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Reactive MnO_(2) template-assisted synthesis of double-shelled PPy hollow nanotubes to boost microwave absorption

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Journal of Materials Science & Technology 2023年第15期146卷 145-153页

作者： Huiling gu Ji Huang na li Hua Yang Gang Chen Chengjun Dong Chunhong Gong Hongtao guan School of Materials and Energy Yunnan UniversityKunming 650091China College of Chemistry and Chemical Engineering Henan UniversityKaifeng 475004China

Microwave absorbing materials(MAMs)with wide effective absorption bandwidth(EAB)and low filling ratio are highly desirable for practical *** design in components and structures is one of the effective strategies to achieve MAMs with high ***,double-shelled hollow(DSH)polypyrrole(PPy)nanotubes were synthesized with hydrochloric acid(HCl)and sodium pstyrene sulfonate(SS)co-doping polymerization process using manganese dioxide(MnO_(2))nanorods as a self-sacrifice *** the increase of HCl concentration,the 1D MnO_(2) core diminishes gradually to form the MnO_(2)@PPy coaxial nanostructures and finally the DSH PPy nanotube,which tunes the microwave absorption ***,the DSH PPy nanotubes exhibit excellent microwave absorption of an optimal reflection loss of–50.4 dB and a wide EAB of 7.7 GHz with a low filling ratio of 5 wt%in a paraffin wax *** excellent microwave absorption is believed to be mainly attributed to the enhanced synergistic effects of interfacial polarization and conduction loss arising from the unique DSH structure and the co-doping polymerization.

关键词： PPy nanotube MnO_(2)template Double-shelled hollow structure Microwave absorption

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRnas and long non-coding Rnas differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Gene knockout or inhibition of macrophage migration inhibitory factor alleviates lipopolysaccharide-induced liver injury via inhibiting inflammatory response

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 469-477页

作者： Yu-Lei gu li-li Xiao De-Jian li Yan-na liu Chang-Ju Zhu Shui-Jun Zhang Emergency Department the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Open and Key Laboratory of Hepatobiliary&Pancreatic Surgery and Digestive Organ Transplantation at Henan Province Zhengzhou 450052China Zhengzhou Engineering Laboratory of Organ Transplantation Technique and Application Zhengzhou 450052China

Background:liver injury is one of the most common complications during *** migration inhibitory factor(MIF)is an important proinflammatory *** study explored the role of MIF in the lipopolysaccharide(LPS)-induced liver injury through genetically manipulated mouse ***:The model of LPS-induced liver injury was established in wild-type and Mif-knockout C57/BL6 *** levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBil)were detected,and the expressions of MIF,tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were *** histopathology was conducted to assess liver ***,the inhibitions of MIF with(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester(ISO-1)and 4-iodo-6-phenylpyrimidine(4-IPP)were used to evaluate their therapeutic potential of liver ***:Compared with wild-type mice,the liver function indices and inflammation factors presented no significant difference in the Mif-/-*** 72 h of the LPS-induced liver injury,serum levels of ALT,AST,and TBil as well as TNF-αand IL-1βwere significantly increased,but the knockout of Mif attenuated liver injury and inflammatory *** liver tissue,m Rna levels of TNF-α,IL-1βand NF-κB p65 were remarkably elevated in LPS-induced liver injury,while the knockout of Mif reduced these ***,in LPS-induced liver injury,the inhibitions of MIF with ISO-1 and 4-IPP alleviated liver injury and slightly attenuated inflammatory ***,compared to mice with LPS-induced liver injury,Mif knockout or MIF inhibitions significantly prolonged the survival of the ***:In LPS-induced liver injury,the knockout of Mif or MIF inhibitions alleviated liver injury and slightly attenuated inflammatory response,thereby prolonged the survival of the *** MIF may be an important strategy to protect the liver from injury during sepsis.

关键词： Sepsis liver injury Migration inhibitory factor Gene knockout Inflammation

Inorganic nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy

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nano-Micro Letters 2019年第4期11卷 308-325页

作者： Jie Wang Lan Fang Ping li Lang Ma Weidan na Chong Cheng Yueqing gu Dawei Deng Department of Pharmaceutical Engineering and Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198People’s Republic of China Institute of Chemistry and Biochemistry Freie Universitat BerlinTakustrasse 314195 BerlinGermany State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory of natural Medicines National R&D Center for Chinese Herbal Medicine ProcessingChina Pharmaceutical UniversityNanjing 211198People’s Republic of China

Recently emerged cancer immunochemotherapy has provided enormous new possibilities to replace traditional chemotherapy in fighting ***,the treatment efficacy is hampered by tumor hypoxiainduced immunosuppression in tumor microenvironment(TME).Herein,we fabricated a self-oxygenation/degradable inorganic nanozyme with a core-shell structure to relieve tumor hypoxia in cancer *** integrating the biocompatible CaO2 as the oxygen-storing component,this strategy is more effective than the earlier designed nanocarriers for delivering oxygen or H2O2,and thus provides remarkable oxygenation and long-term capability in relieving hypoxia throughout the tumor ***,in vivo tests validate that the delivery system can successfully relieve hypoxia and reverse the immunosuppressive TME to favor antitumor immune responses,leading to enhanced chemoimmunotherapy with cytotoxic T lymphocyte-associated antigen 4 ***,a facile,robust and effective strategy is proposed to improve tumor oxygenation by using self-decomposable and biocompatible inorganic nanozyme reactor,which will not only provide an innovative pathway to relieve intratumoral hypoxia,but also present potential applications in other oxygen-favored cancer therapies or oxygen deficiency-originated diseases.

关键词： Inorganic nanozyme Self-oxygenation nanoreactor Biodegradable nanomedicine Immunochemotherapy Cancer treatment

基于Citespace对人工智能在骨创伤研究的可视化分析

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中国组织工程研究 2025年第3期29卷 493-502页

作者：宋浩然张玉强谷娜智晓东王伟锦州医科大学附属第一医院骨科辽宁省锦州市121000 锦州医科大学骨外科学研究所辽宁省锦州市121000 锦州医科大学附属第一医院放射科辽宁省锦州市121000

背景:人工智能在医疗领域的发展日益迅速,在骨创伤领域的应用研究不断增多。文章旨在通过文献计量学分析,分析近年来人工智能在骨创伤领域中的研究热点,并预测未来的研究趋势。目的:总结人工智能技术在骨创伤领域的应用发展历程、研究... 详细信息

背景:人工智能在医疗领域的发展日益迅速,在骨创伤领域的应用研究不断增多。文章旨在通过文献计量学分析,分析近年来人工智能在骨创伤领域中的研究热点,并预测未来的研究趋势。目的:总结人工智能技术在骨创伤领域的应用发展历程、研究现状、热点和未来发展趋势,以期为今后的研究提供新的见解。方法:选择Web of Science核心集数据库中,时间跨度设为自建库至2023年8月,检索人工智能、机器学习、深度学习应用于骨创伤相关的文献420篇。通过人工筛选,导出与文章相关的文献共202篇,采用Citespace软件进行国家、机构、被引期刊和引文分析等的合作和关键词的共现等可视化分析。结果与结论:①分析筛选后纳入的202篇文献,总体发文量呈上升趋势,且在未来研究潜力巨大。研究中心性最高和发文量排名第一的国家均为美国。加州大学(美国)是发文量最多的研究机构。②人工智能在骨创伤研究中最常用的前5个关键词是深度学习、人工智能、骨密度、机器学习、诊断,中心性最高的关键词为骨密度,关键词数量最多的为深度学习。③共被引频次前10位的参考文献分别从多个方面介绍了人工智能技术应用于骨创伤领域诊断的可行性研究,其中8篇涉及骨关节损伤与深卷积神经网络,1篇涉及深度学习在CT检查中检测骨质疏松从而预防脆性骨折,1篇通过人工智能识别皮肤纹理变的特征应用于骨的特征性识别的相关性研究。④今后,人工智能的研究热点将主要集中在骨关节创伤和骨质疏松引发的骨折特异性研究上,未来研究趋势主要集中在提升人工智能算法的性能上,使用人工智能新技术对骨损伤进行精准划分和快速高效诊断,尤其是针对复杂和隐匿性骨折的诊断,通过建立有限元分析模型,实现对骨创伤的更加标准化评估。

关键词：人工智能骨创伤骨折机器学习深度学习文献计量学 Web of Science 影像诊断 Citespace 可视化分析

Diurnal variability of the planetary boundary layer height estimated from radiosonde data

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Earth and Planetary Physics 2020年第5期4卷 479-492页

作者： Jie gu YeHui Zhang na Yang Rui Wang School of Hydrology and Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China State Oceanic Administration Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China

Diurnal variations in the planetary boundary layer height(PBLH)at different latitudes over different surface characteristics are described,based on 45 years(1973−2017)of radiosonde *** PBLH is determined from the radiosonde data by the bulk Richardson number(BRN)method and verified by the parcel method and the potential temperature gradient *** general,the BRN method is able to represent the height of the convective boundary layer(BL)and neutral residual layer cases but has relatively large uncertainty in the stable BL *** diurnal cycle of the PBLH over land is quite different from the cycle over ocean,as are their seasonal *** stations over land,the PBLH shows an apparent diurnal cycle,with a distinct maximum around 15:00 LT,and seasonal variation,with higher values in *** with the PBLH over land,over oceans the PBLH diurnal cycles are quite mild,the PBLHs are much lower,and the seasonal changes are less *** seasonal variations in the median PBLH diurnal cycle are positively correlated with the near-surface temperature and negatively correlated with the near-surface relative ***,although at most latitudes the daytime PBLH exhibits,over these 45 years,a statistically significant increasing trend at most hours between 12:00 LT and 18:00 LT over both land and ocean,there is no significant trend over either land or ocean in the nighttime PBLH for almost all the studied latitudes.

关键词： planetary boundary layer height diurnal cycle radiosonde

Size-dependent spatio-temporal dynamics of eukaryotic plankton community near nuclear power plant in Beibu gulf,China

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Journal of Oceanology and limnology 2021年第5期39卷 1910-1925页

作者： lizhou liN Haifeng gu Zhaohe LUO na WANG Department 1 Third Institute of OceanographyMinistry of NaturalResourcesXiamen 361005China

Pico-and nano-eukaryotic plankton are important members of marine *** understand their community structure and spatio-temporal variations in the Beibu gulf,and to study the impact of Changjiang Nuclear Power Plant(CNPP)located in the northwest coast of the Hainan Island on the eukaryotic plankton,we studied these issues in the coastal water near CNPP bimonthly from February 2018 to January 2019 via 18 S Illumina *** results reveal a higher genetic alphadiversity and less beta-diversity of the plankton community in small-size(0.45-5μm and 5-20μm)fractions than in large-size(20-200μm and>20μm)*** small-sized phytoplankton,including Micromonas(Chlorophyta)and Minutocellus(Bacillariophyta),as well as heterotrophic plankton,including Paraphysomonas(Chrysophyceae),Ellobiopsis(Dinoflagellates),and Syndiniales(Dinoflagellates),took up a considerable proportion in eukaryotic plankton *** addition,it showed a slight temperature increase and no significant difference in eukaryotic plankton community between the outfall of CNPP and other sampling sites,suggesting that the impact of the thermal discharge from the CNPP on local eukaryotic plankton community was limited.

关键词： nuclear power plant the Beibu gulf eukaryotic plankton community high-throughput sequencing picoplankton nanoplankton

An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

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Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng gu Haiyuan li Baoming li national Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN

Identification of nonlinear process described by neural fuzzy Hammerstein-Wiener model using multi-signal processing

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Advances in Manufacturing 2023年第4期11卷 694-707页

作者： Feng li li Jia Ya gu College of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001JiangsuPeople’s Republic of China School of Mechatronics Engineering and Automation Shanghai UniversityShanghai200444People’s Republic of China School of Electrical Engineering and Automation Changshu Institute of TechnologyChangshu215500JiangsuPeople’s Republic of China

In this study,a novel approach for nonlinear process identification via neural fuzzy-based Hammerstein-Wiener model with process disturbance by means of multi-signal processing is *** Hammerstein-Wiener model consists of three blocks where a dynamic linear block is sandwiched between two static nonlinear ***-signal sources are designed for achieving identification separation of the Hammerstein-Wiener *** correlation analysis theory is utilized for estimating unknown parameters of output nonlinearity and linear block using separable signals,thus the interference of process disturbance is ***,the immeasurable intermediate variable and immeasurable noise term in identification model is taken over by auxiliary model output and estimate residuals,and then auxiliary model-based recursive extended least squares parameter estimation algorithm is derived to calculate parameters of the input nonlinearity and noise ***,convergence analysis of the suggested identification scheme is derived using stochastic process *** simulation results indicate that proposed identification approach yields high identification accuracy and has good robustness.

关键词： Nonlinear process Parameter identification Hammerstein-Wiener model Neural fuzzy model Multiple signal processing