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Spectrum analysis of interval process model and its application in uncertain vibration analysis

Science China(Technological Sciences) 2024年第8期67卷 2549-2564页

作者： li JinWu JIANG Chao ni BingYu State Key Laboratory of Advanced Design and Manufacturing Technology for Vehicle College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China

In recent years, the authors have extended the traditional interval method into the time dimension to develop a new mathematical tool called the “interval process model” for quantifying time-varying or dynamic uncertainties. This model employs upper and lower bounds instead of precise probability distributions to quantify uncertainty in a parameter at any given time point. It is anticipated to complement the conventional stochastic process model in the coming years owing to its relatively low dependence on experimental samples and ease of understanding for engineers. Building on our previous work, this paper proposes a spectrum analysis method to describe the frequency domain characteristics of an interval process, further strengthening the theoretical foundation of the interval process model and enhancing its applicability for complex engineering problems. In this approach, we first define the zero midpoint function interval process and its auto/cross-power spectral density(PSD) functions. We also deduce the relationship between the auto-PSD function and the auto-covariance function of the stationary zero midpoint function interval process. Next, the auto/cross-PSD function matrices of a general interval process are defined, followed by the introduction of the concepts of PSD function matrix and cross-PSD function matrix for interval process vectors. The spectrum analysis method is then applied to random vibration problems, leading to the creation of a spectrum-analysis-based interval vibration analysis method that determines the PSD function for the system displacement response under stationary interval process excitations. Finally, the effectiveness of the formulated spectrum-analysis-based interval vibration analysis approach is verified through two numerical examples.

关键词： interval process spectrum analysis power spectral density(PSD) time-varying uncertainty uncertain vibration analysis

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Application of plant DNA metabarcoding of lake sediments for monitoring vegetation compositions on the Tibetan Plateau

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Science China Earth Sciences 2024年第11期67卷 3594-3609页

作者： Kai WU Kai li Weihan JIA Kathleen R.STOOF-LEICHSENRING Ulrike HERZSCHUH Jian ni Mengna liAO fang TIAN College of life Sciences Zhejiang Normal University Polar Terrestrial Environmental Systems Research Group Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Institute of Environmental Science and Geography University of Potsdam Institute of Biochemistry and Biology University of Potsdam College of Resource Environment and Tourism Capital Normal University

Benefiting from the rapid development of environmental DNA(eDNA) technologies, sedimentary DNA(sedDNA)emerges as a promising tool for monitoring plant compositions in remote regions. The Tibetan Plateau(TP), renowned for its harsh environment and numerous ponds and lakes, presents a potentially demanding region for the application of sedDNA on vegetation investigations. Here, we used the g and h universal primers for the P6 loop region of the chloroplast trn L(UAA)intron to amplify plant DNA in surface sediments from 59 ponds and small lakes on the southwestern TP. The applicability and limitations of using plant DNA metabarcoding for modern vegetation monitoring and palaeo-vegetation reconstructions have been assessed by comparing sedDNA, pollen, and vegetation survey data. Our results showed that plant DNA metabarcoding recorded 186 terrestrial taxa, of which 30.1% can be identified at the species level. The plant sedDNA approach can effectively disclose the dominant plant taxa(including Asteraceae, Cyperaceae and Poaceae) and significant vegetation assemblages in the vicinity of the investigated sites. The number of taxa and taxonomic resolution of plant sedDNA exceeded that of pollen analysis(75 taxa detected, 5.3% can be identified at species level). Unlike pollen that retains a broad spectrum of regional plant signals(including Pinus and Artemisia), plant sedDNA mirrors very local plants, underscoring its utility in local vegetation monitoring and reconstructions. To conclude, plant DNA metabarcoding of(small) lake sediments warrant increased attention in the future for local vegetation monitoring and reconstructions on the TP.

关键词： Sedimentary DNA (sedDNA) Metabarcoding Pollen Vegetation composition Tibetan Plateau

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The CBL-interacting protein kinase OsCIPK1 phosphorylated by SAPK10 positively regulates responses to ABA and osmotic stress in rice

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The Crop Journal 2024年第2期12卷 364-374页

作者： Caihua Qin Xing Fan Qianqian fang Lan ni Mingyi Jiang College of life Sciences State Key Laboratory of Crop Genetics&Germplasm Enhancement and UtilizationKey Laboratory of Crop Physiology Ecology and Production ManagementMinistry of AgricultureNanjing Agricultural UniversityNanjing 210095JiangsuChina

SubclassⅢsucrose nonfermenting1-related protein kinase 2s(SnRK2s)function in ABA and abiotic stress responses by unknown *** found that osmotic stress/ABA-activated protein kinase 10(SAPK10),a member of rice SnRK2s,physically interacted with CBL-interacting protein kinase 1(OsCIPK1).OsCIPK1 expression was up-regulated by ABA and PEG treatment,and overexpression increased the ABA sensitivity of seed germination and root growth and plant osmotic stress *** stress or ABA-induced activation of OsCIPK1 is dependent on ***10 phosphorylates Thr-24 of OsCIPK1 in vitro,and this phosphorylation increases the activity of OsCIPK1 and positively regulates the function of OsCIPK1 in ABA responses and plant osmotic stress *** study suggests that OsCIPK1 is a direct phosphorylated substrate of SAPK10,and SAPK10-mediated phosphorylation of OsCIPK1 functions in ABA signaling and increases rice osmotic stress tolerance.

关键词： Rice ABA Osmotic stress OsCIPK1 SAPK10

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Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration

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Nano Research 2024年第8期17卷 7449-7460页

作者： Yin Yuan lijun Chen Jing Yang Sining Zhou Yangxin fang Qi Zhang ning Zhang Yifei li li Yuan Fan Jia Shuo ni Charlie Xiang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Biology The David H.Koch Institute for Integrative Cancer Research at MITMassachusetts Institute of TechnologyCambridgeMA 02139USA Research Units of Infectious disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China Innovative Precision Medicine(IPM)Group Hangzhou 311215China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USADepartment of ImmunologyHarvard Medical SchoolBoston MA 02115USA Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China

Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis ***,limited sources and poor tissue-homing efficiency limit their clinical *** this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet *** were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for *** this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse ***,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting *** recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone *** study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.

关键词： mesenchymal stem cells microfluidics bone marrow homing stem cell niche postmenopausal osteoporosis

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A chiral fluorescent probe for molecular recognition of basic amino acids in solutions and cells

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Chinese Chemical Letters 2024年第10期35卷 364-369页

作者： Chuan-Zhi ni Ruo-Ming li fang-Qi Zhang Qu-Ao-Wei li Yuan-Yuan Zhu Jie Zeng Shuang-Xi Gu School of Chemistry and Environmental Engineering School of Chemical Engineering&PharmacyPharmaceutical Research InstituteHubei Key Laboratory of Novel Reactor and Green Chemical TechnologyWuhan Institute of TechnologyWuhan 430205China Nanjing Pusheng Biomedical Co. Ltd.Nanjing 210033China

A novel and readily available binaphthyl-based fluorescent probe(S)-1 was designed and synthesized.(S)-1 can be used to not only chemoselectively discriminate 3 basic amino acids out of common amino acids,but also enantioselectively recognize ***,enantioselective imaging of histidine in cells was achieved for the first time by the probe(S)-*** performances endowed it potential application in the chiral analysis of basic amino acids in asymmetric synthesis and cell imaging for diagnosis of diseases caused by racemization of *** magnetic resonance(NMR)and mass spectrometry investigations suggested that different reaction extent of(S)-1 with L/D-histidine and different product structures generated the observed enantioselective fluorescent *** molecular structures and thermodynamic stability of the complexes,formed from(S)-1+Zn2+and enantiomers of histidine,were calculated by Gaussian 16 based on density functional theory(DFT)to validate the above action mechanism.

关键词： Fluorescent probe Chiral recognition Enantioselectivity Chemoselectivity Basic amino acids Cell imaging

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Polyelectrolyte complex-based thermochromic hydrogels containing carbonized polymer dots for smart windows with fast response,excellent solar modulation ability,and high durability

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SmartMat 2024年第2期5卷 124-136页

作者： Yuting Wang Xu fang Siheng li ni An Hongyu Pan Junqi Sun State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchunChina

Thermochromic smart windows have gained increasing popularity in light modulation and energy management in ***,the fabrication of flexible thermochromic smart windows with high luminous transmittance(Tlum),tailorable critical temperature(τc),strong solar modulation ability(ΔTsol),and long-term durability remains a huge *** this study,hydrogel-based thermochromic smart windows are fabricated by sandwiching thermochromic hydrogels of polyallylamine hydrochloride,polyacrylic acid,and carbonized polymer dots(CPDs)complexes between two pieces of transparent *** from the incorporation of nanosized CPDs,the thermochromic hydrogel has an ultrahigh Tlum of~98.7%,a desirableτc of~24.2℃,aΔTsol of~89.3%and a rapid transition time of~3 s from opaque state to transparent ***,the thermochromic hydrogel exhibits excellent anti-freezing ability,tight adhesion toward various substrates,and excellent self-healing *** self-healing capability enables the fabrication of large-area smart windows by welding multiple hydrogel *** smart windows retain their original thermochromic properties after being stored under ambient conditions for at least 147 days or undergoing 10,000 uninterrupted heating/cooling *** model houses with smart windows can achieve a temperature reduction of 9.2℃,demonstrating the excellent indoor temperature modulation performance of the smart windows.

关键词： carbonized polymer dots polyelectrolyte complexes smart windows thermochromic hydrogels

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AI enhances drug discovery and development

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National Science Review 2024年第3期11卷 52-54页

作者： fang Bai Shiliang li Honglin li Shanghai Institute for Advanced Immunochemical Studies and School of life Science and Technology ShanghaiTech University lingang Laboratory Innovation Center for AI and Drug Discovery East China Normal University

The advent of the third wave of artificial intelligence(AI) heralds a new era in drug discovery. AI-powered techniques can be characteristic of identifying features that are difficult for humans to interpret from big ...

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A deep learning model enabled multi-event recognition for distributed optical fiber sensing

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Science China(Information Sciences) 2024年第3期67卷 291-307页

作者： Yujiao li Xiaomin CAO Wenhao ni Kuanglu YU Institute of Information Science School of Computer and Information TechnologyBeijing Jiaotong University Beijing Key Laboratory of Advanced Information Science and Network Technology Beijing Jiaotong University

Fiber optic sensors that utilize backscattered light offer distributed real-time measurements and have been seen tremendous improvements in sensing distance and spatial resolution over the last ***, these improvements in sensor capabilities lead to a significant increase in the amount of data that needs to be processed. Traditional processing schemes are no longer adequate, so the development of novel signal processing methods is critical. Phase-sensitive optical time domain reflectometry(Φ-OTDR) is now applied in various applications for multi-event recognition, and it would usually be difficult, sometimes even unrealistic to label all the acquired samples due to its real-time and seamless monitoring nature. To fully take advantage of the information contained within the large number of unlabeled samples, which were formerly not utilized and hence wasted, we propose a semi-supervised model to boost the event classification performance of Φ-OTDR. The model extracts respectively the temporal features and the spatial bidirectional features together with a dual attention mechanism. Its classification accuracy has been improved up to 96.9%with only 1230 labeled samples. In addition, our model shows significant advantages when the number of labeled samples is reduced. Importantly, our method improves the accuracy of multi-event classification without any modification to the optical setup.

关键词： $\Phi$-OTDR event recognition semi-supervised learning mean teacher MT-ACNN-SA-BiLSTM

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Exploring battery material failure mechanisms through synchrotron X-ray characterization techniques

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Journal of Energy Chemistry 2024年第7期94卷 128-135页

作者： lingzhe fang Xiaozhao liu Tao li Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA X-ray Science Division and Joint Center forEnergy Storage Research Argonne National LaboratoryLemontIL6439UA

Rechargeable battery cycling performance and related safety have been persistent *** is crucial to decipher the capacity fading induced by electrode material failure via a range of *** these,synchrotron-based X-ray techniques with high flux and brightness play a key role in understanding degradation *** this comprehensive review,we summarize recent advancements in degra-dation modes and mechanisms that were revealed by synchrotron X-ray ***,an overview of X-ray absorption spectroscopy and X-ray scattering techniques is introduced for charac-terizing failure phenomena at local coordination atomic environment and long-range order crystal struc-ture scale,*** last,we envision the future of exploring material failure mechanism.

关键词： Battery failure Synchrotron-based techniques X-ray scattering X-ray absorption spectroscopy

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Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying liu Shuai Ye Xin-ni li Wei-Guang li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

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