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Internal limiting membrane peeling combined with silicone oil or air tamponade for highly myopic foveoschisis

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1079-1085页

作者： Jin Deng Wen-Tao Sun Ke Gong li-ping wang Feng-Zhi li Xi’an People’s Hospital(Xi’an Fourth Hospital) Shaanxi Eye HospitalAffiliated People’s Hospital of Northwest UniversityXi’an 70004Shaanxi ProvinceChina

AIM:To compare the efficacy of pars plana vitrectomy(PPV)combined with internal limiting membrane(ILM)and silicone oil or sterile air tamponade for the treatment of myopic foveoschisis(MF)in highly myopic ***:This retrospective study included 48 myopic eyes of 40 patients with MF and axial lengths(ALs)ranging from 26-32 mm treated between January 2020 and January *** patients were underwent PPV combined with ILM peeling followed by sterile air or silicone oil tamponade and followed up at least *** on the features on spectral-domain optical coherence tomography(SD-OCT),the eyes were divided into the MF-only group(Group A,n=15 eyes),MF with central foveal detachment group(Group B,n=20 eyes),and MF with lamellar macular hole group(Group C,n=13 eyes).According to AL,eyes were further divided into three groups:Group D(26.01-28.00 mm,n=12 eyes),Group E(28.01-30.00 mm,n=26 eyes),and Group F(30.01-32.00 mm,n=10 eyes).The best-corrected visual acuity(BCVA),central foveal thickness(CFT),and complications were ***:The patients included 16 males and 24 females with the mean age of 56±*** BCVA and CFT improved in all groups after surgery(P0.05).The intergroup differences of BCVA and CFT postoperatively were statistically significant in Group D,E,and *** eyes were injected with sterile air,and 28 eyes were injected with silicone oil for tamponade based on the ***,there was no statistically significant difference among Groups D,E,and F in terms of the results of sterile air or silicone oil *** mean recovery time was 5.9mo for MF patients subjected to silicone oil tamponade and 7.7mo for patients subjected to sterile air tamponade,and the difference was not statistically ***:PPV and ILM peeling combined with silicone oil or sterile air tamponade can achieve good results for MF in highly myopic eyes with ALs

关键词： axial length myopic foveoschisis highly myopic internal limiting membrane pars plana vitrectomy

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Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

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Journal of Pharmaceutical Analysis 2024年第3期14卷 335-347页

作者： Ding-Jun Hao Yue Qin Shi-Jie Zhou Bu-Huai Dong Jun-Song Yang Peng Zou li-ping wang Yuan-Ting Zhao Department of Spine Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Anesthesiology Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Cardiovascular Medicine Honghui HospitalXi'an Jiaotong UniversityXi'an710054China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengdu610041China

Hyaluronan and proteoglycan link protein 1(Hapln1)supports active cardiomyogenesis in zebrafish hearts,but its regulation in mammal cardiomyocytes is *** study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therapeutic value in myocardial infarction with human induced pluripotent stem cell(hiPSC)-derived cardiomyocytes(CMs)and an adult mouse model of myocardial ***-CMs and adult mice with myocardial infarction were used as in vitro and in vivo models,*** single-cell RNA sequencing data were retrieved for bioinformatic *** results showed that recombinant human Hapln1(rhHapln1)promotes the proliferation of hiPSC-CMs in a dose-dependent *** a physical binding protein of Hapln1,versican interacted with Nodal growth differentiation factor(NODAL)and growth differentiation factor 11(GDF11).GDF11,but not NODAL,was expressed by ***11 expression was unaffected by rhHapln1 ***,this molecule was required for rhHapln1-mediated activation of the transforming growth factor(TGF)-β/Drosophila mothers against decapentaplegic protein(SMAD)2/3 signaling in hiPSC-CMs,which stimulates cell dedifferentiation and *** mouse Hapln1(rmHapln1)could induce cardiac regeneration in the adult mouse model of myocardial *** addition,rmHapln1 induced hiPSC-CM *** conclusion,Hapln1 can stimulate the dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping and subsequent activation of the TGF-β/SMAD2/3 signaling ***1 might be an effective hiPSC-CM dedifferentiation and proliferation agent and a potential reagent for repairing damaged hearts.

关键词： Hapln1 Versican GDF11 iPSC-CMs Cardiomyocyte proliferation

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Serum inflammatory markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for mycoplasma severity

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World Journal of Clinical Cases 2024年第22期12卷 4940-4946页

作者： li-ping wang Zhong-Hua Hu Jun-Sheng Jiang Jie Jin Department of Pediatrics The First People's Hospital of Linping DistrictHangzhou 310000Zhejiang ProvinceChina Department of Pediatrics Changzhou Children HospitalChangzhou 213100Jiangsu ProvinceChina

BACKGROUND Mycoplasma pneumoniae pneumonia(MPP)significantly impacts pediatric health,necessitating markers for early severe disease *** To investigate the correlation between serum inflammatory marker and the severity of MPP in *** A prospective study was carried out from January 2023 to November 2023.A total of 160 children with MPP who underwent treatment were selected:80 had severe MPP and 80 had mild *** and laboratory data were collected at the time of hospital admission and during *** operating characteristic curves were utilized to assess the diagnostic and prognostic for severe *** Fever duration and length of hospitalization in pediatric patients with severe MPP exceeded those with mild *** incidence of pleural effusion,lung consolidation,and bronchopneumonia on imaging was markedly elevated in the severe MPP cohort compared to the mild MPP *** contrast to the mild cohort,there was a notable increase in C-reactive protein(CRP),procalcitonin(PCT),erythrocyte sedimentation rate,lactic dehydrogenase,D-dimer,and inflammatory cytokines[interleukin(IL)-6,IL-8,IL-10 and tumor necrosis factor(TNF)-α]in the severe MPP group were significantly *** Serum inflammatory markers(CRP,PCT,IL-6,D-dimer,IL-10 and TNF-α)were considered as predictors in children with severe MPP.

关键词： Cytokine Mycoplasma pneumoniae pneumonia Children,Community-acquired pneumonia levels Interleukin-6 D-dimer

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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan Jing-Jing Zhao liang liu Dong-Sheng Zhang li-ping wang Wen-Wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo li Yan Tang Wei-Hong Zhang Jie-Yao li Xiao Zheng Qi-Jing wang Yong-Qiang li Tong Xiang li Zhou Shuang-Ning Yang Chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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环辛二烯氘代、开环易位聚合及其聚合物的固相催化加成

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高分子学报 2024年第6期55卷 738-749页

作者：杜杰刘孟王丽萍郭彪谭欣欣罗文华中国工程物理研究院材料研究所绵阳621907

氘(氚)代聚合物是一类很有前景的惯性约束聚变靶材料.为制备具有较多加氚位点的氘代聚合物,开展了环辛二烯的氘代及开环易位聚合实验研究.对1,5-环辛二烯反应过程中间产物组分进行分析,研究了其氘代反应机理.通过核磁共振波谱(1H-NMR、2... 详细信息

氘(氚)代聚合物是一类很有前景的惯性约束聚变靶材料.为制备具有较多加氚位点的氘代聚合物,开展了环辛二烯的氘代及开环易位聚合实验研究.对1,5-环辛二烯反应过程中间产物组分进行分析,研究了其氘代反应机理.通过核磁共振波谱(1H-NMR、2H-NMR、13C-NMR)分析,表明环辛二烯氘代后的副产物为氘代环辛烯.研究了温度、添加剂、反应时间对产物氘代率及副产物生成率的影响,获得了优化的反应条件,并制备了氘代率高达96%的氘代1,3-环辛二烯.开展了(氘代)1,3-环辛二烯的开环易位聚合实验,其中大量连续共轭双键的存在导致聚合物结晶使得其溶解性较差.在5 wt%的Pd/BaSO4与Grubbs二代催化剂的存在下,开展了聚1,3-环辛二烯、氘代1,3-环辛二烯与氘代环辛烯共聚物的固相催化加氘实验,均可加氘至接近饱和,在此过程中伴随着明显的氢同位素交换反应.发展了一种均相固相催化氢同位素加成的方法,有望实现在已成型的氘代聚合物靶丸上直接加氚,从而制备氘-氚代聚合物靶丸.

关键词：氘代机理氘代聚合物开环易位聚合固相催化氘化

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近断层地震动下多跨简支梁桥地震响应及减震研究

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兰州理工大学学报 2024年第4期50卷 103-111页

作者：李旺平杨雄焦应乾裴银海石岩兰州理工大学土木工程学院甘肃兰州730050

为研究近断层地震动下多跨简支梁桥的地震响应及其减震措施,以1座4跨简支梁桥为研究对象,选取3组分别考虑滑冲效应、向前方向性效应及无脉冲效应的近断层地震动和1组远断层地震动作为输入,分析主梁、桥墩和支座等的响应和损伤.发现速度... 详细信息

为研究近断层地震动下多跨简支梁桥的地震响应及其减震措施,以1座4跨简支梁桥为研究对象,选取3组分别考虑滑冲效应、向前方向性效应及无脉冲效应的近断层地震动和1组远断层地震动作为输入,分析主梁、桥墩和支座等的响应和损伤.发现速度脉冲型近断层地震动对桥梁纵横向的位移均有放大作用,既会增加桥墩和支座的损伤程度,也会增加梁间纵向碰撞次数和碰撞力峰值.为此提出“防屈曲支撑(BRB)+粘滞阻尼器”的组合减震系统,并对粘滞阻尼器的布置形式和参数对减震效果的影响进行了分析.结果表明:该减震方案可有效降低桥墩和支座的损伤、减小主梁纵向位移;且阻尼器布置在主梁与桥台间更有利于减震控制;建议粘滞阻尼系数C梁间取3 000 kN·s/m,台梁间取4 000 kN·s/m,速度相关系数α取0.4.

关键词：简支梁桥近断层地震动地震响应组合减震系统损伤控制

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Understanding Human and Machine Interaction from Decision Perspective: An Empirical Study Based on the Game of Go

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Journal of Systems Science & Complexity 2024年第2期37卷 647-667页

作者： ZHAO ping li Xuerong wang Shouyang Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

The authors aim to interpret human and AI interactions from the decision *** authors decompose the interaction analysis into the following main components in the context of interactions:Individual behavior patterns,interaction relationships,and comprehensive *** authors interpret intertemporal decisions from a physical perspective and employ cross-discipline concepts and methodologies to extract the behavior characteristics of players in the empirical case *** the individual behavior patterns,the authors find that human players prefer short-term periods to AI in *** interaction relationship analysis reveals a dynamic relationship between possible short-term co-movement and nearly counter-movement in the long *** authors apply principal component analysis to descriptive indicators and discover a regular decision *** main behavior pattern of players in the game of Go is switching between careful and daring *** differences in the decision hierarchies imply a discrepancy of patience between humans and AI.

关键词： Coherence analysis decision hierarchy machine behaviour multitaper spectral analysis

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Driving role of climatic and socioenvironmental factors on human brucellosis in China:machine-learning-based predictive analyses

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Infectious Diseases of Poverty 2023年第2期12卷 87-100页

作者： Hui Chen Meng-Xuan lin li-ping wang Yin-Xiang Huang Yao Feng li-Qun Fang Lei wang Hong-Bin Song li-Gui wang Center for Disease Control and Prevention of Chinese People’s liberation Army 20 Dong-Da-Jie StreetFengtai DistrictBeijing100071China Academy of Military Medical Sciences Academy of Military Science of Chinese People’s Liberation Army27 Taiping RoadHaidian DistrictBeijing100036China Chinese Centre for Disease Control and Prevention No.155 Changbai RoadChangping DistrictBeijing102206China School of Biological Science and Medical Engineering Beihang University37 Xueyuan RoadHaidian DistrictBeijing100191China Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijingChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology20 Dong-Da StreetFengtai DistrictBeijing100071China

Background Brucellosis is a common zoonotic infectious disease in *** study aimed to investigate the incidence trends of brucellosis in China,construct an optimal prediction model,and analyze the driving role of climatic factors for human *** Using brucellosis incidence,and the socioeconomic and climatic data for 2014–2020 in China,we performed spatiotemporal analyses and calculated correlations with brucellosis incidence in China,developed and compared a series of regression and Seasonal Autoregressive Integrated Moving Average X(SARIMAX)models for brucellosis prediction based on socioeconomic and climatic data,and analyzed the relationship between extreme weather conditions and brucellosis incidence using copula *** In total,327,456 brucellosis cases were reported in China in 2014–2020(monthly average of 3898 cases).The incidence of brucellosis was distinctly seasonal,with a high incidence in spring and summer and an average annual peak in *** incidence rate was highest in the northern regions’arid and continental climatic zones(1.88 and 0.47 per million people,respectively)and lowest in the tropics(0.003 per million people).The incidence of brucellosis showed opposite trends of decrease and increase in northern and southern China,respectively,with an overall severe epidemic in northern *** regression models using socioeconomic and climatic data cannot predict brucellosis *** SARIMAX model was suitable for brucellosis *** were significant negative correlations between the proportion of extreme weather values for both high sunshine and high humidity and the incidence of brucellosis as follows:high sunshine,r=−0.59 and−0.69 in arid and temperate zones;high humidity,r=−0.62,−0.64,and−0.65 in arid,temperate,and tropical *** Significant seasonal and climatic zone differences were observed for brucellosis incidence in ***,humidity,and wind speed significantly influenced brucello

关键词： Human brucellosis Socioeconomics Climatic Extreme weather Copula model

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Combination of cataract surgery with intravitreal injection of dexamethasone intravitreal implant(Ozurdex)for uveitis-induced cataract

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International Journal of Ophthalmology(English edition) 2023年第3期16卷 361-366页

作者： Jin Deng Wen-Tao Sun Hua Ai li-ping wang Xi’an People’s Hospital(Xi’an Fouth Hospital) Shaanxi Eye HospitalAffiliated People’s Hospital of Northwest UniversityXi’an 710004Shaanxi ProvinceChina

AIM:To evaluate the long-term results of patients with chronic uveitis-induced cataract by phacoemulsification with IOL implantation and intravitreal injection of dexamethasone(DEX)intravitreal implant(Ozurdex).METHODS:The study included 32 eyes of 26 patients treated with DEX implant due to chronic uveitis-induced cataract and followed up for at least a ***-corrected visual acuity(BCVA),intraocular pressure(IOP),anterior chamber reaction,central macular thickness(CMT),intraoperative and postoperative complications and uveitis recurrence were analyzed ***:A successful surgery was performed in all *** average follow-up period was *** female/male ratio was 13/*** age was 45.65±3.83y(range 26 to 65y).Etiologically,rheumatic arthritis occurred in 6 patients(18.75%),ankylosing spondylitis in 4(12.50%),HLA-B27 associated uveitis in 3(9.38%),Vogt-KoyanagiHarada-associated uveitis in 4(12.50%),Behcet’s disease in 2(6.25%),and 7(21.88%)suffered from unknown *** 32 eyes had varying degrees of improvement at 12mo after surgery,with 2 eyes showing BCVA of 0.1 or below(6.25%),6 having 0.1-0.5(18.75%),18 of 0.5-1.0(56.25%),and 6 of 1.0 or above(18.75%).No cases with increased IOP were *** values of mean CMT was increased at day 1,decreased at 1,3mo after surgery and increased at 6,12mo after *** severe uveitis reactions,such as fibrinous exudates in the anterior chamber and exudative membrane formation on the anterior surface of the IOL,were observed after ***:The present studies show that intravitreal injection of Ozudex during cataract operation can provide a new option for the clinical treatment of uveitis-induced cataract.

关键词： uveitis-induced cataract dexamethasone implant intravitreal injection

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Rheological Behaviors of Polymers with Nanoparticles Tethered at Each End

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Chinese Journal of Polymer Science 2024年第3期42卷 400-406,I0009页

作者： Song-Qi Zhang Wen-Qing wang Jia-ping lin li-Quan wang Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

The polymer with nanoparticles tethered at each end is a unique model for unraveling the effect of chain ends on the polymer dynamics. We investigated the rheological behavior of this kind of polymer by using nonequilibrium molecular dynamics simulation. The effect of polymer lengths and nanoparticle radii on the complex moduli and viscosity was examined. The dependence of complex moduli on the frequency becomes less pronounced as the polymer is short or the nanoparticle is large. The shear thinning behavior was revealed for these systems, and the scaling exponent of complex viscosity with respect to the frequency was found to change from-1/2 to-3/4 as the polymer shortens or the nanoparticle enlarges. The rheological behavior was further explained by analyzing the mean square distance of nanoparticles. The simulation results were compared with the existing experimental finding, showing an agreement. The work provides information for understanding the chain end effect on polymer rheology.

关键词： Polymer rheology Modulus Viscosity Molecular dynamics

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