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Fermatean Hesitant Fuzzy Prioritized Heronian Mean Operator and Its Application in Multi-Attribute Decision Making

Computers, Materials & Continua 2023年第5期75卷 3203-3222页

作者： Chuan-Yang Ruan Xiang-Jing Chen li-na han School of Business Administration Guangdong University of Finance and EconomicsGuangzhou510320China Antai College of Economics and Management Shanghai Jiaotong UniversityShanghai 200030China Guangdong Institute of Scientific and Technical Information Guangzhou510033China

In real life,incomplete information,inaccurate data,and the preferences of decision-makers during qualitative judgment would impact the process of decision-making.As a technical instrument that can successfully handle uncertain information,Fermatean fuzzy sets have recently been used to solve the multi-attribute decision-making(MADM)problems.This paper proposes a Fermatean hesitant fuzzy information aggregation method to address the problem of fusion where the membership,non-membership,and priority are considered simultaneously.Combining the Fermatean hesitant fuzzy sets with Heronian Mean operators,this paper proposes the Fermatean hesitant fuzzy Heronian mean(FHFHM)operator and the Fermatean hesitant fuzzyweighted Heronian mean(FHFWHM)operator.Then,considering the priority relationship between attributes is often easier to obtain than the weight of attributes,this paper defines a new Fermatean hesitant fuzzy prioritized Heronian mean operator(FHFPHM),and discusses its elegant properties such as idempotency,boundedness and monotonicity in detail.Later,for problems with unknown weights and the Fermatean hesitant fuzzy information,aMADM approach based on prioritized attributes is proposed,which can effectively depict the correlation between attributes and avoid the influence of subjective factors on the results.Finally,a numerical example of multi-sensor electronic surveillance is applied to verify the feasibility and validity of the method proposed in this paper.

关键词： Fermatean hesitant fuzzy set multi-attribute decision-making Heronian mean operator prioritized operator

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Enhanced strength and toughness in 40CrNiMo steels by austempering below martensite start temperature

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Journal of Iron and Steel Research(International) 2022年第5期29卷 810-818页

作者： Xiao-xiao liu Zheng Zhang Jie Zhang Ran Yang Cheng-shuang Yu Jun-wei Qiao li-na han College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Zhejiang Laifual Drive Co. Ltd.Shaoxing312462ZhejiangChina

The austempering above and below martensite transition temperature(M_(s))was employed in a medium-carbon low-alloy 40CrNiMo steel,and the bainite and martensite multiphase microstructures with different volume fractions were obtained.Here,the effect of pre-existing martensite on subsequent transformation of bainite microstructure and mechanical properties is focused and researched.The microstructure with a volume fraction of pre-existing martensite(V_(PM)),bainite(V_(B)),and martensite/austenite(V_(M/A))constituents of approximately 28%,46%,and 26%,respectively could be obtained by austenitizing below M_(s)(280℃)for 1 h,and an optimum combination of strength,ductility,and impact toughness(yield strength of 1420 MPa,ultimate tensile strength of 1795 MPa,total elongation of 7.9%,and V-notch impact value of 37 J)was achieved.The considerable enhancement of mechanical properties in the sample austenitized below M_(s)is mainly ascribed to the formation of the pre-existing martensite,resulting in an effective reduction in the size of the bainite plates and martensite/austenite constituents.

关键词： Austempering Pre-existing martensite Bainite plate Multiphase microstructure Mechanical property

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Growth differentiation factor 15 predicts cardiovascular events in stable coronary artery disease

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Journal of Geriatric Cardiology 2023年第7期20卷 527-537页

作者： Juan WANG li-na han Dao-Sheng AI Xin-Yu WANG Wan-Jing ZhanG Xiao-Rong XU Hong-Bin liU Jing ZhanG Pan WANG Xu li Mu-Lei CHEN Heart Center of Beijing Chao-Yang Hospital Capital Medical UniversityBeijing Key Laboratory of HypertensionBeijingChina Department of Cardiology the Second Medical CenterNational Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina Academy for Advanced Interdisciplinary Studies Peking University National Institute of Biological SciencesZhongguancun Life Science ParkTsinghua UniversityBeijingChina

BACKGROUND Growth differentiation factor 15(GDF-15)has been explored as a potential biomarker for various inflammatory diseases and cardiovascular events.This study aimed to assess the predictive role of GDF-15 levels in cardiovascular events and all-cause mortality,considering traditional risk factors and other biomarkers.METHODS A prospective study was conducted and 3699 patients with stable coronary artery disease(CAD)were enrolled into the research.Baseline GDF-15 levels were measured.Median follow-up was 3.1 years during the study.We analyzed clinical variables and several biomarkers.Multivariable Cox regression analysis was performed to evaluate prognostic performance of GDF-15 levels in predicting myocardial infarction(MI),heart failure,stroke,cardiovascular death,and non-cardiovascular death.RESULTS Baseline GDF-15 levels for 3699 patients were grouped by quartile(≤1153,1153-1888,1888-3043,>3043 ng/L).Higher GDF-15 levels were associated with older age,male gender,history of hypertension,and elevated levels of N-terminal pro Btype natriuretic peptide(NT-pro BNP),soluble suppression of tumorigenesis-2(sST2),and creatine(each with Plished risk factors and biomarkers in Cox proportional hazards models,a 1 standard deviation(SD)increase in GDF-15 was associated with elevated risk of clinical events[hazard ratio(HR)=2.18,95%confidence interval(CI):(1.52-3.11)],including:MI[HR=2.8395%CI:(1.03-7.74)],heart failure[HR=2.7195%CI:(1.18-6.23)],cardiovascular and non-cardiovascular death[HR=2.48,95%CI(1.49-4.11)]during the median follow up of 3.1 years.CONCLUSIONS Higher levels of GDF-15 consistently provides prognostic information for cardiovascular events and all cause death,independent of clinical risk factors and other biomarkers.GDF-15 could be considered as a valuable addition to future risk prediction model in secondary prevention for predicting clinical events in patient with stable CAD.

关键词： cardiovascular elevated coronary

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Effect of exogenous hydrogen sulfide in the nucleus tractus solitarius on gastric motility in rats

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World Journal of Gastroenterology 2023年第29期29卷 4557-4570页

作者： Hong-Zhao Sun Chen-Yu li Yuan Shi Jin-Jin li Yi-Ya Wang li-na han Lu-Jie Zhu Ya-Fei Zhang College of life Science Qi Lu Normal UniversityZhangqiu 250200Shandong ProvinceChina

BACKGROUND Hydrogen sulfide(H2S)is a recently discovered gaseous neurotransmitter in the nervous and gastrointestinal systems.It exerts its effects through multiple signaling pathways,impacting various physiological activities.The nucleus tractus solitarius(NTS),a vital nucleus involved in visceral sensation,was investigated in this study to understand the role of H2S in regulating gastric function in rats.AIM To examine whether H2S affects the nuclear factor kappa-B(NF-κB)and transient receptor potential vanilloid 1 pathways and the neurokinin 1(NK1)receptor in the NTS.METHODS Immunohistochemical and fluorescent double-labeling techniques were employed to identify cystathionine beta-synthase(CBS)and c-Fos co-expressed positive neurons in the NTS during rat stress.Gastric motility curves were recorded by inserting a pressure-sensing balloon into the pylorus through the stomach fundus.Changes in gastric motility were observed before and after injecting different doses of naHS(4 nmol and 8 nmol),physiological saline,Capsazepine(4 nmol)+naHS(4 nmol),pyrrolidine dithiocarbamate(PDTC,4 nmol)+naHS(4 nmol),and L703606(4 nmol)+naHS(4 nmol).RESULTS We identified a significant increase in the co-expression of c-Fos and CBS positive neurons in the NTS after 1 h and 3 h of restraint water-immersion stress compared to the expressions observed in the control group.Intra-NTS injection of naHS at different doses significantly inhibited gastric motility in rats(Pline,first injection NF-κB inhibitor PDTC or transient receptor potential vanilloid 1(TRPV1)antagonist Capsazepine or NK1 receptor blockers L703606 and then injection naHS did not produce significant changes(P>0.05).CONCLUSION NTS contains neurons co-expressing CBS and c-Fos,and the injection of naHS into the NTS can suppress gastric motility in rats.This effect may be mediated by activating TRPV1 and NK1 receptors via the NF-κB channel.

关键词： Nucleus tractus solitarius Hydrogen sulfide Gastric motility Nuclear factor kappa-B Transient receptor potential vanilloid 1

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Application and Exploration of Big Data Mining in Clinical Medicine

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Chinese Medical Journal 2016年第6期129卷 731-738页

作者： Yue Zhang Shu-li Guo li-na han Tie-ling li Department of Cardiovascular Internal Medicine Nanlou Branch of Chinese People's Liberation Army General Hospital Beijing 100853 China State Key Laboratory of Intelligent Control and Decision Schoot of Automation Beijing Institute of Technology Beijing 100081 China Department of Cadre Physiotherapy Chinese People's Liberation Army General Hospital Beijing 100853 China

Objective： To review theories and technologies of big data mining and their application in clinical medicine. Data Sources： literatures published in English or Chinese regarding theories and technologies of big data mining and the concrete applications of data mining technology in clinical medicine were obtained from PubMed and Chinese Hospital Knowledge Database from 1975 to 2015. Study Selection： Original articles regarding big data mining theory/technology and big data mining＇s application in the medical field were selected. Results： This review characterized the basic theories and technologies of big data mining including fuzzy theory, rough set theory, cloud theory, Dempster-Shafer theory, artificial neural network, genetic algorithm, inductive learning theory, Bayesian network, decision tree, pattern recognition, high-performance computing, and statistical analysis. The application of big data mining in clinical medicine was analyzed in the fields of disease risk assessment, clinical decision support, prediction of disease development, guidance of rational use of drugs, medical management, and evidence-based medicine. Conclusion： Big data mining has the potential to play an important role in clinical medicine.

关键词： Big Data Clinical Medicine Data Mining

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Influence of Er_2O_3 content on microstructure and mechanical properties of ZTA-TiO_2 composites

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Journal of Rare Earths 2019年第3期37卷 299-304页

作者： Yudong Sui li'na han Yehua Jiang Quan Shan School of Materials Science and Engineering Kunming University of Science and Technology

The influence of Er_2 O_3 addition on the phase evolution and mechanical properties of sintered(1600 ℃,4 h) ZTA(yttria stabilized zirconia toughened alumina)-TiO_2 composites was investigated. The SEM and XRD results reveal the formation of a new erbium zirconium oxide,Zr_3 Er_4 O_(12),with a granulate morphology when Er_2 O_3 content is higher than 1 wt%. The grain sizes of both Al_2 O_3 and yttria-stabilized zirconia phases decrease with an increase in the Er_2 O_3 content. The relative density, Vickers hardness and fracture toughness of the composites are found to be strongly dependent on their grain sizes, relative densities and the formation of the Zr_3 Er_4 O_(12) secondary phases. The composite with 5 wt% Er_2 O_3 shows the highest relative density(99.93%), Vickers hardness(1752 HV) and fracture toughness(7.92 MPa·m^(1/2)).

关键词： Er2O3 Microstructure Vickers hardness Fracture toughness ZTA-TiO2 ceramic composite Rare earths

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Advances in monoclonal antibody application in myocarditis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 676-687页

作者： li-na han Shuang HE Yu-tang WANG li-ming YANG Si-yu liU Ting ZhanG Department of Cardiovascular Internal Medicine Nanlou Branch of Chinese PLA General Hospital

Monoclonal antibodies have become a part of daily preparation technologies in many laboratories. Attempts have been made to apply monoclonal antibodies to open a new train of thought for clinical treatments of autoimmune diseases, inflammatory diseases, cancer, and other immune-associated diseases. This paper is a prospective review to anticipate that monoclonal antibody application in the treatment of myocarditis, an inflammatory disease of the heart, could be a novel approach in the future. In order to better understand the current state of the art in monoclonal antibody techniques and advance applications in myocarditis, we, through a significant amount of literature research both domestic and abroad, developed a systematic elaboration of monoclonal antibodies, pathogenesis of myocarditis, and application of monoclonal antibodies in myocarditis. This paper presents review of the literature of some therapeutic aspects of monoclonal antibodies in myocarditis and dilated cardiomyopathy to demonstrate the advance of monoclonal antibody application in myocarditis and a strong anticipation that monoclonal antibody application may supply an effective therapeutic approach to relieve the severity of myocarditis in the future. Under conventional therapy, myocarditis is typically associated with congestive heart failure as a progressive outcome, indicating the need for alternative therapeutic strategies to improve long-term results. Reviewing some therapeutic aspects of monoclonal antibodies in myocarditis, we recently found that monoclonal antibodies with high purity and strong specificity can accurately act on target and achieve definite progress in the treatment of viral myocarditis in rat model and may meet the need above. However, several issues remain. The technology on how to make a higher homologous and weak immunogenic humanized or human source antibody and the treatment mechanism of monoclonal antibodies may provide solutions for these open issues. If we are to further stimulate progress in the area of clinical

关键词：心脏疾病临床冠状动脉调查结果

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Novel biomarkers for cardiovascular risk prediction

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Journal of Geriatric Cardiology 2017年第2期14卷 135-150页

作者： Juan WANG Guo-Juan TAN li-na han Yong-Yi BAI Miao HE Hong-Bin liU Department of Cardiology Internal Medicine Nanlou Branch of Chinese PLA General Hospital Beijing China Department of Radiology Nanlou Branch of Chinese PLA General Hospital Beijing China Department of Emergency the Central Hospital of China National Petroleum Corporation Langfang Hebei China

心血管的疾病(CVD ) 是死亡和世界范围的残疾的领先的原因。CVD 的主要预防依赖于在公开事件的发展前长识别高风险的个人的能力。这为精确风险层化加亮需要。越来越多的新奇 biomarkers 被识别了预言心血管的事件。Biomarkers 玩在关于... 详细信息

心血管的疾病(CVD ) 是死亡和世界范围的残疾的领先的原因。CVD 的主要预防依赖于在公开事件的发展前长识别高风险的个人的能力。这为精确风险层化加亮需要。越来越多的新奇 biomarkers 被识别了预言心血管的事件。Biomarkers 玩在关于心血管的事件的管理的定义，预知，和决策的一个关键角色。这评论集中于许多有希望的 biomarkers 提供诊断、预示的信息。心肌的织物特定的 biomarker 心脏的 troponin，为心脏的 troponin 的高敏感的试金，和心类型丰满的酸绑定 proteinall 帮助在跟随症状的早小时诊断心肌的梗塞(MI ) 。象生长区别 factor-15，高敏感的 C 反应的蛋白质，纤维蛋白原，和尿酸那样的煽动性的标记预言 MI 和死亡。联系怀孕的血浆蛋白质 A， myeloperoxidase，和矩阵 metalloproteinases 预言急性冠的症候群的风险。联系脂蛋白的 phospholipase A2 和能分泌的 phospholipase A2 预言事件和周期性的心血管的事件。最后，提高了肽， ST2， endothelin-1， mid-regional-pro-adrenomedullin， copeptin，和 galectin-3 都是的 natriuretic 很好验证了预言跟随 MI 的死亡和心失败并且为心失败提供风险层化信息。很快发展中的新区域例如对 micro-Rna 的评价，也被探索。所有 biomarkers 反映动脉粥样硬化的发展的不同方面。

关键词：生物标志物心血管疾病风险预测基质金属蛋白酶妊娠相关血浆蛋白A 心肌梗死磷脂酶A2 生长分化因子

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Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal micro- circulation

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Journal of Geriatric Cardiology 2015年第4期12卷 353-365页

作者： li ZhanG Zhuo-Kun GAN li-na han Hao WANG Jie BAI Guo-Juan TAN Xiao-Xia li Ya-Ping XU Yu ZHOU Mei-liang GONG Mo-Si liN Xiao-Yang han Department of Cardiology Internal Medicine Nanlou Branch of Chinese PLA General Hospital Beijing China VIP Cardiovascular Department Navy General Hospital Beijing China Department of Clinical Laboratory Nanlou Branch of Chinese PLA General Hospital Beijing China Department of Ultrasonography Nanlou Branch of Chinese PLA General Hospital Beijing China School of Chemical Biology and Pharmaceutical Sciences Capital Medical University Beijing China Department of Pharmacy Out-patient Clinic of Aerospace City General Armament Hospital Beijing China

BackgroundMyocardial 梗塞(MI ) 多半贡献了心失败(HF ) 的增加的流行。由于减少的心脏的功能，内脏的血流动减少，引起在到肠的障碍的绒毛和损坏的局部缺血。heme oxygenase-1 (HO-1 ) 的正式就职能阻止，或减少应力和发炎的效果。因... 详细信息

BackgroundMyocardial 梗塞(MI ) 多半贡献了心失败(HF ) 的增加的流行。由于减少的心脏的功能，内脏的血流动减少，引起在到肠的障碍的绒毛和损坏的局部缺血。heme oxygenase-1 (HO-1 ) 的正式就职能阻止，或减少应力和发炎的效果。因此，效果和有 HF 的老鼠的肠上的 HO-1 它的机制是有通过左冠的动脉的结扎的心失败的 investigated.MethodsMale Wistar 老鼠与 < 的左室的喷射部分被识别；45% 通过 echocardiography 然后基于他们收到了的腹注射的类型划分了成各种各样的试验性的组[MI：盐；MI + 钴 protoporphyrin (CoPP ) ：CoPP 答案；并且 MI + 听 mesoporphyrin IX 二氯化物(简单网络管理协议) ：简单网络管理协议答案] 。没有冠的结扎，控制组由老鼠组成。Echocardiography 在结扎以后为一条基线和八个星期在结扎前被执行以便评估老鼠的心脏的功能。细菌的 translocation (BT ) 发生， mesenteric microcirculation，在静脉浆液的内毒素的数量， HO-1 的回肠层次，碳氧化物(公司) ，氮的氧化物(没有) ， interleukin (IL )-10, 瘤坏死 factor-α；(TNF-α；) ，并且在收到 MI + CoPP 注射的 operation.ResultsThe 老鼠在心脏的功能展出了恢复以后，回肠形态学八个星期被决定，在形态学的 mesenteric microcirculation 和变化的改善，更低的 BT 发生，在浆液的减小并且肠阻塞没有并且 TNF-α；与 MI 相比的在肠阻塞的 HO-1，公司，和 interleukin-10 (IL-10 ) 的层次，和举起层次组织(P <；0.05 ) 。收到了 MI + 简单网络管理协议注射的老鼠展出了对 MI 反的结果(P <；0.05 ) group.ConclusionsHO-1 由通过 CO 小径禁止 microcirculation 的发炎和改善与 HF 在老鼠的肠上施加了保护的效果。这保护的效果能从心脏的功能的恢复是独立的。

关键词： Wistar大鼠血红素加氧酶-1 保护作用炎症反应心力衰竭微循环肠道血红素氧合酶-1

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The future of remote ECG monitoring systems

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Journal of Geriatric Cardiology 2016年第6期13卷 528-530页

作者： Shu-li GUO li-na han Hong-Wei liU Quan-Jin SI De-Feng KONG Fu-Su GUO School of Automation Beijing Institute of Technology Beijing China Department of Cardiology lnternal Medicine Nanlou Branch of Chinese PLA General Hospital Beijing China

监视系统的遥远的 ECG 为遥远的心脏监测器正在成为平凡医药设备。在最近的年里，监视系统的遥远的 ECG 在监视心疾病的各种各样的类型被使用了，并且 ECG 的传播和接收的质量在保留的遥远的过程期间发信号进展。然而，在那里留下伴随... 详细信息

监视系统的遥远的 ECG 为遥远的心脏监测器正在成为平凡医药设备。在最近的年里，监视系统的遥远的 ECG 在监视心疾病的各种各样的类型被使用了，并且 ECG 的传播和接收的质量在保留的遥远的过程期间发信号进展。然而，在那里留下伴随挑战。这份报告集中于监视系统的遥远的 ECG 的三个部件：病人(终端用户)，医生工作站，和遥远的服务器，在便携系统，在遥远的传播的包损失，便携式的 ECG 监视系统，耐心的 ECG 数据收集系统，和 ECG 上考察并且评估逼近的挑战包括即时处理表明传播圣片断， R 波浪， RR 间隔和 QRS 飘动，等等。这篇论文试着澄清未来 ECG 的发展策略遥远的监视，它能在指导监视的遥远的 ECG 的研究和发展是有用的。

关键词：心电监护系统远程服务器数据采集系统心脏疾病远程传输心电监测电信号传输医疗设备

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