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嵌入式远程测控系统的设计

机械工程师 2009年第2期 67-69页

作者：梁冰茹陈海燕李孟平哈尔滨理工大学自动化学院控制理论与控制工程系哈尔滨150080

文中旨在提出一种测控系统的实现方法,通过把嵌入式操作系统μc/os-ii移植到S3C44B0X上和TCP/IP协议,实现了远程测量和控制,使系统具有信息化、网络化功能。

关键词：远程测控 μc/os-ii的移植 TCP/IP协议 S3C44B0X

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge Dai li Rongrong Zhong Qiang liu Fanglian Chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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内质网应激及介导细胞凋亡信号转导研究进展

生物医学工程与临床 2018年第2期22卷 214-220页

作者：张利平孟燕元小冬钱琳琳张萍淑华北理工大学附属开滦总医院河北唐山063000

近年来,内质网应激(ERS)和它所诱导的细胞凋亡被认为在慢性疾病、神经退行性疾病、癌症和糖尿病等疾病的病理生理中发挥重要作用。当内质网(ER)正常功能紊乱时,会扰乱细胞内环境,引起ERS,从而激活一系列进化保守的自我保护性信号通路统... 详细信息

近年来,内质网应激(ERS)和它所诱导的细胞凋亡被认为在慢性疾病、神经退行性疾病、癌症和糖尿病等疾病的病理生理中发挥重要作用。当内质网(ER)正常功能紊乱时,会扰乱细胞内环境,引起ERS,从而激活一系列进化保守的自我保护性信号通路统称为未折叠蛋白质反应(UPR)。最初,UPR旨在恢复ER内部平衡,保护细胞存活,但如果这些尝试失败,UPR将转而激活凋亡级联反应,导致细胞凋亡。文章对ERS反应进行介绍,综述了ERS激活跨膜蛋白激酶(IRE1)、蛋白激酶R样内质网激酶(PERK)、活化转录因子6(ATF6)介导的促存活通路及ERS介导的包括增强子结合蛋白同源蛋白(CHOP)、半胱天冬氨酸蛋白12(Caspase12)、c-Jun氨基末端激酶(JNK)等促细胞凋亡途径的可能机制。

关键词：内质网应激细胞凋亡未折叠蛋白反应 Caspase12 蛋白激酶R样内质网激酶(PERK) 跨膜蛋白激酶(IRE1) 活化转录因子6(ATF6)

基于生物信息学方法分析不同证型组肝癌组织中差异表达MicroRNA

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时珍国医国药 2015年第10期26卷 2549-2552页

作者：曹海明武哲丽叶小卫陈新林李梦萍付顺军毛思颖广州中医药大学广东广州510405 广州市中医医院广东广州510130 中山大学附属第一医院广东广州510080

目的探索肝癌中特异性表达的microRNA与所调控的靶基因网络关系、差异基因与细胞通路改变的关系及不同证型组间的表达差异。方法通过对肝癌组织样本进行miRNA芯片技术进行筛选,获得不同证型肝癌组织与正常肝组织中差异性表达miRNA,再用G... 详细信息

目的探索肝癌中特异性表达的microRNA与所调控的靶基因网络关系、差异基因与细胞通路改变的关系及不同证型组间的表达差异。方法通过对肝癌组织样本进行miRNA芯片技术进行筛选,获得不同证型肝癌组织与正常肝组织中差异性表达miRNA,再用GO分析对这些miRNA进行靶基因预测和靶基因功能富集分析,得到网络调控的关键miRNA和受调控作用的关键靶基因及其功能,最后用PCR验证相关miRNA及比较不同中医证型组表达的差异。结果初步筛选出肝癌组织中明显上调的关键miRNA12个,下调的关键miRNA10个,GO分析发现靶基因与调控其他基因表达、细胞分化、生长、增殖、凋亡、生长因子受体通路、细胞粘附、血管生成和细胞运动等多项生物学过程有关。进一步的PCR验证也发现不同证型组间存在miRNA表达的差异。结论肝癌组织中差异性表达的miRNA及其所调控的靶基因与肝细胞发生癌变、癌细胞转移和肿瘤内血管生成等多个细胞学进程中的多个靶点起到关键作用,不同证型组肝癌组miRNA表达谱具有独自的特征。

关键词：肝癌 MicroRNA 生物信息学

四方和正交YBa_2Cu_3O_(7-x)体系的输运性质

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物理学报 1989年第3期38卷 511-515页

作者：阮耀钟胡学龙李立平孟光耀胡俊宝蒋志红张裕恒中国科学技术大学物理系中国科学技术大学材料科学系

测量了一系列在不同淬火温度下制得的单相YBa_2Cu_3O_(7-x)样品的电阻和热电势率。热电势率与温度的关系表明,在正交结构的超导体中,存在声子曳引峰,而在四方结构的样品中,声子曳引峰消失,说明电-声子相互作用对超导电性有影响。根据热... 详细信息

测量了一系列在不同淬火温度下制得的单相YBa_2Cu_3O_(7-x)样品的电阻和热电势率。热电势率与温度的关系表明,在正交结构的超导体中,存在声子曳引峰,而在四方结构的样品中,声子曳引峰消失,说明电-声子相互作用对超导电性有影响。根据热电势率数据,估算了样品的费密能和载流子浓度。

关键词：四方正交结构超导体输运性质

Global trends and hotspots of type 2 diabetes in children and adolescents:A bibliometric study and visualization analysis

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World Journal of Diabetes 2025年第1期16卷 140-168页

作者： Fang-Shuo Zhang Hai-Jing li Xue Yu Yi-ping Song Yan-Feng Ren Xuan-Zhu Qian Jia-li liu Wen-Xun li Yi-Ran Huang Kuo Gao School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus(T2DM)among children and adolescents *** to rapid disease progression,severe long-term cardiorenal complications,a lack of effective treatment strategies,and substantial socioeconomic burdens,it has become an urgent public health issue that requires management and *** T2DM differs from adult *** a significant increase in our understanding of youth-onset T2DM over the past two decades,the related review and evidence-based content remain *** To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research *** This study utilized the terms“children”,“adolescents”,and“type 2 diabetes”,retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection(SCI,SSCI,ESCI).Utilizing CiteSpace and VoSviewer software,we analyze and visually represent the annual output of literature,countries involved,and participating *** allows us to predict trends in this research *** analysis encompasses co-cited authors,journal overlays,citation overlays,time-zone views,keyword analysis,and reference analysis,*** A total of 9210 articles were included,and the annual publication volume in this field showed a steady growth *** United States had the highest number of publications and the highest *** United States also had the most research institutions and the strongest research *** global hot journals were primarily diabetes professional journals but also included journals related to nutrition,endocrinology,and *** analysis showed that research related to endothelial dysfunction,exposure risk,cardiac metabolic risk,changes in gut microbiota,the impact on comorbidities and outcomes,etc.,were emerging *** have maintained their popularity in this field,sugges

关键词： Child Adolescent Type 2 diabetes mellitus Bibliometrics Knowledge mapping Visualization CiteSpace VOSviewer

Bloodletting Acupuncture at Jing-Well Points Alleviates Myocardial Injury in Acute Altitude Hypoxic Rats by Activating HIF-1 α/BNIP3 Signaling-Mediated Mitochondrial Autophagyand Decreasing Oxidative Stress

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Chinese Journal of Integrative Medicine 2023年第2期29卷 170-178页

作者： WANG Chao li meng-xin li Yun-di li Yong-ping Department of Traditional Chinese Medicine Medical Institute of Qinghai UniversityXining 810000China

Objective: To explore the protective effect and possible mechanisms of bloodletting acupuncture at Jing-well points(BAJP) pre-treatment on acute hypobaric hypoxia(AHH)-induced myocardium injury rat. Methods:Seventy-five rats were randomly divided into 5 groups by a random number table: a control group(n=15), a model group(n=15), a BAJP group(n=15), a BAJP+3-methyladenine(3-MA) group(n=15), and a BANA(bloodletting at nonacupoint;tail bleeding, n=15) group. Except for the control group, the AHH rat model was established in the other groups, and the corresponding treatment methods were adopted. Enzyme-linked immunosorbent assay(EliSA) was used to detect creatine kinase isoenzyme MB(CK-MB) and cardiac troponins I(CTn I) levels in serum and superoxide dismutase(SOD) and malondialdehyde(MDA) levels in myocardial tissue. Hematoxylin-eosin(HE)staining was used to observe myocardial injury, and terminal deoxynucleotidyltransferase-mediated d UTP-biotin nick end labeling(TUNEL) staining was used to observe cell apoptosis. Transmission electron microscopy detection was used to observe mitochondrial damage and autophagosomes in the myocardium. The mitochondrial membrane potential of the myocardium was analyzed with the fluorescent dye JC-1. Mitochondrial respiratory chain complex(complex Ⅰ, Ⅲ, and Ⅳ) activities and ATPase in the myocardium were detected by mitochondrial respiratory chain complex assay kits. Western blot analysis was used to detect the autophagy index and hypoxia inducible factor-1α(HIF-1α)/Bcl-2 and adenovirus E1B 19k Da-interacting protein 3(BNIP3) signaling. Results:BAJP reduced myocardial injury and inhibited myocardial cell apoptosis in AHH rats. BAJP pretreatment decreased MDA levels and increased SOD levels in AHH rats(all P<0.01). Moreover, BAJP pretreatment increased the mitochondrial membrane potential(P<0.01), mitochondrial respiratory chain complex(complexes Ⅰ, Ⅲ, and Ⅳ)activities(P<0.01), and mitochondrial ATPase activity in AHH rats(P<0.05). The re

关键词： acute hypobaric hypoxia bloodletting acupuncture at Jing-well points autophagy myocardium injury mitochondrial damage Chinese medicine

接种量对产气肠杆菌同步糖化暗发酵产氢的影响

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中国沼气 2017年第2期35卷 24-27页

作者：张甜张全国张志萍李亚猛路朝阳刘会亮河南农业大学农业部可再生能源新材料与装备重点实验室郑州450002

文章以小麦秸秆为原料,研究了不同接种量对产气肠杆菌同步糖化发酵产氢的影响,以期寻求最佳的接种量条件。试验以累积产氢量、产氢速率等指标来分析产气肠杆菌利用小麦秸秆进行同步糖化发酵产氢的潜力及其可行性。结果表明:在以反应液... 详细信息

文章以小麦秸秆为原料,研究了不同接种量对产气肠杆菌同步糖化发酵产氢的影响,以期寻求最佳的接种量条件。试验以累积产氢量、产氢速率等指标来分析产气肠杆菌利用小麦秸秆进行同步糖化发酵产氢的潜力及其可行性。结果表明:在以反应液体积为200 mL,底物为5 g小麦秸秆,酶负荷为150 mg·g^(-1)秸秆、初始pH值为6.5,温度为35℃的条件下,接种量为30%时产氢效果最好,此时的累积产气量达到737 mL,累积产氢量达到293mL,最大产氢速率为35.42 mL·h^(-1)L^(-1)。该实验研究为秸秆类生物质同步糖化厌氧暗发酵产氢的进一步研究奠定了基础并提供了科学参考。

关键词：接种量产气肠杆菌同步糖化生物制氢

Analysis of the Transformation-induced Plasticity Effect during the Dynamic Deformation of High-manganese Steel

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Journal of Materials Science & Technology 2015年第2期31卷 191-198页

作者： Huizhen Wang Xiurong Sun ping Yang Weimin Mao li meng School of Materials Science and Engineering University of Science and Technology Beijing

The transformation-induced plasticity(TRIP) effect and resistance characteristics to adiabatic shear failure at high strain rates of high-manganese steel were investigated by using scanning electron microscopy and electron backscattering diffraction. Results showed that the high-manganese steel exhibited excellent strain hardening effect and resistance to adiabatic shear failure because of the TRIP effect. The TRIP effect occurred during dynamic deformation and showed two distinct stages,namely,the smooth TRIP process before the formation of adiabatic shear band(ASB) and the inhibited TRIP process during further deformation. In the first stage,the martensitic transformation showed slight orientation dependence and weak variant selection,which promoted the TRIP effect. In the second stage,reverse martensitic transformation occurred. Adiabatic shear bands(ASBs) developed typical shear microtextures {111}. In microtextures,two groups of fine grains are in a twin relationship and uniform distribution,which restrained the formation of holes and cracks within the ASBs and enhanced damage resistance after ASB formation.

关键词： High-manganese steel Martensitic transformation Ad