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基于数字孪生的复杂机械产品多学科协同设计建模技术

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计算机集成制造系统 2019年第6期25卷 1307-1319页

作者：李琳利李浩顾复丁宁顾新建罗国富浙江大学机械工程学院浙江省先进制造技术重点实验室浙江杭州310027 西门子(中国有限公司郑州分公司河南郑州450007 郑州轻工业大学河南省机械装备智能制造重点实验室河南郑州450002

数字孪生技术能够实现产品物理模型和信息模型的融合与迭代优化,从而缩短产品研发周期、降低返工成本。针对复杂产品多学科协同性差、研发成本高的难题,将数字孪生的理念引入到复杂机械产品多学科协同设计中。分析了多学科协同设计和数... 详细信息

数字孪生技术能够实现产品物理模型和信息模型的融合与迭代优化,从而缩短产品研发周期、降低返工成本。针对复杂产品多学科协同性差、研发成本高的难题,将数字孪生的理念引入到复杂机械产品多学科协同设计中。分析了多学科协同设计和数字孪生的研究进展,从全生命周期的视角探讨了产品、生产及其性能数字孪生模型的信息表达、集成与数据交互问题,给出了数字孪生的演变过程模型;在分析产品数字孪生多阶段建模过程的基础上,设计了一个产品数字孪生多学科协同设计建模参考架构,提出了机电一体化的多学科协同设计与虚拟工程方法和产品数字孪生多学科协同设计关键技术,通过优化仿真和虚拟调试构建了复杂机械产品的数字孪生模型,解决了产品全生命周期中机械、电气和自动化等多学科系统的信息物理融合问题。通过案例验证了所提数字孪生多学科建模理论及其优化方法的可行性。

关键词：数字孪生复杂机械产品多学科协同设计机电一体化虚拟调试产品全生命周期管理信息物理系统建模

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辽河干流河岸带土壤有机磷酸酯污染特征研究

中国环境科学 2020年第6期40卷 2598-2603页

作者：罗庆吴中平谷雷严单岳孙丽娜沈阳大学区域污染环境生态修复教育部重点实验室辽宁沈阳110044

本研究分析了辽河干流河岸带土壤中有机磷酸酯(OPEs)的含量水平,阐明了其空间分布特征,探讨了OPEs含量与土壤总有机碳(TOC)的关系,评估了OPEs造成的潜在生态风险.结果表明,13种OPEs在辽河干流河岸带土壤中的总浓度范围为19.6~89.4ng/g,... 详细信息

本研究分析了辽河干流河岸带土壤中有机磷酸酯(OPEs)的含量水平,阐明了其空间分布特征,探讨了OPEs含量与土壤总有机碳(TOC)的关系,评估了OPEs造成的潜在生态风险.结果表明,13种OPEs在辽河干流河岸带土壤中的总浓度范围为19.6~89.4ng/g,平均浓度为44.2ng/g,处于国内外研究的较低水平;河岸带土壤中OPEs的含量总体上表现为上游较低、中下游较高,辽河上游主要由烷基OPEs和TPPO(Triphenylphosphine oxide)组成,辽河中下游主要是烷基OPEs;辽河干流河岸带土壤中OPEs的含量与土壤TOC含量没有相关性,这与OPEs的疏水特性有关;各OPEs单体的危害熵以及12种OPEs的总危害熵均低于1,表明辽河干流河岸带土壤中OPEs造成的生态风险较小.

关键词：辽河干流河岸带土壤有机磷酸酯空间分布生态风险

Different types of drug abusers prefrontal cortex activation patterns and based on machine-learning classification

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Journal of Innovative Optical Health Sciences 2022年第2期15卷 83-92页

作者： Banghua Yang Xuelin gu Shouwei Gao lin Feng Yan Ding Xu Wen Wang School of Mechanical and Electrical Engineering and Automation Shanghai University Shanghai 200444P.R.China Shanghai Drug Rehabilitation Administration Bureau Shanghai 200080 P.R.China Department of Radiology&Functional and Molecular Imaging Key Lab of Shaanxi Province Tangdu Hospital Fourth Military Medical University Xi'anShaanxi 710038P.R.China Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of Education ShanghaiP.R.China Shanghai Intelligent Engineering Technology Research Center for Addiction and Rehabilitation Minhang District 200240 ShanghaiP.R.China

Drug addiction can cause abnormal brain activation changes,which are the root cause of drug craving and brain function *** study enrolled drug abusers to determine the effects of different drugs on brain activation.A functional near-infrared spectroscopy(fNIRS)device was used for the *** study was designed with an experimental paradigm that included the induction of resting and drug addiction *** collected the fNIRS data of 30 drug users,including 10 who used heroin,10 who used Methamphetamine,and 10 who used mixed ***,using Statistical Analysis,the study analyzed the activations of eight functional areas of the left and right hemispheres of the prefrontal cortex of drug addicts who respectively used heroin,Methamphetamine,and mixed drugs,including Left/Right-Dorsolateral prefrontal cortex(L/R-DLPFC),Left/Right-Ventrolateral prefrontal cortex(L/R-VLPFC),Left/Right-Fronto-polar prefrontal cortex(L/R-FPC),and Left/Right Orbitofrontal Cortex(L/R-OFC).Second,referencing the degrees of activation of oxyhaemoglobin concentration(HbO2),the study made an analysis and got the specific activation patterns of each group of the ***,after taking out data which are related to the addicts who recorded high degrees of activation among the three groups of addicts,and which had the same channel numbers,the paper classified the different drug abusers using the data as the input data for Convolutional Neural Networks(CNNs).The average three-class accuracy is 67.13%.It is of great significance for the analysis of brain function errors and personalized rehabilitation.

关键词： Drug addiction fNIRS machine-learning di®erent drug users brain regions activation

Output-based event-triggered control of nonlinear systems under deception attacks

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Output-based event-triggered control of nonlinear systems un...

Evaluation of NBI absorption and fast ion stored energy to improve thermal energy confinement time calculation in EAST

第40届中国控制会议

作者： Fuqiang li lisai Gao Xiaoqing gu Baozhou Zheng College of Sciences Henan Agricultural University School of Mechatronics Engineering and Automation Shanghai University

This paper studies event-triggered output-based security control of nonlinear system under deception attacks obeying a Bernoulli distribution. Firstly, to save system resources of a T-S fuzzy system, an output-based discrete event-triggered mechanism（ETM） is introduced, which excludes Zeno behavior absolutely. Secondly, a closed-loop T-S fuzzy system model is built, which integrates parameters of the nonlinear plant, the ETM, stochastic attacks, fuzzy dynamic output feedback controller and network-induced delays in a unified framework. Thirdly, sufficient conditions for asymptotic stability of the T-S fuzzy system are derived, and the design method of a fuzzy output-based security controller is presented. Finally, an example illustrates effectiveness of the proposed method.

关键词： T-S fuzzy system event-triggered control dynamic output feedback control deception attacks

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Plasma Science and Technology 2020年第2期22卷 54-59页

作者： Xiang gu Biao SHEN Jinping QIAN Siye DING Hongfei DU Youwen SUN Bingjia XIAO Bin WU Jinfang WANG Juan HUANG Jiale CHEN Kai li guoqiang li Dalong CHEN Shuliang CHEN Muquan WU Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China University of Science and Technology of China Hefei 230026People's Republic of China

The absorption of neutral beam power and the fast ion stored energy in EAST plasmas with neutral beam injection(NBI)is analyzed to improve the calculation of thermal energy confinement *** neutral beam power absorption and fast ion stored energy are systematically calculated using the TRANSP code,through the investigation of global parameters including plasma current,line averaged density and beam *** have shown that scaling laws for the NBI absorption coefficient and fast ion energy rate are obtained through statistical analysis.A comparison of the confinement improvement factor H98y2 with these new scaling laws against those assuming fixed coefficients is given.

关键词： thermal energy confinement time neutral beam absorption fast ion energy

The relationship between PFOS and PFOA and the onset of preeclampsia——a nested case-control study

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The relationship between PFOS and PFOA and the onset of pree...

Self-tuning virtual synchronous generator control for improving frequency stability in autonomous photovoltaic-diesel microgrids

2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Ying Zhao Weirong gu Xiaotian li Yu Xiong Obstetrics and Gynecology Hospital Fudan University

Background: There is increasing evidences that perfluoroalkyl substances may contribute to preeclampsia. The objective of our study is to evaluate the association between perfluoroocatane sulfonate(PFOS) and perfluorooctanoic acid(PFOA) exposure and preeclampsia during second trimester pregnancy. Methods: This nested case-control study was performed in the Obstetrics and Gynecology Hospital of Fudan University from January 1 st, 2016 to December 31 th. Serum samples were collected during 16-20 gestational weeks among 174 women(86 cases and 88 controls). PFOS and PFOA levels were analyzed by high performance liquid chromatography-mass spectrometry. Multiple Logistic regression analysis model was used to analyze the association between the serum PFOS and PFOA *** in pregnancies and the risk of preeclampsia. Results: We found that the maternal serum PFOS and PFOA concentrations were significantly higher in preeclampsia cases compared with controls(PFOS: OR=1.139,95%CI=1.087-1.195, P nalysis, serum PFOS and PFOA concentrations in different categories of preeclampsia patients, including severe/mild and early/late-onset preeclampsia patients, were all significantly higher than controls(P x + 2 s, serum PFOS and PFOA concentrations were divided into three levels to analyze the risk of preeclampsia. Preeclampsia risk was increased in patients exposed to high concentrations of PFOS(> 12 ng/ml) and PFOA(> 25 ng/ml), comparing with low concentrations(PFOS: OR=50.73,95%CI=15.48-166.28;PFOA: OR=2.47, 95%CI=1.11-5.48). Conclusions: Our findings suggested an increased risk of preeclampsia among women with high level exposure of PFOS and PFOA.

关键词： exposure,PFOA,PFOS,preeclampsia pregnancy

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Journal of Modern Power Systems and Clean Energy 2018年第3期6卷 482-494页

作者： Rongliang SHI Xing ZHANG Chao HU Haizhen XU Jun gu Wei CAO School of Electrical Engineering and Automation Hefei University of Technology Sungrow Power Supply Co.Ltd.

This paper investigates the use of a virtual synchronous generator(VSG) to improve frequency stability in an autonomous photovoltaic-diesel microgrid with energy storage. VSG control is designed to emulate inertial response and damping power via power injection from/to the energy storage system. The effect of a VSG with constant parameters(CP-VSG) on the system frequency is analyzed. Based on the case study, self-tuning algorithms are used to search for optimal parameters during the operation of the VSG in order to minimize the amplitude and rate of change of the frequency variations. The performances of the proposed self-tuning(ST)-VSG, the frequency droop method, and the CP-VSG are evaluated by comparing their effects on attenuating frequency variationsunder load variations. For both simulated and experimental cases, the ST-VSG was found to be more efficient than the other two methods in improving frequency stability.

关键词： Virtual synchronous generator(VSG) Frequency stability Autonomous microgrid Self-tuning algorithm Energy storage system

转铁蛋白修饰的阿霉素隐形脂质体的制备及体外细胞试验

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中国药科大学学报 2008年第2期39卷 111-115页

作者：李学明丁丽燕顾立周维娜平其能中国药科大学药剂学教研室南京210009 南京工业大学制药与生命科学学院南京210009

目的:用转铁蛋白(Tf)修饰盐酸阿霉素隐形脂质体(SL),以增加药物在肿瘤部位的积蓄,从而增加药物向肿瘤细胞内的转运。方法:采用薄膜超声法制备空白脂质体,硫酸铵梯度法装载盐酸阿霉素(DOX);通过膜材DSPE-PEG2000-COOH上的活性羧基末端与T... 详细信息

目的:用转铁蛋白(Tf)修饰盐酸阿霉素隐形脂质体(SL),以增加药物在肿瘤部位的积蓄,从而增加药物向肿瘤细胞内的转运。方法:采用薄膜超声法制备空白脂质体,硫酸铵梯度法装载盐酸阿霉素(DOX);通过膜材DSPE-PEG2000-COOH上的活性羧基末端与Tf上的氨基连接制备Tf修饰的隐形脂质体(Tf-SL);采用凝胶柱-UV法测定脂质体中DOX的包封率,双辛丁酸试剂盒测定蛋白结合效率;通过流式细胞试验和激光共聚焦显微试验考察肝癌细胞HepG2对SL包封的DOX(DOX-SL)及Tf-SL包封的DOX(Tf-DOX-SL)的结合或摄取情况,并观察两种脂质体对HepG2细胞的体外杀伤作用。结果:Tf-DOX-SL的平均粒径为(62±17)nm,药物平均包封率为96.4%,蛋白结合效率为100.28μg Tf/μmol磷脂。与DOX-SL相比,Tf-DOX-SL与肝癌细胞HepG2的结合及摄取均增加。48 h细胞毒试验表明Tf-DOX-SL对HepG2细胞的杀伤作用(IC50=20.4μmol/L)明显优于DOX-SL(IC50=166.2μmol/L)(P<0.01)。结论:Tf修饰的隐形脂质体可作为肿瘤靶向的载体通过受体介导的方式促进DOX向肿瘤细胞内的传递。

关键词：阿霉素隐形脂质体转铁蛋白受体介导体外细胞实验

Response-guided treatment of cirrhotic chronic hepatitis B patients: Multicenter prospective study

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World Journal of Gastroenterology 2015年第2期21卷 653-660页

作者： Er-li gu Yi-Qi Yu Jia-li Wang Yan-Yan Ji Xiu-Yun Ma Qing Xie Hong-Ying Pan Shan-Min Wu Jun li Cheng-Wei Chen Xiao-Wei Xu Yue-Er Wang guang-Bi Yao Hong Wang Wen-Hong Zhang Department of Gastroenterology and Hepatology Jing’an District Central Hospital Jing’an Branch of Huashan Hospital Fudan University Department of Infectious Diseases Huashan HospitalFudan University Department of Infectious Diseases Ditan Hospital Department of Hepatology Department of Infectious DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong University Department of Infectious Diseases The 6th People’s Hospital of Hangzhou Shanghai Public Health Clincal Center Department of Infectious Diseases Jiangsu Provincial Hospital Department of Hepatology Shanghai Liver Disease Research Center of Nanjing Military Area Department of Infectious Diseases The 1st Affiliated Hospital of Zhejiang University MOH and MOE Key Laboratory of Medical Molecular Virology Shanghai Medical CollegeFudan University Institutes of Biomedical Sciences Fudan University

AIM: To observe the effect of response-guided add-on therapy with adefovir(ADV) and lamivudine(LAM) in cirrhotic hepatitis B(CHB) ***: A total of 100 patients with CHB and cirrhosis were divided into three arms according to hepatitis B virus(HBV) Dna level after 24 wk LAM monotherapy: Arm A(complete response, HBV Dna ≤ 60 IU/m L, n = 49), Arm B(partial response, HBV Dna: 60-2000 IU/m L, n = 31) and Arm C(inadequate response, HBV Dna > 2000 IU/m L, n = 20). ADV was added to LAM at week 48 in Arms A and B, but at week 24 in Arm C. Virological response, YMDD mutations, biochemical response, and liver function were ***: Comparison of the three arms demonstrated that early complete virologic response at week 24was associated with maintained viral suppression(undetectable rate of HBV Dna at week 144 was 95.96%, 66.67% and 35.29%, respectively, P = 0.000) and reduced YMDD mutations(mutation rate at week 144 was 0%, 3.23% and 15%, respectively, P = 0.015) after 144 wk treatment. For patients who failed to achieve complete virological response at week 24, switching to combination therapy further decreased HBV Dna level by 1 log10 IU/m L. All three arms obtained biochemical benefits including decline of alanine aminotransferase and elevation of albumin. In patients who developed HBV Dna breakthrough for YMDD mutations, ADV add-on therapy did not induce further multiple drug resistance to LAM or ***: Optimized response-guided add-on therapy of ADV and LAM maintains long-term suppression of HBV Dna and improves liver function in CHB patients with compensated liver cirrhosis.

关键词： Hepatitis B Cirrhosis Adefovir dipivoxil Lamivudin