0.69 mm, respectively, and in the acellular nerve allografts group were 6.46 ± 0.58 mm and 6.43 ± 0.59 mm, respectively. After a minimum of 4-year follow-up, meaningful recoveries of deltoid and biceps muscles in the direct repair group were 88.89% and 85.19%, respectively, while they were 70.83% and 66.67% in the acellular nerve allografts group. Time to C5/C6 reinnervation was shorter in the direct repair group compared with the acellular nerve allografts group. Direct repair facilitated the restoration of shoulder abduction and elbow flexion. Thus

关键词： nerve regeneration contralateral C7 nerve root transfer nerve graft brachial plexus avulsion injury direct repair human acellular nerve allograft shoulder function elbow function nerve transfer phrenic nerve accessary nerve neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Various changes in cryopreserved acellular nerve allografts at-80°C

引用

Neural Regeneration Research 2018年第9期13卷 1643-1649页

作者： Yan-Yan Huang Xiao-Lu Xu Xi-Jun Huang Jiang-Hui liu Jian Qi Shuang Zhu Zhao-Wei Zhu Bo He Qing-Tang Zhu Yang-Bin Xu li-qiang gu Xiao-lin liu Department of Plastic Surgery The First Affiliated Hospital of Sun Yat-sen University Yale School of Medicine New HavenCT Department of Orthopedic and Microsurgery the First Affiliated Hospital of Sun Yat-sen University Department of Emergency the First Affiliated Hospital of Sun Yat-sen University Department of Joint and Orthopedic Orthopedic CenterZhujiang Hospital of Southern Medical University

The experimental design evaluated histological,mechanical,and biological properties of allogeneic decellularized nerves after cryopreservation in a multi-angle,multi-directional manner to provide evidence for long-term preservation.Acellular nerve allografts from human and rats were cryopreserved in a cryoprotectant（10% fetal bovine serum,10% dimethyl sulfoxide,and 5% sucrose in RPMI1640 medium） at-80°C for 1 year,followed by thawing at 40°C or 37°C for 8 minutes.The breaking force of acellular nerve allografts was measured using a tensile test.Cell survival was determined using L-929 cell suspensions.Acellular nerve allografts were transplanted into a rat model with loss of a 15-mm segment of the left sciatic nerve.Immunohistochemistry staining was used to measure neurofilament 200 expression.Hematoxylin-eosin staining was utilized to detect relative muscle area in gastrocnemius muscle.Electron microscopy was applied to observe changes in allograft ultrastructure.There was no obvious change in morphological appearance or ultrastructure,breaking force,or cytotoxicity of human acellular nerve allografts after cryopreservation at-80°C.Moreover,there was no remarkable change in neurofilament 200 expression,myelin sheath thickness,or muscle atrophy when fresh or cryopreserved rat acellular nerve allografts were applied to repair nerve injury in rats.These results suggest that cryopreservation can greatly extend the storage duration of acellular nerve tissue allografts without concomitant alteration of the physiochemical and biological properties of the engineered tissue to be used for transplantation.

关键词： nerve regeneration acellular nerve allografts cryopreservation storage transplantation nerve neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Indefinite metacavities coupled to a mirror:bound states in the continuum with anomalous resonance scaling

引用

Photonics Research 2024年第3期12卷 598-607页

作者： qiang ZHANG PEIXIANG li ZHIYUAN gu SHAODING liU ZEJUN DUAN College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Advanced Transducers and Intelligent Control System Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China

Indefinite metacavities(IMCs)made of hyperbolic metamaterials show great advantages in terms of extremely small mode volume due to large wave vectors endowed by the unique hyperbolic dispersion.However,quality(Q)factors of IMCs are limited by Ohmic loss of metals and radiative loss of leaked waves.Despite the fact that Ohmic loss of metals is inevitable in IMCs,the radiative loss can be further suppressed by leakage engineering.Here we propose a mirror coupled IMC structure which is able to operate at Fabry–Pérot bound states in the continuum(BICs)while the hyperbolic nature of IMCs is retained.At the BIC point,the radiative loss of magnetic dipolar cavity modes in IMCs is completely absent,resulting in a considerably increased Q factor(>90).Deviating from the BIC point,perfect absorption bands(>0.99)along with a strong near-field intensity enhancement(>1.8×10^(4))appear when the condition of critical coupling is almost fulfilled.The proposed BICs are robust to the geometry and material composition of IMCs and anomalous scaling law of resonance is verified during the tuning of optical responses.We also demonstrate that the Purcell effect of the structure can be significantly improved under BIC and quasi-BIC regimes due to the further enhanced Q factor to mode volume ratio.Our results provide a new train of thought to design ultra-small optical nanocavities that may find many applications benefitting from strong light–matter interactions.

关键词： hyperbolic mirror definite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Torque limit-based Inertial Control Method Based on Delayed Support for Primary Frequency Control of Wind Turbines

引用

Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 561-570页

作者： Wei gu Zaiyu Chen Qun li Minghui Yin qiang li Yun Zou School of Automation Nanjing University of Science and TechnologyNanjing 210094China State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing 211103China

To avoid the secondary frequency dip caused by the steep drop of the electrical power of wind turbines(WTs)at the end of frequency support stage,the torque limit-based iner-tial control(TliC)method sets the power reference as a linear function of rotor speed,rather than the step form for the step-wise inertial control.However,the compensation effect on the frequency nadir(FN)caused by the load surge is weakened as the TliC power is no longer in the step form.Specifically,the maximum point of the frequency response component(FRC)contributed by TliC occurs earlier than the minimum point of FRC corresponding to the load surge,so that the FN cannot be adequately raised.Therefore,this paper first investigates the relation between the peak and nadir times of FRCs stimulated by the TliC and load power.On this basis,with the compensation principle of matching the peak and nadir times of FRCs,the improved TliC method based on delayed support is proposed.Finally,the effectiveness of the proposed method is validated via the experiments on the test bench of wind-integrated power system.

关键词： Wind turbine frequency response component torque limit inertial control delayed support

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cytochrome P45026A1 Contributes to the Maintenance of Neuropathic Pain

引用

Neuroscience Bulletin 2024年第3期40卷 293-309页

作者： De-li Cao ling-Jie Ma Bao-Chun Jiang qiang gu Yong-Jing Gao Institute of Pain Medicine and Special Environmental Medicine Co-innovation Center of NeuroregenerationNantong UniversityNantong226019China Nantong University Medical School Nantong226001China Department of Pain Management The Affiliated Hospital of Nantong UniversityNantong226001China

The cytochrome P450 proteins(CYP450s)have been implicated in catalyzing numerous important biological reactions and contribute to a variety of diseases.CYP26A1,a member of the CYP450 family,carries out the oxidative metabolism of retinoic acid(RA),the active metabolite of vitamin A.Here we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation(SNL).CYP26A1 was mainly expressed in spinal neurons and astrocytes.HPLC analysis displayed that the content of all-trans-RA(at-RA),the substrate of CYP26A1,was reduced in the spinal cord on day 7 after SNL.Inhibition of CYP26A1 by siRNA or inhibition of CYP26A1-mediated at-RA catabolism by talarozole relieved the SNL-induced mechanical allodynia during the maintenance phase of neuropathic pain.Talarozole also reduced SNL-induced glial activation and proinflammatory cytokine production but increased anti-inflammatory cytokine(IL-10)production.The RA receptors RARα,RXRβ,and RXRγwere expressed in spinal neurons and glial cells.The promoter of Il-10 has several binding sites for RA receptors,and at-RA directly increased Il-10 mRNA expression in vitro.Finally,intrathecal IL-10 attenuated SNL-induced neuropathic pain and reduced the activation of astrocytes and microglia.Collectively,the inhibition of CYP26A1-mediated at-RA catabolism alleviates SNL-induced neuropathic pain by promoting the expression of IL-10 and suppressing glial activation.CYP26A1 may be a potential therapeutic target for the treatment of neuropathic pain.

关键词： CYP26A1 Microglia Astrocytes ERK P38 IL-10 Neuropathic pain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spin-Dependent Term of Thermodynamic Quantity Around a Black Hole

引用

Communications in Theoretical Physics 2008年第1期49卷 126-128页

作者： li gu-qiang Department of Physics Zhanjiang Normal College Zhanjiang 524048 China

在有全球单极的 Schwarzschild-anti-de 保姆黑洞附近的理想的相对论的气体的状态的熵密度，精力密度，压力，和方程被使用砖墙方法调查。有纺纱依赖的亚铅术语存在并且为任何旋转域的改正的表达式为分级的地与那很不同，这被显示出。这... 详细信息

在有全球单极的 Schwarzschild-anti-de 保姆黑洞附近的理想的相对论的气体的状态的熵密度，精力密度，压力，和方程被使用砖墙方法调查。有纺纱依赖的亚铅术语存在并且为任何旋转域的改正的表达式为分级的地与那很不同，这被显示出。这些 thermodynamical 数量在扁平的空间时间花象那些的一样的表格的平常的结果仅仅为领先的术语成立。

关键词：热力学热处理黑洞真空状态

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of TeO_x-SiO_2 film with excellent third-order nonlinear optical properties by electrochemically induced sol-gel method

引用

Chinese Chemical Letters 2011年第11期22卷 1359-1362页

作者： qiang li Min gu State and Local Joint Engineering Laboratory of Methane Drainage in Complex Coal Gas Seam Key Lab for the Exploitation of Southwestern Resources and the Environmental Disaster Control Engineering of Education Ministry College of Resources and Environmental Science Chongqing University Chongqing 400044 China

TeOx-SiO2 composite films having third-order nonlinearities were prepared by electrochemically induced sol-gel deposition method on ITO substrate.The third-order optical nonlinearities of the films were measured by Z-scan technique.The third-order nonlinear susceptibilities（χ^（（3））） of the as-prepared films are 5.9×10^（-7） to 4.29×10^（-6）esu.The surface morphology and composition of the films were characterized by SEM/EDX,which identified that Te metallic particles well dispersed in TeO_x-SiO_2 gel films.

关键词： TeOx-SiO2 composite Electrochemically induced sol-gel method Third-order nonlinearities Z-scan

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dilaton Black Hole Tunneling Radiation in de Sitter Universe

引用

Communications in Theoretical Physics 2009年第3期51卷 453-454页

作者： li gu-qiang School of Physics Science ＆ Technology Zhanjiang Normal University Zhanjiang 524048 China

经由来自在 de 保姆宇宙的 dilaton 黑人洞的通道的兜售的放射用 Parikh Wilczek 的方法被调查。我们证明如果自我重力的相互作用和精力保存被考虑，修改放射光谱从准确热光谱背离并且满足单一的理论。

关键词： Hawking辐射宇宙西特隧道黑洞引力相互作用能源节约统一理论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emergent symmetry in quantum phase transition:From deconfined quantum critical point to gapless quantum spin liquid

引用

Science Bulletin 2024年第2期69卷 190-196页

作者： Wen-Yuan liu Shou-Shu Gong Wei-qiang Chen Zheng-Cheng gu Department of Physics The Chinese University of Hong KongHong KongChina Division of Chemistry and Chemical Engineering California Institute of TechnologyPasadena CA 91125USA School of Physical Sciences Great Bay UniversityDongguan 523000China Great Bay Institute for Advanced Study Dongguan 523000China Department of Physics and Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The emergence of exotic quantum phenomena in frustrated magnets is rapidly driving the development of quantum many-body physics,raising fundamental questions on the nature of quantum phase transitions.Here we unveil the behaviour of emergent symmetry involving two extraordinarily representative phenomena,i.e.,the deconfined quantum critical point(DQCP)and the quantum spin liquid(QSL)state.Via large-scale tensor network simulations,we study a spatially anisotropic spin-1/2 square-lattice frustrated antiferromagnetic(AFM)model,namely the J1x-J1y-J2 model,which contains anisotropic nearestneighbor couplings J1x,J1y and the next nearest neighbor coupling J2.For small J1y/J1x,by tuning J2,a direct continuous transition between the AFM and valence bond solid phase is observed.With growing J1y/J1x,a gapless QSL phase gradually emerges between the AFM and VBS phases.We observe an emergent O(4)symmetry along the AFM–VBS transition line,which is consistent with the prediction of DQCP theory.Most surprisingly,we find that such an emergent O(4)symmetry holds for the whole QSL–VBS transition line as well.These findings reveal the intrinsic relationship between the QSL and DQCP from categorical symmetry point of view,and strongly constrain the quantum field theory description of the QSL phase.The phase diagram and critical exponents presented in this paper are of direct relevance to future experiments on frustrated magnets and cold atom systems.

关键词： Tensor network Quantum phase transition Emergent symmetry Quantum spin liquid Deconfined quantum critical point Anisotropic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：