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A 7-year-old boy with recurrent cyanosis and tachypnea:A case report

World Journal of Clinical Cases 2022年第20期10卷 6974-6980页

作者： Shu li li-na chen lin Zhong Department of Pediatric Pulmonology and Immunology West China Second University Hospital of Sichuan UniversityChengdu 610066Sichuan ProvinceChina Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationWest China Second University Hospital of Sichuan UniversityChengdu 610066Sichuan ProvinceChina

BACKGROUND Brain tumors are the most common solid tumors in children and comprise 25%of all malignancies in children.Common presentations include headache,nausea and vomiting,gait abnormality,papilledema,and epileptic seizure;however,some symptoms can be very insidious,with atypical and misleading manifestations.CASE SUMMARY Here,we report a 7-year-old boy who presented with recurrent cyanosis and tachypnea after exercise for 2 years.His body mass index was 26.43 kg/m2.Hepatosplenomegaly,blood gas analysis,biochemical parameters,chest computed tomography scan,and echocardiograph suggested type II respiratory failure,pulmonary heart disease,and mild liver injury.Non-invasive breathing support,antibiotics,and anti-heart failure therapy were given.The patient’s pulse oxygen saturation increased to over 95%when he was awake but dropped to 50%-60%,accompanied by cyanosis,during sleep while receiving high-flow nasal cannula oxygen.Sleep-related breathing disorder was suspected.In the intensive care unit,however,polysomnography was unavailable.Brain magnetic resonance imaging revealed a space-occupying(cerebellum and brainstem)lesion,which was later confirmed to be pleomorphic xanthoastrocytoma by surgery and histopathology by tissue biopsy.CONCLUSION When treating patients with cyanosis and tachypnea,a broad differential diagnosis should be considered,including brain tumor.

关键词： Respiratory failure Pulmonary heart disease Sleep-related breathing disorders Pleomorphic xanthoastrocytoma Children Case report

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Pulmonary lymphomatoid granulomatosis in a 4-year-old girl:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5380-5386页

作者： Jia-Wei Yao li Qiu Ping liang Han-Min liu li-na chen Division of Pediatric Pulmonology Chengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610091Sichuan ProvinceChina Division of Pediatric Pulmonology and Immunology Key Laboratory of Birth Defects and Related Diseases of Women and ChildrenMinistry of EducationWest China Second University Hospital of Sichuan UniversityNHC Key Laboratory of ChronobiologyChengdu 610041Sichuan ProvinceChina

BACKGROUND Pulmonary lymphomatoid granulomatosis(PLG)is a lymphoproliferative disease associated with Epstein-Barr viral infection occurring mainly in adults and rarely in children.It is characterized by multiple pulmonary nodules.Its diagnosis depends on lung biopsy findings.Most patients are immunodeficient,and it commonly presents in children undergoing chemotherapy for leukemia.We report the case of a child with PLG caused by a mutation in the macrophageexpressed gene 1(MPEG1),suggesting possible PLG occurrence in children undergoing treatment for pulmonary nodular lesions.CASE SUMMARY This study reports a case of PLG without apparent immunodeficiency,suggesting the possibility of this disease occurrence during the treatment of pulmonary nodular lesions in children.Initially,the cause was assumed to be an atypical pathogen.Following conventional anti-infective treatment,chest computed tomography findings revealed that there were still multiple nodules in the lungs.Additionally,the patient was found to be infected with the Epstein-Barr virus.Histopathological examination of the resected lung revealed lymphoproliferative lesions with necrosis.Small lymphocytes,plasma cells,and histiocytes were observed in the background,although Reed-Sternberg cells were absent.Immunohistochemical staining[CD20(+),CD30(+),and CD3(+)]and EBV-encoded small Rna1/2 in situ hybridization of small lymphocytes revealed approximately 200 cells/high-power field.Whole exon sequencing of the patient revealed a mutation in the MPEG1.The patient was eventually diagnosed with PLG and transferred to the Department of Pediatric Oncology for bone marrow transplantation.CONCLUSION As PLG is rare and fatal,it should be suspected in clinical settings when treatment of initial diagnosis is ineffective.

关键词： Pulmonary lymphomatoid granulomatosis Child Epstein-Barr virus Lymphoproliferative disease Leukemia Case report

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CDKN1C gene mutation causing familial Silver–Russell syndrome:A case report and review of literature

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World Journal of Clinical Cases 2023年第19期11卷 4655-4663页

作者： Jie li li-na chen Hai-Lan He Department of Paediatrics Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Cyclin-dependent kinase inhibitor 1C(CDKN1C)is a cell proliferation inhibitor that regulates the cell cycle and cell growth through G1 cell cycle arrest.CDKN1C mutations can lead to IMAGe syndrome(CDKN1C allele gain-of-function mutations lead to intrauterine growth restriction,metaphyseal dysplasia,adrenal hypoplasia congenital,and genitourinary malformations).We present a Silver-Russell syndrome(SRS)pedigree that was due to a missense mutation affecting the same amino acid position,279,in the CDKN1C gene,resulting in the amino acid substitution p.Arg279His(c.836G>A).The affected family members had an SRS phenotype but did not have limb asymmetry or adrenal insufficiency.The amino acid changes in this specific region were located in a narrow functional region that contained mutations previously associated with IMAGe syndrome.In familial SRS patients,the PCna region of CDKN1C should be analysed.Adrenal insufficiency should be excluded in all patients with functional CDKN1C variants.CASE SUMMARY We describe the case of an 8-year-old girl who initially presented with short stature.Her height was 91.6 cm,and her weight was 10.2 kg.Physical examination revealed that she had a relatively large head,an inverted triangular face,a protruding forehead,a low ear position,sunken eye sockets,and irregular cracked teeth but no limb asymmetry.Family history:The girl’s mother,greatgrandmother,and grandmother’s brother also had a prominent forehead,triangular face,and severely proportional dwarfism but no limb asymmetry or adrenal insufficiency.Exome sequencing of the girl revealed a new heterozygous CDKN1C(NM_000076.2)c.836G>A mutation,resulting in a variant with a predicted evolutionarily highly conserved arginine substituted by histidine(p.Arg279His).The same causative mutation was found in both the proband’s mother,great-grandmother,and grandmother’s brother,who had similar phenotypes.Thus far,we found an SRS pedigree,which was due to a missense mutation affecting the same amino acid position,279,in the CDKN1C gene

关键词： CDKN1C Gene Silver-Russell syndrome Mutation Case report

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Effects of muddy water irrigation with different sediment gradations on nitrogen transformation in agricultural soil of Yellow River Basin

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Water Science and Engineering 2022年第3期15卷 228-236页

作者： li-na chen Zi-long Zhao Guo-mian Guo Jiang li Wen-bo Wu Fang-xiu Zhang Xiang Zhang College of Agricultural Science and Engineering Hohai UniversityNanjing 211100China Key Laboratory of Integrated Regulation and Resource Development on Shallow Lake of Ministry of Education Hohai UniversityNanjing 210098China College of Environment Hohai UniversityNanjing 210098China Key Laboratory of Lower Yellow River Channel and Estuary Regulation of Ministry of Water Resources Zhengzhou 450003China Yellow River Institute of Hydraulic Research Zhengzhou 450003China

Muddy water irrigation has been widely practiced in the Yellow River Basin for agricultural production and is an important method of economical and intensive utilization of water resources.In this study,the effects of sediment gradation,sand content,and soil moisture content on nitrogen(N)transformation were studied through a series of experimental tests.The results indicated that muddy water irrigation significantly affected agricultural soil physical and biological properties as well as N transformation.Soil bulk density,total porosity,pH,and microbial enzyme activities significantly correlated with N transformation as affected by the interaction between sediment and soil moisture.Sediment addition generally increased the soil bulk density and reduced the soil porosity and pH significantly,and the optimum moisture for promotion of the N transformation rate was 80%of the water-filled pore space.Therefore,muddy water irrigation has a potentially long-term influence on agricultural N cycles in semi-arid regions of northwestern China.This could provide a theoretical basis for scientific and rational use of muddy water for irrigation.

关键词： Yellow River Basin Muddy water irrigation Soil properties Nitrogen transformation Sediment

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Machine learning-based prediction of pregnancy outcomes in couples with non-obstructive azoospermia using micro-TESE for ICSI: a retrospective cohort study

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生殖与发育医学(英文) 2024年第1期08卷 24-31页

作者： Jia Lei chen Pei-Gen chen li-na Fang Cong Zhang Jing chen Pan-Yu Reproductive Medicine Center The Sixth Affiliated Hospital 3. Sun Yat-sen University 4. Guangzhou 510275 5. China

Objective: To develop a clinically applicable tool for predicting clinical pregnancy, providing individualized patient counseling, and helping couples with non-obstructive azoospermia (NOA) decide whether to use fresh or cryopreserved spermatozoa for oocyte insemination before microdissection testicular sperm extraction (mTESE).Methods: A total of 240 couples with NOA who underwent mTESE-ICSI were divided into two groups based on the type of spermatozoa used for intracytoplasmic sperm injection (ICSI): the fresh and cryopreserved groups. After evaluating several machine learning algorithms, logistic regression was selected. Using LASSO regression and 10-fold cross-validation, the factors associated with clinical pregnancy were analyzed.Results: The area under the curves (AUCs) for the fresh and cryopreserved groups in the Logistic Regression-based prediction model were 0.977 and 0.759, respectively. Compared with various modeling algorithms, Logistic Regression outperformed machine learning in both groups, with an AUC of 0.945 for the fresh group and 0.788 for the cryopreserved group.Conclusion: The model accurately predicted clinical pregnancies in NOA couples.

关键词： Cryopreserved spermatozoa Fresh spermatozoa Logistic regression Microdissection testicular sperm extraction

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A survey of high risk factors affecting retinopathy in full-term infants in China

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 177-180页

作者： li-na chen Xiao-Ping He and li-Ping Huang Department of Ophthalmology Boai Hospital of Zhongshan Zhongshan 528000 Guangdong Province China

AIM: To investigate the possible relationship between the influencing factors occurring before and during birth in full-term infants and the outcome of retinopathy. METHODS: Totally 816 full-term infants admitted in the neonate intensive unit of Boai Hospital of Zhongshan between 1 May, 2008 and 30 June, 2011 were included in the study. Fundus examination was performed and evaluated individually on them at the age of 48 hours after delivery, 2 weeks and 1 month. Some possible risk factors happening prenatally or during delivery such as pregnant related hypertension, placenta previa, placental abruption etc, as well as some neonatal risk factors such as neonatal asphyxia, hypoxic-ischemic encephalopathy (HIE), low birth weight etc, were recorded and evacuated. Then the effect of the risk factors of full-term infants on retinopathy was studied. RESULTS: The incidence of retinal hemorrhage of full-term infants with prenatal pregnant related hypertension (PRH) of the mother (43.6%) was significantly higher than that of full-term infants without (8.0%). (Pnal hemorrhage of full-term infants with neonatal asphyxia and /or hypoxic-ischemic encephalopathy (HIE)(29.3%) was significantly higher than that of those without (15.7%), but correlation was not found between the severity of retina hemorrhage and the degree of hypoxic disease. A pale color of optic disc was associated with a low birth weight of full-term infant. Full-term infants with birth weigh-less than 2500g had a significant higher incidence of retinopathy than those with birth weight equal or more than 2500g( Pnatal factors such as PRH, and some neonatal risk factors such as asphyxia, hypoxic-ischemic encephalopathy, and low birth weight.

关键词： full-term infant high risk factor retinopathy

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Impacts of air pollution and meteorological conditions on dry eye disease among residents in a northeastern Chinese metropolis:a six-year crossover study in a cold region

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light(Science & Applications) 2023年第9期12卷 1757-1770页

作者： cheng-Wei Lu Jing Fu Xiu-Fen liu Zhi-Hua Cui Wei-Wei chen li Guo Xiao-Lan li Yu Ren Fei Shao li-na chen Ji-Long Hao Opthalmology Department The First Hospital of Jilin UniversityChangchun 130021China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China College of New Energy and Environment Jilin UniversityChangchun 130021China China College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China Shenyang Institute of Atmospheric Environment China Meteorological AdministrationShenyang 110166China

The purpose of this study is to explore the associations among dry eye disease(DED),air pollution,and meteorological conditions in the cold region of a northeastern Chinese metropolis(i.e.,Changchun).Data on ambient air pollutants and meteorological parameters as well as diagnosed DED outpatients during 2015–2021 were collected.The associations between DED and environmental factors were analysed at multiple time scales using various statistical methods(i.e.,correlation,regression and machine learning).Among the 10,809 DED patients(21,617 eyes)studied,64.60%were female and 35.40%were male.A higher frequency of DED was observed in March and April,followed by January,August and October.Individual and multiple factor models showed the positive importance of particles with aerodynamic diametersna.Our results revealed the quantitative associations among air pollutants,meteorological conditions and DED outpatients in cold regions,highlighting the importance of coordinated policies in air pollution control and climate change mitigation.

关键词： pollution meteorological northeastern

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A review on recent developments of vanadium-based cathode for rechargeable zinc-ion batteries

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Tungsten 2021年第3期3卷 289-304页

作者： Yan Wu Tian-Yi Song li-na chen School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Chemistry Center of Super-Diamond and Advanced Films(COSDAF)City University of Hong KongHong Kong 999077China

Benefiting from their high safety,low cost,and excellent performance,aqueous zinc-ion batteries are regarded as a promising candidate for next-generation commercial energy storage devices.High-performance cathodes are urgently needed to accelerate practical application of zinc-ion batteries(ZIBs).Among various cathodes reported previously,vanadium-based materials attract a great deal of attention since they hold high capacity and good cycling stability.Though fruitful achievements have been made,there are amounts of crystal structures and energy storage mechanisms are still unclear,which will significantly affect performance of full batteries.This review presents a comprehensive overview of structure characteristics,relevant electrochemical behavior,and proposed energy storage mechanisms of reported vanadium-based materials which provide effective Zn-storage performance.Meanwhile,recent developments of vanadium-based materials for ZIBs are systematically summarized.Last but not least,the future perspectives are also discussed.We hope that this review can provide suggestions to design high-performance electrode materials and promote the development of ZIBs.

关键词： Aqueous zinc-ion batteries Vanadium-based materials Cathode Structure Energy storage mechanism

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Sleep fragmentation as an important clinical characteristic of sleep disorders in Parkinson's disease: a preliminary study

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Chinese Medical Journal 2019年第15期132卷 1788-1795页

作者： Guo-En Cai Shan Luo li-na chen Jian-Ping Lu Yu-Jie Huang Qin-Yong Ye Department of Neurology Fujian Medical University Union Hospital Fuzhou Fujian 350001 China Department of Radiology Longyan First Hospital Affiliated to Fujian Medical University Longyan Fujian 364000 China Department of Ultrasound Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou Fujian 350025 China

Background:Sleep disorders are one of the earliest non-motor symptoms of Parkinson's disease (PD).Sleep disorders could,therefore,have value for recognition and diagnosis in PD.However,no unified classification and diagnostic criteria exist to evaluate sleep disorders by polysomnography (PSG).Utilizing PSG to monitor sleep processes of patients with PD and analyze sleep disorder characteristics and their relationship with demographic parameters could aid in bridging this gap.This preliminary study aimed to evaluate the clinical characteristic of sleep disorders in PD using PSG.Methods:PSG was used to evaluate sleep disorders in 27 patients with PD and 20 healthy volunteers between August 2015 and July 2018 in Fujian Medical University Union Hospital.Total sleep time (TST),sleep efficiency (SE),total wake time,and other parameters were compared between the two groups.Finally,the correlation between sleep disorders and age,disease duration,Unified Parkinson's Disease Rating Scale-Ⅲ scores,Hoehn-Yahr stage,and levodopa dose were analyzed.The main statistical methods included Chi-square test,two independent samples t test,Fisher exact test,and Pearson correlation.Results:Sleep fragmentation in the PD group was significantly increased (74.1%) while difficulty falling asleep and early awakening were not,as compared to healthy controls.No significant differences were found in time in bed,sleep latency (SL),non-rapid eye movement (NREM) stage 1 (N1),N1%,N2,N2%,N3%,and NREM% between PD and control groups;but TST (327.96± 105.26 min vs.414.67 ± 78.31 min,P =0.003),SE (63.26%± 14.83% vs.76.8%± 11.57%,P =0.001),R N3 (20.00 [39.00] min vs.61.50 [48.87] min,P=0.001),NREM (262.59 ± 91.20 min vs.337.17± 63.47 min,P=0.003),rapid-eyemovement (REM)(32.50 [33.00] min vs.85.25 [32.12] min,P liminary study supported that sleep fragmentation was an important

关键词： Parkinson's disease Sleep fragmentation Polysomnography Clinical characteristic

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Effect of controlled rolling/controlled cooling parameters on microstructure and mechanical properties of the novel pipeline steel

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Advances in Manufacturing 2014年第3期2卷 265-274页

作者： Min Jiang li-na chen Jin He Guang-Yao chen Chong-He li Xiong-Gang Lu Shanghai Key Laboratory of Modern Metallurgy & Materials Processing Shanghai University Baoshan Iron & Steel Co. Ltd. Shanghai Special Casting Engineering Technology Research Center

The study of controlled rolling/controlled cooling process parameters which affect the microstructure and mechanical properties of a novel pipeline steel has been optimized by the orthogonal experiment with four factors and three levels in this paper. However, the parameters of thermo-mechanical control process （TMCP） optimized by the Gleeble-3500 hot simulator could not satisfy performance requirements of the X100 pipeline steel. In order to improve the performance of this steel, the influence of finish cooling temperature （FCT） on the microstructure and property is studied in detail. It is found that, as this steel is thermo-mechanically treated by this set of parameters （the start heating temperature, finish rolling temperature （FRT）, FCT and cooling rate of 1,180 ℃, 810 ℃, 350 ℃ and 35 ℃/s, respectively）, the micro- structures are mainly composed of granular bainite （GB） and acicular ferrite （AF）. The effective grain sizes are below 20 μm; the steel reaches the optimal balance between the strength and the toughness; the yield strength is 695 MPa; the tensile strength is 768 MPa; the elongation is 16.6 %; the impact energy is 262 J at room temperature. All indexes could meet the requirements of X100 pipeline steel.

关键词： Controlled rolling/controlled cooling Finishcooling temperature （FCT） Microstructure ~ Mechanicalproperties X100 pipeline steel

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